SlideShare ist ein Scribd-Unternehmen logo
1 von 47
Futile medical care
‫المجدية‬ ‫غير‬ ‫الطبية‬ ‫الرعاية‬
Dr. Qutaiba Abdullah AlDoori
Burn & Reconstructive Surgery
AZADI Teaching Hospital
Futile medical
care
• The Word Futile• means unavailing , useless
• ‫جدوى‬ ‫ذي‬ ‫غير‬,‫تحته‬ ‫طائل‬ ‫ال‬
• unsuccessful, failing , fruitless,
• useless, ineffectual, vain, unfruitful,
unproductive,
Apoptosis and
Regeneration
Introduction
• Apoptosis ;
• (one of innate immune response)
• Apoptosis can be induced indirectly in response to
overwhelming physical injury.1
• Major burns associated with massive
inflammatory response can alter cellular
kinetics ,3
Introduction
• There is a ‘cytokine storm’ can lead to alterations
in Na+-K+ ATPases and thereby result in
electrophysiological membrane dysfunction .3
Introduction
Both
early apoptosis and delayed necrosis
are present in the zone of ischemia,
contributing to injury progression.4
• Approximately
• half {½} of the cells in the zone of
• stasis undergo apoptosis or necrosis as a result
of oxidative stress, ongoing inflammation, and
decreased blood flow due
• to microthrombosis.
• Andreas Bergmann1,* and Hermann Stelle
• Systemic factors such as advanced age, diabetes,
and other chronic illnesses increase risk for
“conversion from Partial T to FT Burn wound.”
Introduction
• calcium influx
• into the cytoplasm and triggers a subsequent
cascade leading to apoptosis.
• Greek prefix (apo) attached to a Greek stem (ptosis)
• “falling to death”
• Is it reversible ⁈ mitochondria if swell
• organelles that act like a digestive &respiratory
system in cells ,
Introduction
Futile medical care
• Is the continued provision of medical care or
treatment to a patient when there is no
reasonable hope of a cure or benefit.
• Some proponents of evidence-based
medicine suggest discontinuing the use of any
treatment that has not been shown to provide a
measurable benefit
A ‘do not
resuscitate’ (DNR)
order is not
the equivalent of a
‘do not care’ (DNC)
consideration.
Futile medical care
• Futile care is distinct from euthanasia because
• euthanasia involves active intervention to end life,
while withholding futile medical care does not
encourage or hasten the natural onset of death .
‫الشفقة‬ ‫بدافع‬ ‫قتل‬ =EEuthanasia
Arguments against providing
futile care include potential harm
to
• 1/ Patient , (Increasing duration of pain)
• 2/ Family members , (Fake hope )
• 3/ Caregivers with little or no likely
benefits,
• 4/ Diversion of resources to support the
futile care In spite to be directed to
provide care to patients that could
respond to care.
Futile medical care
• The issue of futile care in clinical medicine
generally involves two questions.
• The first concerns the identification of those
clinical scenarios where ? the care would be
futile.
• The second concerns the range of ethical options
when ? care is determined at which level of no
more improvement to be futile.
SCIENTIFIC CONSIDERATIONS
•
Pt. admitted over 7 years
(jan2012-dec.2018)
•2076 patients
1640
adult
79%
435
pediatric
21%
2076 patient over 7 years
Every three hours one child dies from a burn
related accident
@ World Health Organization /Int J Burn Trauma 2018;8(1):6-16
21%
Death
Suicides
Expected =
(435)
5%
(103)Death
un expected 2076
Total
No.
pt.
Discharged
Healthy
(1538)
74%
Number of patients over 6 years
538 dead
at hospital
Pt. admitted over 7 years (jan2012-dec.2018)
Dead patients
Sales
1st Qtr 2nd Qtr 3rd Qtr 4th Qtr
103=19%
Un expected
death,
Total death
over 7 year
538
patients
435 =81%
Expected death
Palliatve
care
Do-Not-Resuscitate Orders
• Two kinds of medical futility are often
distinguished:
• 1. Quantitative futility, where the likelihood
benefit of interventions to the patient is
exceedingly poor, (frequent dressing )
• 2. Qualitative futility, where the quality of benefit
an intervention will produce is exceedingly poor;
(isolation and surgical operations )
A ‘do not
resuscitate’ (DNR)
order is not
the equivalent of a
‘do not care’ (DNC)
consideration.
95% OF THEM
SUICIDAL
ATTEPMPT
95 % BSAB
30 Yr
17 inh inj
Baux= 142 %
probability of death
Very limited CHANCES TO SAVE patient
attempted suicide by fire
“It is futile to continue to treat this patient,”
• Futility does not apply to treatments globally, to a
patient, or to a general medical situation. Instead,
• It refers to a particular intervention at a
particular time, for a specific patient.
80 % BSAB
27 YEARS
17 INH.INJURY+
Baux =124
But
sometime
can save
those with
specific
injury
specific
age 95%
BSAB
partial
thickness
95% BSAB
17 Yr
17 inh inj
Baux =129 probability of
death
How to decide
Many
prognostic
scoring systems
are available for
burn
patients.
Lunanaut
scoring system
• Mortality
• was seen in 94%
patients with
score >200.
Jabalpur prognostic scoring system
Cut off value of score ≥12 was associated
with significantly higher mortality
General prognostic indicators
• Clinical
indicators
• Baux 1949
• ABSI Tobiasen 1982
• many others
• Specific prognostic
indicators
• Creatin kinase CK Electrical injury
• C Reactive Protien SIR
• Procalcitonin SIR
• TNF @ was suppressed in nonsurvivors. SIR
• Interleukin 8 & 10 SIR
• S. Lactate global tissue hypoxia >4 Met.Acidosis
• Erythroblast HYPOXIA
