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Basic knowledge of
 microcirculation
Summary
• First part: Great blood circulatory system
• Second part: Introduction of microcirculation
  (definition, function, constitution, characteristics and
  importance)
• Last part:How to test microcirculation (start,
  observation index, anlysis and correct judgment, give
  professional advice )
First part
• Great Blood Circulation
Second part


Introduction of microcirculation
What is microcirculation?
The middle part of Artery and Vein
End part of circulation system
Important component of organs
What is the function of
     microcirculation?
• The microcirculation is the
  principal avenue for the delivery of
  oxygen , nutrition and exit of the
  substances involved in the
  metabolism of every cell of the
  tissues.
Constitution of
       microcirculation
• Small artery
• Arteriole
• capillary
• Slender artery
• Small artery
Capillary wall is made of
        endothelial cells, basilar
      membrane, and peripheral cells


Vessel walls: arteriole is thicker



Vessel caliber: venule is bigger
Characteristics of
         microcirculation
• End part of circulation system
• Important component of organs
• Common property of vessels, special
  characteristics of organs
• The channels of blood, the place for
  exchange
• Modulated by nerve system, body fluid,
  and also modulated by locality.
Characteristics of
          microcirculation
• ①The total length of capillaries is about
  90-110 thousand kilometers (one and half
  the perimeters of the earth 6,356.8km )
• ② About 10 billion capillary vessels, the
  area can reach 500~700 m2
• ③ The wall of the capillary of the
  microcirculation is very thin. (20~30 μ m)
• ④ The capillaries are very small in size
  (one twentieth of a man’s hair. )
The importance of
          microcirculation
• Regulation

 Stable regulation:


       Body flux   Organs flux   Blood pressure


 Emergent regulation:


      Local organs and tissues
What is the
        microcirculation
           disorder ?
• Microcirculation disorder means changes
  in the form of capillaries or changes in
  the pattern of the blood flow .
• If the capillaries of the microcirculation
  are distorted and the capillaries are
  blocked, necrosis of cell will occur due
  to ischemia and anoxia.
What diseases may microcirculation
         disorder cause?
• ① Nervous System:
• Low blood supply to brain area which can lead
  to dizziness, headache, insomnia, deterioration
  of memory, weakness of nervous system,
  stroke etc
• ② Cardiovascular System:
• Obstruction in microcirculation can lead to
  Chest oppression, arrhythmia, Heart or Chest
  pain etc
• ③ Digestive System:
• Gastric functional problems, poor digestion,
  can lead to gastritis, stomach ulcers etc
• ④ Muscular and bone joint system:
  Microcirculation disturbance of muscular and
  joint system can lead to general muscular
  pain, numbness, cold extremities, can also
  lead to inflammation of vessels, Varicose veins
  and joint pains etc
• ⑤Women Diseases:
• Many Women related diseases have relation
  with microcirculation like painful menstruation,
  abnormal menstruation and tumor of the
  uterus etc
• ⑥ Skin:
• As body gets old the micro vessels of skin
  reduces, so less blood and oxygen supply lead
  to low nourishment of skin thus also results in
  poor elasticity of skin, dark pouches around
  eyes etc.
In Conclusion
• Obstruction in the microcirculation can lead to
  many old age related diseases like: Brain
  Atrophy, Old age Dementia, Stroke, High
  blood pressure, coronary heart disease, Frozen
  shoulder, Osteoporosis etc
What will cause disorder of
          microcirculation?
• Causes

   Ischemia reperfusion injury
   Endothelial cell damage
                                    Hypercholesterolemia
   Platelet aggregation            Oxygen free radical
   High blood viscosity            high blood sugar
                                    Some immunological
                                  reaction
                                    Toxin, virus
Last part


How to test microcirculation
How to test the
        microcirculation?
• The nail bed is easy to view and is
  richly endowed with capillaries
  very close to the skin surface
  beneath the nail.
How to start?
• Firstly you should know some information
  about the people who will be tested

