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IJRET: International Journal of Research in Engineering and Technology eISSN: 2319-1163 | pISSN: 2321-7308
_______________________________________________________________________________________
Volume: 02 Issue: 12 | Dec-2013, Available @ http://www.ijret.org 144
PERFORMANCE ANALYSIS OF LINKAGE LEARNING TECHNIQUES
IN GENETIC ALGORITHMS
R. Lakshmi1
, K. Vivekanandan2
1
Assistant Professor, Department of Computer Science, Pondicherry University , Puducherry, India, rlakshmiselva@yahoo.co.in
2
Professor, Department of Computer Science, Pondicherry Engineering College, Puducherry, India, k.vivekanandan@pec.edu
Abstract
One variance of Genetic Algorithms is a Linkage Learning Genetic Algorithm (LLGA) enhances the efficiencies of Simple
Genetic Algorithm (SGA) while solving NP hard Problems. Discovery of Linkage Learning Technique is an important task in GA.
Almost all existing Linkage Learning Techniques follow either random approach or probabilistic approaches. This makes repeated
passes over the population to determine the relationship between individuals. SGA with random linkage technique is simple but
may take long time to converge to the optimal solutions. This paper uses a linkage learning operator called Gene Silencing which
is an inspired mechanism from biological systems. The Gene Silencing mechanism is used to improve the linkages by preserving
the building blocks in an individual from the disruption of recombination processes such as Crossover and Mutation. It converges
quickly to the optimal solution without compromising the diversification on search spaces. To prove this phenomenon, the
Travelling Sales Person problem (TSP) has been chosen to retain the order of cities in a tour. Experiments carried out on different
TSP benchmark instances taken from TSPLIB which is a standard library for TSP problems. These benchmark instances have also
been applied on various linkage learning techniques and analyses the performance of these techniques with Gene Silencing (GS)
mechanism. The performance analysis has been made on experimental results with respect to optimal solution and convergence
speed.
Index Terms: Linkage Learning, Gene Silencing, Building Blocks, Genetic Algorithm, TSPLIB, Performance Analysis
--------------------------------------------------------------------***----------------------------------------------------------------------
1. INTRODUTION
Genetic algorithm is an adaptive heuristic search algorithm
based on the evolutionary ideas of natural selection and
genetics. Genetic Algorithms have proved to be efficient in
handling complex NP-Hard problems in the recent past. A
wide variety of Genetic Algorithms have been devised to
solve a range of problems. Genetic algorithms differ from
each other in terms of solution representation, genetic
operators used, termination criteria, etc. These existing
algorithms, in no way, mark the end of the search for a
better Genetic Algorithm, there is always a scope for further
improvement of these Genetic Algorithms.
Genetic algorithms work very well if the genes belonging to
the same building block are tightly linked together within
the chromosome. Otherwise, if these genes are spread all
over the chromosome, building blocks are very hard to be
created and easy to be destroyed by the recombination
operator. Genetic algorithms cannot perform well under
such circumstances. Traditional genetic algorithms suffer
from the linkage problem and they are unable to learn the
linkage among genes. Traditional genetic algorithms require
the users to possess prior domain knowledge of the problem
so that the genes on chromosomes can be correctly arranged
with respect to the chosen operators. When problem domain
knowledge is available, the problem can be solved easily
using traditional genetic algorithms with an appropriate
chromosome representation. However, when that knowledge
is not available, one way to handle the problem is to make
the GA capable of adapting and learning the linkages that
exist within the chromosome.
The performance of any GA is mainly based on four
parameters namely optimal solutions, convergence rate,
diversification and error rate. The performance of SGA is
enriched by adapting the linkage learning methods inside the
genetic algorithms which learns the relationships among
genes in chromosomes. There is several linkage learning
techniques available for real and binary coded genetic
algorithms. Though many linkage learning techniques like
Bayesian Optimization Algorithms (BOA) [23], Adaptive
Linkage Crossover (ADX) [1], Dependency Structure
Matrix (DSM) [10], Estimation of Distribution Algorithm
(EDA) [2], Masked Operator (MO) [17], Linkage
Identification by Non Linearity Check (LINC) for binary
chromosomes [5], Gene Silencing (GS) [9] [20] [21] is also
used to improve the linkages exist within the chromosome
of any coded representation. So far there is no any
IJRET: International Journal of Research in Engineering and Technology eISSN: 2319-1163 | pISSN: 2321-7308
_______________________________________________________________________________________
Volume: 02 Issue: 12 | Dec-2013, Available @ http://www.ijret.org 145
performance comparison made on various linkage learning
techniques. The objective of this paper is to compare the
efficiency of different linkage learning techniques with the
Gene Silencing method. The results proved effective with
Gene Silencing and are quite comparable.
