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ALZHEIMER’S DISEASE:
PATHOGENESIS,
DIAGNOSIS AND
TREATMENT
Devashish Mehta*, Amar Goyal, Kuldeep K.
Sharma.
devashishmehta...
INTRODUCTION
 Alzheimer's disease is a
neurodegenerative brain disorder.
 It is the most common form of dementia.
 It u...
CAUSES OF AD
 Increasing age
 History of a head injury
 Risk factors for blood vessel
disease such as smoking
 Heredit...
Signs and Symptoms
At early stages of AD :
 Impairment in Memory
 Aphasia
 Apraxia
 Agnosia
 Mood changes
 Loss of s...
At progressive AD:
 Increasing short-term memory loss
and confusion
 Feelings of restlessness
 Loss of appetite
 Perso...
Stages of AD
 Stage 1: Normal
 Stage 2: Normal aged forgetfulness
 Stage 3: Mild cognitive impairment
 Stage 4: Mild A...
PATHOGENSIS
Pathophysiology
 R.O.S.( Reactive oxygen species)
generation.
 Deposition of Amyloid β( Aβ42)
 Hyperphosphorylation of ...
Healthy Brain vs AD Brain
DIAGNOSIS OF AD
• Psychiatric assessments.
• Mental status examination and neuro
psychological assessment.
• Laboratory te...
TREATMENT STRATGIES
 Non – Pharmacological
 Meditation
 YOGA
 Panchkarma
 Pharmacological
 Allopathic
 Ayurvedic
Allopathic Treatment
 Cholinesterase inhibitor( eg.-
Donepezil, Galantamine, Tacrine)
 HMG Co A reductase inhibitor(eg.-...
Ayurvedic Treatment
 Brahmi Vati
 Shunkhpushpi
 Jatamansi
 Badam
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Alzheimer’s disease

Basics of AD.

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Alzheimer’s disease

  1. 1. ALZHEIMER’S DISEASE: PATHOGENESIS, DIAGNOSIS AND TREATMENT Devashish Mehta*, Amar Goyal, Kuldeep K. Sharma. devashishmehta7754@gmail.com
  2. 2. INTRODUCTION  Alzheimer's disease is a neurodegenerative brain disorder.  It is the most common form of dementia.  It usually starts in late middle age or in old age(above 65years).  It is characterized by progressive memory loss.  Formation of Neurofibrillary tangles and plaques containing beta-amyloid cells.
  3. 3. CAUSES OF AD  Increasing age  History of a head injury  Risk factors for blood vessel disease such as smoking  Heredity  Obesity  High blood pressure  High cholesterol
  4. 4. Signs and Symptoms At early stages of AD :  Impairment in Memory  Aphasia  Apraxia  Agnosia  Mood changes  Loss of spontaneity and initiative
  5. 5. At progressive AD:  Increasing short-term memory loss and confusion  Feelings of restlessness  Loss of appetite  Personality changes
  6. 6. Stages of AD  Stage 1: Normal  Stage 2: Normal aged forgetfulness  Stage 3: Mild cognitive impairment  Stage 4: Mild Alzheimer’s  Stage 5: Moderate Alzheimer’s disease  Stage 6: Moderately severe Alzheimer’s disease  Stage 7: Severe Alzheimer’s disease
  7. 7. PATHOGENSIS
  8. 8. Pathophysiology  R.O.S.( Reactive oxygen species) generation.  Deposition of Amyloid β( Aβ42)  Hyperphosphorylation of Tau Protein  Neurofibrillary Tangles (NFT) Formation  Inflammation
  9. 9. Healthy Brain vs AD Brain
  10. 10. DIAGNOSIS OF AD • Psychiatric assessments. • Mental status examination and neuro psychological assessment. • Laboratory tests. • Brain imaging : CT scan, MRI • CSF Examination • Electro-encephalogram (EEG)
  11. 11. TREATMENT STRATGIES  Non – Pharmacological  Meditation  YOGA  Panchkarma  Pharmacological  Allopathic  Ayurvedic
  12. 12. Allopathic Treatment  Cholinesterase inhibitor( eg.- Donepezil, Galantamine, Tacrine)  HMG Co A reductase inhibitor(eg.- Simvastatin, Atorvastatin, Lovastatin)  Non- Statin Hypolipidaemics (eg.- Probucol)  NMDA receptor antagonist
  13. 13. Ayurvedic Treatment  Brahmi Vati  Shunkhpushpi  Jatamansi  Badam

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