Resume/CV for Nicholas Young; research scientist at The Ohio State University Wexner Medical Center in the Division of Rheumatology and Immunology

1. CURRICULUM VITAE
NAME
Nicholas Young, Ph.D.
POSITION TITLE
Research Scientist
ADDRESS
RM S2056 Davis Medical Research Center
480 Medical Center Dr.
Columbus OH 43210
EDUCATION/TRAINING
INSTITUTION AND LOCATION DEGREE
(if applicable)
YEAR(s) FIELD OF STUDY
The Ohio State University, College of Biological
Sciences Columbus, OH
B.S. 1997-2001 Microbiology major
Biochemistry minor
The Ohio State University, College of Medicine,
Integrated Biomedical Sciences Program Columbus,
OH
Ph.D. 2001-2007 Biochemical and
Molecular Disease
Mechanisms
The Ohio State University Medical Center,
Department of Internal Medicine
Postdoctoral
training
2009-2015 Division of Immunology
and Rheumatology
A. Personal Statement
Graduate school
• Basic scientific discovery, extensive molecular biology, and some animal model work in the field
of brain cancer pathology (Glioblastoma Multiforme)
• Manage, lead, design/plan, and interpret the work of myself, lab technician, graduate student,
undergraduate lab personnel, and rotating graduate students
Clinical research in industry
• Successful transition from academia to industry as a clinical scientist leading and managing a
team of 12 laboratory technicians
• High individual productivity and leader in the creation of lab-wide initiatives and policies to
increase overall output and efficiency
Academic research
• Manage and direct all laboratory operations for the Chief of Immunology and Rheumatology
• Designed and established active human subject and animal research projects associated with
myositis, Sjogren’s syndrome, systemic lupus erythematosus, rheumatoid arthritis,
inflammation, cancer immunology, and exercise science
• Director of collaborative research projects with a bench-to-bedside scope; starting with basic
scientific discovery, moving to animal models, performing preclinical validation, and advancing
to clinical trials
• Extensive molecular biology, assay development, basic scientific discovery, animal model
development, and human subject work in immunology and cancer biology
• My translational research has resulted in a clinical trial of a patented anti-inflammatory drug
(nanoemulsified curcumin; collaboration with the Department of Pharmacology at Ohio State)

2. • My preclinical validation studies resulted in a clinical trial with a novel diagnostic imaging drug
for rheumatoid arthritis (Lymphoseek; collaboration with Navidea Biopharmaceuticals)
• 2 pending patent applications for anti-inflammatory therapeutics to treat autoimmune disease
• Manage and lead research projects both inter and intra-university as well as those with the
pharmaceutical industry
I have developed team-oriented communication, mentorship, management, and teaching skills through my
experience. I hope to use this foundation of microbiology, immunology, and oncology to instruct the use of
biological solutions through the use of a systems biology approach to treat disease.
B. Positions
Department of Internal Medicine, Division of Immunology and Rheumatology Columbus, OH
The Ohio State University Medical Center May 2015-present
Research Scientist
Supervisor: Dr. Wael Jarjour
Our laboratory researches translational immunology using mouse models and human subject research
to investigate novel therapeutics in Sjögren’s syndrome, systemic lupus erythematosus, myositis, and
rheumatoid arthritis.
Department of Internal Medicine, Division of Immunology and Rheumatology Columbus, OH
The Ohio State University Medical Center June 2009-May 2015
Post Doctoral Researcher
Supervisor: Dr. Wael Jarjour
The research project deals with the pathology of systemic autoimmune disorders as influenced by either
regulatory T-cells or estrogen.
Gerson Lehrman Group / Council Management Platform Columbus, OH
Consultant January 2012-present
Paid (hourly) consultant for projects dealing with companies soliciting information on scientific
equipment, experiments, kits, etc. relevant to my research experience.