• Platelet count Reduction associated with sepsis & bad
prognosis .
The Baux Score continues to provide a
simple logical Ratio of the
Risk of mortality & Survival after
major burn injury
AGE + BSAB% (+/0 ) Inh inj 17
It is increasingly common, and it can
be give decisions by nonspecialist
about initial triage , management
planning .
But futility of care should be
made after consultation with a
specialist burn service.
30 % BSAB
40 Yr
17 inh inj
Baux= 87 %
probability of death
35 % BSAB
30 Yr
17 inh inj
Baux= 82 %
probability of death
25 % BSAB
40 Yr
17 inh inj
Baux= 82 %
probability of death
35 % BSAB
20 Yr
17 inh inj
Baux= 72 %
probability of death
20 % BSAB
30 Yr
17 inh inj
Baux= 67 %
probability of death
23 % BSAB
30 Yr
17 inh inj
Baux= 60%
probability of death
23 % BSAB
24 Yr
17 inh inj
Baux= 64 % probability
of death
First step Evaluation
Burns can be categorized into the following three main
types:
• 1• Those that can be treated with minimal efforts
• (e.g., by clean dressings and available analgesics).
• 2• Those that are not survivable without specialized
• care. Special care must be established, and success will
depend on the degree of medical care given .
Patients must be transported to facilities where
successful treatment can be performed and is funded..
• 3• Those that cannot be treated successfully even in a
specialized care centre .
• So those patients are deemed futile , and ‘comfort
care’ must be provided.
• End-of-life care
• should be a mutual and agreeable
choice by the patient/surrogate,
with the understanding by the
healthcare team that treatment
has become futile.
Palliative care
end-of-life care
• patients for whom survival is highly
unlikely.
• DIRECTED FOR
References
• 1 ] M.B. Zollo, J.C. Moskop, and C.E. Kahn Jr., “Knowing the Score: Using Predictive Scoring
• Systems in
• Clinical Practice,” American Journal of Critical Care 5 (1996): 147-150.
• 2 ] David F. Kelly, Medical Care at the End of Life: A Catholic Perspective (Washington, DC:
• Georgetown
• University Press, 2006), 42-44.
• 3 ] Osler T, Glance LG, Hosmer DW. Simplified estimates of the probability of death after burn
• injuries: extending and updating the Baux score. J Trauma. 2010;68:690–697 PubMed
• 4 ] Tobiasen J, Hiebert JH, Edlich RF. Prediction of burn mortality. Surg Gynecol Obstet.
• 1982;154:711–71PubMed
• 5 ] Gomez M, Wong DT, Stewart TE, Redelmeier DA, Fish JS. The FLAMES score
• accurately predicts mortality risk in burn patients. J Trauma. 2008;65(3):636–45.
• 6 ] Jackson DM. The treatment of burns: an exercise in emergency surgery. Ann R Coll Surg
• Engl. 1953; 13:236–57.
• 7 ] Iain Harris and Scott A. Murray, “Can Palliative Care Reduce Futile Treatment? A
• Systematic Review,”British Medical Journal of Supportive and Palliative Care 3 (2013): 389-
• 394.
• 8 ] Gerstein AD, Phillips TJ, Rogers GS, Gilchrest BA: Wound healing and aging. Dermatol
• Clin, 11(4): 749-57, 1993.
• 9 ] Hotchkiss RS, et al. Rapid onset of intestinal epithelial and lymphocyte apoptotic cell death in
• patients with trauma and shock. Crit Care Med. 2000; 28:3207–3217. [PubMed: 11008984]
• 10 ] Chen W, et al. Cytokine cascades induced by mechanical trauma injury alter voltage-gated
• sodium channel activity in intact cortical neurons. J Neuroinflammation. 2017; 14:73. [PubMed:
• 28359334]
• 11 ] Pfeifer R, Heussen N, Michalewicz E, Hilgers RD, Pape HC. Incidence of adult respiratory
• distress syndrome in trauma patients: a systematic review and meta-analysis over a period of
• three decades. J Trauma Acute Care Surg. 2017; 83:496–506. [PubMed: 28590348]
• 12 ] Levy G, et al. Parasympathetic stimulation via the vagus nerve prevents systemic organ
• dysfunction by abrogating gut injury and lymph toxicity in trauma and hemorrhagic shock.
• Shock. 2013; 39:39–44. [PubMed: 23247120]
• 13 ] Lee MA, Yatani A, Sambol JT, Deitch EA. Role of gut-lymph factors in the induction of
• burn-induced and trauma-shock-induced acute heart failure. Int J Clin Exp Med. 2008; 1:171–
• 180. [PubMed: 19079671]
• 14 ] Tiesi G, et al. Early trauma-hemorrhage-induced splenic and thymic apoptosis is gutmediated
• and toll-like receptor 4-dependent. Shock. 2013; 39:507–513. [PubMed: 23542401]
• 15 ] Sordi R, et al. Artesunate protects against the organ injury and dysfunction induced by
• severe hemorrhage and resuscitation. Ann Surg. 2017; 265:408–417. [PubMed: 28059970]
• 16 ] Shupp JW, Nasabzadeh TJ, Rosenthal DS, et al. A review of the local pathophysiologic
• bases of burn wound progression. J Burn Care Res. 2010;31(6):849-873.
• 17]Hengetal,(2015).RevisedBauxScoreandupdatedCharlsoncomorbidityindexareindependentlyas
• sociatedwithmortalityinburnsintensivecarepatients.Burns.41(7):1420-7.
• 18] Sheppard NN, Hemington-Gorse S, Shelley OP, Philp B, Dziewulski P. Prognostic scoring
• systems in burns: a review. Burns 2011;37(8):1288–95.
• 19] Wearn C et al.: Outcomes of burns in the elderly: revised estimates from the Birmingham
• Burn Centre. Burns, 41(6): 1161-8, 2015.
• 20] Thombs BD, Singh VA, Halonen J, Diallo A, Milner SM. The effects of preexisting medical
• comorbidities on mortality and length of hospital stay in acute burn injury: Evidence from a
• national sample of 31,338 adult patients. Ann Surg 2007;245:629-34.

