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Individual Brain Charting,
a high-resolution fMRI dataset
for cognitive mapping of the human brain
Ana Lu´ısa Pinho
Juan Jes´us Torre
Parietal Team, Inria-Saclay
NeuroSpin, CEA-Saclay
France
@ALuisaPinho
@JuanTresols
Open Science Room
From statistical to biological validity
OHBM Rome, Italy
11th
of June 2019
Background and motivations
In cognitive neuroscience:
Brain systems
⇐⇒
Mental functions
Background and motivations
In cognitive neuroscience:
Brain systems
⇐⇒
Mental functions
tackle one psychological domain
Background and motivations
In cognitive neuroscience:
Brain systems
⇐⇒
Mental functions
tackle one psychological domain
be specific enough to accurately isolate brain
processes
Background and motivations
In cognitive neuroscience:
Brain systems
⇐⇒
Mental functions
tackle one psychological domain
be specific enough to accurately isolate brain
processes
⇓
Very hard to achieve!
Lack of generality.
Background and motivations
In cognitive neuroscience:
Brain systems
⇐⇒
Mental functions
Task-fMRI experiments allow to:
link brain systems to behavior
Features of the IBC dataset
High spatial-resolution fMRI data
(1.5mm)
Features of the IBC dataset
High spatial-resolution fMRI data
(1.5mm)
TR = 2s
Features of the IBC dataset
High spatial-resolution fMRI data
(1.5mm)
TR = 2s
Task-wise dataset:
Many tasks
Features of the IBC dataset
High spatial-resolution fMRI data
(1.5mm)
TR = 2s
Task-wise dataset:
Many tasks
Fixed cohort - 13 healthy adults
Features of the IBC dataset
High spatial-resolution fMRI data
(1.5mm)
TR = 2s
Task-wise dataset:
Many tasks
Fixed cohort - 13 healthy adults
Fixed environment
NeuroSpin platform, CEA-Saclay, France
Siemens 3T Magnetom Prismafit
64-channel coil
Features of the IBC dataset
High spatial-resolution fMRI data
(1.5mm)
TR = 2s
Task-wise dataset:
Many tasks
Fixed cohort - 13 healthy adults
Fixed environment
Inclusion of other MRI modalities
NeuroSpin platform, CEA-Saclay, France
Siemens 3T Magnetom Prismafit
64-channel coil
Features of the IBC dataset
High spatial-resolution fMRI data
(1.5mm)
TR = 2s
Task-wise dataset:
Many tasks
Fixed cohort - 13 healthy adults
Fixed environment
Inclusion of other MRI modalities
Not a longitudinal study!
NeuroSpin platform, CEA-Saclay, France
Siemens 3T Magnetom Prismafit
64-channel coil
Experimental designs
Event-related design
Experimental designs
Event-related design
Naturalistic stimuli
Experimental designs
Event-related design
Naturalistic stimuli
Continuous stimulation
First release
Tasks
ARCHI tasks
Pinel, P. et al. (2007)
First release
Tasks
ARCHI tasks
Pinel, P. et al. (2007)
Standard
Cognitive concepts:
visual/auditory
arithmetic processing
visual word recognition
vertical/horizontal
checkerboard
auditory sentence
recognition
sentence processing
response selection
left/right finger response
execution
First release
Tasks
ARCHI tasks
Pinel, P. et al. (2007)
Standard
Spatial
Cognitive concepts:
visual/auditory
arithmetic processing
visual word recognition
vertical/horizontal
checkerboard
auditory sentence
recognition
sentence processing
response selection
left/right finger response
execution
visual tool/body
recognition
visual tracking
grasping
hand chirality/side
recognition
First release
Tasks
ARCHI tasks
Pinel, P. et al. (2007)
Standard
Spatial
Social
Cognitive concepts:
visual/auditory
arithmetic processing
visual word recognition
vertical/horizontal
checkerboard
auditory sentence
recognition
sentence processing
response selection
left/right finger response
execution
visual tool/body
recognition
visual tracking
grasping
hand chirality/side
recognition
sounds/voice perception
animacy
perception/decision
motion detection
theory-of-mind
First release
Tasks
ARCHI tasks
Pinel, P. et al. (2007)
Standard
Spatial
Social
Emotional
Cognitive concepts:
visual/auditory
arithmetic processing
visual word recognition
vertical/horizontal
checkerboard
auditory sentence
recognition
sentence processing
response selection
left/right finger response
execution
visual tool/body
recognition
visual tracking
grasping
hand chirality/side
recognition
sounds/voice perception
animacy
perception/decision
motion detection
theory-of-mind
emotion expression
identification
facial trustworthiness
recognition
gender discrimination
First release
Tasks
ARCHI tasks
Pinel, P. et al. (2007)
Standard
Spatial
Social
Emotional
HCP tasks
Barch, D. M. et al. (2013)
Cognitive concepts:
visual/auditory
arithmetic processing
visual word recognition
vertical/horizontal
checkerboard
auditory sentence
recognition
sentence processing
response selection
left/right finger response
execution
visual tool/body
recognition
visual tracking
grasping
hand chirality/side
recognition
sounds/voice perception
animacy
perception/decision
motion detection
theory-of-mind
emotion expression
identification
facial trustworthiness
recognition
gender discrimination
First release
Tasks
ARCHI tasks
Pinel, P. et al. (2007)
Standard
Spatial
Social
Emotional
HCP tasks
Barch, D. M. et al. (2013)
Emotion
Cognitive concepts:
visual/auditory