In this paper linkage learning has been explored on TSP
problem. There are more than 256 solutions of various
approaches including mathematical approaches, dynamic
programming methods and evolutionary algorithms exit to
solve TSP problem. From the literature survey, it has been
already proved that solving TSP with enormous data using
mathematical models and dynamic programming approaches
are more time consuming processes. These approaches may
take years of years to return the optimal path when the data
set is huge. When genetic algorithm [24] [25] is applied, it
converges fast to return the optimal path. The linkage
learning genetic algorithm works even better when compare
to simple GA. This paper uses gene silencing mechanism to
identify the linkages in a chromosome. In the experiments,
TSP benchmark instances from TSPLIB library have been
used on various linkage learning techniques.
The organization of this paper is as follows: Section 2
discusses the brief study of various linkage learning
techniques. Section 3 discusses the experimental results and
the performance analysis and Section 4 concludes the paper.
2. LINKAGE LEARNING TECHNIQUES
Linkage learning techniques can be classified according to
different facets and aspects like how it can be employed in
the algorithm, representation of chromosomes etc. Linkage
problem is an ordering problem of the chromosome and
addressed to the same issue of building-block (BB)
identification or linkage learning. The success of a simple
genetic algorithm relies upon good coding scheme that puts
genes belonging to the same building blocks together on the
chromosome to provide tight linkage of building blocks.
Based on that the linkage learning techniques are classified
into the following categories:
2.1 Random Linkage Learning Techniques
Random linkage discovery is a costless, effective linkage
recognition technique which performs randomly on
chromosomes to identify the linkages. In this technique few
cities are randomly chosen from a parent and change their
loci, we get Offspring. It computes their fitness values and
compare to find the linkages on both offspring. Offspring
with higher fitness value will contain BBs and have more
chances to survive in the next generation. Selection of
highly fit individuals to the next generation is performed by
one of the selection techniques. Several linkage learning
techniques have been existing in this category such as
Inversion Operator [1], Dynamic Linkage Discovery [2]
Algorithm and so on.
2.2 Algorithmic Approaches
This is multi metric approach model, other than fitness
value it also employs extra measurements to determine the
quality (BBs) of individuals in a population. Estimation of
Distribution Algorithms (EDA), Bayesian Optimization
Algorithm (BOA), Extended Compact Genetic Algorithm
(ECGA) and the like [10] [3] [4] [7] are classified as multi
metric approaches
2.3 Binary Approaches
These approaches are more suitable for binary coded
representation. It does bitwise perturbations in individuals
and detects linkage by checking nonlinearity in the
individual caused by perturbations. Linkage Identification
by Nonlinearity Check (LINC) [5], Linkage Identification
by Monotonicity Detection (LIMD) [6], Gene Expression
Messy GA (GEMA) [4] and the like are [11] [16] more
suitable for binary coded representation.
2.4 Operator Techniques
There are several operator techniques such as Harick’s
Linkage Learning [19], Linkage Evolving Operator [2],
Local Search Method (LSM) [18], and Neighbor Affinity
Value method (NAV) [17] of uni metric approaches
available in GAs to find linkages exist within the
chromosome.
2.5 Gene Silencing Mechanism
The principles of genetic algorithm mimic the process of
natural evolution. The concept of gene silencing [9] could
be adopted in genetic algorithm as an operator where other
natural operators like crossover and mutation are already
being applied for any standard GA. Normally, crossover
operator disrupts the good building blocks, even though they
are considered to be useful to evolve good solutions. Since
gene silencing is heritable, the required genes are preserved
from the disruptions of crossover or mutation and carried
over through successive generations till the optimal solution
is reached. In TSP, Gene silencing [15] is used to preserve
the order of the cities in a tour to obtain optimal distance
and also it makes the GA to converge quickly.
