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Sheet 1




                    Analysis of the progress
                of an antibiotic therapy to control
          the typical symptoms of the Lyme borreliosis
                     infection of G. Torbohm
Sheet 2

          The meaning of the following numbers
              0 = no symptoms

              1 = low symptoms

              2 = constant mild symptoms

              3 = constant symptoms

              4 = constant strong Symptoms

              5 = deep impact on ability to work

              6 = heavy impact on ability to anything

              7 = etc…
Sheet 3 Data basis for the following analysis of progress in a case of Lyme
          borreliosis.              February 2009

Symptoms of Gunnar Torbohm
Day:                                 1     2     3     4     5     6     7     8     9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28
Arthritis in knees, elbows etc.      2     3     4     3     3     4     3     4     2     3     3     2     3     2     3     3     4     5     5     4     3     2     1     0     0     0     0     0
Stiff or painful neck                3     3     2     2     2     3     3     2     2     3     3     3     2     2     2     3     2     2     2     2     3     3     2     2     1     1     1     1
Meningitis infection                 4     4     3     3     3     4     3     3     3     3     3     4     3     3     3     3     3     4     3     3     3     2     2     1     1     1     1     1
Constant headache                    4     4     3     3     3     4     4     3     3     3     4     4     3     3     3     4     5     5     4     4     3     2     1     0     0     0     0     0
Missing ability to concentrate       2     4     2     1     1     4     4     1     1     1     3     2     1     1     2     0     2     4     4     4     3     1     0     0     0     0     0     0
Brain fog                            2     4     2     1     1     4     4     1     1     1     3     2     1     1     2     0     2     4     4     4     3     1     0     0     0     0     0     0
Fatigue                              2     3     2     2     3     3     2     2     3     3     2     2     2     3     2     2     5     5     5     3     2     2     1     0     0     0     0     0
Missing energy in the morning        0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0
Numbness in face/extremities         0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0
Conjunctivitis night + morning       4     3     3     4     4     3     3     4     4     4     3     3     4     3     3     4     5     5     6     5     4     4     2     2     2     2     2     2
Irritable bladder                    2     2     2     2     2     2     2     2     2     2     2     2     2     2     2     2     3     4     4     4     4     4     4     4     4     4     4     4
Constant pain in liver               3     3     3     2     2     2     1     1     2     2     2     3     2     2     2     2     3     3     2     1     0     0     0     0     0     0     0     0
Muscle pain or cramps                0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     1     3     4     4     4     3     3     2     0     0     0     0     0
Pain in prostate gland               2     2     1     1     1     2     2     1     1     2     2     1     1     2     1     1     2     2     2     3     3     4     4     4     3     3     3     2
Quality of sleep in the night        0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0
Verbal competencies                  0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0
Missing energy during day            4     0     0     3     3     4     3     2     4     3     2     2     0     2     4     2     5     4     5     5     4     3     4     3     3     2     1     1
Tachycardia; racing heart at night   2     2     2     2     1     1     1     1     2     2     2     1     1     1     2     2     3     3     3     3     2     2     2     2     1     1     0     0
Bone pain, joint pain                2     2     3     2     2     2     3     3     2     2     2     3     2     2     2     2     4     5     4     3     2     1     0     0     0     0     0     0
Pain in the region of the heart      0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0
Shortness of breath                  0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0
Serious stomach problems             0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     5     5     3     1
Fungal infection                     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     2     3     4     3     2     1
Therapy 1                                                                                                                       Doxycycline 400 mg/d, 2X2, 9:00am/9:00pm
                                                       Nothing at all for about 24 months
Therapy 2                                                                                                                      Fluconazol 200mg/d              X X
Accumulation                         38 39 32 31 31 42 38 30 32 34 36 34 27 29 33 31 51 59 57 52 42 34 26 21 24 22 17 13
Specials                                                                                                                       A                       B                                   C
                                           Mo.




                                                                                     Mo.




                                                                                                                               Mo.




                                                                                                                                                                         Mo.
                                                             Do.




                                                                                                       Do.




                                                                                                                                                 Do.




                                                                                                                                                                                           Do.
                                                       Mi.




                                                                                                 Mi.




                                                                                                                                           Mi.




                                                                                                                                                                                     Mi.
                                                                                                                         So.




                                                                                                                                                                   So.
                                     So.




                                                                               So.
                                                 Di.




                                                                         Sa.



                                                                                           Di.




                                                                                                                                     Di.




                                                                                                                                                                               Di.




                                                                                                                                                                                                       Sa.
                                                                                                                   Sa.




                                                                                                                                                             Sa.
                                                                   Fr.




                                                                                                             Fr.




                                                                                                                                                       Fr.




