Fatigue crack growth under active cycling conditions is simulated using the cohesive zone modeling concept within the framework of the Finite Element Method. To this end, a cyclic cohesive zone model based on a damage evolution equation is extended onto the case of transient thermal loading conditions and is implemented into ANSYS. The thermal and mechanical interaction of the cohesive surfaces is taken into account for both open and closed crack states. By incorporating the temperature dependence of the cohesive zone model parameters, the model is also extended onto cases of nonisothermal fatigue. To speed-up fatigue simulations, the cyclic cohesive zone model is equipped with the cycle jump technique based on direct iteration of the damage evolution equation. The implemented thermomechanical cyclic cohesive zone model is applied to a problem of interfacial debonding between two layers of a power metallization stack subjected to the active thermal cycling.