3. EXPERIMENTATION AND ANALYSIS
This paper conducts an analysis on performance of Gene
Silencing and compares it with the existing Linkage learning
Techniques. The various Linkage Learning methods
IJRET: International Journal of Research in Engineering and Technology eISSN: 2319-1163 | pISSN: 2321-7308
_______________________________________________________________________________________
Volume: 02 Issue: 12 | Dec-2013, Available @ http://www.ijret.org 146
including gene silencing mechanism are implemented in
MATLAB tool on an i5 system with TSP benchmark
instances gr17, wi29, dj38, swis42, att48, eil101, qa194,
uy734, d1291, nu3496, eg7146, gr9882, d15112, d18512
obtained from the standard library TSPLIB. The following
table is one example of many which illustrate the distance
matrix for the benchmark instance gr17.
Fig -1: Intercity distance table for TSP
Table -1: 1 Experimentation Setup
Genetic Algorithm (GA)
Sl.
No.
Parameters Values
1 Population Size 100
2 Selection Tournament Selection with 10%
3 Elitism% 10%
4 Crossover
Two Point Crossover and
Partially Matched Crossover
5 Mutation Swap Mutation
6 Mutation% 5%
7 Termination
Fixed Number (10000)
generations.
Genetic Algorithm with its parameters listed above have
been applied to different linkage learning techniques such as
Local Search method (LSM), Random Linkage Method
(RLM) and Harik’s Crossover technique. Their optimized
solutions are compared with the optimized solutions of Gene
Silencing mechanism which is shown in chart 1.
For each linkage learning technique, the obtained optimal
distance of different TSP benchmark instances have been
collected from 10 runs. For various techniques, the average
case valuses are used in performance analysis.
Chart -1: Optimal Distances of TSP instances on
Different Linkage Learning Techniques
Chart -2: Optimal Distances of TSP instances on
Different Linkage Learning Techniques
The two graphs show the experimental results of different
linkage learning techniques. The chart 1 shows the shortest
distance found by Random method, local search method,
harik’s crossover method and gene silencing. The chart 2
shows the distance generated by Neighbor Affinity Value,
Linkage Evolving Operator, and Inversion Operator and
Gene Silencing operator. From the graph it is clearly proved
that the gene silencing mechanism outperforms the RLM,
LSM, HXM, NAV, LEO and IO.
CONCLUSIONS
The experimental results show that the distance (optimal
solution) for all benchmark instances obtained from gene
silencing is minimum as compared to the distance
obtained from other linkage learning techniques. In this
paper, the linkage learning techniques in the context of the
traveling salesman problem is discussed. Since crossover
and mutation will disrupt the good building blocks in
subsequent generations, a new biologically inspired
operator, Gene Silencing was applied to preserve those good
building blocks which improve the linkages in a
chromosome. A computation was made with all linkage
learning techniques for the Travelling Salesman problem.
From the results it was found that the Gene Silencing in
linkage Learning Genetic algorithm performed better than
the existing algorithms.
IJRET: International Journal of Research in Engineering and Technology eISSN: 2319-1163 | pISSN: 2321-7308
_______________________________________________________________________________________
Volume: 02 Issue: 12 | Dec-2013, Available @ http://www.ijret.org 147
REFERENCES
[1]. R Ayed A. Salman, Kishan Mehrotra, and Chilukuri
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[3]. R H. Kargupta, “Search polynomial complexity, and the
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[4]. R Kargupta, H, “The Gene Expression Messy Genetic
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[5]. M. Munetomo and D. E. Goldberg, “Identifying linkage
by non-linearity check”, IlliGAL Report No. 98012,
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[6]. M. Munetomo and D. E. Goldberg, “Linkage
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[8]. David R. Newman, “The Use of Linkage Learning in
Genetic Algorithm”.
[9]. S.Siva Sathya, S.Kuppuswami, Department of
Computer Science, Pondicherry University, “Gene
Silencing for Course Time-Tabling with Genetic
Algorithm”.