                                                                                                                                                                                                 Fr.
Day of the week:
Sheet 4                     Data basis for the following analysis of progress in a case of Lyme
                            borreliosis.                March 2009

Symptoms of G. Torbohm
Day:                                 1     2     3     4     5     6     7     8     9     10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31
Arthritis in knees, elbows etc.      1     1     1     1     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0
Stiff or painful neck                1     1     1     1     1     1     0     0     0     0     1     1     1     1     2     2     2     2     2     1     1     1     1     1     2     3     3     2     2     2     2
Meningitis infection                 1     1     1     1     1     1     1     1     2     2     2     2     3     3     3     3     3     3     3     2     2     2     2     2     3     4     4     4     3     2     3
Constant headache                    0     0     0     0     0     0     0     0     1     1     1     1     1     1     1     1     1     1     1     1     1     1     1     2     2     2     2     2     2     1     1
Missing ability to concentrate       0     0     0     0     0     0     0     0     0     0     1     1     2     2     2     2     2     2     2     2     1     1     1     0     1     2     2     2     1     0     1
Brain fog                            0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     1     2     2     2     1     0     0
Fatigue                              0     0     0     0     0     0     0     0     0     3     3     1     0     0     0     0     0     0     0     0     0     0     0     0     1     2     2     2     1     0     0
Missing energy in the morning        0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0
Numbness in face/extremities         0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0
Conjunctivitis night + morning       1     1     1     1     1     1     1     1     1     1     1     1     1     1     1     1     1     1     1     1     1     1     1     1     1     1     1     1     1     1     1
Irritable bladder                    4     3     2     2     1     1     1     1     1     1     1     0     0     0     0     0     0     0     0     0     0     0     0     0     1     1     2     2     2     1     1
Constant pain in liver               0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0
Muscle pain or cramps                0     0     0     0     0     0     4     2     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0
Pain in prostate gland               2     1     1     1     1     1     1     1     1     1     0     0     0     1     0     0     1     0     0     1     0     0     0     0     1     2     1     0     0     1     1
Quality of sleep in the night        0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0
Verbal competencies                  0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0
Missing energy during day            1     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     1     2     2     2     2     2     1     0     0
Tachycardia; racing heart at night   0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     2     2     2     1     2
Bone pain, joint pain                0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0
Pain in the region of the heart      0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     1     1     1     1     1     2
Shortness of breath                  0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0
Serious stomach problems             2     3     4     4     0     0     0     0     0     0     0     0     0     0     0     0     0     1     0     0     1     0     1     0     0     0     0     0     0     1     1
Fungal infection                     1     0     0     0     0     0     0     0     2     3     3     2     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     0     ?     ?
Therapie 1                            2X200 mg/d ----------Doxycycline 300 mg/d                                    3X1------------                2 X 200 mg/d Doxycycline 9:00am/9:00pm
Therapie 2                           Fluconazol 100mg/d !!!           X X
accumulation                         14 11 11 11             5     5     8     6     8     12 11       7     8     9     9     9     10 10 9 8 7 6 8 8                               15 22 23 21 15                7     6
specials                                               D           E                       F                                   G       Photo-toxic-reaction on the nose                          H
                                           Mo.




                                                                                                                                                                         Mo.




                                                                                                                                                                                                                   Mo.
                                                                                     Mo.




                                                                                                                               Mo.
                                                             Do.




                                                                                                       Do.




                                                                                                                                                 Do.




                                                                                                                                                                                           Do.
                                                       Mi.




                                                                                                                                           Mi.




                                                                                                                                                                                     Mi.
                                                                                                 Mi.




                                                                                                                         So.
                                     So.




                                                                               So.




                                                                                                                                                                   So.




                                                                                                                                                                                                             So.
                                                                         Sa.




                                                                                                                                                                                                       Sa.
                                                 Di.




                                                                                           Di.




                                                                                                                   Sa.



                                                                                                                                     Di.




                                                                                                                                                             Sa.



                                                                                                                                                                               Di.




                                                                                                                                                                                                                         Di.
                                                                   Fr.




                                                                                                             Fr.




                                                                                                                                                       Fr.