arithmetic processing
visual word recognition
vertical/horizontal
checkerboard
auditory sentence
recognition
sentence processing
response selection
left/right finger response
execution
visual tool/body
recognition
visual tracking
grasping
hand chirality/side
recognition
sounds/voice perception
animacy
perception/decision
motion detection
theory-of-mind
emotion expression
identification
facial trustworthiness
recognition
gender discrimination
visual form recognition
feature comparison
emotional face
recognition
First release
Tasks
ARCHI tasks
Pinel, P. et al. (2007)
Standard
Spatial
Social
Emotional
HCP tasks
Barch, D. M. et al. (2013)
Emotion
Gambling
Cognitive concepts:
visual/auditory
arithmetic processing
visual word recognition
vertical/horizontal
checkerboard
auditory sentence
recognition
sentence processing
response selection
left/right finger response
execution
visual tool/body
recognition
visual tracking
grasping
hand chirality/side
recognition
sounds/voice perception
animacy
perception/decision
motion detection
theory-of-mind
emotion expression
identification
facial trustworthiness
recognition
gender discrimination
visual form recognition
feature comparison
emotional face
recognition
reward processing
punishment processing
First release
Tasks
ARCHI tasks
Pinel, P. et al. (2007)
Standard
Spatial
Social
Emotional
HCP tasks
Barch, D. M. et al. (2013)
Emotion
Gambling
Motor
Cognitive concepts:
visual/auditory
arithmetic processing
visual word recognition
vertical/horizontal
checkerboard
auditory sentence
recognition
sentence processing
response selection
left/right finger response
execution
visual tool/body
recognition
visual tracking
grasping
hand chirality/side
recognition
sounds/voice perception
animacy
perception/decision
motion detection
theory-of-mind
emotion expression
identification
facial trustworthiness
recognition
gender discrimination
visual form recognition
feature comparison
emotional face
recognition
reward processing
punishment processing
left/right hand response
execution
left/right toe response
execution
working memory
First release
Tasks
ARCHI tasks
Pinel, P. et al. (2007)
Standard
Spatial
Social
Emotional
HCP tasks
Barch, D. M. et al. (2013)
Emotion
Gambling
Motor
Language
Cognitive concepts:
visual/auditory
arithmetic processing
visual word recognition
vertical/horizontal
checkerboard
auditory sentence
recognition
sentence processing
response selection
left/right finger response
execution
visual tool/body
recognition
visual tracking
grasping
hand chirality/side
recognition
sounds/voice perception
animacy
perception/decision
motion detection
theory-of-mind
emotion expression
identification
facial trustworthiness
recognition
gender discrimination
visual form recognition
feature comparison
emotional face
recognition
reward processing
punishment processing
left/right hand response
execution
left/right toe response
execution
working memory
story comprehension
First release
Tasks
ARCHI tasks
Pinel, P. et al. (2007)
Standard
Spatial
Social
Emotional
HCP tasks
Barch, D. M. et al. (2013)
Emotion
Gambling
Motor
Language
Relational
Cognitive concepts:
visual/auditory
arithmetic processing
visual word recognition
vertical/horizontal
checkerboard
auditory sentence
recognition
sentence processing
response selection
left/right finger response
execution
visual tool/body
recognition
visual tracking
grasping
hand chirality/side
recognition
sounds/voice perception
animacy
perception/decision
motion detection
theory-of-mind
emotion expression
identification
facial trustworthiness
recognition
gender discrimination
visual form recognition
feature comparison
emotional face
recognition
reward processing
punishment processing
left/right hand response
execution
left/right toe response
execution
working memory
story comprehension
visual pattern
recognition
relational comparison
First release
Tasks
ARCHI tasks
Pinel, P. et al. (2007)
Standard
Spatial
Social
Emotional
HCP tasks
Barch, D. M. et al. (2013)
Emotion
Gambling
Motor
Language
Relational
Social
Cognitive concepts:
visual/auditory
arithmetic processing
visual word recognition
vertical/horizontal
checkerboard
auditory sentence
recognition
sentence processing
response selection
left/right finger response
execution
visual tool/body
recognition
visual tracking
grasping
hand chirality/side
recognition
sounds/voice perception
animacy
perception/decision
motion detection
theory-of-mind
emotion expression
identification
facial trustworthiness
recognition
gender discrimination
visual form recognition
feature comparison
emotional face
recognition
reward processing
punishment processing
left/right hand response
execution
left/right toe response
execution
working memory
story comprehension
visual pattern
recognition
relational comparison
response execution
First release
Tasks
ARCHI tasks
Pinel, P. et al. (2007)
Standard
Spatial
Social
Emotional
HCP tasks
Barch, D. M. et al. (2013)
Emotion
Gambling
Motor
Language
Relational
Social
WM
Cognitive concepts:
visual/auditory
arithmetic processing
visual word recognition
vertical/horizontal