[10]. Yu, T.-L., Goldberg, D. E., Yassine, A. A., & Chen,
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theory: Pilot study of a dependency structure matrix driven
genetic algorithm”, in Proceedings of Artificial Neural
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[12]. Oliver Kramer, Patrick Koch, “Self-Adaptive Partially
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[13]. Chen., “A Text book of Fundamentals of
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Performance analysis of linkage learning techniques

  • 1. IJRET: International Journal of Research in Engineering and Technology eISSN: 2319-1163 | pISSN: 2321-7308 _______________________________________________________________________________________ Volume: 02 Issue: 12 | Dec-2013, Available @ http://www.ijret.org 144 PERFORMANCE ANALYSIS OF LINKAGE LEARNING TECHNIQUES IN GENETIC ALGORITHMS R. Lakshmi1 , K. Vivekanandan2 1 Assistant Professor, Department of Computer Science, Pondicherry University , Puducherry, India, rlakshmiselva@yahoo.co.in 2 Professor, Department of Computer Science, Pondicherry Engineering College, Puducherry, India, k.vivekanandan@pec.edu Abstract One variance of Genetic Algorithms is a Linkage Learning Genetic Algorithm (LLGA) enhances the efficiencies of Simple Genetic Algorithm (SGA) while solving NP hard Problems. Discovery of Linkage Learning Technique is an important task in GA. Almost all existing Linkage Learning Techniques follow either random approach or probabilistic approaches. This makes repeated passes over the population to determine the relationship between individuals. SGA with random linkage technique is simple but may take long time to converge to the optimal solutions. This paper uses a linkage learning operator called Gene Silencing which is an inspired mechanism from biological systems. The Gene Silencing mechanism is used to improve the linkages by preserving the building blocks in an individual from the disruption of recombination processes such as Crossover and Mutation. It converges quickly to the optimal solution without compromising the diversification on search spaces. To prove this phenomenon, the Travelling Sales Person problem (TSP) has been chosen to retain the order of cities in a tour. Experiments carried out on different TSP benchmark instances taken from TSPLIB which is a standard library for TSP problems. These benchmark instances have also been applied on various linkage learning techniques and analyses the performance of these techniques with Gene Silencing (GS) mechanism. The performance analysis has been made on experimental results with respect to optimal solution and convergence speed. Index Terms: Linkage Learning, Gene Silencing, Building Blocks, Genetic Algorithm, TSPLIB, Performance Analysis --------------------------------------------------------------------***---------------------------------------------------------------------- 1. INTRODUTION Genetic algorithm is an adaptive heuristic search algorithm based on the evolutionary ideas of natural selection and genetics. Genetic Algorithms have proved to be efficient in handling complex NP-Hard problems in the recent past. A wide variety of Genetic Algorithms have been devised to solve a range of problems. Genetic algorithms differ from each other in terms of solution representation, genetic operators used, termination criteria, etc. These existing algorithms, in no way, mark the end of the search for a better Genetic Algorithm, there is always a scope for further improvement of these Genetic Algorithms. Genetic algorithms work very well if the genes belonging to the same building block are tightly linked together within the chromosome. Otherwise, if these genes are spread all over the chromosome, building blocks are very hard to be created and easy to be destroyed by the recombination operator. Genetic algorithms cannot perform well under such circumstances. Traditional genetic algorithms suffer from the linkage problem and they are unable to learn the linkage among genes. Traditional genetic algorithms require the users to possess prior domain knowledge of the problem so that the genes on chromosomes can be correctly arranged with respect to the chosen operators. When problem domain knowledge is available, the problem can be solved easily using traditional genetic algorithms with an appropriate chromosome representation. However, when that knowledge is not available, one way to handle the problem is to make the GA capable of adapting and learning the linkages