    Gender             Job
    Figure             Food
    Appearance         Medical history
    Age                Family history
    Smoke              Recently feeling
Observation Indexes
                     1   清晰度      Resolution
                     2   管袢数      Number of capillary loops
                     3   管径       Vessel caliber
3 main               4   管袢长度     Length of capillary loops
aspects:             5   管袢形态     Shape of capillary loops
                     6   流速       Blood flow rate
Shape               7   血管运动性    Motility of Blood vessel
                     8   红细胞聚集    Aggregation of red blood cell
Fluid state         9   白细胞数     Number of white blood cell
                    10   白微栓      White micro embolism
Loop               11   血色       Blood colour
surrounding/        12   渗出       Permeation
                    13   出血       Bleeding
blood vessel ansa
                    14   乳头下静脉丛   Venule clusters under mammary papilla
perimeter           15   乳头       Mammary papilla
                    16   汗腺导管     Sweat ducts
Shape
•   Clarity
•   Number of capillary loops
•   Vessel caliber
•   Normal shape of capillary loops
•   Deformity vessels
•   Short loops
•   Thin loops
•   Tense blood vessel
•   Dilation blood vessel
•   Stagnation blood vessel
•   Hyperplasia vessels
•   Top loop tremendous expansion
Analysis of microcirculation
Shape of vessels

1Clarity




    clear           unclear   blurred
Analysis of microcirculation
Shape of vessels

2. Number of capillary loops:7~10 is normal
Analysis of microcirculation
Shape of vessels

3. Vessel caliber:
 Input loop: 9~13um; Output loop: 11~17 um; Loop top: 15um




       2        3



       1
Analysis of microcirculation
Shape of vessels

 4.Shape of capillary loops: hair-pin shape




       Normal            Normal               Abnormal
Analysis of microcirculation
Shape of vessels
 5. Deformity vessels
Analysis of microcirculation
Shape of vessels
 6. Short loops
Analysis of microcirculation
Shape of vessels
 7. Thin loops
Analysis of microcirculation
Shape of vessels
 8. Tense vessel
Analysis of microcirculation
Shape of vessels
 9. Extensive vessels
Analysis of microcirculation
Shape of vessels
 10. Congestive vessels
Analysis of microcirculation
Shape of vessels
 11. Hyperplasia vessels
Analysis of microcirculation
Shape of vessels
 12. Top loop tremendous expansion
Blood fluid state


1.Blood flow rate
2.Red blood cells aggregation
3.White micro embolism
Analysis of microcirculation
Blood fluid state

   1. Blood flow rate
      Linear flow,
      Linear granular flow,
      Granular flow,
      Fluctuated granular flow,
      Halt
Analysis of microcirculation
Blood fluid state

   2. Red blood cells aggregation
Analysis of microcirculation
Blood fluid state

   3. White micro embolism
White micro embolism is formed by platelet, endothelial cells and
white blood cells via attachment or aggregation,
Irregular shaped, cotton cluster
Can both adhere to vessel wall and flow in vessels
Big volume, 3 times as white blood cell
Most in venule clusters under mammary papilla and obviously in
extensive loops
Loop surrounding
1. Permeation and bleeding
2. Vein clump under nipple:
3. Nipple
Analysis of microcirculation
Loop surrounding

  1. Permeation and bleeding
Analysis of microcirculation
Loop surrounding

  2. Vein clump under nipple:
Analysis of microcirculation
Loop surrounding

   3. Nipple




Waved shape         Slight waved shape   Flat
How to give advice?
• If the person don’t have any bad
  habits, don’t have any disease or
  symptoms, and the
  microcirculation is also good:
• We may ask him to share his
  healthy experience with us.
Just
   Microcirculation
       Disorder

• If the person don’t have any bad
  habits, don’t have any disease or
  symptoms, but have some
  microcirculation disorder from the
  observation:
• We may think that he just may have
  some little disorder about the body, so
  we can give him some products for
  improving health. And give him some
  good suggest about life.
• If the person have some bad
  habits, and have some little
  symptoms, such as feeling tired,
  fragility and so on, also find some
  disorder about the
  microcirculation:
• We can give some products for
  improving the symptoms. And
  some good suggest.
• If the person have don’t have some bad
  habits, but have family history, and
  have some obvious symptoms, and also
  have disorder about the
  microcirculation:
• We could give him some product for
  improving symptoms and also advice
  him to have a inspect in hospital.