Weitere ähnliche Inhalte

Was ist angesagt?

Victoria McCredie minimizing secondary injury #ISICEM19 #IFAD2019
Victoria McCredie minimizing secondary injury #ISICEM19 #IFAD2019Victoria McCredie minimizing secondary injury #ISICEM19 #IFAD2019
Victoria McCredie minimizing secondary injury #ISICEM19 #IFAD2019International Fluid Academy
 
Spinal cord stimulation in neuroparhic cancer pain
Spinal cord stimulation in neuroparhic cancer painSpinal cord stimulation in neuroparhic cancer pain
Spinal cord stimulation in neuroparhic cancer painManish Raj
 
Somatic Experiencing: Reduction of Depression and Anxiety in Homeless Adults ...
Somatic Experiencing: Reduction of Depression and Anxiety in Homeless Adults ...Somatic Experiencing: Reduction of Depression and Anxiety in Homeless Adults ...
Somatic Experiencing: Reduction of Depression and Anxiety in Homeless Adults ...Michael Changaris
 
Dissertation - Somatic Experiencing Treatment for Reduction of Symptoms of De...
Dissertation - Somatic Experiencing Treatment for Reduction of Symptoms of De...Dissertation - Somatic Experiencing Treatment for Reduction of Symptoms of De...
Dissertation - Somatic Experiencing Treatment for Reduction of Symptoms of De...Michael Changaris
 
2014 Proposal Effects of Chronic Stress on Nicotine-Seeking
2014 Proposal Effects of Chronic Stress on Nicotine-Seeking2014 Proposal Effects of Chronic Stress on Nicotine-Seeking
2014 Proposal Effects of Chronic Stress on Nicotine-SeekingEmily Anderson
 
CTAD CSF safety Poster 10 30 13
CTAD CSF safety Poster 10 30 13CTAD CSF safety Poster 10 30 13
CTAD CSF safety Poster 10 30 13Larry Drugdoc
 
Riu008001 0028
Riu008001 0028Riu008001 0028
Riu008001 0028Jonny Luna
 
Community Catastrophizing
Community CatastrophizingCommunity Catastrophizing
Community CatastrophizingPaul Coelho, MD
 
Damn good cpr notes jsw tcep 2015
Damn good cpr notes jsw tcep 2015Damn good cpr notes jsw tcep 2015
Damn good cpr notes jsw tcep 2015wieters
 
Hypothermia in tbi for neuroprotection
Hypothermia in tbi for neuroprotectionHypothermia in tbi for neuroprotection
Hypothermia in tbi for neuroprotectionAbhishek Sharma
 
Maladaptive movement and motor control impairments as underlying mechanism
Maladaptive movement and motor control impairments as underlying mechanismMaladaptive movement and motor control impairments as underlying mechanism
Maladaptive movement and motor control impairments as underlying mechanismMeziat
 
Neural blockade for persistent pain after breast cancer surgery
Neural blockade for persistent pain after breast cancer surgery Neural blockade for persistent pain after breast cancer surgery
Neural blockade for persistent pain after breast cancer surgery Jason Attaman
 
Chronic inflammatory demyelinating Polyradiculoneuropathy
Chronic inflammatory demyelinating Polyradiculoneuropathy Chronic inflammatory demyelinating Polyradiculoneuropathy
Chronic inflammatory demyelinating Polyradiculoneuropathy Ajay Kumar
 

Was ist angesagt? (20)

Victoria McCredie minimizing secondary injury #ISICEM19 #IFAD2019
Victoria McCredie minimizing secondary injury #ISICEM19 #IFAD2019Victoria McCredie minimizing secondary injury #ISICEM19 #IFAD2019
Victoria McCredie minimizing secondary injury #ISICEM19 #IFAD2019
 
Hoffman-Peterson Capstone Poster
Hoffman-Peterson Capstone PosterHoffman-Peterson Capstone Poster
Hoffman-Peterson Capstone Poster
 
Spinal cord stimulation in neuroparhic cancer pain
Spinal cord stimulation in neuroparhic cancer painSpinal cord stimulation in neuroparhic cancer pain
Spinal cord stimulation in neuroparhic cancer pain
 
Research article
Research articleResearch article
Research article
 
Somatic Experiencing: Reduction of Depression and Anxiety in Homeless Adults ...
Somatic Experiencing: Reduction of Depression and Anxiety in Homeless Adults ...Somatic Experiencing: Reduction of Depression and Anxiety in Homeless Adults ...
Somatic Experiencing: Reduction of Depression and Anxiety in Homeless Adults ...
 
Dissertation - Somatic Experiencing Treatment for Reduction of Symptoms of De...
Dissertation - Somatic Experiencing Treatment for Reduction of Symptoms of De...Dissertation - Somatic Experiencing Treatment for Reduction of Symptoms of De...
Dissertation - Somatic Experiencing Treatment for Reduction of Symptoms of De...
 
Triple low
Triple lowTriple low
Triple low
 
Pmr buzz-jan21
Pmr buzz-jan21Pmr buzz-jan21
Pmr buzz-jan21
 
Burt_MS
Burt_MSBurt_MS
Burt_MS
 
2014 Proposal Effects of Chronic Stress on Nicotine-Seeking
2014 Proposal Effects of Chronic Stress on Nicotine-Seeking2014 Proposal Effects of Chronic Stress on Nicotine-Seeking
2014 Proposal Effects of Chronic Stress on Nicotine-Seeking
 
CTAD CSF safety Poster 10 30 13
CTAD CSF safety Poster 10 30 13CTAD CSF safety Poster 10 30 13
CTAD CSF safety Poster 10 30 13
 
Aidp dilemmas
Aidp dilemmasAidp dilemmas
Aidp dilemmas
 
Riu008001 0028
Riu008001 0028Riu008001 0028
Riu008001 0028
 
Community Catastrophizing
Community CatastrophizingCommunity Catastrophizing
Community Catastrophizing
 
Damn good cpr notes jsw tcep 2015
Damn good cpr notes jsw tcep 2015Damn good cpr notes jsw tcep 2015
Damn good cpr notes jsw tcep 2015
 
Hypothermia in tbi for neuroprotection
Hypothermia in tbi for neuroprotectionHypothermia in tbi for neuroprotection
Hypothermia in tbi for neuroprotection
 
Maladaptive movement and motor control impairments as underlying mechanism
Maladaptive movement and motor control impairments as underlying mechanismMaladaptive movement and motor control impairments as underlying mechanism
Maladaptive movement and motor control impairments as underlying mechanism
 
Central Neuropathic Pain after Acute Spinal Cord Injury (NP in SCI): A Case s...
Central Neuropathic Pain after Acute Spinal Cord Injury (NP in SCI): A Case s...Central Neuropathic Pain after Acute Spinal Cord Injury (NP in SCI): A Case s...
Central Neuropathic Pain after Acute Spinal Cord Injury (NP in SCI): A Case s...
 