The University of Phoenix Columbus, OH
Adjunct Faculty September 2010-June 2014
Supervisor: Dr. Tracy Barton-Rouse
On-campus classroom instructor/facilitator for classes offered in nutritional and exercise science with an
educational focus/emphasis on basic biochemistry and disease development and prevention.
Laboratory Corporation of America Dublin, OH
Clinical Scientist December 2007-June 2009
Department of Microbiology
Supervisor: Dr. Kevin Harvey
Organism identification and antibiotic susceptibility profile analysis for a variety of patient samples in a
high volume, productivity driven industrial environment.
Integrated Biomedical Science Graduate Program, Columbus, OH
The Ohio State University, College of Medicine June 2001-September 2007
Graduate Research Associate
Advisor: Dr. James Van Brocklyn
Dissertation title: “Differential Regulation of Glioma Cell Biology by Signal Transduction Activation of
Sphingosine-1-Phosphate Receptor Subtypes”

3. Department of Molecular Virology, Immunology and Medical Genetics, Columbus, OH
The Ohio State University April 2000-June 2001
Laboratory Technician
Supervisor: Dr. Raymond Lang
Project title: “Major Histocompatibility Complex Expression Patterns in Genetically Isolated Populations”
Department of Chemistry, The Ohio State University Columbus OH
Chemical supply maintenance September 1999-April 2000
Supervisor: Mr. John Herrington
Description: chemical and equipment preparation for students
C. Selected Peer-Reviewed Publications
Published
• Young NA, Wu L, Burd CJ, Hampton J, Bruss M, Kaffenberger B, Rajaram MV, Schlesinger L, Amici
S, Guerau M, Severin M, Lovett-Racke A, Jarjour WN. Estrogen-regulated STAT1 activation
promotes TLR8 expression to facilitate signaling via microRNA-21 in systemic lupus erythematosus.
Accepted for publication Clin Immunol; 2016, 176: 12-22.
• Young NA, Williams, M.V, Bruss M, Ariza ME, and Jarjour W. Epstein-Barr virus (EBV) encoded
dUTPase exacerbates the immune pathology of lupus nephritis in vivo by up-regulation of TLR2 and
IL-17. Accepted for publication Int J Immunol Immunother Sept 2016
• Cope FO, Abbruzzese B, Sanders J, Metz W, Young NA, Sturms K, Ralph D,…Rosol T, Jarjour WN,
Toribio R, Scheslinger L, and McGrath, M. The inextricable axis of targeted diagnostic imaging and
therapy: An immunological natural history approach. Nucl Med Biol 2016; 43, 215-225
• Young NA, Wu L, Hampton J, Bruss MS, Kaffenberger BH, Bolon B, Jarjour WN. A chimeric human-
mouse model of Sjögren's Syndrome. Clin immunol 2014; 156(1): 1-8.
• Young NA, Bruss MS, Gardner M, Willis WL, Xiaokui M, Valiente GR, Cao Y, Liu Z, Wu L, Jarjour
WN. Oral administration of nano-emulsion curcumin suppresses LPS-induced NFκB signaling in
inflammation and inhibits macrophage migration. PloS one 2014; 9(11): e111559.
• Young NA, Wu L, Burd CJ, Friedman AK, Kaffenberger B, Rajaram MV et al. Estrogen modulation of
endosome-associated toll-like receptor 8: an IFNα-independent mechanism of sex-bias in systemic
lupus erythematosus. Clin Immunol, 2014; 151(1): p. 66-77.
• Young NA, Sharma R, Friedman AK, Kaffenberger BH, Bolon B, Jarjour WN. Aberrant muscle antigen
exposure in mice is sufficient to cause myositis in a Treg cell-deficient milieu. Arthritis Rheum, 2013;
65:3259-70.
• Young NA, Friedman AK, Kaffenberger B, Rajaram MV, Birmingham DJ, Rovin BH et al. Novel
estrogen target gene ZAS3 is overexpressed in systemic lupus erythematosus. Mol Immunol, 2013;
54:23-31.