Family    On your family tree,there were more than one person had got
History   or died from one disease, such as diabetes, CAD, Cancer etc.
• If the person have some obvious
  symptoms, and he know about his
  disease, such us diabetes, heart disease
  etc:
• We should give some our products and
  at the same time ask him should not
  stop the drug which he used before.
  They can use our product and the drug
  together but not simultaneous.
How to give the correctly
           products?
• We have the prescription for you to
  suggest your client.
Welcome to Contact Us
 If you are interested in the content, or may have some questions
about health and diseases, welcome to contact us, we will provide
                   you with a professional service.
 Tel: 017 22 75 716
 Email: puspa50cent06@gmail.com

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Microcirculation

  • 1. Basic knowledge of microcirculation
  • 2. Summary • First part: Great blood circulatory system • Second part: Introduction of microcirculation (definition, function, constitution, characteristics and importance) • Last part:How to test microcirculation (start, observation index, anlysis and correct judgment, give professional advice )
  • 3. First part • Great Blood Circulation
  • 4. Second part Introduction of microcirculation
  • 5. What is microcirculation? The middle part of Artery and Vein End part of circulation system Important component of organs
  • 6. What is the function of microcirculation? • The microcirculation is the principal avenue for the delivery of oxygen , nutrition and exit of the substances involved in the metabolism of every cell of the tissues.
  • 7. Constitution of microcirculation • Small artery • Arteriole • capillary • Slender artery • Small artery
  • 8. Capillary wall is made of endothelial cells, basilar membrane, and peripheral cells Vessel walls: arteriole is thicker Vessel caliber: venule is bigger
  • 9. Characteristics of microcirculation • End part of circulation system • Important component of organs • Common property of vessels, special characteristics of organs • The channels of blood, the place for exchange • Modulated by nerve system, body fluid, and also modulated by locality.
  • 10. Characteristics of microcirculation • ①The total length of capillaries is about 90-110 thousand kilometers (one and half the perimeters of the earth 6,356.8km ) • ② About 10 billion capillary vessels, the area can reach 500~700 m2 • ③ The wall of the capillary of the microcirculation is very thin. (20~30 μ m) • ④ The capillaries are very small in size (one twentieth of a man’s hair. )
  • 11. The importance of microcirculation • Regulation  Stable regulation: Body flux Organs flux Blood pressure  Emergent regulation: Local organs and tissues
  • 12. What is the microcirculation disorder ? • Microcirculation disorder means changes in the form of capillaries or changes in the pattern of the blood flow . • If the capillaries of the microcirculation are distorted and the capillaries are blocked, necrosis of cell will occur due to ischemia and anoxia.
  • 13. What diseases may microcirculation disorder cause? • ① Nervous System: • Low blood supply to brain area which can lead to dizziness, headache, insomnia, deterioration of memory, weakness of nervous system, stroke etc • ② Cardiovascular System: • Obstruction in microcirculation can lead to Chest oppression, arrhythmia, Heart or Chest pain etc
  • 14. • ③ Digestive System: • Gastric functional problems, poor digestion, can lead to gastritis, stomach ulcers etc • ④ Muscular and bone joint system: Microcirculation disturbance of muscular and joint system can lead to general muscular pain, numbness, cold extremities, can also lead to inflammation of vessels, Varicose veins and joint pains etc
  • 15. • ⑤Women Diseases: • Many Women related diseases have relation with microcirculation like painful menstruation, abnormal menstruation and tumor of the uterus etc • ⑥ Skin: • As body gets old the micro vessels of skin reduces, so less blood and oxygen supply lead to low nourishment of skin thus also results in poor elasticity of skin, dark pouches around eyes etc.
  • 16. In Conclusion • Obstruction in the microcirculation can lead to many old age related diseases like: Brain Atrophy, Old age Dementia, Stroke, High blood pressure, coronary heart disease, Frozen shoulder, Osteoporosis etc
  • 17. What will cause disorder of microcirculation? • Causes  Ischemia reperfusion injury  Endothelial cell damage Hypercholesterolemia  Platelet aggregation Oxygen free radical  High blood viscosity high blood sugar Some immunological reaction Toxin, virus
  • 18. Last part How to test microcirculation
  • 19. How to test the microcirculation? • The nail bed is easy to view and is richly endowed with capillaries very close to the skin surface beneath the nail.