Neural blockade for persistent pain after breast cancer surgery
Neural blockade for persistent pain after breast cancer surgery Neural blockade for persistent pain after breast cancer surgery
Neural blockade for persistent pain after breast cancer surgery
 
Chronic inflammatory demyelinating Polyradiculoneuropathy
Chronic inflammatory demyelinating Polyradiculoneuropathy Chronic inflammatory demyelinating Polyradiculoneuropathy
Chronic inflammatory demyelinating Polyradiculoneuropathy
 

Ähnlich wie A futile medical care by dr qutaiba aldoori

Deborah Stein - Trauma is Risky Business
Deborah Stein - Trauma is Risky BusinessDeborah Stein - Trauma is Risky Business
Deborah Stein - Trauma is Risky BusinessSMACC Conference
 
AJM Sheet: 5 Podiatric Emergencies
AJM Sheet: 5 Podiatric EmergenciesAJM Sheet: 5 Podiatric Emergencies
AJM Sheet: 5 Podiatric EmergenciesPodiatry Town
 
Pain in Sickle Cell Disease.pptx
Pain in Sickle Cell Disease.pptxPain in Sickle Cell Disease.pptx
Pain in Sickle Cell Disease.pptxkowiouABOUDOU1
 
Polytrauma 21 apr 20
Polytrauma 21 apr 20Polytrauma 21 apr 20
Polytrauma 21 apr 20Anup Maurya
 
Polytrauma 21 apr 20
Polytrauma 21 apr 20Polytrauma 21 apr 20
Polytrauma 21 apr 20Anup Maurya
 
Antibiotics a rational approach in the icu
Antibiotics a rational approach in the icuAntibiotics a rational approach in the icu
Antibiotics a rational approach in the icuisakakinada
 
Burn Class for ICU RNs 11 2014
Burn Class for ICU RNs 11 2014Burn Class for ICU RNs 11 2014
Burn Class for ICU RNs 11 2014Wen Murphy
 
Modul Fisiologi Aging Juni 2020.pptx
Modul Fisiologi Aging Juni 2020.pptxModul Fisiologi Aging Juni 2020.pptx
Modul Fisiologi Aging Juni 2020.pptxNurrahmanitaAziza1
 
Susan Mitchell-Care of the Patient with Advanced Dementia: What Physicians Ne...
Susan Mitchell-Care of the Patient with Advanced Dementia: What Physicians Ne...Susan Mitchell-Care of the Patient with Advanced Dementia: What Physicians Ne...
Susan Mitchell-Care of the Patient with Advanced Dementia: What Physicians Ne...jewishhome
 
Anaesthesia for trauma patient dr tanmoy
Anaesthesia  for  trauma  patient dr tanmoyAnaesthesia  for  trauma  patient dr tanmoy
Anaesthesia for trauma patient dr tanmoyDr. Tanmoy Roy
 
The Ageing Summit - London 2016
The Ageing Summit - London 2016The Ageing Summit - London 2016
The Ageing Summit - London 2016Marios Kyriazis
 
Patient safety assistantship Professor Vinod Patel
Patient safety assistantship Professor Vinod PatelPatient safety assistantship Professor Vinod Patel
Patient safety assistantship Professor Vinod PatelVinod0901
 
Biophysical_Agent_Vonny[1].pdf
Biophysical_Agent_Vonny[1].pdfBiophysical_Agent_Vonny[1].pdf
Biophysical_Agent_Vonny[1].pdfAnonymous1nMTZWmz
 
Rethinking DNACPR orders: ethical issues and a proposal for change - Fritz
Rethinking DNACPR orders: ethical issues and a proposal for change - FritzRethinking DNACPR orders: ethical issues and a proposal for change - Fritz
Rethinking DNACPR orders: ethical issues and a proposal for change - Fritzintensivecaresociety
 
The Timeline of Lifesaving Interventions | Stacy Shackelford at TBS23
The Timeline of Lifesaving Interventions | Stacy Shackelford at TBS23The Timeline of Lifesaving Interventions | Stacy Shackelford at TBS23
The Timeline of Lifesaving Interventions | Stacy Shackelford at TBS23scanFOAM
 
Nursing management of burn patient chapter bsc nursing 4 th semester
Nursing management of burn patient chapter bsc nursing 4 th semesterNursing management of burn patient chapter bsc nursing 4 th semester
Nursing management of burn patient chapter bsc nursing 4 th semesterSuryaMohanJha
 

Ähnlich wie A futile medical care by dr qutaiba aldoori (20)

Deborah Stein - Trauma is Risky Business
Deborah Stein - Trauma is Risky BusinessDeborah Stein - Trauma is Risky Business
Deborah Stein - Trauma is Risky Business
 
AJM Sheet: 5 Podiatric Emergencies
AJM Sheet: 5 Podiatric EmergenciesAJM Sheet: 5 Podiatric Emergencies
AJM Sheet: 5 Podiatric Emergencies
 
Pain in Sickle Cell Disease.pptx
Pain in Sickle Cell Disease.pptxPain in Sickle Cell Disease.pptx
Pain in Sickle Cell Disease.pptx
 
Polytrauma 21 apr 20
Polytrauma 21 apr 20Polytrauma 21 apr 20
Polytrauma 21 apr 20
 
Polytrauma 21 apr 20
Polytrauma 21 apr 20Polytrauma 21 apr 20
Polytrauma 21 apr 20
 
Antibiotics a rational approach in the icu
Antibiotics a rational approach in the icuAntibiotics a rational approach in the icu
Antibiotics a rational approach in the icu
 
Burn Class for ICU RNs 11 2014
Burn Class for ICU RNs 11 2014Burn Class for ICU RNs 11 2014
Burn Class for ICU RNs 11 2014
 
Cerebral edema.pptx
Cerebral edema.pptxCerebral edema.pptx
Cerebral edema.pptx
 
Modul Fisiologi Aging Juni 2020.pptx
Modul Fisiologi Aging Juni 2020.pptxModul Fisiologi Aging Juni 2020.pptx
Modul Fisiologi Aging Juni 2020.pptx
 
1200 j lipman
1200 j lipman1200 j lipman
1200 j lipman
 
Ethics
EthicsEthics
Ethics
 
Susan Mitchell-Care of the Patient with Advanced Dementia: What Physicians Ne...
Susan Mitchell-Care of the Patient with Advanced Dementia: What Physicians Ne...Susan Mitchell-Care of the Patient with Advanced Dementia: What Physicians Ne...
Susan Mitchell-Care of the Patient with Advanced Dementia: What Physicians Ne...
 
