1. 12.12.2015 WOC2016
http://www.wocabstracts.org/index.cfm?do=ev.viewEv&ev=3898 1/2
Diagnostic Capability and Artifact Rate
of a Novel Peripapillary Retinal
Thickness Parameter for Glaucoma
Using Three­Dimensional Optical
Coherence Tomography Volume Scans
Presented During: Poster Session (index.cfm?do=ev.viewEv&ev=3647)
Sat, 2/6: 8:00 ­ 18:00
Poster
To compare peripapillary retinal thickness (RT) measurements from three­dimensional (3D) volume
scans with traditional two­dimensional (2D) retinal nerve fiber layer (RNFL) thickness measurements
for diagnostic capability and artifact rate for primary open angle glaucoma (POAG).
Keywords
1. Glaucoma
2. Diagnosis
3. Retinal Nerve Fiber Layer
4. Retinal Thickness
5. Optical Coherence Tomography
Materials / Patients and Methods
We retrospectively reviewed 156 subjects (89 POAG and 67 normals) who had spectral domain OCT
(Spectralis, Heidelberg Engineering, Heidelberg, Germany) imaging from September 2009 to July
2013. Each patient had a 2D circumpapillary RNFL circular scan and a 3D 20° x 20° volumetric scan.
The volume scan was used to calculate RT measurements for three circumpapillary annuli: outer
circumpapillary annuli (OCA) 1 bounded by circle diameters of 2.00 and 3.00 mm, OCA2 with
diameters of 2.22 and 3.45 mm, and OCA3 with diameters of 3.00 and 6.00 mm. Areas under the
receiver operating characteristic (AUROC) curves were calculated for overall and quadrant RT and
RNFL thickness. The circumpapillary RNFL scans and 193 B­scans of the volume scan were reviewed
to determine artifact rates for the two scanning protocols. Statistical significance was established at p
values < 0.05. The 156 subjects were a subset of a larger cohort of 1,188 subjects, for whom 2,313
2D and 3D scans were obtained.
Conclusions
The average age of the 156 subjects was 61.3 ± 35.3 years; 53.9% were females, and 71.2% were
white. The RT quadrants with the best diagnostic capabilities were the inferior quadrants of OCA1 and
OCA2, with AUROC values of 0.959 and 0.945, respectively. The RNFL subdivisions with best
diagnostic capabilities were the inferior quadrant and the global, with AUROC values of 0.930 and
0.909, respectively. The inferior OCA1 RT region had significantly better diagnostic potential relative
to the overall RNFL thickness (P = 0.03). No other comparisons between the RNFL and RT
parameters were
statistically significant. When evaluating for artifact rates for the 156 2D RNFL scans, a total of 67
scans had at least one artifact, representing a B­scan artifact rate of 42.9%. Of the total of 30,108 3D

2. 12.12.2015 WOC2016
http://www.wocabstracts.org/index.cfm?do=ev.viewEv&ev=3898 2/2
RT B­scans (156 volumetric datasets with 193 images each), a total of 2,223 scans had at least one
artifact, representing a B­scan artifact rate of 7.38%.
The diagnostic capability of 3D RT parameters is comparable to, and sometimes better than, 2D
RNFL parameters for diagnosing POAG. RT measurements have a lower artifact rate compared to
RNFL measurements. Assessment of peripapillary RT may be useful in the evaluation of glaucoma.
Author
Teresa Chen, MD
Co­Author(s)
Mustafa Akduman, BS
Firas Alrekabi, PhD
Johannes de Boer, PhD
Ziad Khoueir, MD
Yingna Liu, BA
Christian Que, MD
Huseyin Simavli, MD
Edem Tsikata, PhD
Categories
Ocular Imaging
Language
English