  • 20. How to start? • Firstly you should know some information about the people who will be tested Gender Job Figure Food Appearance Medical history Age Family history Smoke Recently feeling
  • 21. Observation Indexes 1 清晰度 Resolution 2 管袢数 Number of capillary loops 3 管径 Vessel caliber 3 main 4 管袢长度 Length of capillary loops aspects: 5 管袢形态 Shape of capillary loops 6 流速 Blood flow rate Shape 7 血管运动性 Motility of Blood vessel 8 红细胞聚集 Aggregation of red blood cell Fluid state 9 白细胞数 Number of white blood cell 10 白微栓 White micro embolism Loop 11 血色 Blood colour surrounding/ 12 渗出 Permeation 13 出血 Bleeding blood vessel ansa 14 乳头下静脉丛 Venule clusters under mammary papilla perimeter 15 乳头 Mammary papilla 16 汗腺导管 Sweat ducts
  • 22. Shape • Clarity • Number of capillary loops • Vessel caliber • Normal shape of capillary loops • Deformity vessels • Short loops • Thin loops • Tense blood vessel • Dilation blood vessel • Stagnation blood vessel • Hyperplasia vessels • Top loop tremendous expansion
  • 23. Analysis of microcirculation Shape of vessels 1Clarity clear unclear blurred
  • 24. Analysis of microcirculation Shape of vessels 2. Number of capillary loops:7~10 is normal
  • 25. Analysis of microcirculation Shape of vessels 3. Vessel caliber: Input loop: 9~13um; Output loop: 11~17 um; Loop top: 15um 2 3 1
  • 26. Analysis of microcirculation Shape of vessels 4.Shape of capillary loops: hair-pin shape Normal Normal Abnormal
  • 27. Analysis of microcirculation Shape of vessels 5. Deformity vessels
  • 28. Analysis of microcirculation Shape of vessels 6. Short loops
  • 29. Analysis of microcirculation Shape of vessels 7. Thin loops
  • 30. Analysis of microcirculation Shape of vessels 8. Tense vessel
  • 31. Analysis of microcirculation Shape of vessels 9. Extensive vessels
  • 32. Analysis of microcirculation Shape of vessels 10. Congestive vessels
  • 33. Analysis of microcirculation Shape of vessels 11. Hyperplasia vessels
  • 34. Analysis of microcirculation Shape of vessels 12. Top loop tremendous expansion
  • 35. Blood fluid state 1.Blood flow rate 2.Red blood cells aggregation 3.White micro embolism
  • 36. Analysis of microcirculation Blood fluid state 1. Blood flow rate Linear flow, Linear granular flow, Granular flow, Fluctuated granular flow, Halt
  • 37. Analysis of microcirculation Blood fluid state 2. Red blood cells aggregation
  • 38. Analysis of microcirculation Blood fluid state 3. White micro embolism White micro embolism is formed by platelet, endothelial cells and white blood cells via attachment or aggregation, Irregular shaped, cotton cluster Can both adhere to vessel wall and flow in vessels Big volume, 3 times as white blood cell Most in venule clusters under mammary papilla and obviously in extensive loops
  • 39. Loop surrounding 1. Permeation and bleeding 2. Vein clump under nipple: 3. Nipple
  • 40. Analysis of microcirculation Loop surrounding 1. Permeation and bleeding
  • 41. Analysis of microcirculation Loop surrounding 2. Vein clump under nipple:
  • 42. Analysis of microcirculation Loop surrounding 3. Nipple Waved shape Slight waved shape Flat
  • 43. How to give advice? • If the person don’t have any bad habits, don’t have any disease or symptoms, and the microcirculation is also good: • We may ask him to share his healthy experience with us.
  • 44. Just Microcirculation Disorder • If the person don’t have any bad habits, don’t have any disease or symptoms, but have some microcirculation disorder from the observation: • We may think that he just may have some little disorder about the body, so we can give him some products for improving health. And give him some good suggest about life.
  • 45. • If the person have some bad habits, and have some little symptoms, such as feeling tired, fragility and so on, also find some disorder about the microcirculation: • We can give some products for improving the symptoms. And some good suggest.
  • 46. • If the person have don’t have some bad habits, but have family history, and have some obvious symptoms, and also have disorder about the microcirculation: • We could give him some product for improving symptoms and also advice him to have a inspect in hospital. Family On your family tree,there were more than one person had got History or died from one disease, such as diabetes, CAD, Cancer etc.
  • 47. • If the person have some obvious symptoms, and he know about his disease, such us diabetes, heart disease etc: • We should give some our products and at the same time ask him should not stop the drug which he used before. They can use our product and the drug together but not simultaneous.
  • 48. How to give the correctly products? • We have the prescription for you to suggest your client.
  • 49. Welcome to Contact Us If you are interested in the content, or may have some questions about health and diseases, welcome to contact us, we will provide you with a professional service. Tel: 017 22 75 716 Email: puspa50cent06@gmail.com