                                                                                                                                                                                                 Fr.
day of the week:
Sheet 5                         Data basis for the following analysis of progress in a case of Lyme
                                borreliosis                 April 2009
Symptoms of G. Torbohm
day:                                 1     2     3     4     5     6     7     8     9     10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30
Arthritis in knees, elbows etc.      1     1     1     1     1 1 1 1 1 1                         1     1     1     1     1     1     1     1
Stiff or painful neck                2     2     2     2     2 2 2 2 2 2                         2     2     2     2     2     2     2     2
Meningitis infection                 3     2     2     2     2 2 2 2 2 2                         2     2     2     2     2     2     2     2
Constant headache                    2     2     2     2     1 1 1 1 2 2                         2     1     1     2     2     2     2     2
Missing ability to concentrate       1     1     0     0     0 0 0 0 0 0                         0     0     0     0     0     0     0     0
Brain fog                            0     0     0     0     0 0 0 0 0 0                         0     0     0     0     0     0     0     0
Fatigue                              4     2     0     0     2 1 0 0 2 0                         0     0     2     0     2     2     0     2
Missing energy in the morning        0     0     0     0     0 0 0 0 0 0                         0     0     0     0     0     0     0     0
Numbness in face/extremities         0     0     0     0     0 0 0 0 0 0                         0     0     0     0     0     0     0     0
Conjunctivitis night + morning       1     1     1     1     1 1 1 1 1 1                         1     1     1     1     1     1     1     1
Irritable bladder                    1     1     1     1     1 0 0 0 1 1                         1     0     0     0     1     1     1     0
Constant pain in liver               0     0     1     1     1 1 0 0 1 0                         0     1     1     0     0     1     1     1
Muscle pain or cramps                0     0     0     0     0 0 0 0 0 0                         0     0     0     0     0     0     0     0
Pain in prostate gland               1     1     1     1     1 1 1 1 1 1                         1     1     1     1     1     1     1     1
Quality of sleep in the night        0     0     0     0     0 0 0 0 0 0                         0     0     0     0     0     0     0     0
Verbal competencies                  0     0     0     0     0 0 0 0 0 0                         0     0     0     0     0     0     0     0
Missing energy during day            2     1     0     0     0 0 0 0 2 0                         0     2     2     0     0     2     2     1
Tachycardia; racing heart at night   2     1     0     0     0 0 0 0 0 0                         0     0     0     0     0     0     0     0
Bone pain, joint pain                0     0     0     0     0 0 0 0 0 0                         0     0     0     0     0     0     0     0
Pain in the region of the heart      2     2     1     0     0 0 0 0 0 0                         0     0     0     0     0     0     0     0
Shortness of breath                  0     0     0     0     0 0 0 0 0 0                         0     0     0     0     0     0     0     0
Serious stomach problems             4     3     2     1     0 0 0 0 1 1                         0     1     1     1     1     0     0     0
Fungal infection                     ?     ?     ?     ?     ? ? ? 0 0 0                         0     0     0     0     0     0     0     0
Therapie 1                                                     Doxycycline 400mg
Therapie 2 Fluconazol                                        X             X X                   X X                                                    .
accumulation                         17 13 10 10 11 10                    8     8 14        9     9 11 13           9 11 14 12 13
specials                                                     I
                                                                   Mo.




                                                                                                             Mo.




                                                                                                                                                       Mo.




                                                                                                                                                                                                 Mo.
                                           Do.




                                                                                     Do.




                                                                                                                               Do.




                                                                                                                                                                         Do.




                                                                                                                                                                                                                   Do.
                                                                                                                                                                   Mi.




                                                                                                                                                                                                             Mi.
                                     Mi.




                                                                               Mi.




                                                                                                                         Mi.




                                                                                                                                                 So.




                                                                                                                                                                                           So.
                                                             So.




                                                                                                       So.
                                                       Sa.




                                                                                                 Sa.
                                                                         Di.




                                                                                                                   Di.




                                                                                                                                           Sa.



                                                                                                                                                             Di.




                                                                                                                                                                                     Sa.



                                                                                                                                                                                                       Di.
                                                                                           Fr.




                                                                                                                                     Fr.




                                                                                                                                                                               Fr.
                                                 Fr.




day of the week:
Sheet 6                      Specials
A:        Start of Doxycycline 300-400 mg a day.

B:        4 days in bed, sleeping, strong pains, poor concentration…

C:        Symptoms of fungal infection

D:         Serious stomach problems  change from 400 (2X2) to 300 mg
(100X3)!!!

E:        First time dancing after 15 jeers

F:        Symptoms of fungal infection

G:        Photo-toxic-reaction on the nose

H:        2 days in bed, sleeping, strong pains, poor concentration…

I:        There is a microbiological, scientific explanation behind the rest of the
          symptoms!?
Sheet 7 - Overview without further information
    Graphic analysis of a therapy period with Doxicycline under the
    Diagnosis of a Lyme disease infection of Mr G. Torbohm starting on
    the16th February 2009.


                                       Serie1




                    A B       C         D       E   F                    H



1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 31 33 35 37 39 41 43 45 47 49 51 53 55 57 59
Sheet 8 - The level of Doxicycline and the progress of the symptoms
 Graphic analysis of a therapy period with Doxicycline under the Diagnosis
 of a Lyme disease infection of Mr G. Torbohm starting on 16 February
 2009.