4. • Young N, Pearl DK, Van Brocklyn JR. Sphingosine-1-phosphate regulates glioblastoma cell
invasiveness through the urokinase plasminogen activator system and CCN1/Cyr61. Mol Cancer
Res, 2009; 7:23-32.
• Young N Regulation of Invasiveness of Glioblastoma Multiforme Cell Lines and Tumor Stem Cells by
Sphingosine Kinase and Sphingosine 1-Phosphate Reveals Potential Molecular Therapeutic Targets.
https:kb.osu.edu/dspace/handle/1811/29390. August 2007.
• Young N and Van Brocklyn JR. Roles of sphingosine-1-phosphate (S1P) receptors in malignant
behavior of glioma cells. Differential effects of S1P2 on cell migration and invasiveness. Exp Cell Res,
2007; 313(8): p. 1615-27.
• Young N and JR Van Brocklyn. Signal transduction of sphingosine-1-phosphate G protein-coupled
receptors. ScientificWorldJournal, 2006; 6: p. 946-66.
• Van Brocklyn JR, Young N, and Roof R. Sphingosine-1-phosphate stimulates motility and
invasiveness of human glioblastoma multiforme cells. Cancer Lett, 2003; 199(1): p. 53-60.
In-process
• Sharma J, Hampton J, Yong M, Blazek A, Jarjour WN, and Young NA. The therapeutic application of
extracellular vesicles from mesenchymal stem cells to inhibit autoimmune-mediated inflammatory
processes in systemic lupus erythematosus. Submitted to Frontiers in Immunology
• Aqel S, Agarwal S, Hampton J, Jones K, Wu L-C, Powell N, Sherridan J, Bruss M, Jarjour WN, and
Young NA. Stress is detrimental and moderate exercise is beneficial in an animal model of lupus
nephritis: extra-medicinal influences patients may have in autoimmune disease. Submitted to
Immunology and Cell Biology
• Carey H, Ghosh S, Hildreth III E, Cabrera J, Kurmashev D, Young NA, Jarjour WN, Toribio R, Sharma
S, and Ostrowski M, PU.1, Mitf, and Their Novel Co-Partner, Eomes, Set up a Transcription Factor
Network That Is Critical for Osteoclast Differentiation. Submitted to Journal of Experimental Medicine
• Blazek A, Knapik D, Young NA, Wu LC, Jarjour W, Agarwal S. Exercise suppresses systemic
inflammation via inhibition of NF-kB activation in monocytes.
• Willis W, Wu L-C, Young NA, Freitas M, and Jarjour WN. Title redacted due to highly sensitive nature
of the project.
D. Oral Presentations and Awards
• “Myocarditis is Detected by MRI in Lupus Nephritis-Induced Cardiovascular Disease and Correlates
with Fibrosis and Pro-inflammatory Cytokine Expression in a Mouse Model” at The European
League Against Rheumatism (EULAR) Annual European Congress of Rheumatology meeting June
8-11, 2016 in London, England. Awarded a third consecutive travel bursary to attend.
• “Novel Therapeutic Inhibitor Cocktail Suppresses Extracellular Vesicle-Mediated Inflammation Induced
by micro-RNA in a Humanized Mouse Model of Lupus” at the International Society for Extracellular
Vesicles (ISEV) in Rotterdam, the Netherlands May 3-7, 2016.

5. • “Progression of Lupus Pathology is Correlative with Cardiac Magnetic Resonance Imaging
Abnormalities, Diminished Function, and Inflammatory Histopathology in an Animal Model” at American
College of Rheumatology Meeting in San Francisco, CA, November 6-11, 2015.
• Applications of in vivo Bioluminescent Imaging to Investigate NF-kB-mediated Inflammation
Longitudinally in Mice” at the Emerging Investigators Conference sponsored by the Arthritis Foundation
in Aurora, OH, September 18-19, 2015.