checkerboard
auditory sentence
recognition
sentence processing
response selection
left/right finger response
execution
visual tool/body
recognition
visual tracking
grasping
hand chirality/side
recognition
sounds/voice perception
animacy
perception/decision
motion detection
theory-of-mind
emotion expression
identification
facial trustworthiness
recognition
gender discrimination
visual form recognition
feature comparison
emotional face
recognition
reward processing
punishment processing
left/right hand response
execution
left/right toe response
execution
working memory
story comprehension
visual pattern
recognition
relational comparison
response execution
visual face/place
recognition
tool/body/place/face
maintenance
updating
First release
Tasks
ARCHI tasks
Pinel, P. et al. (2007)
Standard
Spatial
Social
Emotional
HCP tasks
Barch, D. M. et al. (2013)
Emotion
Gambling
Motor
Language
Relational
Social
WM
RSVP Language
Cognitive concepts:
visual/auditory
arithmetic processing
visual word recognition
vertical/horizontal
checkerboard
auditory sentence
recognition
sentence processing
response selection
left/right finger response
execution
visual tool/body
recognition
visual tracking
grasping
hand chirality/side
recognition
sounds/voice perception
animacy
perception/decision
motion detection
theory-of-mind
emotion expression
identification
facial trustworthiness
recognition
gender discrimination
visual form recognition
feature comparison
emotional face
recognition
reward processing
punishment processing
left/right hand response
execution
left/right toe response
execution
working memory
story comprehension
visual pattern
recognition
relational comparison
response execution
visual face/place
recognition
tool/body/place/face
maintenance
updating
visual
pseudo-word/string
recognition
syntactic parsing
string/word maintenance
First release
Tasks
ARCHI tasks
Pinel, P. et al. (2007)
Standard
Spatial
Social
Emotional
HCP tasks
Barch, D. M. et al. (2013)
Emotion
Gambling
Motor
Language
Relational
Social
WM
RSVP Language
Cognitive concepts:
visual/auditory
arithmetic processing
visual word recognition
vertical/horizontal
checkerboard
auditory sentence
recognition
sentence processing
response selection
left/right finger response
execution
visual tool/body
recognition
visual tracking
grasping
hand chirality/side
recognition
sounds/voice perception
animacy
perception/decision
motion detection
theory-of-mind
emotion expression
identification
facial trustworthiness
recognition
gender discrimination
visual form recognition
feature comparison
emotional face
recognition
reward processing
punishment processing
left/right hand response
execution
left/right toe response
execution
working memory
story comprehension
visual pattern
recognition
relational comparison
response execution
visual face/place
recognition
tool/body/place/face
maintenance
updating
visual
pseudo-word/string
recognition
syntactic parsing
string/word maintenance
59 independent conditions
226 contrasts
Future releases
Next release is coming up soon!
Mental-Time Travel Gauthier, B., & van Wassenhove, V. (2016a,b)
Positive-Incentive Value Lebreton, M. et al. (2015)
Theory-of-Mind + Pain Matrices Dodell-Feder, D. et al. (2010) / Jacoby, N. et al. (2015)
Visual Short-Term Memory + Enumeration Knops, A. et al. (2014)
Self-Reference Effect Genon, S. et al. (2014)
Future releases
Next release is coming up soon!
Mental-Time Travel Gauthier, B., & van Wassenhove, V. (2016a,b)
Positive-Incentive Value Lebreton, M. et al. (2015)
Theory-of-Mind + Pain Matrices Dodell-Feder, D. et al. (2010) / Jacoby, N. et al. (2015)
Visual Short-Term Memory + Enumeration Knops, A. et al. (2014)
Self-Reference Effect Genon, S. et al. (2014)
First + Second release:
127 independent conditions
279 contrasts
Future releases
Next release is coming up soon!
Mental-Time Travel Gauthier, B., & van Wassenhove, V. (2016a,b)
Positive-Incentive Value Lebreton, M. et al. (2015)
Theory-of-Mind + Pain Matrices Dodell-Feder, D. et al. (2010) / Jacoby, N. et al. (2015)
Visual Short-Term Memory + Enumeration Knops, A. et al. (2014)
Self-Reference Effect Genon, S. et al. (2014)
First + Second release:
127 independent conditions
279 contrasts
Other releases:
Visual system: Passive-Watching of Naturalistic Scenes + Movie
Watching + Retinotopy
Anatomical data + Resting-State
Tonotopy, Biological Motion and more...
Behavioral protocols
Behavioral protocols
Software Tools:
Analysis pipeline
Data access
Raw MRI data
Link
Data access
Raw MRI data
Link
ds000244 Link
Data access
Raw MRI data
Link
ds000244 Link
Data organization: BIDS Specification
Data access
Raw MRI data
Link
ds000244 Link
Data organization: BIDS Specification
Behavioral Protocols
hbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocols
Data access
Raw MRI data
Link
ds000244 Link
Data organization: BIDS Specification
Behavioral Protocols
hbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocols
• More public repositories of behavioral protocols to reproduce
experiments!
• Normatives to describe the experimental paradigms!