that exist within the chromosome. The performance of any GA is mainly based on four parameters namely optimal solutions, convergence rate, diversification and error rate. The performance of SGA is enriched by adapting the linkage learning methods inside the genetic algorithms which learns the relationships among genes in chromosomes. There is several linkage learning techniques available for real and binary coded genetic algorithms. Though many linkage learning techniques like Bayesian Optimization Algorithms (BOA) [23], Adaptive Linkage Crossover (ADX) [1], Dependency Structure Matrix (DSM) [10], Estimation of Distribution Algorithm (EDA) [2], Masked Operator (MO) [17], Linkage Identification by Non Linearity Check (LINC) for binary chromosomes [5], Gene Silencing (GS) [9] [20] [21] is also used to improve the linkages exist within the chromosome of any coded representation. So far there is no any
  • 2. IJRET: International Journal of Research in Engineering and Technology eISSN: 2319-1163 | pISSN: 2321-7308 _______________________________________________________________________________________ Volume: 02 Issue: 12 | Dec-2013, Available @ http://www.ijret.org 145 performance comparison made on various linkage learning techniques. The objective of this paper is to compare the efficiency of different linkage learning techniques with the Gene Silencing method. The results proved effective with Gene Silencing and are quite comparable. In this paper linkage learning has been explored on TSP problem. There are more than 256 solutions of various approaches including mathematical approaches, dynamic programming methods and evolutionary algorithms exit to solve TSP problem. From the literature survey, it has been already proved that solving TSP with enormous data using mathematical models and dynamic programming approaches are more time consuming processes. These approaches may take years of years to return the optimal path when the data set is huge. When genetic algorithm [24] [25] is applied, it converges fast to return the optimal path. The linkage learning genetic algorithm works even better when compare to simple GA. This paper uses gene silencing mechanism to identify the linkages in a chromosome. In the experiments, TSP benchmark instances from TSPLIB library have been used on various linkage learning techniques. The organization of this paper is as follows: Section 2 discusses the brief study of various linkage learning techniques. Section 3 discusses the experimental results and the performance analysis and Section 4 concludes the paper. 2. LINKAGE LEARNING TECHNIQUES Linkage learning techniques can be classified according to different facets and aspects like how it can be employed in the algorithm, representation of chromosomes etc. Linkage problem is an ordering problem of the chromosome and addressed to the same issue of building-block (BB) identification or linkage learning. The success of a simple genetic algorithm relies upon good coding scheme that puts genes belonging to the same building blocks together on the chromosome to provide tight linkage of building blocks. Based on that the linkage learning techniques are classified into the following categories: 2.1 Random Linkage Learning Techniques Random linkage discovery is a costless, effective linkage recognition technique which performs randomly on chromosomes to identify the linkages. In this technique few cities are randomly chosen from a parent and change their loci, we get Offspring. It computes their fitness values and compare to find the linkages on both offspring. Offspring with higher fitness value will contain BBs and have more chances to survive in the next generation. Selection of highly fit individuals to the next generation is performed by one of the selection techniques. Several linkage learning techniques have been existing in this category such as Inversion Operator [1], Dynamic Linkage Discovery [2] Algorithm and so on. 2.2 Algorithmic Approaches This is multi metric approach model, other than fitness value it also employs extra measurements to determine the quality (BBs) of individuals in a population. Estimation of Distribution Algorithms (EDA), Bayesian Optimization Algorithm (BOA), Extended Compact Genetic Algorithm (ECGA) and the like [10] [3] [4] [7] are classified as multi metric approaches 2.3 Binary Approaches These approaches are more suitable for binary coded representation. It does bitwise perturbations in individuals and detects linkage by checking nonlinearity in the individual caused by perturbations. Linkage Identification by Nonlinearity Check (LINC) [5], Linkage Identification by Monotonicity Detection (LIMD) [6], Gene Expression Messy GA (GEMA) [4] and the like are [11] [16] more suitable for binary coded representation. 