• “Manocept, a derivative of FDA-approved 99mTc-Tilmanocept, exhibits diagnostic potential by
specifically identifying macrophages in rheumatoid arthritis: a novel application of an existing drug”.
The European League Against Rheumatism (EULAR) Annual European Congress of Rheumatology
meeting June 10-13, 2014 in Rome, Italy. Awarded a travel bursary to attend this conference.
• “Estrogen-mediated TLR8 expression via STAT1 facilitates endogenous miRokine ligand activation
by exosomes containing miR-21: a novel innate inflammatory pathway in systemic lupus
erythematosus”. The Federation of Clinical Immunology Societies (FOCIS) annual meeting June 24-
27, 2014 in San Diego, CA. Recipient of a second consecutive travel award given to selected
abstracts to attend this conference.
• "Bioluminescent Imaging of Histidyl-Transfer RNA Synthetase-Induced Myositis Reveals Early-
Phase Involvement of NF-kB-Mediated Inflammation", American College of Rheumatology Meeting
in Boston, MA, November 14-19, 2014.
• “Estrogen and endosomal TLRs in lupus: too much of a good thing takes its toll on the body”, Emerging
Investigators Conference sponsored by the Arthritis Foundation in Roanoke, WV, September 19-20,
2014.
• “A Chimeric Human-Mouse Model of Sjögren's Syndrome” at The Federation of Clinical Immunology
Societies (FOCIS) annual meeting June 24-28, 2014 in Chicago, IL. Recipient of a travel award
given to selected abstracts to attend this conference.
• “Exercise Suppresses Systemic Inflammation of NFκB Activation in Monocytes” at The European
League Against Rheumatism (EULAR) Annual European Congress of Rheumatology meeting June 11-
14, 2014 in Paris, France. This abstract was selected (one of 13) for inclusion in one of the official
EULAR Press Conferences from over 4000 abstracts; it was found to demonstrate particularly high
interest to the press and to be representative of the quality of scientific research presented at EULAR
2014.
• Presented per invitation of the Physiology research group at aTyr Pharma my work related to tRNA
synthetase-induced myositis, the macrophage-directed anti-inflammatory effect of our novel nano-
emulsion curcumin formulation, and our clinical development of a novel lymphoseek-derived imaging
drug (manocept-Cy3) for use in diagnostic imaging and disease monitoring in rheumatoid arthritis. June
1-3, 2014. San Diego, CA.
• Presented work on muscle auto-antigens in myositis at the American College of Rheumatology 79th
Meeting during the “Myositis and Myopathies: Novel Insights into Disease Pathogenesis” concurrent
abstract oral presentation session. November 4, 2012 in Washington, D.C.
• Presented research entitled “Estrogen Regulation of STAT4 Expression and Intracellular Toll-Like
Receptors Reveals Distinct Gender-Bias: Insights into Hormonal Contributions to Systemic Lupus
Erythematosus Pathogenesis” at the Immunology Roundtable lecture series at The Ohio State
University Medical Center on March 11, 2011 in Columbus, OH.

6. • Presented work on regulatory T cells and the role of muscle antigens in myositis at the American
College of Rheumatology 76th Meeting during the “Muscle Biology, Myositis and Myopathies: Insights
into the Pathogenesis and Outcomes of Myositis” concurrent abstract oral presentation session.
November 9, 2010 in Atlanta, GA.
• Presented research project exploring estrogen’s effects in autoimmunity and was awarded a "Notable
Research" designation (given to the top 10% of over 3000 abstracts) at the American College of
Rheumatology 75th Meeting in Philidelphia, PA October 15-23, 2009.
• Presented thesis work per invitation of Research and Development Division of Genzyme Corporation to
the Lipid Storage Disorders Department. October 5, 2007. Boston, MA
• Presented dissertation defense seminar of thesis. September 5, 2007. Columbus, Ohio
• Received Third Place in poster presentation competition at the 21st annual Edward F. Hayes Graduate
Research Forum. April 21, 2007. Columbus, OH
• Presented a “Research in Progress” seminar at the Integrated Biomedical Sciences Program research
seminar series. April 5, 2007. Columbus, OH
• Presented graduate research at The Ohio State University College of Medicine Research Day annually.