Exploring Hospice Care
Exploring Hospice CareExploring Hospice Care
Exploring Hospice Care
 
Anaesthesia for trauma patient dr tanmoy
Anaesthesia  for  trauma  patient dr tanmoyAnaesthesia  for  trauma  patient dr tanmoy
Anaesthesia for trauma patient dr tanmoy
 
The Ageing Summit - London 2016
The Ageing Summit - London 2016The Ageing Summit - London 2016
The Ageing Summit - London 2016
 
Patient safety assistantship Professor Vinod Patel
Patient safety assistantship Professor Vinod PatelPatient safety assistantship Professor Vinod Patel
Patient safety assistantship Professor Vinod Patel
 
Biophysical_Agent_Vonny[1].pdf
Biophysical_Agent_Vonny[1].pdfBiophysical_Agent_Vonny[1].pdf
Biophysical_Agent_Vonny[1].pdf
 
Rethinking DNACPR orders: ethical issues and a proposal for change - Fritz
Rethinking DNACPR orders: ethical issues and a proposal for change - FritzRethinking DNACPR orders: ethical issues and a proposal for change - Fritz
Rethinking DNACPR orders: ethical issues and a proposal for change - Fritz
 
The Timeline of Lifesaving Interventions | Stacy Shackelford at TBS23
The Timeline of Lifesaving Interventions | Stacy Shackelford at TBS23The Timeline of Lifesaving Interventions | Stacy Shackelford at TBS23
The Timeline of Lifesaving Interventions | Stacy Shackelford at TBS23
 
Nursing management of burn patient chapter bsc nursing 4 th semester
Nursing management of burn patient chapter bsc nursing 4 th semesterNursing management of burn patient chapter bsc nursing 4 th semester
Nursing management of burn patient chapter bsc nursing 4 th semester
 

Kürzlich hochgeladen

TransientOffsetin14CAftertheCarringtonEventRecordedbyPolarTreeRings
TransientOffsetin14CAftertheCarringtonEventRecordedbyPolarTreeRingsTransientOffsetin14CAftertheCarringtonEventRecordedbyPolarTreeRings
TransientOffsetin14CAftertheCarringtonEventRecordedbyPolarTreeRingsSérgio Sacani
 
Phenolics: types, biosynthesis and functions.
Phenolics: types, biosynthesis and functions.Phenolics: types, biosynthesis and functions.
Phenolics: types, biosynthesis and functions.Silpa
 
Gwalior ❤CALL GIRL 84099*07087 ❤CALL GIRLS IN Gwalior ESCORT SERVICE❤CALL GIRL
Gwalior ❤CALL GIRL 84099*07087 ❤CALL GIRLS IN Gwalior ESCORT SERVICE❤CALL GIRLGwalior ❤CALL GIRL 84099*07087 ❤CALL GIRLS IN Gwalior ESCORT SERVICE❤CALL GIRL
Gwalior ❤CALL GIRL 84099*07087 ❤CALL GIRLS IN Gwalior ESCORT SERVICE❤CALL GIRLkantirani197
 
Biogenic Sulfur Gases as Biosignatures on Temperate Sub-Neptune Waterworlds
Biogenic Sulfur Gases as Biosignatures on Temperate Sub-Neptune WaterworldsBiogenic Sulfur Gases as Biosignatures on Temperate Sub-Neptune Waterworlds
Biogenic Sulfur Gases as Biosignatures on Temperate Sub-Neptune WaterworldsSérgio Sacani
 
GBSN - Microbiology (Unit 3)Defense Mechanism of the body
GBSN - Microbiology (Unit 3)Defense Mechanism of the body GBSN - Microbiology (Unit 3)Defense Mechanism of the body
GBSN - Microbiology (Unit 3)Defense Mechanism of the body Areesha Ahmad
 
Chemistry 5th semester paper 1st Notes.pdf
Chemistry 5th semester paper 1st Notes.pdfChemistry 5th semester paper 1st Notes.pdf
Chemistry 5th semester paper 1st Notes.pdfSumit Kumar yadav
 
Human & Veterinary Respiratory Physilogy_DR.E.Muralinath_Associate Professor....
Human & Veterinary Respiratory Physilogy_DR.E.Muralinath_Associate Professor....Human & Veterinary Respiratory Physilogy_DR.E.Muralinath_Associate Professor....
Human & Veterinary Respiratory Physilogy_DR.E.Muralinath_Associate Professor....muralinath2
 
Reboulia: features, anatomy, morphology etc.
Reboulia: features, anatomy, morphology etc.Reboulia: features, anatomy, morphology etc.
Reboulia: features, anatomy, morphology etc.Silpa
 
FAIRSpectra - Enabling the FAIRification of Spectroscopy and Spectrometry
FAIRSpectra - Enabling the FAIRification of Spectroscopy and SpectrometryFAIRSpectra - Enabling the FAIRification of Spectroscopy and Spectrometry
FAIRSpectra - Enabling the FAIRification of Spectroscopy and SpectrometryAlex Henderson
 
(May 9, 2024) Enhanced Ultrafast Vector Flow Imaging (VFI) Using Multi-Angle ...
(May 9, 2024) Enhanced Ultrafast Vector Flow Imaging (VFI) Using Multi-Angle ...(May 9, 2024) Enhanced Ultrafast Vector Flow Imaging (VFI) Using Multi-Angle ...
(May 9, 2024) Enhanced Ultrafast Vector Flow Imaging (VFI) Using Multi-Angle ...Scintica Instrumentation
 
Selaginella: features, morphology ,anatomy and reproduction.
Selaginella: features, morphology ,anatomy and reproduction.Selaginella: features, morphology ,anatomy and reproduction.
Selaginella: features, morphology ,anatomy and reproduction.Silpa
 
GBSN - Biochemistry (Unit 2) Basic concept of organic chemistry
GBSN - Biochemistry (Unit 2) Basic concept of organic chemistry GBSN - Biochemistry (Unit 2) Basic concept of organic chemistry
GBSN - Biochemistry (Unit 2) Basic concept of organic chemistry Areesha Ahmad
 
Factory Acceptance Test( FAT).pptx .
Factory Acceptance Test( FAT).pptx       .Factory Acceptance Test( FAT).pptx       .
Factory Acceptance Test( FAT).pptx .Poonam Aher Patil
 
development of diagnostic enzyme assay to detect leuser virus
development of diagnostic enzyme assay to detect leuser virusdevelopment of diagnostic enzyme assay to detect leuser virus
development of diagnostic enzyme assay to detect leuser virusNazaninKarimi6
 
The Mariana Trench remarkable geological features on Earth.pptx
The Mariana Trench remarkable geological features on Earth.pptxThe Mariana Trench remarkable geological features on Earth.pptx
The Mariana Trench remarkable geological features on Earth.pptxseri bangash
 