2.4 Operator Techniques There are several operator techniques such as Harick’s Linkage Learning [19], Linkage Evolving Operator [2], Local Search Method (LSM) [18], and Neighbor Affinity Value method (NAV) [17] of uni metric approaches available in GAs to find linkages exist within the chromosome. 2.5 Gene Silencing Mechanism The principles of genetic algorithm mimic the process of natural evolution. The concept of gene silencing [9] could be adopted in genetic algorithm as an operator where other natural operators like crossover and mutation are already being applied for any standard GA. Normally, crossover operator disrupts the good building blocks, even though they are considered to be useful to evolve good solutions. Since gene silencing is heritable, the required genes are preserved from the disruptions of crossover or mutation and carried over through successive generations till the optimal solution is reached. In TSP, Gene silencing [15] is used to preserve the order of the cities in a tour to obtain optimal distance and also it makes the GA to converge quickly. 3. EXPERIMENTATION AND ANALYSIS This paper conducts an analysis on performance of Gene Silencing and compares it with the existing Linkage learning Techniques. The various Linkage Learning methods
  • 3. IJRET: International Journal of Research in Engineering and Technology eISSN: 2319-1163 | pISSN: 2321-7308 _______________________________________________________________________________________ Volume: 02 Issue: 12 | Dec-2013, Available @ http://www.ijret.org 146 including gene silencing mechanism are implemented in MATLAB tool on an i5 system with TSP benchmark instances gr17, wi29, dj38, swis42, att48, eil101, qa194, uy734, d1291, nu3496, eg7146, gr9882, d15112, d18512 obtained from the standard library TSPLIB. The following table is one example of many which illustrate the distance matrix for the benchmark instance gr17. Fig -1: Intercity distance table for TSP Table -1: 1 Experimentation Setup Genetic Algorithm (GA) Sl. No. Parameters Values 1 Population Size 100 2 Selection Tournament Selection with 10% 3 Elitism% 10% 4 Crossover Two Point Crossover and Partially Matched Crossover 5 Mutation Swap Mutation 6 Mutation% 5% 7 Termination Fixed Number (10000) generations. Genetic Algorithm with its parameters listed above have been applied to different linkage learning techniques such as Local Search method (LSM), Random Linkage Method (RLM) and Harik’s Crossover technique. Their optimized solutions are compared with the optimized solutions of Gene Silencing mechanism which is shown in chart 1. For each linkage learning technique, the obtained optimal distance of different TSP benchmark instances have been collected from 10 runs. For various techniques, the average case valuses are used in performance analysis. Chart -1: Optimal Distances of TSP instances on Different Linkage Learning Techniques Chart -2: Optimal Distances of TSP instances on Different Linkage Learning Techniques The two graphs show the experimental results of different linkage learning techniques. The chart 1 shows the shortest distance found by Random method, local search method, harik’s crossover method and gene silencing. The chart 2 shows the distance generated by Neighbor Affinity Value, Linkage Evolving Operator, and Inversion Operator and Gene Silencing operator. From the graph it is clearly proved that the gene silencing mechanism outperforms the RLM, LSM, HXM, NAV, LEO and IO. CONCLUSIONS The experimental results show that the distance (optimal solution) for all benchmark instances obtained from gene silencing is minimum as compared to the distance obtained from other linkage learning techniques. In this paper, the linkage learning techniques in the context of the traveling salesman problem is discussed. Since crossover and mutation will disrupt the good building blocks in subsequent generations, a new biologically inspired operator, Gene Silencing was applied to preserve those good building blocks which improve the linkages in a chromosome. A computation was made with all linkage learning techniques for the Travelling Salesman problem. From the results it was found that the Gene Silencing in linkage Learning Genetic algorithm performed better than the existing algorithms.
