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Magnetic Resonance
Imaging of the Rhesus
Monkey Brain
•   Roland Tammer
•   Sabine Hofer
•   Klaus-Dietmar Merboldt
•   Jens Frahm

ISBN: 978-3-525-40424-9
Website:
http://www.v-r.de/en/items/978-3-525-
    40424-9

All images are low resolution samples.
Magnetic Resonance
 Imaging of the
 Rhesus Monkey
 Brain
Magnetic resonance imaging (MRI) of
   the central nervous system plays an
   increasingly important role in the
   neurosciences involving humans
   and animals. Nonhuman primates
   are of special relevance because of
   their immunological, physiological,
   and behavioral similarities to
   humans. Therefore, the lack of
   detailed anatomical MRI data of the
   rhesus monkey brain was a strong
   motivation for this work. It provides
   the first comprehensive in vivo MRI
   atlas of the living macaque brain at
Three-dimensional coverage of the
   brain in horizontal, coronal, and
   sagittal sections at
   unprecedented 0.5 mm
   isotropic spatial resolution is at
   the core of the atlas with an
   indication of anatomical
   structures. Multiple contrasts
   are supplied compatible with
   human MRI.
Advanced techniques such as
   magnetic resonance
   angiography and diffusion
   tensor imaging are exploited
   for a visualization of the
   intracranial vasculature and
   the virtual reconstruction of
   nerve fiber tracts, respectively.
“Readability” for the non-expert is
   ensured by a simple
   introduction into the principles
   and applications of MRI.
   Detailed descriptions cover all
   aspects of animal handling,
   experimental procedures, and
   image presentation in a
   stereotaxic coordinate
   system.
The atlas is expected to serve as
   a reference source for easy
   identification of anatomical
   structures in the rhesus
   monkey brain. It is a “must” on
   the desktop of primatologists
   and neuroscientists in a broad
   range of disciplines.
Table of Content

7     Preface
9     Introduction
11    Technical Aspects
11    Magnetic Resonance Imaging
12    Image Contrast
14    Experimental Details
15    Animals
16    Image Presentation
19    Anatomical MRI
20    Horizontal Sections
108   Coronal Sections
181   Sagittal Sections
208   Surface Reconstructions
220   Intracranial Vasculature
220   Magnetic Resonance Angiography
221   Experimental Details
222   Intracranial Arteries
226   Nerve Fiber Tracts
226   Diffusion Tensor Imaging
228   Fiber Tractography
229   Experimental Details
232   Major Nerve Fibers
244   Anatomical Variability
249   Abbreviations
250   References
252   Index
262   Authors
Jens Frahm      Sabine Hofer




Klaus-Dietmar   Jens Frahm
Merboldt
Roland Tammer

    Roland Tammer, Ph.D., is Scientific
    assistant at Biomedizinische NMR
    Forschungs GmbH and DFG Center for
    Molecular Physiology of the Brain,
    Göttingen.

   Vita
1996 Doctoral degree in veterinary
   medicine, Justus-Liebig-Universität,
   Giessen, Germany; 1994 Small animal
   veterinary surgeon; 2000 Scientific
   assistant, Deutsches Primatenzentrum
   GmbH, Göttingen, Germany.

   Main Focus
Magnetic resonance imaging studies of
   laboratory animals.
Sabine Hofer

    Sabine Hofer, Ph.D., is Scientific
    assistant at Biomedizinische NMR
    Forschungs GmbH and Bernstein
    Center for Computational
    Neuroscience, Göttingen, Germany.


    Main Focus
Structural and functional aspects of the
    primate central nervous system with the
    use of functional magnetic resonance
    imaging, diffusion tensor imaging, and
    fiber tractography; comparative
    neuroanatomy of human and nonhuman
    primates.
Klaus-Dietmar Merboldt

    Klaus-Dietmar Merboldt, Ph.D., is
    senior scientist at Biomedizinische NMR
    Forschungs
    GmbH, Göttingen, Germany.

   Vita
1984 Doctoral degree in physical
   chemistry, Georg-August-
   Universität, Göttingen, Germany; 1985
   Scientific assistant, Max-Planck-Institut
   für biophysikalische
   Chemie, Göttingen, Germany.

   Main Focus
Advanced methods for functional magnetic
   resonance imaging of human brain
   activation and diffusion tensor imaging
   of nerve fibers.
Jens Frahm

    Jens Frahm, Ph.D., is director of
    Biomedizinische NMR Forschungs
    GmbH (non-
    profit), Göttingen, Germany and
    Professor for physical
    chemistry, Georg-August-
    Universität, Göttingen.

   Vita
1977 Doctoral degree in physical
   chemistry, Georg-August-
   Universität, Göttingen, Germany; 1982
   Head of Biomedical NMR research
   group, Max-Planck-Institut für
   biophysikalische Chemie
   Göttingen, Germany.