Cyanide resistant respiration pathway.pptx
Cyanide resistant respiration pathway.pptxCyanide resistant respiration pathway.pptx
Cyanide resistant respiration pathway.pptxSilpa
 
Thyroid Physiology_Dr.E. Muralinath_ Associate Professor
Thyroid Physiology_Dr.E. Muralinath_ Associate ProfessorThyroid Physiology_Dr.E. Muralinath_ Associate Professor
Thyroid Physiology_Dr.E. Muralinath_ Associate Professormuralinath2
 
Genome sequencing,shotgun sequencing.pptx
Genome sequencing,shotgun sequencing.pptxGenome sequencing,shotgun sequencing.pptx
Genome sequencing,shotgun sequencing.pptxSilpa
 
Climate Change Impacts on Terrestrial and Aquatic Ecosystems.pptx
Climate Change Impacts on Terrestrial and Aquatic Ecosystems.pptxClimate Change Impacts on Terrestrial and Aquatic Ecosystems.pptx
Climate Change Impacts on Terrestrial and Aquatic Ecosystems.pptxDiariAli
 

Kürzlich hochgeladen (20)

TransientOffsetin14CAftertheCarringtonEventRecordedbyPolarTreeRings
TransientOffsetin14CAftertheCarringtonEventRecordedbyPolarTreeRingsTransientOffsetin14CAftertheCarringtonEventRecordedbyPolarTreeRings
TransientOffsetin14CAftertheCarringtonEventRecordedbyPolarTreeRings
 
Phenolics: types, biosynthesis and functions.
Phenolics: types, biosynthesis and functions.Phenolics: types, biosynthesis and functions.
Phenolics: types, biosynthesis and functions.
 
Gwalior ❤CALL GIRL 84099*07087 ❤CALL GIRLS IN Gwalior ESCORT SERVICE❤CALL GIRL
Gwalior ❤CALL GIRL 84099*07087 ❤CALL GIRLS IN Gwalior ESCORT SERVICE❤CALL GIRLGwalior ❤CALL GIRL 84099*07087 ❤CALL GIRLS IN Gwalior ESCORT SERVICE❤CALL GIRL
Gwalior ❤CALL GIRL 84099*07087 ❤CALL GIRLS IN Gwalior ESCORT SERVICE❤CALL GIRL
 
Biogenic Sulfur Gases as Biosignatures on Temperate Sub-Neptune Waterworlds
Biogenic Sulfur Gases as Biosignatures on Temperate Sub-Neptune WaterworldsBiogenic Sulfur Gases as Biosignatures on Temperate Sub-Neptune Waterworlds
Biogenic Sulfur Gases as Biosignatures on Temperate Sub-Neptune Waterworlds
 
GBSN - Microbiology (Unit 3)Defense Mechanism of the body
GBSN - Microbiology (Unit 3)Defense Mechanism of the body GBSN - Microbiology (Unit 3)Defense Mechanism of the body
GBSN - Microbiology (Unit 3)Defense Mechanism of the body
 
Chemistry 5th semester paper 1st Notes.pdf
Chemistry 5th semester paper 1st Notes.pdfChemistry 5th semester paper 1st Notes.pdf
Chemistry 5th semester paper 1st Notes.pdf
 
Human & Veterinary Respiratory Physilogy_DR.E.Muralinath_Associate Professor....
Human & Veterinary Respiratory Physilogy_DR.E.Muralinath_Associate Professor....Human & Veterinary Respiratory Physilogy_DR.E.Muralinath_Associate Professor....
Human & Veterinary Respiratory Physilogy_DR.E.Muralinath_Associate Professor....
 
Reboulia: features, anatomy, morphology etc.
Reboulia: features, anatomy, morphology etc.Reboulia: features, anatomy, morphology etc.
Reboulia: features, anatomy, morphology etc.
 
FAIRSpectra - Enabling the FAIRification of Spectroscopy and Spectrometry
FAIRSpectra - Enabling the FAIRification of Spectroscopy and SpectrometryFAIRSpectra - Enabling the FAIRification of Spectroscopy and Spectrometry
FAIRSpectra - Enabling the FAIRification of Spectroscopy and Spectrometry
 
(May 9, 2024) Enhanced Ultrafast Vector Flow Imaging (VFI) Using Multi-Angle ...
(May 9, 2024) Enhanced Ultrafast Vector Flow Imaging (VFI) Using Multi-Angle ...(May 9, 2024) Enhanced Ultrafast Vector Flow Imaging (VFI) Using Multi-Angle ...
(May 9, 2024) Enhanced Ultrafast Vector Flow Imaging (VFI) Using Multi-Angle ...
 
Selaginella: features, morphology ,anatomy and reproduction.
Selaginella: features, morphology ,anatomy and reproduction.Selaginella: features, morphology ,anatomy and reproduction.
Selaginella: features, morphology ,anatomy and reproduction.
 
GBSN - Biochemistry (Unit 2) Basic concept of organic chemistry
GBSN - Biochemistry (Unit 2) Basic concept of organic chemistry GBSN - Biochemistry (Unit 2) Basic concept of organic chemistry
GBSN - Biochemistry (Unit 2) Basic concept of organic chemistry
 
Factory Acceptance Test( FAT).pptx .
Factory Acceptance Test( FAT).pptx       .Factory Acceptance Test( FAT).pptx       .
Factory Acceptance Test( FAT).pptx .
 