                Start
                                                Serie1

                                 February       March 09



                        2 X 200 mg Doxycyclin / d   3 X 100 mg Doxycyclin / d   2 X 200 mg Doxycyclin / d




1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 31 33 35 37 39 41 43 45 47 49 51 53 55 57 59
Sheet 9 - Moments of a rising level in the symptoms
       Graphic analysis of a therapy period with Doxicycline under the
       Diagnosis of a Lyme disease infection of Mr G. Torbohm starting on
       16 February 2009.

                                           Serie1


                    Start


                                February   March 09




                            ?      ?                  ?                     ?

1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 31 33 35 37 39 41 43 45 47 49 51 53 55 57 59
Sheet 10 Explanations of the rising level of symptoms
    Graphic analysis of a therapy period with Doxicycline under the Diagnosis
    of a Lyme disease infection of Mr G. Torbohm starting on 16 February
    2009.

                                               Serie1


                    Start


                                   February    March 09                Why is the progress stopping ?



                    Herxheimer-                           Fluconazol
                      Reaction                                                                 ?
                                                        Disco

                                  Fluconazol




1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 31 33 35 37 39 41 43 45 47 49 51 53 55 57 59
Sheet 11 - Overview of progress without further information
      from the16th February to the 18th of April 2009.

      The Question is how to deal with the rest of the symptoms while
      taking a high doses of oral Doxicycline?




                                                        ?


       February                       March                         April

1   4 7 10 13 16 19 22 25 28 31 34 37 40 43 46 49 52 55 58 61 64 67 70 73 76
Sheet 12




           The current treatment started after two
           years without any pharmaceutics therapy
           at all.
           Lets have a closer look on some of the
           symptoms at the beginning of the therapy
           and their response to Doxycycline.
The beginning of the therapy cycle on the 16the of February 09.
Sheet 13
                      The red arrow represents the progress in a short form 
Symptoms of: Gunnar Torbohm
Day:                     1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28
Arthritis in knees,
elbows etc.
                        2 3 4 3 3 4 3 4 2 3 3 2 3 2 3 3 4 5 5 4 3 2 1 0 0 0 0 0                               ?

Stiff or painful neck   3 3 2 2 2 3 3 2 2 3 3 3 2 2 2 3 2 2 2 2 3 3 2 2 1 1 1 1                               ?

Meningitis infection    4 4 3 3 3 4 3 3 3 3 3 4 3 3 3 3 3 4 3 3 3 2 2 1 1 1 1 1                               ?

Constant headache       4 4 3 3 3 4 4 3 3 3 4 4 3 3 3 4 5 5 4 4 3 2 1 0 0 0 0 0                               ?
Missing ability to                                                                                            ?
concentrate
                        2 4 2 1 1 4 4 1 1 1 3 2 1 1 2 0 2 4 4 4 3 1 0 0 0 0 0 0
Fatigue                 2 3 2 2 3 3 2 2 3 3 2 2 2 3 2 2 5 5 5 3 2 2 1 0 0 0 0 0                               ?
Conjunctivitis night +                                                                                        ?
morning
                       4 3 3 4 4 3 3 4 4 4 3 3 4 3 3 4 5 5 6 5 4 4 2 2 2 2 2 2

Constant pain in liver 3 3 3 2 2 2 1 1 2 2 2 3 2 2 2 2 3 3 2 1 0 0 0 0 0 0 0 0                                ?
Muscle pain or                                                                                                ?X
cramps
                        0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 3 4 4 4 3 3 2 0 0 0 0 0
Pain in prostate                                                                                              ?
gland
                        2 2 1 1 1 2 2 1 1 2 2 1 1 2 1 1 2 2 2 3 3 4 4 4 3 3 3 2
Missing energy                                                                                                ?
during day
                        4 0 0 3 3 4 3 2 4 3 2 2 0 2 4 2 5 4 5 5 4 3 4 3 3 2 1 1

Bone pain, joint pain 2 2 3 2 2 2 3 3 2 2 2 3 2 2 2 2 4 5 4 3 2 1 0 0 0 0 0 0                                 ?