2004-2006, 2009-2014. Columbus, OH
E. Selected Press Releases and Articles Highlighting My Contributions to Science
• Newsmax November 6, 2014. Curcumin Eases Inflammation, Boosts Health: Study
http://www.newsmaxhealth.com/Health-News/curcumin-curry-tumeric-inflammation/2014/11/06/id/605787/
• Science Daily June 12, 2014. Regular exercise beneficial in suppressing inflammation in rheumatic
disease.
http://www.sciencedaily.com/releases/2014/06/140612085353.htm
• The Wall Street Journal October 24, 2013. Navidea Biopharmaceuticals Manocept(TM) Platform
Featured in Nature Outlook: Medical Imaging.
http://ir.navidea.com/phoenix.zhtml?c=68527&p=irol-newsArticle&ID=1867999
• Nature Outlook: Medical Imaging October 31, 2013 issue of Nature. Innovations in receptor-targeted
precision imaging at Navidea: diagnosis up close and personal.
http://www.nature.com/nature/outlook/medical-imaging/pdf/navidea-white-paper.pdf
• Nature Reviews Rheumatology October 1, 2013. Inflammatory myopathies: TREG-cell deficiency
and abnormal muscle antigen exposure important to the development of myositis. Ray K. Nat Rev
Rheumatol;9:638.
http://www.ncbi.nlm.nih.gov/pubmed/24080863
• Global Medical Discovery. A chimeric human-mouse model of Sjögren’s syndrome. 04/11/2015
https://globalmedicaldiscovery.com/key-scientific-articles/a-chimeric-human-mouse-model-of-sjogrens-syndrome/
• Newswise April 15, 2014. Immune System Genes Activated by Estrogen May Hold Clues to Lupus
Origin. New study supports connection between estrogen and autoimmune disease
http://www.newswise.com/articles/immune-system-genes-activated-by-estrogen-may-hold-clues-to-lupus-origin

7. • Science Daily February 10, 2015. First humanized mouse model of Sjögren’s syndrome opens door to
study other autoimmune diseases
http://www.sciencedaily.com/releases/2015/02/150210083541.htm
• YouTube June 12th
, 2014. EULAR Press Conference- EULAR press office - Dr Nicholas Young
https://www.youtube.com/watch?v=uvPP1t98DGs
• Orthopedics this week June 18th, 2014. Regular Exercise Helps Suppress Inflammation.
http://ryortho.com/breaking/regular-exercise-helps-suppress-inflammation/
• Biotech Week April 17, 2013. Studies from Ohio State University Yield New Data on Molecular
Immunology. (NewsRx)
http://www.newsrx.com/newsletters/Biotech-Week/2013-04-17/60417201316UW.html
• Arthritis research UK June 16th
, 2014. Exercise 'can help to prevent inflammation associated with
rheumatic disease'.
http://www.arthritisresearchuk.org/news/general-news/2014/june/exercise-can-help-to-prevent-
inflammation-associated-with-rheumatic-disease.aspx
• Medical News Today (MNT) June 15, 2014. Exercise results in physiological changes that suppress
inflammation in rheumatic disease.
http://www.medicalnewstoday.com/releases/278185.php
• Business Standard November 14, 2014. Health benefits of curcumin just got better.
http://www.business-standard.com/article/news-ani/health-benefits-of-curcumin-just-got-better-
114110700194_1.html
• Ohio State University OnCampus publication and the Center for Clinical and Translational
Science Newsroom. November 6th
, 2014. New Research Adds Spice to Curcumin’s Health-Promoting
Benefits.
http://oncampus.osu.edu/research-adds-spice-to-curcumins-health-promoting-benefits/
• WorldNetDaily (WND). November 14th
, 2014. Chuck Norris explains what's better than calcium.