Data access
Analysis Pipeline
hbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis code
Data access
Analysis Pipeline
hbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis code
Data derivatives
Collection id=4438 Link
Data access
Analysis Pipeline
hbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis code
Data derivatives
Collection id=4438 Link
doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105
Results
IBC reproduces ARCHI and HCP
storyvs.math
social-interactionmotionvs.random
motion
punishementvs.reward
tonguevs.anymotion
rightfootvs.anymotion
leftfootvs.anymotion
righthandvs.anymotion
lefthandvs.anymotion
faceimagevs.shapeoutline
relationalprocessingvs.visualmatching
toolimagevs.anyimage
placeimagevs.anyimage
faceimagevs.anyimage
bodyimagevs.anyimage
2-backvs.0-back
sentencereadingvs.sentencelistening
sentencereadingvs.checkerboard
lefthandvs.righthand
horizontalcheckerboardvs.verticalcheckerboard
mentalsubtractionvs.sentencereading
saccadesvs.fixation
leftorrighthandvs.handpalm
orback
objectgraspingvs.orientationjudgment
social-interactionmotionvs.random
motion
false-beliefstoryvs.mechanisticstory
false-belieftalevs.mechanistictale
expressionintentionvs.genderassessment
facetrustyvs.genderassessment
story vs. math
social-interaction motion vs. random motion
punishement vs. reward
tongue vs. any motion
right foot vs. any motion
left foot vs. any motion
right hand vs. any motion
left hand vs. any motion
face image vs. shape outline
relational processing vs. visual matching
tool image vs. any image
place image vs. any image
face image vs. any image
body image vs. any image
2-back vs. 0-back
sentence reading vs. sentence listening
sentence reading vs. checkerboard
left hand vs. right hand
horizontal checkerboard vs. vertical checkerboard
mental subtraction vs. sentence reading
saccades vs. fixation
left or right hand vs. hand palm or back
object grasping vs. orientation judgment
social-interaction motion vs. random motion
false-belief story vs. mechanistic story
false-belief tale vs. mechanistic tale
expression intention vs. gender assessment
face trusty vs. gender assessment
HCP contrasts ARCHI contrasts
IBCcontrasts
0.6
0.4
0.2
0.0
0.2
0.4
0.6
0.8
ARCHI batteries:
Pinel, P. et al. (2007)
HCP batteries:
Barch, D. M. et al.
(2013)
IBC reproduces ARCHI and HCP
ARCHI batteries:
Pinel, P. et al. (2007)
HCP batteries:
Barch, D. M. et al.
(2013)
Brain coverage
Group-level F-map pFWE < 0.05
x=27x=12x=-13x=-28x=-43 -80
-40
0
40
80
Comprehensive brain coverage of functional activity
already in the first release!
Activation similarity fits task similarity
archiemotional
archisocial
archispatial
archistandard
hcpemotion
hcpgambling
hcplanguagehcpmotor
hcprelational
hcpsocial
hcpwmrsvplanguagearchi emotional
archi social
archi spatial
archi standard
hcp emotion
hcp gambling
hcp language
hcp motor
hcp relational
hcp social
hcp wm
rsvp language 0
1
archiemotional
archisocial
archispatial
archistandard
hcpemotion
hcpgambling
hcplanguagehcpmotor
hcprelational
hcpsocial
hcpwmrsvplanguage
archi emotional
archi social
archi spatial
archi standard
hcp emotion
hcp gambling
hcp language
hcp motor
hcp relational
hcp social
hcp wm
rsvp language 0
1
Variability of Functional Signatures
Individual z-maps
Variability of Functional Signatures
0.0 0.1 0.2 0.3 0.4
sentence reading vs. sentence listening
sentence reading vs. checkerboard
left hand vs. right hand
horizontal checkerboard vs. vertical checkerboard
mental subtraction vs. sentence reading
saccades vs. fixation
left or right hand vs. hand palm or back
object grasping vs. orientation judgment
social-interaction motion vs. random motion
false-belief story vs. mechanistic story
false-belief tale vs. mechanistic tale
expression intention vs. gender assessment
face trusty vs. gender assessment
face image vs. shape outline
punishement vs. reward
0.0 0.1 0.2 0.3 0.4
tongue vs. any motion
right foot vs. any motion
left foot vs. any motion
right hand vs. any motion
left hand vs. any motion
story vs. math
relational processing vs. visual matching
social-interaction motion vs. random motion
tool image vs. any image
place image vs. any image
face image vs. any image
body image vs. any image
2-back vs. 0-back
read pseudowords vs. consonant strings
read words vs. consonant strings
read words vs. read pseudowords
read sentence vs. read jabberwocky
read sentence vs. read words
Average and standard deviation of map correlation across subjects
Effect of subject and task on brain activity
Per-voxel one-way ANOVA qFDR < 0.05
x=10
L R
z=10 -28
-14
0
14
28
L R
y=-50
Subject effect
x=10
L R
z=10 -37
-19
0
19
37
L R
y=-50
Condition effect
x=-6
L R
z=3 -12
-5.9
0
5.9
12
L R
y=45
Phase encoding effect
Effect of subject and task on brain activity
Per-voxel one-way ANOVA qFDR < 0.05
x=10
L R
z=10 -28
-14
0
14
28
L R
y=-50
Subject effect
x=10
L R
z=10 -37
-19
0
19
37
L R
y=-50
Condition effect
x=-6
L R
z=3 -12
-5.9
0
5.9
12
L R
y=45
Phase encoding effect
IBC data is suitable for cognitive mapping
and individual-brain modeling!