Accumulation            38 39 32 31 31 42 38 30 32 34 36 34 27 29 33 31 51 59 57 52 42 34 26 21 24 22 17 13    
Sheet 14




           Lets have a closer look to the symptoms
           are left under a powerful Doxycycline
           therapy and their location in the different
           body systems after about 60 Days of
           treatment.
Sheet 15
               The red arrow represents the progress in a short form.
               The X symbolises a non significant progress of a symptom.
 Symptoms of: Gunnar Torbohm in April 2009
 Day:                     1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28
 Arthritis in knees, etc. 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 
 Stiff or painful neck    2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2                                         ?
 Meningitis infection         3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2                                     ?
 Constant headache            2 2 2 2 1 1 1 1 2 2 2 1 1 2 2 2 2 2                                     ?
 Concentration                1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0X
 Fatigue                      4 2 0 0 2 1 0 0 2 0 0 0 2 0 2 2 0 2                                     ?
 Conjunctivitis               1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1                                     ?
 Constant pain in liver       0 0 1 1 1 1 0 0 1 0 0 1 1 0 0 1 1 1                                     ?
 Muscle pain or cramps        0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0X
 Pain in prostate gland       1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1                                     ?
 Missing energy during                                                                                 ?
                              2 1 0 0 0 0 0 0 2 0 0 2 2 0 0 2 2 1 
 day
 Bone pain, joint pain        0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0X
 Accumulation                 17 13 10 10 11 10 8 8 14 9 9 11 13 9 11 14 12 13 
Sheet 16

          It seems that some of the persistent
    symptoms are related to the brain-blood-barrier.
    This also explains the symptoms in the prostate
               gland and the conjunctivitis!

         Nervous system                         Joints
     •     Stiff or painful neck       •   Arthritis in knees, etc.
     •     Meningitis infection        •   Stiff or painful neck
     •     Constant headache
     •     Fatigue
     •     Conjunctivitis
     •     Pain in prostate gland
     •     Missing energy during day
Sheet 17



             To me there occur two questions
           I would like to ask you as my doctor.

                 Is there evident research on
          the effectiveness of different antibiotics
       and their concentrations including Doxycycline
           to eradicate different genospecies of
              Borrelia burgdorferi sensu lato?
                               &
           How to get a constant and significant
          influence on the persisting symptoms?
Sheet 18

           The answer to the first question is yes:

           The Dissertation of Dr. Martin Sicklinger
             analyses the in-vitro-sensitivity of
               Borrelia burgdorferi sensu lato
              against four different Antibiotics.

               A comparison of genospecies
                        Borrelia afzelii,
                      Borrelia garinii and
              Borrelia burgdorferi sensu stricto.


                  University of Munich 2006
Sheet 19

  Abstract of this Dissertation
  •Amoxicillin was especially effective against Borrelia
  burgdorferi sensu stricto,
  •Azithromycin showed very good results against
  Borrelia garinii,
  •while Borrelia afzelii reacted very sensitive to
  Ceftriaxon.
  •Doxycycline showed evidently worse results in this
  in-vitro-test and on top of that the highest range of
  clusters in the test results.
Sheet 20




       The answer to the second question is still open.

 Please give me advise about the next steps of treatment.


                          Dr. Powell
       New Hayesbank Surgery, Bybrook, Kennington,
                   Ashford, Kent, TN24 9JZ
is still open to support my therapy and asks for advice too.

It would be helpful if you could send a short letter of advice.

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Bevor get labeled as ME patient 2009