+971581248768>> SAFE AND ORIGINAL ABORTION PILLS FOR SALE IN DUBAI AND ABUDHA...
+971581248768>> SAFE AND ORIGINAL ABORTION PILLS FOR SALE IN DUBAI AND ABUDHA...+971581248768>> SAFE AND ORIGINAL ABORTION PILLS FOR SALE IN DUBAI AND ABUDHA...
+971581248768>> SAFE AND ORIGINAL ABORTION PILLS FOR SALE IN DUBAI AND ABUDHA...
 
development of diagnostic enzyme assay to detect leuser virus
development of diagnostic enzyme assay to detect leuser virusdevelopment of diagnostic enzyme assay to detect leuser virus
development of diagnostic enzyme assay to detect leuser virus
 
The Mariana Trench remarkable geological features on Earth.pptx
The Mariana Trench remarkable geological features on Earth.pptxThe Mariana Trench remarkable geological features on Earth.pptx
The Mariana Trench remarkable geological features on Earth.pptx
 
Cyanide resistant respiration pathway.pptx
Cyanide resistant respiration pathway.pptxCyanide resistant respiration pathway.pptx
Cyanide resistant respiration pathway.pptx
 
Thyroid Physiology_Dr.E. Muralinath_ Associate Professor
Thyroid Physiology_Dr.E. Muralinath_ Associate ProfessorThyroid Physiology_Dr.E. Muralinath_ Associate Professor
Thyroid Physiology_Dr.E. Muralinath_ Associate Professor
 
Genome sequencing,shotgun sequencing.pptx
Genome sequencing,shotgun sequencing.pptxGenome sequencing,shotgun sequencing.pptx
Genome sequencing,shotgun sequencing.pptx
 
Climate Change Impacts on Terrestrial and Aquatic Ecosystems.pptx
Climate Change Impacts on Terrestrial and Aquatic Ecosystems.pptxClimate Change Impacts on Terrestrial and Aquatic Ecosystems.pptx
Climate Change Impacts on Terrestrial and Aquatic Ecosystems.pptx
 