Exploring individual cognitive topographies
Exploring individual cognitive topographies
Tasks consistently map brain networks across individuals.
Concluding remarks
Data acquisition till 2022
Concluding remarks
Data acquisition till 2022
Final dataset:
50 acquisitions per participant
Concluding remarks
Data acquisition till 2022
Final dataset:
50 acquisitions per participant
Share your protocols
with us!
Concluding remarks
Data acquisition till 2022
Final dataset:
50 acquisitions per participant
Share your protocols
with us!
Encoding models for cognitive mapping
Concluding remarks
Data acquisition till 2022
Final dataset:
50 acquisitions per participant
Share your protocols
with us!
Encoding models for cognitive mapping
Thanks!
Bertrand Thirion
...and to
the IBC volunteers!!!
For more information, consult: project.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBC
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Individual Brain Charting, a high-resolution fMRI dataset for cognitive mapping of the human brain

  • 1. Individual Brain Charting, a high-resolution fMRI dataset for cognitive mapping of the human brain Ana Lu´ısa Pinho Juan Jes´us Torre Parietal Team, Inria-Saclay NeuroSpin, CEA-Saclay France @ALuisaPinho @JuanTresols Open Science Room From statistical to biological validity OHBM Rome, Italy 11th of June 2019
  • 2. Background and motivations In cognitive neuroscience: Brain systems ⇐⇒ Mental functions
  • 3. Background and motivations In cognitive neuroscience: Brain systems ⇐⇒ Mental functions tackle one psychological domain
  • 4. Background and motivations In cognitive neuroscience: Brain systems ⇐⇒ Mental functions tackle one psychological domain be specific enough to accurately isolate brain processes
  • 5. Background and motivations In cognitive neuroscience: Brain systems ⇐⇒ Mental functions tackle one psychological domain be specific enough to accurately isolate brain processes ⇓ Very hard to achieve! Lack of generality.
  • 6. Background and motivations In cognitive neuroscience: Brain systems ⇐⇒ Mental functions Task-fMRI experiments allow to: link brain systems to behavior
  • 7. Features of the IBC dataset High spatial-resolution fMRI data (1.5mm)
  • 8. Features of the IBC dataset High spatial-resolution fMRI data (1.5mm) TR = 2s
  • 9. Features of the IBC dataset High spatial-resolution fMRI data (1.5mm) TR = 2s Task-wise dataset: Many tasks
  • 10. Features of the IBC dataset High spatial-resolution fMRI data (1.5mm) TR = 2s Task-wise dataset: Many tasks Fixed cohort - 13 healthy adults
  • 11. Features of the IBC dataset High spatial-resolution fMRI data (1.5mm) TR = 2s Task-wise dataset: Many tasks Fixed cohort - 13 healthy adults Fixed environment NeuroSpin platform, CEA-Saclay, France Siemens 3T Magnetom Prismafit 64-channel coil
  • 12. Features of the IBC dataset High spatial-resolution fMRI data (1.5mm) TR = 2s Task-wise dataset: Many tasks Fixed cohort - 13 healthy adults Fixed environment Inclusion of other MRI modalities NeuroSpin platform, CEA-Saclay, France Siemens 3T Magnetom Prismafit 64-channel coil
  • 13. Features of the IBC dataset High spatial-resolution fMRI data (1.5mm) TR = 2s Task-wise dataset: Many tasks Fixed cohort - 13 healthy adults Fixed environment Inclusion of other MRI modalities Not a longitudinal study! NeuroSpin platform, CEA-Saclay, France Siemens 3T Magnetom Prismafit 64-channel coil
  • 18. First release Tasks ARCHI tasks Pinel, P. et al. (2007) Standard Cognitive concepts: visual/auditory arithmetic processing visual word recognition vertical/horizontal checkerboard auditory sentence recognition sentence processing response selection left/right finger response execution
  • 19. First release Tasks ARCHI tasks Pinel, P. et al. (2007) Standard Spatial Cognitive concepts: visual/auditory arithmetic processing visual word recognition vertical/horizontal checkerboard auditory sentence recognition sentence processing response selection left/right finger response execution visual tool/body recognition visual tracking grasping hand chirality/side recognition
  • 20. First release Tasks ARCHI tasks Pinel, P. et al. (2007) Standard Spatial Social Cognitive concepts: visual/auditory arithmetic processing visual word recognition vertical/horizontal checkerboard auditory sentence recognition sentence processing response selection left/right finger response execution visual tool/body recognition visual tracking grasping hand chirality/side recognition sounds/voice perception animacy perception/decision motion detection theory-of-mind
  • 21. First release Tasks ARCHI tasks Pinel, P. et al. (2007) Standard Spatial Social Emotional Cognitive concepts: visual/auditory arithmetic processing visual word recognition vertical/horizontal checkerboard auditory sentence recognition sentence processing response selection left/right finger response execution visual tool/body recognition visual tracking grasping hand chirality/side recognition sounds/voice perception animacy perception/decision motion detection theory-of-mind emotion expression identification facial trustworthiness recognition gender discrimination