  • 1. Sheet 1 Analysis of the progress of an antibiotic therapy to control the typical symptoms of the Lyme borreliosis infection of G. Torbohm
  • 2. Sheet 2 The meaning of the following numbers 0 = no symptoms 1 = low symptoms 2 = constant mild symptoms 3 = constant symptoms 4 = constant strong Symptoms 5 = deep impact on ability to work 6 = heavy impact on ability to anything 7 = etc…
  • 3. Sheet 3 Data basis for the following analysis of progress in a case of Lyme borreliosis. February 2009 Symptoms of Gunnar Torbohm Day: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 Arthritis in knees, elbows etc. 2 3 4 3 3 4 3 4 2 3 3 2 3 2 3 3 4 5 5 4 3 2 1 0 0 0 0 0 Stiff or painful neck 3 3 2 2 2 3 3 2 2 3 3 3 2 2 2 3 2 2 2 2 3 3 2 2 1 1 1 1 Meningitis infection 4 4 3 3 3 4 3 3 3 3 3 4 3 3 3 3 3 4 3 3 3 2 2 1 1 1 1 1 Constant headache 4 4 3 3 3 4 4 3 3 3 4 4 3 3 3 4 5 5 4 4 3 2 1 0 0 0 0 0 Missing ability to concentrate 2 4 2 1 1 4 4 1 1 1 3 2 1 1 2 0 2 4 4 4 3 1 0 0 0 0 0 0 Brain fog 2 4 2 1 1 4 4 1 1 1 3 2 1 1 2 0 2 4 4 4 3 1 0 0 0 0 0 0 Fatigue 2 3 2 2 3 3 2 2 3 3 2 2 2 3 2 2 5 5 5 3 2 2 1 0 0 0 0 0 Missing energy in the morning 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Numbness in face/extremities 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Conjunctivitis night + morning 4 3 3 4 4 3 3 4 4 4 3 3 4 3 3 4 5 5 6 5 4 4 2 2 2 2 2 2 Irritable bladder 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 4 4 4 4 4 4 4 4 4 4 4 Constant pain in liver 3 3 3 2 2 2 1 1 2 2 2 3 2 2 2 2 3 3 2 1 0 0 0 0 0 0 0 0 Muscle pain or cramps 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 3 4 4 4 3 3 2 0 0 0 0 0 Pain in prostate gland 2 2 1 1 1 2 2 1 1 2 2 1 1 2 1 1 2 2 2 3 3 4 4 4 3 3 3 2 Quality of sleep in the night 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Verbal competencies 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Missing energy during day 4 0 0 3 3 4 3 2 4 3 2 2 0 2 4 2 5 4 5 5 4 3 4 3 3 2 1 1 Tachycardia; racing heart at night 2 2 2 2 1 1 1 1 2 2 2 1 1 1 2 2 3 3 3 3 2 2 2 2 1 1 0 0 Bone pain, joint pain 2 2 3 2 2 2 3 3 2 2 2 3 2 2 2 2 4 5 4 3 2 1 0 0 0 0 0 0 Pain in the region of the heart 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Shortness of breath 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Serious stomach problems 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 3 1 Fungal infection 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 3 4 3 2 1 Therapy 1 Doxycycline 400 mg/d, 2X2, 9:00am/9:00pm Nothing at all for about 24 months Therapy 2 Fluconazol 200mg/d X X Accumulation 38 39 32 31 31 42 38 30 32 34 36 34 27 29 33 31 51 59 57 52 42 34 26 21 24 22 17 13 Specials A B C Mo. Mo. Mo. Mo. Do. Do. Do. Do. Mi. Mi. Mi. Mi. So. So. So. So. Di. Sa. Di. Di. Di. Sa. Sa. Sa. Fr. Fr. Fr. Fr. Day of the week:
  • 4. Sheet 4 Data basis for the following analysis of progress in a case of Lyme borreliosis. March 2009 Symptoms of G. Torbohm Day: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 Arthritis in knees, elbows etc. 1 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Stiff or painful neck 1 1 1 1 1 1 0 0 0 0 1 1 1 1 2 2 2 2 2 1 1 1 1 1 2 3 3 2 2 2 2 Meningitis infection 1 1 1 1 1 1 1 1 2 2 2 2 3 3 3 3 3 3 3 2 2 2 2 2 3 4 4 4 3 2 3 Constant headache 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 1 1 Missing ability to concentrate 0 0 0 0 0 0 0 0 0 0 1 1 2 2 2 2 2 2 2 2 1 1 1 0 1 2 2 2 1 0 1 Brain fog 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2 2 2 1 0 0 Fatigue 0 0 0 0 0 0 0 0 0 3 3 1 0 0 0 0 0 0 0 0 0 0 0 0 1 2 2 2 1 0 0 Missing energy in the morning 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Numbness in face/extremities 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Conjunctivitis night + morning 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Irritable bladder 4 3 2 2 1 1 1 1 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 2 2 2 1 1 Constant pain in liver 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Muscle pain or cramps 0 0 0 0 0 0 4 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Pain in prostate gland 2 1 1 1 1 1 1 1 1 1 0 0 0 1 0 0 1 0 0 1 0 0 0 0 1 2 1 0 0 1 1 Quality of sleep in the night 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Verbal competencies 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Missing energy during day 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2 2 2 2 2 1 0 0 Tachycardia; racing heart at night 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 1 2 Bone pain, joint pain 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Pain in the region of the heart 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 2 Shortness of breath 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Serious stomach problems 2 3 4 4 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 1 0 0 0 0 0 0 1 1 Fungal infection 1 0 0 0 0 0 0 0 2 3 3 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ? ? Therapie 1 2X200 mg/d ----------Doxycycline 300 mg/d 3X1------------ 2 X 200 mg/d Doxycycline 9:00am/9:00pm Therapie 2 Fluconazol 100mg/d !!! X X accumulation 14 11 11 11 5 5 8 6 8 12 11 7 8 9 9 9 10 10 9 8 7 6 8 8 15 22 23 21 15 7 6 specials D E F G Photo-toxic-reaction on the nose H Mo. Mo. Mo. Mo. Mo. Do. Do. Do. Do. Mi. Mi. Mi. Mi. So. So. So. So. So. Sa. Sa. Di. Di. Sa. Di. Sa. Di. Di. Fr. Fr. Fr. Fr. day of the week:
  • 5. Sheet 5 Data basis for the following analysis of progress in a case of Lyme borreliosis April 2009 Symptoms of G. Torbohm day: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 Arthritis in knees, elbows etc. 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Stiff or painful neck 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 Meningitis infection 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 Constant headache 2 2 2 2 1 1 1 1 2 2 2 1 1 2 2 2 2 2 Missing ability to concentrate 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Brain fog 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Fatigue 4 2 0 0 2 1 0 0 2 0 0 0 2 0 2 2 0 2 Missing energy in the morning 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Numbness in face/extremities 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Conjunctivitis night + morning 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Irritable bladder 1 1 1 1 1 0 0 0 1 1 1 0 0 0 1 1 1 0 Constant pain in liver 0 0 1 1 1 1 0 0 1 0 0 1 1 0 0 1 1 1 Muscle pain or cramps 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Pain in prostate gland 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Quality of sleep in the night 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Verbal competencies 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Missing energy during day 2 1 0 0 0 0 0 0 2 0 0 2 2 0 0 2 2 1 Tachycardia; racing heart at night 2 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Bone pain, joint pain 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Pain in the region of the heart 2 2 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Shortness of breath 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Serious stomach problems 4 3 2 1 0 0 0 0 1 1 0 1 1 1 1 0 0 0 Fungal infection ? ? ? ? ? ? ? 0 0 0 0 0 0 0 0 0 0 0 Therapie 1 Doxycycline 400mg Therapie 2 Fluconazol X X X X X . accumulation 17 13 10 10 11 10 8 8 14 9 9 11 13 9 11 14 12 13 specials I Mo. Mo. Mo. Mo. Do. Do. Do. Do. Do. Mi. Mi. Mi. Mi. Mi. So. So. So. So. Sa. Sa. Di. Di. Sa. Di. Sa. Di. Fr. Fr. Fr. Fr. day of the week:
  • 6. Sheet 6 Specials A: Start of Doxycycline 300-400 mg a day. B: 4 days in bed, sleeping, strong pains, poor concentration… C: Symptoms of fungal infection D: Serious stomach problems  change from 400 (2X2) to 300 mg (100X3)!!! E: First time dancing after 15 jeers F: Symptoms of fungal infection G: Photo-toxic-reaction on the nose H: 2 days in bed, sleeping, strong pains, poor concentration… I: There is a microbiological, scientific explanation behind the rest of the symptoms!?
  • 7. Sheet 7 - Overview without further information Graphic analysis of a therapy period with Doxicycline under the Diagnosis of a Lyme disease infection of Mr G. Torbohm starting on the16th February 2009. Serie1 A B C D E F H 1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 31 33 35 37 39 41 43 45 47 49 51 53 55 57 59
  • 8. Sheet 8 - The level of Doxicycline and the progress of the symptoms Graphic analysis of a therapy period with Doxicycline under the Diagnosis of a Lyme disease infection of Mr G. Torbohm starting on 16 February 2009. Start Serie1 February March 09 2 X 200 mg Doxycyclin / d 3 X 100 mg Doxycyclin / d 2 X 200 mg Doxycyclin / d 1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 31 33 35 37 39 41 43 45 47 49 51 53 55 57 59
  • 9. Sheet 9 - Moments of a rising level in the symptoms Graphic analysis of a therapy period with Doxicycline under the Diagnosis of a Lyme disease infection of Mr G. Torbohm starting on 16 February 2009. Serie1 Start February March 09 ? ? ? ? 1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 31 33 35 37 39 41 43 45 47 49 51 53 55 57 59
  • 10. Sheet 10 Explanations of the rising level of symptoms Graphic analysis of a therapy period with Doxicycline under the Diagnosis of a Lyme disease infection of Mr G. Torbohm starting on 16 February 2009. Serie1 Start February March 09 Why is the progress stopping ? Herxheimer- Fluconazol Reaction ? Disco Fluconazol 1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 31 33 35 37 39 41 43 45 47 49 51 53 55 57 59
  • 11. Sheet 11 - Overview of progress without further information from the16th February to the 18th of April 2009. The Question is how to deal with the rest of the symptoms while taking a high doses of oral Doxicycline? ? February March April 1 4 7 10 13 16 19 22 25 28 31 34 37 40 43 46 49 52 55 58 61 64 67 70 73 76