A futile medical care by dr qutaiba aldoori

  • 1. Futile medical care ‫المجدية‬ ‫غير‬ ‫الطبية‬ ‫الرعاية‬ Dr. Qutaiba Abdullah AlDoori Burn & Reconstructive Surgery AZADI Teaching Hospital
  • 2. Futile medical care • The Word Futile• means unavailing , useless • ‫جدوى‬ ‫ذي‬ ‫غير‬,‫تحته‬ ‫طائل‬ ‫ال‬ • unsuccessful, failing , fruitless, • useless, ineffectual, vain, unfruitful, unproductive,
  • 4. Introduction • Apoptosis ; • (one of innate immune response) • Apoptosis can be induced indirectly in response to overwhelming physical injury.1 • Major burns associated with massive inflammatory response can alter cellular kinetics ,3
  • 5. Introduction • There is a ‘cytokine storm’ can lead to alterations in Na+-K+ ATPases and thereby result in electrophysiological membrane dysfunction .3
  • 6. Introduction Both early apoptosis and delayed necrosis are present in the zone of ischemia, contributing to injury progression.4
  • 7. • Approximately • half {½} of the cells in the zone of • stasis undergo apoptosis or necrosis as a result of oxidative stress, ongoing inflammation, and decreased blood flow due • to microthrombosis. • Andreas Bergmann1,* and Hermann Stelle • Systemic factors such as advanced age, diabetes, and other chronic illnesses increase risk for “conversion from Partial T to FT Burn wound.” Introduction
  • 8. • calcium influx • into the cytoplasm and triggers a subsequent cascade leading to apoptosis. • Greek prefix (apo) attached to a Greek stem (ptosis) • “falling to death” • Is it reversible ⁈ mitochondria if swell • organelles that act like a digestive &respiratory system in cells , Introduction
  • 9. Futile medical care • Is the continued provision of medical care or treatment to a patient when there is no reasonable hope of a cure or benefit. • Some proponents of evidence-based medicine suggest discontinuing the use of any treatment that has not been shown to provide a measurable benefit
  • 10. A ‘do not resuscitate’ (DNR) order is not the equivalent of a ‘do not care’ (DNC) consideration.
  • 11. Futile medical care • Futile care is distinct from euthanasia because • euthanasia involves active intervention to end life, while withholding futile medical care does not encourage or hasten the natural onset of death . ‫الشفقة‬ ‫بدافع‬ ‫قتل‬ =EEuthanasia
  • 12. Arguments against providing futile care include potential harm to • 1/ Patient , (Increasing duration of pain) • 2/ Family members , (Fake hope ) • 3/ Caregivers with little or no likely benefits, • 4/ Diversion of resources to support the futile care In spite to be directed to provide care to patients that could respond to care.
  • 13. Futile medical care • The issue of futile care in clinical medicine generally involves two questions. • The first concerns the identification of those clinical scenarios where ? the care would be futile. • The second concerns the range of ethical options when ? care is determined at which level of no more improvement to be futile.
  • 15. Pt. admitted over 7 years (jan2012-dec.2018) •2076 patients
  • 16. 1640 adult 79% 435 pediatric 21% 2076 patient over 7 years Every three hours one child dies from a burn related accident @ World Health Organization /Int J Burn Trauma 2018;8(1):6-16
  • 17. 21% Death Suicides Expected = (435) 5% (103)Death un expected 2076 Total No. pt. Discharged Healthy (1538) 74% Number of patients over 6 years 538 dead at hospital Pt. admitted over 7 years (jan2012-dec.2018)
  • 18. Dead patients Sales 1st Qtr 2nd Qtr 3rd Qtr 4th Qtr 103=19% Un expected death, Total death over 7 year 538 patients 435 =81% Expected death Palliatve care
  • 19. Do-Not-Resuscitate Orders • Two kinds of medical futility are often distinguished: • 1. Quantitative futility, where the likelihood benefit of interventions to the patient is exceedingly poor, (frequent dressing ) • 2. Qualitative futility, where the quality of benefit an intervention will produce is exceedingly poor; (isolation and surgical operations )
  • 20. A ‘do not resuscitate’ (DNR) order is not the equivalent of a ‘do not care’ (DNC) consideration.
  • 21. 95% OF THEM SUICIDAL ATTEPMPT 95 % BSAB 30 Yr 17 inh inj Baux= 142 % probability of death
  • 22. Very limited CHANCES TO SAVE patient attempted suicide by fire
  • 23. “It is futile to continue to treat this patient,” • Futility does not apply to treatments globally, to a patient, or to a general medical situation. Instead, • It refers to a particular intervention at a particular time, for a specific patient. 80 % BSAB 27 YEARS 17 INH.INJURY+ Baux =124
  • 24. But sometime can save those with specific injury specific age 95% BSAB partial thickness 95% BSAB 17 Yr 17 inh inj Baux =129 probability of death
  • 25.
  • 26. How to decide Many prognostic scoring systems are available for burn patients.
  • 27. Lunanaut scoring system • Mortality • was seen in 94% patients with score >200.
  • 28. Jabalpur prognostic scoring system Cut off value of score ≥12 was associated with significantly higher mortality
  • 29. General prognostic indicators • Clinical indicators • Baux 1949 • ABSI Tobiasen 1982 • many others • Specific prognostic indicators • Creatin kinase CK Electrical injury • C Reactive Protien SIR • Procalcitonin SIR • TNF @ was suppressed in nonsurvivors. SIR • Interleukin 8 & 10 SIR • S. Lactate global tissue hypoxia >4 Met.Acidosis • Erythroblast HYPOXIA • Platelet count Reduction associated with sepsis & bad prognosis .
  • 30. The Baux Score continues to provide a simple logical Ratio of the Risk of mortality & Survival after major burn injury AGE + BSAB% (+/0 ) Inh inj 17 It is increasingly common, and it can be give decisions by nonspecialist about initial triage , management planning .
  • 31. But futility of care should be made after consultation with a specialist burn service.
  • 32. 30 % BSAB 40 Yr 17 inh inj Baux= 87 % probability of death
  • 33. 35 % BSAB 30 Yr 17 inh inj Baux= 82 % probability of death
  • 34. 25 % BSAB 40 Yr 17 inh inj Baux= 82 % probability of death
  • 35. 35 % BSAB 20 Yr 17 inh inj Baux= 72 % probability of death
  • 36. 20 % BSAB 30 Yr 17 inh inj Baux= 67 % probability of death
  • 37. 23 % BSAB 30 Yr 17 inh inj Baux= 60% probability of death
  • 38. 23 % BSAB 24 Yr 17 inh inj Baux= 64 % probability of death
  • 39.
  • 41.
  • 42. Burns can be categorized into the following three main types: • 1• Those that can be treated with minimal efforts • (e.g., by clean dressings and available analgesics). • 2• Those that are not survivable without specialized • care. Special care must be established, and success will depend on the degree of medical care given . Patients must be transported to facilities where successful treatment can be performed and is funded.. • 3• Those that cannot be treated successfully even in a specialized care centre . • So those patients are deemed futile , and ‘comfort care’ must be provided.
  • 43. • End-of-life care • should be a mutual and agreeable choice by the patient/surrogate, with the understanding by the healthcare team that treatment has become futile.
  • 44. Palliative care end-of-life care • patients for whom survival is highly unlikely. • DIRECTED FOR
  • 45.
  • 46. References • 1 ] M.B. Zollo, J.C. Moskop, and C.E. Kahn Jr., “Knowing the Score: Using Predictive Scoring • Systems in • Clinical Practice,” American Journal of Critical Care 5 (1996): 147-150. • 2 ] David F. Kelly, Medical Care at the End of Life: A Catholic Perspective (Washington, DC: • Georgetown • University Press, 2006), 42-44. • 3 ] Osler T, Glance LG, Hosmer DW. Simplified estimates of the probability of death after burn • injuries: extending and updating the Baux score. J Trauma. 2010;68:690–697 PubMed • 4 ] Tobiasen J, Hiebert JH, Edlich RF. Prediction of burn mortality. Surg Gynecol Obstet. • 1982;154:711–71PubMed • 5 ] Gomez M, Wong DT, Stewart TE, Redelmeier DA, Fish JS. The FLAMES score • accurately predicts mortality risk in burn patients. J Trauma. 2008;65(3):636–45. • 6 ] Jackson DM. The treatment of burns: an exercise in emergency surgery. Ann R Coll Surg • Engl. 1953; 13:236–57. • 7 ] Iain Harris and Scott A. Murray, “Can Palliative Care Reduce Futile Treatment? A • Systematic Review,”British Medical Journal of Supportive and Palliative Care 3 (2013): 389- • 394. • 8 ] Gerstein AD, Phillips TJ, Rogers GS, Gilchrest BA: Wound healing and aging. Dermatol • Clin, 11(4): 749-57, 1993. • 9 ] Hotchkiss RS, et al. Rapid onset of intestinal epithelial and lymphocyte apoptotic cell death in • patients with trauma and shock. Crit Care Med. 2000; 28:3207–3217. [PubMed: 11008984] • 10 ] Chen W, et al. Cytokine cascades induced by mechanical trauma injury alter voltage-gated • sodium channel activity in intact cortical neurons. J Neuroinflammation. 2017; 14:73. [PubMed: • 28359334]
  • 47. • 11 ] Pfeifer R, Heussen N, Michalewicz E, Hilgers RD, Pape HC. Incidence of adult respiratory • distress syndrome in trauma patients: a systematic review and meta-analysis over a period of • three decades. J Trauma Acute Care Surg. 2017; 83:496–506. [PubMed: 28590348] • 12 ] Levy G, et al. Parasympathetic stimulation via the vagus nerve prevents systemic organ • dysfunction by abrogating gut injury and lymph toxicity in trauma and hemorrhagic shock. • Shock. 2013; 39:39–44. [PubMed: 23247120] • 13 ] Lee MA, Yatani A, Sambol JT, Deitch EA. Role of gut-lymph factors in the induction of • burn-induced and trauma-shock-induced acute heart failure. Int J Clin Exp Med. 2008; 1:171– • 180. [PubMed: 19079671] • 14 ] Tiesi G, et al. Early trauma-hemorrhage-induced splenic and thymic apoptosis is gutmediated • and toll-like receptor 4-dependent. Shock. 2013; 39:507–513. [PubMed: 23542401] • 15 ] Sordi R, et al. Artesunate protects against the organ injury and dysfunction induced by • severe hemorrhage and resuscitation. Ann Surg. 2017; 265:408–417. [PubMed: 28059970] • 16 ] Shupp JW, Nasabzadeh TJ, Rosenthal DS, et al. A review of the local pathophysiologic • bases of burn wound progression. J Burn Care Res. 2010;31(6):849-873. • 17]Hengetal,(2015).RevisedBauxScoreandupdatedCharlsoncomorbidityindexareindependentlyas • sociatedwithmortalityinburnsintensivecarepatients.Burns.41(7):1420-7. • 18] Sheppard NN, Hemington-Gorse S, Shelley OP, Philp B, Dziewulski P. Prognostic scoring • systems in burns: a review. Burns 2011;37(8):1288–95. • 19] Wearn C et al.: Outcomes of burns in the elderly: revised estimates from the Birmingham • Burn Centre. Burns, 41(6): 1161-8, 2015. • 20] Thombs BD, Singh VA, Halonen J, Diallo A, Milner SM. The effects of preexisting medical • comorbidities on mortality and length of hospital stay in acute burn injury: Evidence from a • national sample of 31,338 adult patients. Ann Surg 2007;245:629-34.