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2006: Artificial Immune Systems - The Past, The Present, And The Future?

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Leandro de Castro
Leandro de Castro

ICARIS 2006 (International Conference on Artificial Immune Systems), Instituto Gulbenkian, Portugal

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Artificial Immune Systems: The Past, the Present. And the Future? Leandro Nunes de Castro Catholic University of Santos [email_address] , Support: CNPq, FAPESP ICARIS 2006, Institute Gulbenkian, Portugal
Outline ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
What this talk is about... ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Immunology for Non-Immunologists ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Immunology for Non-Immunologists
Immunology for Non-Immunologists ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Immunology for Non-Immunologists ,[object Object]
Immunology for Non-Immunologists Innate and Adaptive Immunity
Immunology for Non-Immunologists ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Immunology for Non-Immunologists
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Immunology for Non-Immunologists
[object Object],Immunology for Non-Immunologists
[object Object],Immunology for Non-Immunologists
Some Theories and Processes Immunology for Non-Immunologists
[object Object],Immunology for Non-Immunologists
Immunology for Non-Immunologists ,[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Immunology for Non-Immunologists
Immunology for Non-Immunologists ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Immunology for Non-Immunologists ,[object Object]
[object Object],Immunology for Non-Immunologists
Part I AIS: The Past
The Early Days ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The Early Days: A Bit of History ,[object Object],[object Object],[object Object]
The Early Days: A Bit of History ,[object Object],[object Object],[object Object],[object Object],[object Object]
The Early Days: A Bit of History ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Previous Years: Some Numbers ,[object Object],34 60 2006 37 (54%) 68 2005 34 (59%) 58 2004 26 (63%) 41 2003 26 ? 2002 Acceptance Submissions ICARIS
An Immune Engineering Framework ,[object Object],[object Object],[object Object],[object Object]
The Immune Engineering Framework
Immune Engineering Framework ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Immune Engineering Framework ,[object Object],[object Object],[object Object]
Immune Engineering Framework
Immune Engineering Framework ,[object Object],[object Object],[object Object],[object Object]
Immune Engineering Framework ,[object Object],[object Object],[object Object]
Immune Engineering Framework ,[object Object],[object Object],[object Object],[object Object],[object Object]
Immune Engineering Framework ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Immune Engineering Framework ,[object Object],[object Object],[object Object],[object Object],[object Object]
Immune Engineering Framework Perform the dynamics and metadynamics of the system: how the immune cells and molecules are going to interact with each other and the antigens, and their survival Immune network Generation of a set of nonself detectors for anomaly detection Negative selection Perform the dynamics of the system: how the immune cells and molecules are going to interact with antigens Clonal selection Promote learning (adaptation) through somatic hypermutation and natural selection Affinity maturation Introduction and/or maintenance of population diversity and/or variation Somatic hypermutation Quantify affinities (match Ab-Ag; Ab-Ab) Affinity function Generation of cellular and molecular repertoires Bone-marrow models Usual Role Mechanism/Principle
Immune Engineering Framework ,[object Object],[object Object],[object Object]
Immune Engineering Framework ,[object Object],[object Object]
Immune Engineering Framework ,[object Object],[object Object]
Immune Engineering Framework ,[object Object],[object Object]
Immune Engineering Framework ,[object Object],[object Object],[object Object],[object Object]
Immune Engineering Framework ,[object Object],[object Object],[object Object],Rate of population variation Network stimulation Network suppression Death of unstimulatedelements Influx of new elements = - + -
Immune Engineering Framework ,[object Object],[object Object],Network sensitivity for the idiotype Change in antibody concentration Change in cell-surface molecules
Immune Engineering Framework ,[object Object],[object Object],For each antigen, do Clonal selection and expansion Affinity maturation Clonal interactions Clonal suppression Network construction End For Network suppression Diversity End
Part II AIS: The Present Features, Difficulties and Current Investigations
AIS: The Present ,[object Object],[object Object],[object Object],[object Object]
AIS: The Present ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
AIS: The Present ,[object Object],[object Object],[object Object],[object Object],[object Object]
AIS: The Present ,[object Object],[object Object],[object Object],[object Object],[object Object]
AIS: The Present ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Part III: And the Future?
Broadening the Viewpoint ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
And the Future? ,[object Object],[object Object],[object Object],[object Object]
And the Future? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
To Conclude… ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
References ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
References ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
References ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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2006: Artificial Immune Systems - The Past, The Present, And The Future?

  • 1. Artificial Immune Systems: The Past, the Present. And the Future? Leandro Nunes de Castro Catholic University of Santos [email_address] , Support: CNPq, FAPESP ICARIS 2006, Institute Gulbenkian, Portugal
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  • 8. Immunology for Non-Immunologists Innate and Adaptive Immunity
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  • 14. Some Theories and Processes Immunology for Non-Immunologists
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  • 21. Part I AIS: The Past
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  • 37. Immune Engineering Framework Perform the dynamics and metadynamics of the system: how the immune cells and molecules are going to interact with each other and the antigens, and their survival Immune network Generation of a set of nonself detectors for anomaly detection Negative selection Perform the dynamics of the system: how the immune cells and molecules are going to interact with antigens Clonal selection Promote learning (adaptation) through somatic hypermutation and natural selection Affinity maturation Introduction and/or maintenance of population diversity and/or variation Somatic hypermutation Quantify affinities (match Ab-Ag; Ab-Ab) Affinity function Generation of cellular and molecular repertoires Bone-marrow models Usual Role Mechanism/Principle
  • 38.
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  • 46. Part II AIS: The Present Features, Difficulties and Current Investigations
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  • 52. Part III: And the Future?
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