Hinweis der Redaktion

  1. Through this two pictures, we can see that this is the blood circulation system, the heart pump the blood throughout the body in vessels
  2. 但微血管的形态和结构在各脏器都各有特点,如小肠绒毛、肺泡、肝、骨髓微血管的排列,形态和结构都不完全相同。甚至同一脏器不同部位, Stabilize body circulation Guarantee the temporary change of local circulation
  3. 标准足球场的面积: 68 米 ×105 米 , 面积 为 7140 平方米
  4. 正常的微循环图形为发夹形,血管直,输入枝和输出枝平行且管径比例为 1 : 1.5 ,血管清晰,排列整齐、分布均匀,数目正常。 正常状态:甲襞毛细血管排列整齐,分布均匀,管袢清晰可见。 异常状态:排列紊乱,管袢模糊不清,可能因为缺氧,血流不畅,亚健康等引起。
  5. 微循环检测中,管袢数的改变具有重要的临床意义。以远心端第 1 排血管袢中部二分之一以上为管袢计数区,低于此线者不计,模糊不清者不计,在计数时不应改变焦距,以免将不同深度的另一排管袢计入。 1mm 范围内的均计入。如下图本尺度内管袢数应为 6 条: 异常: A 、管袢细小而多:缺氧、慢性肺心病 B 、管袢少:低血压、循环血量不足、末梢血管收缩(细动脉收缩)感染性休克。
  6. ③ 管径 :是指血管中上部的直径,测量部位为血管袢的中部,要避开节段性扩张或收缩处。分为输入枝管径、输出枝管径、袢顶直径、管长。 正常血管管径粗细均匀,输入值为 9--13mm 输出值: 11--17mm 如果血管粗细不均匀,表明血管调节不稳定,循环状态不良,在过度疲劳中比较常见。
  7. (一)正常型为发夹形,异常为交叉和畸形,交叉的比例数应不超过 30% ,畸形应不超过 10% Normal shape likes the hair clip, exceptionally for overlapping and abnormal, the overlapping proportion number should not surpass 30%, the abnormal should not surpass 10%
  8. 1 、心脑血管疾病,糖尿病、结缔组织疾病等全身性疾病或局部真菌感染外伤等容易出现血管畸形 2 、动脉硬化、糖尿病时畸形严重,比例过高。 3 、胶原性疾病、雷诺病、精神病时,变异形血管增多。 Explanation: 1st, the blood vessel of heart and brain disease, the diabetes, the connective tissue disease and so on, with contract whole body disease or the partial fungus infection and flesh wound and other organization disease is easy to appear the blood vessel to be abnormal 2nd, when arteriosclerosis, diabetes with serious abnormal, and the proportion excessive highly. 3rd, collagen disease, Reynold sickness, neurosis, the variation of blood vessel increases. Explanation: 1st, the blood vessel of heart and brain disease, the diabetes, the connective tissue disease and so on, with contract whole body disease or the partial fungus infection and flesh wound and other organization disease is easy to appear the blood vessel to be abnormal 2nd, when arteriosclerosis, diabetes with serious abnormal, and the proportion excessive highly. 3rd, collagen disease, Reynold sickness, neurosis, the variation of blood vessel increases.
  9. 说明:管袢短小说明末梢供血不良,外周循环不良,皮肤退行性病变,萎缩,与动脉硬化、糖尿病、冠心病、缺血性疾病有关 Explained: The blood vessel ansa short prompts that the supply of ending blood is not good, peripheral circulation is not good, the skin retrograde affection, atrophia, with the arteriosclerosis, the diabetes, the coronary disease, ischemic disease to concern.
  10. 说明:管袢纤细与高血压、冠心病、末梢供血不足、缺血性疾病、糖尿病后期、老年动脉硬化症有关。 Explained: The tube ansa slenderly with the hypertension, the coronary disease, the ending blood insufficiency, ischemic disease, the late diabetes, the old age arteriosclerosis concerns.
  11. 血管输入枝变细,输出枝变粗,比例变大,表明动脉处于高度紧张状态,血管痉挛,静脉血液回流不良,在高血压、动脉硬化、头痛时常见。 A blood vessel input thinning, output coarsening, the proportion increase, indicated the artery is at the highly tight condition, the vasospasm, the vein blood backflow is not good, when hypertension, arteriosclerosis, headache is common.
