1. XI. Pathophysiology
Modifiable
•
Non- Modifiable
•
Environment uncovered
Gender
stock water
Bite of Aedes Aegypti
Virus penetration to skin
Virus infects and replicate inside the Langerhans cell (immunity of the skin)
Langerhans cell release interferon (to limit the spread of infection)
Infected Langerhans cells go to the lymphatic (alert the immune system)
Then goes to the circulation
Results in viremia (high level of virus in bloodstream)
Activation of immune response
Lymphocytes
Neutrophils and White blood cells
Release of pyrogen
Reset of hypothalamus
FEVER
Increase blood pressure in vessel
RASH
11