  • 22. First release Tasks ARCHI tasks Pinel, P. et al. (2007) Standard Spatial Social Emotional HCP tasks Barch, D. M. et al. (2013) Cognitive concepts: visual/auditory arithmetic processing visual word recognition vertical/horizontal checkerboard auditory sentence recognition sentence processing response selection left/right finger response execution visual tool/body recognition visual tracking grasping hand chirality/side recognition sounds/voice perception animacy perception/decision motion detection theory-of-mind emotion expression identification facial trustworthiness recognition gender discrimination
  • 23. First release Tasks ARCHI tasks Pinel, P. et al. (2007) Standard Spatial Social Emotional HCP tasks Barch, D. M. et al. (2013) Emotion Cognitive concepts: visual/auditory arithmetic processing visual word recognition vertical/horizontal checkerboard auditory sentence recognition sentence processing response selection left/right finger response execution visual tool/body recognition visual tracking grasping hand chirality/side recognition sounds/voice perception animacy perception/decision motion detection theory-of-mind emotion expression identification facial trustworthiness recognition gender discrimination visual form recognition feature comparison emotional face recognition
  • 24. First release Tasks ARCHI tasks Pinel, P. et al. (2007) Standard Spatial Social Emotional HCP tasks Barch, D. M. et al. (2013) Emotion Gambling Cognitive concepts: visual/auditory arithmetic processing visual word recognition vertical/horizontal checkerboard auditory sentence recognition sentence processing response selection left/right finger response execution visual tool/body recognition visual tracking grasping hand chirality/side recognition sounds/voice perception animacy perception/decision motion detection theory-of-mind emotion expression identification facial trustworthiness recognition gender discrimination visual form recognition feature comparison emotional face recognition reward processing punishment processing
  • 25. First release Tasks ARCHI tasks Pinel, P. et al. (2007) Standard Spatial Social Emotional HCP tasks Barch, D. M. et al. (2013) Emotion Gambling Motor Cognitive concepts: visual/auditory arithmetic processing visual word recognition vertical/horizontal checkerboard auditory sentence recognition sentence processing response selection left/right finger response execution visual tool/body recognition visual tracking grasping hand chirality/side recognition sounds/voice perception animacy perception/decision motion detection theory-of-mind emotion expression identification facial trustworthiness recognition gender discrimination visual form recognition feature comparison emotional face recognition reward processing punishment processing left/right hand response execution left/right toe response execution working memory
  • 26. First release Tasks ARCHI tasks Pinel, P. et al. (2007) Standard Spatial Social Emotional HCP tasks Barch, D. M. et al. (2013) Emotion Gambling Motor Language Cognitive concepts: visual/auditory arithmetic processing visual word recognition vertical/horizontal checkerboard auditory sentence recognition sentence processing response selection left/right finger response execution visual tool/body recognition visual tracking grasping hand chirality/side recognition sounds/voice perception animacy perception/decision motion detection theory-of-mind emotion expression identification facial trustworthiness recognition gender discrimination visual form recognition feature comparison emotional face recognition reward processing punishment processing left/right hand response execution left/right toe response execution working memory story comprehension
  • 27. First release Tasks ARCHI tasks Pinel, P. et al. (2007) Standard Spatial Social Emotional HCP tasks Barch, D. M. et al. (2013) Emotion Gambling Motor Language Relational Cognitive concepts: visual/auditory arithmetic processing visual word recognition vertical/horizontal checkerboard auditory sentence recognition sentence processing response selection left/right finger response execution visual tool/body recognition visual tracking grasping hand chirality/side recognition sounds/voice perception animacy perception/decision motion detection theory-of-mind emotion expression identification facial trustworthiness recognition gender discrimination visual form recognition feature comparison emotional face recognition reward processing punishment processing left/right hand response execution left/right toe response execution working memory story comprehension visual pattern recognition relational comparison
  • 28. First release Tasks ARCHI tasks Pinel, P. et al. (2007) Standard Spatial Social Emotional HCP tasks Barch, D. M. et al. (2013) Emotion Gambling Motor Language Relational Social Cognitive concepts: visual/auditory arithmetic processing visual word recognition vertical/horizontal checkerboard auditory sentence recognition sentence processing response selection left/right finger response execution visual tool/body recognition visual tracking grasping hand chirality/side recognition sounds/voice perception animacy perception/decision motion detection theory-of-mind emotion expression identification facial trustworthiness recognition gender discrimination visual form recognition feature comparison emotional face recognition reward processing punishment processing left/right hand response execution left/right toe response execution working memory story comprehension visual pattern recognition relational comparison response execution