http://www.wnd.com/2014/11/chuck-norris-explains-whats-better-than-calcium/#5S5lc2KteDi6TEhY.99
Selected International Press Coverage
• Gaianews.it (article in Italian) June 6th
, 2014. L’esercizio fisico riduce l’infiammazione nelle malattie
reumatiche.
http://gaianews.it/salute/lesercizio-fisico-riduce-linfiammazione-nelle-malattie-reumatiche-55946.html
• lainformacion.com (article in Spanish) June 12th
, 2014. El ejercicio regular ayuda a suprimir la
inflamación en la enfermedad reumática.
http://noticias.lainformacion.com/salud/genetica/el-ejercicio-regular-ayuda-a-suprimir-la-inflamacion-en-la-enfermedad-reumatica_r4dYVbrVhHjhZPOJi5gTw2/
• Системная красная волчанка (article in Russian) November 10, 2014. Куркума обладает
выраженным противовоспалительным действием
http://lupus.com.ua/kurkuma-obladaet-virazhennim-protivovospalitelnim-deystviem-1724
• Zdravotnické Noviny (article in Czech) July 3rd, 2014. O čem také revmatologové diskutovali v
pařížském kongresovém centru. Pravidelné cvičení prospěšné při potlačování zánětu?
http://www.zdravky.cz/kongresovy-list/aktualne/eular-2014

8. • perpustakaan.or.id (article in Indonesian) June 13th
, 2014. Olahraga Teratur Bermanfaat untuk
Menekan Peradangan pada Penyakit Rematik.
http://perpustakaan.or.id/olahraga-teratur-bermanfaat-untuk-menekan-peradangan-pada-penyakit-
rematik/1934/
• Regalos Para Mujeres Originales (article in Spanish) July 28th
, 2014. El ejercicio regular beneficiosa
en la supresión de la inflamación en la enfermedad reumática
http://regalosparamujeresoriginales.com/el-ejercicio-regular-beneficiosa-en-la-supresion-de-la-inflamacion-
en-la-enfermedad-reumatica/
• About Why. (article in German). Neue Forschung für mehr Geschmack auf die gesundheitlichen
Vorteile von Curcumin
http://de.about-why.com/gesundheit/kolitis/neue-forschung-fur-mehr-geschmack-auf-die-gesundheitlichen-
vorteile-von-cur.php
• Nguon News. (article in Vietnamese). Curcumin loai moi giup gia tang kha nang chong viem toan
November 10th
, 2014
http://tinhnghe.com.vn/nghien-cuu-khoa-hoc/curcumin-loai-moi-giup-gia-tang-kha-nang-chong-viem-toan-than.html
F. Selected Poster Abstracts Presented at International Meetings
• Young N, Van Brocklyn JR. Regulation Of Glioma Cell Proliferation, Migration, And Invasion Through
S1P Receptor Subtype Activation. Society of Neuro-oncology Ninth Annual Meeting November 18-21.
2004. Toronto, Canada.
• Young N, Van Brocklyn JR. S1P Receptor Subtype Contributions To Human Glioblastoma Multiforme
Cell Mitogenesis, Invasion, Migration And Adhesion. FASEB Lysophospholipid Mediators in Health and
Disease Conference 2005 June 11–16. 2005. Snowmass Village, CO.
• Young N. Sphingosine Kinase-1: Key Regulator Sphingosine 1-phosphate Receptor Subtype
Signaling And Potential Therapeutic Target In Minimizing Glioblastoma Multiforme Pathobiology.
October 5, 2007. Genzyme Corporation. Boston, MA.
• Young N., James H., Shupnik M., and Jarjour W. N. TLR8 and STAT4 Expression Is up-Regulated
Differentially by Estrogen Stimulation of Peripheral Blood Mononuclear Cells From Patients with
Systemic Lupus Erythematosus. American College of Rheumatology 75th Meeting. October 15-23,
2009.Philidelphia, PA.