   Main Focus
Development and application of magnetic
   resonance imaging techniques for
   noninvasive studies of animals and
•   263 Pages with many coloured
    illustrations
•   ca. 30,5 cm x 35,5 cm (12 inch x
    14 inch)
•   ISBN 978-3-525-40424-9
•   Webpage at Vandenhoeck &
    Ruprecht
•   Flickr Page with more pictures
•   This presentation on Scribd
•   This presentation on Slideshare

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MRI Atlas ISBN 978-3-525-40424-9

  • 1. Magnetic Resonance Imaging of the Rhesus Monkey Brain • Roland Tammer • Sabine Hofer • Klaus-Dietmar Merboldt • Jens Frahm ISBN: 978-3-525-40424-9 Website: http://www.v-r.de/en/items/978-3-525- 40424-9 All images are low resolution samples.
  • 2. Magnetic Resonance Imaging of the Rhesus Monkey Brain Magnetic resonance imaging (MRI) of the central nervous system plays an increasingly important role in the neurosciences involving humans and animals. Nonhuman primates are of special relevance because of their immunological, physiological, and behavioral similarities to humans. Therefore, the lack of detailed anatomical MRI data of the rhesus monkey brain was a strong motivation for this work. It provides the first comprehensive in vivo MRI atlas of the living macaque brain at
  • 3. Three-dimensional coverage of the brain in horizontal, coronal, and sagittal sections at unprecedented 0.5 mm isotropic spatial resolution is at the core of the atlas with an indication of anatomical structures. Multiple contrasts are supplied compatible with human MRI.
  • 4. Advanced techniques such as magnetic resonance angiography and diffusion tensor imaging are exploited for a visualization of the intracranial vasculature and the virtual reconstruction of nerve fiber tracts, respectively.
  • 5. “Readability” for the non-expert is ensured by a simple introduction into the principles and applications of MRI. Detailed descriptions cover all aspects of animal handling, experimental procedures, and image presentation in a stereotaxic coordinate system.
  • 6. The atlas is expected to serve as a reference source for easy identification of anatomical structures in the rhesus monkey brain. It is a “must” on the desktop of primatologists and neuroscientists in a broad range of disciplines.
  • 7. Table of Content 7 Preface 9 Introduction 11 Technical Aspects 11 Magnetic Resonance Imaging 12 Image Contrast 14 Experimental Details 15 Animals 16 Image Presentation 19 Anatomical MRI 20 Horizontal Sections 108 Coronal Sections 181 Sagittal Sections 208 Surface Reconstructions 220 Intracranial Vasculature 220 Magnetic Resonance Angiography 221 Experimental Details 222 Intracranial Arteries 226 Nerve Fiber Tracts 226 Diffusion Tensor Imaging 228 Fiber Tractography 229 Experimental Details 232 Major Nerve Fibers 244 Anatomical Variability 249 Abbreviations 250 References 252 Index 262 Authors
  • 8. Jens Frahm Sabine Hofer Klaus-Dietmar Jens Frahm Merboldt
  • 9. Roland Tammer Roland Tammer, Ph.D., is Scientific assistant at Biomedizinische NMR Forschungs GmbH and DFG Center for Molecular Physiology of the Brain, Göttingen. Vita 1996 Doctoral degree in veterinary medicine, Justus-Liebig-Universität, Giessen, Germany; 1994 Small animal veterinary surgeon; 2000 Scientific assistant, Deutsches Primatenzentrum GmbH, Göttingen, Germany. Main Focus Magnetic resonance imaging studies of laboratory animals.
  • 10. Sabine Hofer Sabine Hofer, Ph.D., is Scientific assistant at Biomedizinische NMR Forschungs GmbH and Bernstein Center for Computational Neuroscience, Göttingen, Germany. Main Focus Structural and functional aspects of the primate central nervous system with the use of functional magnetic resonance imaging, diffusion tensor imaging, and fiber tractography; comparative neuroanatomy of human and nonhuman primates.
  • 11. Klaus-Dietmar Merboldt Klaus-Dietmar Merboldt, Ph.D., is senior scientist at Biomedizinische NMR Forschungs GmbH, Göttingen, Germany. Vita 1984 Doctoral degree in physical chemistry, Georg-August- Universität, Göttingen, Germany; 1985 Scientific assistant, Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany. Main Focus Advanced methods for functional magnetic resonance imaging of human brain activation and diffusion tensor imaging of nerve fibers.
  • 12. Jens Frahm Jens Frahm, Ph.D., is director of Biomedizinische NMR Forschungs GmbH (non- profit), Göttingen, Germany and Professor for physical chemistry, Georg-August- Universität, Göttingen. Vita 1977 Doctoral degree in physical chemistry, Georg-August- Universität, Göttingen, Germany; 1982 Head of Biomedical NMR research group, Max-Planck-Institut für biophysikalische Chemie Göttingen, Germany. Main Focus Development and application of magnetic resonance imaging techniques for noninvasive studies of animals and
  • 13. 263 Pages with many coloured illustrations • ca. 30,5 cm x 35,5 cm (12 inch x 14 inch) • ISBN 978-3-525-40424-9 • Webpage at Vandenhoeck & Ruprecht • Flickr Page with more pictures • This presentation on Scribd • This presentation on Slideshare