  12. 血管输入、输出枝明显扩张,粗细不均,血流减慢,轻度红细胞聚集,表明血管紧张性降低,血液回流不良,在疲劳、自主神经调节异常、血黏度变高、高脂血症常见。 Blood vessel input and output branch are obvious expansion, uneven caliber, the blood stream with lower speed, the mild red blood cell gathers, indicated blood vessel anxiety reduces, the blood backflow is not good, in weary, the autonomic nerve adjustment exceptionally, the blood viscosity high, the high blood lipid is common.
  13. 血管中有明显淤血现象,血流变慢,红细胞聚集严重,在红斑狼疮、雷诺病、系统性硬化病、肺心病常见。 In the blood vessel has the obvious the stagnation blood , the blood stream slows down, the red blood cell gathers seriously, in the lupus erythematosus, the Reynold sickness, the systematic scleroderma, the heart disease from lung disorders is common.
  14. 增生型血管在慢性缺血性疾病、肿瘤中常见
  15. 是系统性硬化疾病的表现
  16. 1 、   红细胞聚集是最基本的病理反应之一 聚集的红细胞不能像正常的红细胞那样运输氧,从而影响组织细胞的物质交换和能量传递,严重聚集的红细胞在动脉中不能解聚时则成为异物或栓塞微血管,引起局部组织坏死,或被网状内皮细胞吞噬。 2 、   静脉中红细胞聚集会引起粘度增高,进一步引起血流停滞,导致血管病加重,动脉中会形成局部狭窄,加重动脉疾病,导致组织结构的严重病变。 红细胞聚集是导致脑血管意外的重要危险因素,如导致高血压、冠心病出现心绞痛、心梗。 1st, the red blood cell gathers is the red blood cell which one of most basic pathological reactions gathers cannot like the normal red blood cell such to transport the oxygen therapy, thus the influence organization cell material interchange and the energy transfer, seriously gather the red blood cell when the artery cannot the depolymerization becomes the foreign matter or the embolism blood capillary, causes the partial organization necrosis, or is swallowed by the lattice endothelial cell. 2nd, in the vein the red blood cell gathers the assembly to cause the viscosity to advance, further causes the blood stream to stagnate, causes the angiopathy to aggravate, in the artery can form partial is narrow, aggravates the artery disease, causes the organizational structure the serious pathological change. 3rd, the red blood cell gathers is causes the blood vessel of brain accident the important dangerous factor, like causes the hypertension, the coronary disease to have the angina pectoris, the heart stem.
  17. 只有微循环检测仪可以直接观测到白微栓,正确发现血液的白微栓非常重要,一旦血液中发现了小血栓将是非常危险的。 血流中会出现白色的微小血栓,它随血液在全身流动,一旦因为血管变细、扭曲变形而堵塞血管(特别是中老年人),就会出现相应的疾病,轻则头昏、失眠、眩晕、嘴唇麻木、 心慌、胸闷 ,如果出现大面积的脑部或心脏堵塞则会造成半身不遂、语言 障碍、心肌梗塞等。因此应通过微循环的检查及早发现血栓,积极抗栓溶栓,疏通微循环,防患于未然。
  18. ①      渗出 :是指血管内血浆成分过量地通透血管壁并存积于微血管周围的一种现象,是常见的微循环的改变之一。特征:管袢周围间隙扩大、明亮;管袢影像模糊,长度缩短。   ②      出血 :红细胞出至血管外的现象。 微循环血管出血,是重要的表现,应结合顾客是否患心脑血管疾病情况进行分析,提醒顾客及时进行预防。
  19. pneumocardial disease 肺心病 ; rheumatism 风湿病 ;rheumatoid arthritis 类风湿性关节炎 ; 明显扩张的乳头下静脉丛在老年性肺心病、风湿病、类风湿性关节炎、皮肤萎缩、骨质疏松、右心衰竭、高血压、冠心病、消化系统疾病、泌尿疾病,大面积炎症、结缔组织疾病等常见。
  20. 乳头正常呈锯齿状、波浪形,异常可见浅波纹和平坦。 乳头的形状的反映了身体的免疫力的情况,因为乳头的形状是和心脏的动力,血管的弹性等有关,所以,波浪形越明显,表明免疫力越强。