• Young N., A.K. Friedman, B. Kaffenberger, L.C. Wu, M. Shupnik, and W.N. Jarjour. Estrogen
Stimulation of Endosomal Toll-like Receptor Expression Lowers the Threshold of Activation in PBMCs
and Contributes to the Gender Bias of Systemic Lupus Erythematosus. American College of
Rheumatology 77th Meeting. November 4-9, 2011. Chicago, IL.
• Young N., A.K. Friedman, B. Kaffenberger, F. Madiai, L.C. Wu, and W.N. Jarjour. ZAS3 is
overexpressed in Peripheral Blood Mononuclear Cells in Systemic Lupus Erythematosus patients and
is regulated by estrogen: a cause of the dysreguated IL-2 response? American College of
Rheumatology 77th Meeting. November 4-9, 2011. Chicago, IL.
• Young N., A.K. Friedman, and W.N. Jarjour. Transplantation of Primary Human Sjogren’s Syndrome
PBMCs Induces Dramatic Target Organ Infiltration Relative to Healthy Subjects in a Chimera Mouse
Model of Disease Pathology. American College of Rheumatology 77th Meeting. November 4-9, 2011.
Chicago, IL.

9. • Erwin EA, Young N, Friedman A, Platts-Mills TAE, Jarjour WN. Toll-like receptor expression with
testosterone in peripheral blood lymphocytes in adults with eosinophilic esophagitis. Presented at
FOCIS meeting. 2012.
• Young NA, Friedman AK, Kaffenberger BH, James H, Wu LC, Shupnik MA, Jarjour WN. Estrogen
Modulation of Endosome-Associated Toll-Like Receptors and ZAS3: An Underlying Mechanism of
Gender-Bias in Systemic Lupus Erythematosus? Accepted at EULAR, June 2012.
• Ardoin SP, Young NA, Friedman AK, Jarjour WN, Rovin BH, Hebert L, Birmingham D, Zhang XL,
Jensen P. Do Serum Hepcidin 25 Levels Predict SLE Renal or Non-Renal Flares? Accepted for oral
presentation at ACR. Arthritis Rheum. 2012;62 Suppl 10 :36
• Young NA, Sharma R, Friedman AK, Kaffenberger BH, Jarjour WN. Myosin Skews Effector Immune
Cells of Scurfy Mice to Target Muscles in an Adoptive Transfer Model of Myositis. Accepted for oral
presentation at ACR. Arthritis Rheum. 2012. 2012;62 Suppl 10 :715
• Young NA, Friedman AK, Wu LC, Jarjour WN. Estrogen Modulation of ZAS3 Is Mediated Through
Estrogen Receptor α: An Underlying Mechanism of Gender-Bias in Systemic Lupus Erythematosus?
Arthritis Rheum. 2012. 2012;62 Suppl 10 :292
• Young N, Bruss M, Agarwal N, Wu LC, Shupnik MA, and Jarjour WN. Estrogen Receptor Alpha
Mediates Sex-Biased Systemic Lupus Erythematosus Pathogenesis through Toll-Like Receptor 8.
Accepted at the FOCIS meeting in Boston, MA on June 27-30, 2013. Final FOCIS 2013 Abstract
Number T.70.
• Young N, Wu LC, Bruss M, Burd C, Shupnik M, and Jarjour WN. Estrogen Modulates the Expression
of Endosome-Associated Tool-Like Receptor 8 through Estrogen Receptor-α which may contribute to
Sex-bias in SLE. Arthritis Rheum. 2013; 65 Suppl 10 :270-271
• Young N, Wu LC, Bruss M, Valiente G, Burd C, and Jarjour WN. Estrogen-induced STAT1 and STAT4
expression is Estrogen Receptor α dependent and IFNα Independent: A Novel Mechanism for sex-bias
in Systemic Lupus Erythematosus Pathogenesis? Arthritis Rheum. 2013; 65 Suppl 10 :274
• Knapik D, Perera P, Young N, Blazek A, Eubank T, Wu LC, Jarjour WN, Agarwal S. Exercise
Suppresses Systemic Inflammation via Inhibition of NF-κB Activation in Monocytes. Arthritis Rheum.