  • 12. Sheet 12 The current treatment started after two years without any pharmaceutics therapy at all. Lets have a closer look on some of the symptoms at the beginning of the therapy and their response to Doxycycline.
  • 13. The beginning of the therapy cycle on the 16the of February 09. Sheet 13 The red arrow represents the progress in a short form  Symptoms of: Gunnar Torbohm Day: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 Arthritis in knees, elbows etc. 2 3 4 3 3 4 3 4 2 3 3 2 3 2 3 3 4 5 5 4 3 2 1 0 0 0 0 0 ? Stiff or painful neck 3 3 2 2 2 3 3 2 2 3 3 3 2 2 2 3 2 2 2 2 3 3 2 2 1 1 1 1 ? Meningitis infection 4 4 3 3 3 4 3 3 3 3 3 4 3 3 3 3 3 4 3 3 3 2 2 1 1 1 1 1 ? Constant headache 4 4 3 3 3 4 4 3 3 3 4 4 3 3 3 4 5 5 4 4 3 2 1 0 0 0 0 0 ? Missing ability to ? concentrate 2 4 2 1 1 4 4 1 1 1 3 2 1 1 2 0 2 4 4 4 3 1 0 0 0 0 0 0 Fatigue 2 3 2 2 3 3 2 2 3 3 2 2 2 3 2 2 5 5 5 3 2 2 1 0 0 0 0 0 ? Conjunctivitis night + ? morning 4 3 3 4 4 3 3 4 4 4 3 3 4 3 3 4 5 5 6 5 4 4 2 2 2 2 2 2 Constant pain in liver 3 3 3 2 2 2 1 1 2 2 2 3 2 2 2 2 3 3 2 1 0 0 0 0 0 0 0 0 ? Muscle pain or ?X cramps 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 3 4 4 4 3 3 2 0 0 0 0 0 Pain in prostate ? gland 2 2 1 1 1 2 2 1 1 2 2 1 1 2 1 1 2 2 2 3 3 4 4 4 3 3 3 2 Missing energy ? during day 4 0 0 3 3 4 3 2 4 3 2 2 0 2 4 2 5 4 5 5 4 3 4 3 3 2 1 1 Bone pain, joint pain 2 2 3 2 2 2 3 3 2 2 2 3 2 2 2 2 4 5 4 3 2 1 0 0 0 0 0 0 ? Accumulation 38 39 32 31 31 42 38 30 32 34 36 34 27 29 33 31 51 59 57 52 42 34 26 21 24 22 17 13 
  • 14. Sheet 14 Lets have a closer look to the symptoms are left under a powerful Doxycycline therapy and their location in the different body systems after about 60 Days of treatment.
  • 15. Sheet 15 The red arrow represents the progress in a short form. The X symbolises a non significant progress of a symptom. Symptoms of: Gunnar Torbohm in April 2009 Day: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 Arthritis in knees, etc. 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1  Stiff or painful neck 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2  ? Meningitis infection 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2  ? Constant headache 2 2 2 2 1 1 1 1 2 2 2 1 1 2 2 2 2 2  ? Concentration 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0X Fatigue 4 2 0 0 2 1 0 0 2 0 0 0 2 0 2 2 0 2  ? Conjunctivitis 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1  ? Constant pain in liver 0 0 1 1 1 1 0 0 1 0 0 1 1 0 0 1 1 1  ? Muscle pain or cramps 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0X Pain in prostate gland 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1  ? Missing energy during ? 2 1 0 0 0 0 0 0 2 0 0 2 2 0 0 2 2 1  day Bone pain, joint pain 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0X Accumulation 17 13 10 10 11 10 8 8 14 9 9 11 13 9 11 14 12 13 
  • 16. Sheet 16 It seems that some of the persistent symptoms are related to the brain-blood-barrier. This also explains the symptoms in the prostate gland and the conjunctivitis! Nervous system Joints • Stiff or painful neck • Arthritis in knees, etc. • Meningitis infection • Stiff or painful neck • Constant headache • Fatigue • Conjunctivitis • Pain in prostate gland • Missing energy during day
  • 17. Sheet 17 To me there occur two questions I would like to ask you as my doctor. Is there evident research on the effectiveness of different antibiotics and their concentrations including Doxycycline to eradicate different genospecies of Borrelia burgdorferi sensu lato? & How to get a constant and significant influence on the persisting symptoms?
  • 18. Sheet 18 The answer to the first question is yes: The Dissertation of Dr. Martin Sicklinger analyses the in-vitro-sensitivity of Borrelia burgdorferi sensu lato against four different Antibiotics. A comparison of genospecies Borrelia afzelii, Borrelia garinii and Borrelia burgdorferi sensu stricto. University of Munich 2006
  • 19. Sheet 19 Abstract of this Dissertation •Amoxicillin was especially effective against Borrelia burgdorferi sensu stricto, •Azithromycin showed very good results against Borrelia garinii, •while Borrelia afzelii reacted very sensitive to Ceftriaxon. •Doxycycline showed evidently worse results in this in-vitro-test and on top of that the highest range of clusters in the test results.
  • 20. Sheet 20 The answer to the second question is still open. Please give me advise about the next steps of treatment. Dr. Powell New Hayesbank Surgery, Bybrook, Kennington, Ashford, Kent, TN24 9JZ is still open to support my therapy and asks for advice too. It would be helpful if you could send a short letter of advice.