  • 29. First release Tasks ARCHI tasks Pinel, P. et al. (2007) Standard Spatial Social Emotional HCP tasks Barch, D. M. et al. (2013) Emotion Gambling Motor Language Relational Social WM Cognitive concepts: visual/auditory arithmetic processing visual word recognition vertical/horizontal checkerboard auditory sentence recognition sentence processing response selection left/right finger response execution visual tool/body recognition visual tracking grasping hand chirality/side recognition sounds/voice perception animacy perception/decision motion detection theory-of-mind emotion expression identification facial trustworthiness recognition gender discrimination visual form recognition feature comparison emotional face recognition reward processing punishment processing left/right hand response execution left/right toe response execution working memory story comprehension visual pattern recognition relational comparison response execution visual face/place recognition tool/body/place/face maintenance updating
  • 30. First release Tasks ARCHI tasks Pinel, P. et al. (2007) Standard Spatial Social Emotional HCP tasks Barch, D. M. et al. (2013) Emotion Gambling Motor Language Relational Social WM RSVP Language Cognitive concepts: visual/auditory arithmetic processing visual word recognition vertical/horizontal checkerboard auditory sentence recognition sentence processing response selection left/right finger response execution visual tool/body recognition visual tracking grasping hand chirality/side recognition sounds/voice perception animacy perception/decision motion detection theory-of-mind emotion expression identification facial trustworthiness recognition gender discrimination visual form recognition feature comparison emotional face recognition reward processing punishment processing left/right hand response execution left/right toe response execution working memory story comprehension visual pattern recognition relational comparison response execution visual face/place recognition tool/body/place/face maintenance updating visual pseudo-word/string recognition syntactic parsing string/word maintenance
  • 31. First release Tasks ARCHI tasks Pinel, P. et al. (2007) Standard Spatial Social Emotional HCP tasks Barch, D. M. et al. (2013) Emotion Gambling Motor Language Relational Social WM RSVP Language Cognitive concepts: visual/auditory arithmetic processing visual word recognition vertical/horizontal checkerboard auditory sentence recognition sentence processing response selection left/right finger response execution visual tool/body recognition visual tracking grasping hand chirality/side recognition sounds/voice perception animacy perception/decision motion detection theory-of-mind emotion expression identification facial trustworthiness recognition gender discrimination visual form recognition feature comparison emotional face recognition reward processing punishment processing left/right hand response execution left/right toe response execution working memory story comprehension visual pattern recognition relational comparison response execution visual face/place recognition tool/body/place/face maintenance updating visual pseudo-word/string recognition syntactic parsing string/word maintenance 59 independent conditions 226 contrasts
  • 32. Future releases Next release is coming up soon! Mental-Time Travel Gauthier, B., & van Wassenhove, V. (2016a,b) Positive-Incentive Value Lebreton, M. et al. (2015) Theory-of-Mind + Pain Matrices Dodell-Feder, D. et al. (2010) / Jacoby, N. et al. (2015) Visual Short-Term Memory + Enumeration Knops, A. et al. (2014) Self-Reference Effect Genon, S. et al. (2014)
  • 33. Future releases Next release is coming up soon! Mental-Time Travel Gauthier, B., & van Wassenhove, V. (2016a,b) Positive-Incentive Value Lebreton, M. et al. (2015) Theory-of-Mind + Pain Matrices Dodell-Feder, D. et al. (2010) / Jacoby, N. et al. (2015) Visual Short-Term Memory + Enumeration Knops, A. et al. (2014) Self-Reference Effect Genon, S. et al. (2014) First + Second release: 127 independent conditions 279 contrasts
  • 34. Future releases Next release is coming up soon! Mental-Time Travel Gauthier, B., & van Wassenhove, V. (2016a,b) Positive-Incentive Value Lebreton, M. et al. (2015) Theory-of-Mind + Pain Matrices Dodell-Feder, D. et al. (2010) / Jacoby, N. et al. (2015) Visual Short-Term Memory + Enumeration Knops, A. et al. (2014) Self-Reference Effect Genon, S. et al. (2014) First + Second release: 127 independent conditions 279 contrasts Other releases: Visual system: Passive-Watching of Naturalistic Scenes + Movie Watching + Retinotopy Anatomical data + Resting-State Tonotopy, Biological Motion and more...
  • 38. Data access Raw MRI data Link
  • 39. Data access Raw MRI data Link ds000244 Link
  • 40. Data access Raw MRI data Link ds000244 Link Data organization: BIDS Specification
  • 41. Data access Raw MRI data Link ds000244 Link Data organization: BIDS Specification Behavioral Protocols hbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocols
  • 42. Data access Raw MRI data Link ds000244 Link Data organization: BIDS Specification Behavioral Protocols hbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocolshbp-brain-charting/public protocols • More public repositories of behavioral protocols to reproduce experiments! • Normatives to describe the experimental paradigms!