  • 4. IJRET: International Journal of Research in Engineering and Technology eISSN: 2319-1163 | pISSN: 2321-7308 _______________________________________________________________________________________ Volume: 02 Issue: 12 | Dec-2013, Available @ http://www.ijret.org 147 REFERENCES [1]. R Ayed A. Salman, Kishan Mehrotra, and Chilukuri K. Mohan, “Adaptive Linkage Crossover” [2]. R Ying-ping Chen, A Survey of Linkage Learning Techniques in Genetic and Evolutionary Algorithm [3]. R H. Kargupta, “Search polynomial complexity, and the fast messy genetic algorithm. Technical Report 95008, University of Illinois at Urbana Champaign, Urbana, IL, October 1995. [4]. R Kargupta, H, “The Gene Expression Messy Genetic Algorithm”, Evolutionary Computation, Proceedings of IEEE International Conference on Volume, Issue, and 20-22 Pages: 814 – 819, May 2009. [5]. M. Munetomo and D. E. Goldberg, “Identifying linkage by non-linearity check”, IlliGAL Report No. 98012, University of Illinois at Urbana-Champaign, Urbana, IL, 2010. [6]. M. Munetomo and D. E. Goldberg, “Linkage Identification by Non – Monotonicity Detection for overlapping functions”, IlliGAL Report No.99005, University of Illinois at Urbana-Champaign, Urbana, IL, Genetic and Evolutionary Computation Conference, January 2011. [7]. Chen, Y.-p., Peng, W.-C., & Jian, M.-c, “Particle swarm optimization with recombination and dynamic linkage discovery”, IEEE Transactions on Systems, Vol. 37(6): pp.1460–1470, 2007. [8]. David R. Newman, “The Use of Linkage Learning in Genetic Algorithm”. [9]. S.Siva Sathya, S.Kuppuswami, Department of Computer Science, Pondicherry University, “Gene Silencing for Course Time-Tabling with Genetic Algorithm”. [10]. Yu, T.-L., Goldberg, D. E., Yassine, A. A., & Chen, Y.-p, “Genetic algorithm design inspired by organizational theory: Pilot study of a dependency structure matrix driven genetic algorithm”, in Proceedings of Artificial Neural Networks in Engineering, ANNIE, pp. 327–332, 2003 [11]. Jian, M.-C., & Chen, Y.-p, “Introducing recombination with dynamic linkage discovery to particle swarm optimization”, in Proceedings of ACM SIGEVO Genetic and Evolutionary Computation Conference (GECCO-2006), pp. 85–86, EI, 2006 [12]. Oliver Kramer, Patrick Koch, “Self-Adaptive Partially Mapped Crossover”, proceedings of Genetic and Evolution Computation Conference, pp. 593 – 697, ACM, July 2007. [13]. Chen., “A Text book of Fundamentals of Microbiology”. [14]. Gene Silencing Technique offers new strategy for treating,curing disease, Science Daily, 2005. [15]. Lakshmi R, Vivekanandan K. Gene Silencing in Linkage Learning Genetic Algorithm, page 2, conference proceeding of NCFC, 2012. [16]. Chen Y-P, Goldberg DE., “An analysis of a reordering operator with tournament selection on a GA-hard problem”, Lecture Notes in Computer Science (LNCS) 2003; 2723: 825–836. [17]. Corcoran AL, Roger L, Wainwright, “Reducing disruption of superior building blocks in genetic algorithms”, Proceedings of the, ACM SIGAPP Symposium on Applied Computing, Feb 2003. [18]. Ray SS, Bandyopadhyay S, Pal SK. New Operators of Genetic Algorithms for Traveling Salesman Problem, Evolutionary Computation CEC2004;2(1):1457-1464. [18]. Murata T, Miyata S. Gene Linkage Identification in Permutation Problems for Local Search and Genetic Local Search’, Systems, Man and Cybernetics. IEEE International Conference 2005; 2(10-12): 1920 – 1924. [19]. G. R. Harik, “Learning gene linkage to efficiently solve problems of bounded difficulty using Genetic Algorithms”, University of Michigan, Ann Arbor, IlliGAL Report No. 97005, 1997 [20]. R.Lakshmi et.l , “A New Biological Operator in Genetic Algorithm for Class Scheduling Problem”, International Journal of Computer Applications (0975 – 8887), Volume 60– No.12, December 2012. [21]. R.Lakshmi , K.Vivekanandan, “Interference Induced Silencing in Travelling Sales Person Problem using Linkage Learning Genetic Algorithm”, IJESR, March 2013/ Volume- 3/Issue-3/Article No-12/2670-2679 ISSN 2277-2685. [22]. Domingo Ortiz-Boyer, Cesar Hervas Martnez CIXL2: A Crossover Operator for Evolutionary Algorithms Based on Population Features. [23]. Martin pelican et.al,”BOA: The Bayesian Optimization Algorithm”, Illigal Report No.99003, jan 2009. [24]. Kalyanmoy Deb, Amarendra Kumar, “Real coded Genetic Algorithms with Simulated Binary Crossover : Studies on Multimodal and Multi objective Problems [25]. Andrej Kazakov, “Travelling Salesman Problem: Local Search and Divide and Conquer working together”, Independent Research Review, University of Southmapton, March 2009