A comprehensive presentation on Metabolism of Zinc and its clinical significance for MBBS,BDS,B.Tech,B.Pharma and Biotechnology students for self-study.

1. Metabolism of Zinc and its clinical significance
Dr. RohiniC Sane

2. Zinc Metabolism
Rohini C Sane

3. Zinc Metabolism
Highest content
↓
BODY ZINC CONTENT -2gm
SERUM ZINC LEVELS (physiological ):
100 micrograms /dl

4. Zinc Metabolism
absorption of dietary Zinc : DUODENUM
Inhibitors of absorption of dietary Zinc : Copper, Calcium ,Cobalt ,Iron, Phytates
Zinc & Copper competitors ( Zinc used in Wilson’s Disease as it decreases dietary Copper absorption in duodenum )
Zinc storage in human body : LIVER ( Metallothionein )

5. Dietary sources of Zinc:
ØDietary sources of
Zinc:
a) Beans
b) Cheese
c) Grains
d) Nuts
e) Meats

6. Functions of Zinc

7. Zinc Metabolism
qDaily dietary Requirement-
For Adults :15 mg
For children: 10 mg
qDaily dietary Requirement
increases –
Pregnancy
Lactation

8. Zinc Metabolism
vCauses of Zinc deficiency
a) Nephrotic syndrome
b) Hemolytic anemia ‘myocardial infarction’
c) Infection
d) Achrodermititis ( Zinc absorption defective )
vSymptoms of Zinc deficiency
a) Poor wound healing
b) Lesions in skin ( of mouth , nose ,fingers )
c) Spermatogenesis
d) Dermatitis/dementia / depression
e) Alopecia

9. Zinc toxicity: causes and symptoms
qZinc toxicity :
1. Welders : inhalation of Zinc oxide fumes
2. Rat poisons contain Zinc compounds
3. symptoms of Zinc toxicity :
a) Ulcer
b) Pancreatitis
c) anemia
d) vomiting
e) Pulmonary fibrosis
qsymptoms of severe of Zinc toxicity :
a) Headache
b) Fever
c) Leukocytosis
d) Anemia
e) Platelet aggregation
f) Phagocytosis

10. Zinc excess (toxicity ) and deficiency

11. Functions of Zinc
qFunctions of Zinc
1. for > 300 enzymes Zinc is a cofactor of enzymes ( LDH ,Alkaline phosphatase ,Carbonic
anhydrase , SOD , Carboxy peptidase )
2. RNA polymerase requires Zn for protein biosynthesis .
3. Extra cellular Super oxide dismutase is Zn dependent.
4. Zn –functions as an antioxidant.
5. synthesis of retinol binding protein require Zinc
6. Zinc required for immunological functions.
7. Zinc supplementation useful for treating acute diarrhea.
8. Zinc supplementation improves birth weight of babies.
9. Zinc plays important role in “ Insulin “ storage in beta pancreatic cells
10. ( commercial Protamine = Zinc insulate ) .
11. Gusten –Saliva taste sensation

12. Functions of Zinc –cofactor of RNA polymerase
RNA polymerase requires Zn for protein biosynthesis

13. Zinc –as an antioxidant
3 Extra cellular Super oxide dismutase is Zn dependent.
4. Zn –functions as an antioxidant.

14. Functions of Zinc as an antioxidant

15. Functions of Zinc as an antioxidant

16. Chaperon proteins and Zinc

17. Zinc and insulin storage in beta pancreatic cells
9. Zinc plays important role in “ Insulin “ storage in beta pancreatic cells
10. ( commercial Protamin = Zinc insulate ) .

18. Zinc as an anti -cancer agent