  • 43. Data access Analysis Pipeline hbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis code
  • 44. Data access Analysis Pipeline hbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis code Data derivatives Collection id=4438 Link
  • 45. Data access Analysis Pipeline hbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis codehbp-brain-charting/public analysis code Data derivatives Collection id=4438 Link doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105doi.org/10.1038/sdata.2018.105
  • 47. IBC reproduces ARCHI and HCP storyvs.math social-interactionmotionvs.random motion punishementvs.reward tonguevs.anymotion rightfootvs.anymotion leftfootvs.anymotion righthandvs.anymotion lefthandvs.anymotion faceimagevs.shapeoutline relationalprocessingvs.visualmatching toolimagevs.anyimage placeimagevs.anyimage faceimagevs.anyimage bodyimagevs.anyimage 2-backvs.0-back sentencereadingvs.sentencelistening sentencereadingvs.checkerboard lefthandvs.righthand horizontalcheckerboardvs.verticalcheckerboard mentalsubtractionvs.sentencereading saccadesvs.fixation leftorrighthandvs.handpalm orback objectgraspingvs.orientationjudgment social-interactionmotionvs.random motion false-beliefstoryvs.mechanisticstory false-belieftalevs.mechanistictale expressionintentionvs.genderassessment facetrustyvs.genderassessment story vs. math social-interaction motion vs. random motion punishement vs. reward tongue vs. any motion right foot vs. any motion left foot vs. any motion right hand vs. any motion left hand vs. any motion face image vs. shape outline relational processing vs. visual matching tool image vs. any image place image vs. any image face image vs. any image body image vs. any image 2-back vs. 0-back sentence reading vs. sentence listening sentence reading vs. checkerboard left hand vs. right hand horizontal checkerboard vs. vertical checkerboard mental subtraction vs. sentence reading saccades vs. fixation left or right hand vs. hand palm or back object grasping vs. orientation judgment social-interaction motion vs. random motion false-belief story vs. mechanistic story false-belief tale vs. mechanistic tale expression intention vs. gender assessment face trusty vs. gender assessment HCP contrasts ARCHI contrasts IBCcontrasts 0.6 0.4 0.2 0.0 0.2 0.4 0.6 0.8 ARCHI batteries: Pinel, P. et al. (2007) HCP batteries: Barch, D. M. et al. (2013)
  • 48. IBC reproduces ARCHI and HCP ARCHI batteries: Pinel, P. et al. (2007) HCP batteries: Barch, D. M. et al. (2013)
  • 49. Brain coverage Group-level F-map pFWE < 0.05 x=27x=12x=-13x=-28x=-43 -80 -40 0 40 80 Comprehensive brain coverage of functional activity already in the first release!
  • 50. Activation similarity fits task similarity archiemotional archisocial archispatial archistandard hcpemotion hcpgambling hcplanguagehcpmotor hcprelational hcpsocial hcpwmrsvplanguagearchi emotional archi social archi spatial archi standard hcp emotion hcp gambling hcp language hcp motor hcp relational hcp social hcp wm rsvp language 0 1 archiemotional archisocial archispatial archistandard hcpemotion hcpgambling hcplanguagehcpmotor hcprelational hcpsocial hcpwmrsvplanguage archi emotional archi social archi spatial archi standard hcp emotion hcp gambling hcp language hcp motor hcp relational hcp social hcp wm rsvp language 0 1
  • 51. Variability of Functional Signatures Individual z-maps
  • 52. Variability of Functional Signatures 0.0 0.1 0.2 0.3 0.4 sentence reading vs. sentence listening sentence reading vs. checkerboard left hand vs. right hand horizontal checkerboard vs. vertical checkerboard mental subtraction vs. sentence reading saccades vs. fixation left or right hand vs. hand palm or back object grasping vs. orientation judgment social-interaction motion vs. random motion false-belief story vs. mechanistic story false-belief tale vs. mechanistic tale expression intention vs. gender assessment face trusty vs. gender assessment face image vs. shape outline punishement vs. reward 0.0 0.1 0.2 0.3 0.4 tongue vs. any motion right foot vs. any motion left foot vs. any motion right hand vs. any motion left hand vs. any motion story vs. math relational processing vs. visual matching social-interaction motion vs. random motion tool image vs. any image place image vs. any image face image vs. any image body image vs. any image 2-back vs. 0-back read pseudowords vs. consonant strings read words vs. consonant strings read words vs. read pseudowords read sentence vs. read jabberwocky read sentence vs. read words Average and standard deviation of map correlation across subjects
  • 53. Effect of subject and task on brain activity Per-voxel one-way ANOVA qFDR < 0.05 x=10 L R z=10 -28 -14 0 14 28 L R y=-50 Subject effect x=10 L R z=10 -37 -19 0 19 37 L R y=-50 Condition effect x=-6 L R z=3 -12 -5.9 0 5.9 12 L R y=45 Phase encoding effect
  • 54. Effect of subject and task on brain activity Per-voxel one-way ANOVA qFDR < 0.05 x=10 L R z=10 -28 -14 0 14 28 L R y=-50 Subject effect x=10 L R z=10 -37 -19 0 19 37 L R y=-50 Condition effect x=-6 L R z=3 -12 -5.9 0 5.9 12 L R y=45 Phase encoding effect IBC data is suitable for cognitive mapping and individual-brain modeling!
  • 56. Exploring individual cognitive topographies Tasks consistently map brain networks across individuals.
  • 58. Concluding remarks Data acquisition till 2022 Final dataset: 50 acquisitions per participant
  • 59. Concluding remarks Data acquisition till 2022 Final dataset: 50 acquisitions per participant Share your protocols with us!
  • 60. Concluding remarks Data acquisition till 2022 Final dataset: 50 acquisitions per participant Share your protocols with us! Encoding models for cognitive mapping
  • 61. Concluding remarks Data acquisition till 2022 Final dataset: 50 acquisitions per participant Share your protocols with us! Encoding models for cognitive mapping
  • 62. Thanks! Bertrand Thirion ...and to the IBC volunteers!!! For more information, consult: project.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBCproject.inria.fr/IBC Visit us tomorrow at the poster session: #W585
  • 63. WINRePo1 www.facebook.com/WiNRepository/ - www.winrepo.org - over 1,100 profiles - easy search - recommendations Repository for Women in Neuroscience Support the project: ➢sign up ➢spread the word ➢submit recommendations