2013; 65 Suppl 10 :491
• Knapik D, Perera P, Young N, Blazek A, Eubank T, Wu LC, Jarjour WN, Agarwal S. “ Exercise
Suppresses Systemic Inflammation via Inhibition of NF-κB Activation in Monocytes. “ Accepted as
poster for the 60th
Annual Meeting of the ORS, March 15-18, 2014, New Orleans
• Rosol T, Jarjour WN, Young N, Toribio R, Scheslinger L, Cope F, Imaging of macrophages in immune-
mediated inflammatory disease and cartilage antibody-induced arthritis in mice using Cy3-tilmanocept.
Accepted at Keystone Symposia. February 2014
• Young N, Wu LC, Bruss M, Kaffenberger B, Bolon B, Jarjour WN. A Chimeric Human-Mouse Model of
Sjögren’s Syndrome. Podium presentation at Federation of Clinical Immunology Societies (FOCIS)
meeting. June 25-26, 2014 Chicago, IL
• Amici S, Young N, Wu LC, Guerau-de-Arellano M, Jarjour WN. Gene Array Analysis Reveals Selective
Estrogen-Mediated Expression in Peripheral Blood Mononuclear Cells of Patients with Systemic Lupus
Erythematosus. Accepted for Poster Presentation at American College of Rheumatology Conference,
November 14-19, 2014

10. • Young N, Schlesinger LS, Rosol T, Cope F, and Jarjour WN. Manocept-Cy3 localizes CD206 +
macrophages in synovial tissue and fluid from rheumatoid arthritis patients. Accepted for Poster
Presentation at American College of Rheumatology Conference, November 14-19, 2014
• Young N, Valiente G, Wu LC, Bruss M, Burg CJ and Jarjour WN. Estrogen-Mediated STAT1 Activation
by Estrogen Receptor α Induces TLR8. Accepted for Poster Presentation at American College of
Rheumatology Conference, November 14-19, 2014
• Young NA, Bruss MS, Gardner M, Willis WL, Mo X, Valiente GC, Cao Y, Liu Z, Wu LC, and Jarjour
WN. Oral Administration for Nano-Emulsion Curcumin in Mice Suppresses Inflammatory-Induced
NFkB Signaling and Macrophage Migration. Accepted for Poster Presentation at American College of
Rheumatology Conference, November 14-19, 2014
• Young NA, Wu LC, Bruss MS, Jarjour WN and Ascherman DP. Bioluminescent Imaging of Histidyl-
Transfer RNA Synthetase-Induced Myositis Reveals Early-Phase Involvement of NF-Kb-Mediated
Inflammation. Accepted for Podium Presentation at American College of Rheumatology Conference,
November 14-19, 2014
• Alloush J, Young N, McElhanon K, Jarjour WN and Weisleder N. Contribution of Tripartite Motif
Proteins Modulating Membrane Repair to the Pathogenesis of Autoimmune-Mediated Myositis.
Accepted for Poster Presentation at American College of Rheumatology Conference, November 14-19,
2014.
• Young NA, Blazek A, Knapik D, Wu LC, Jarjour W, Agarwal S. Moderate exercise is beneficial and
social stress is detrimental to disease progression in an animal model of lupus nephritis: extra-
medicinal contributors patients possess that can influence autoimmune disease. EULAR June 10-13,
2015 in Rome, Italy.
• Young NA, Williams, M.V, Bruss M, Ariza ME, and Jarjour W. Epstein-Barr virus (EBV) encoded
dUTPase exacerbates the immune pathology of lupus nephritis in vivo by up-regulation of TLR2 and IL-
17. FOCIS June 24-27, 2015 in San Diego, CA.
G. Medical, Graduate, Other Students, and Staff/Faculty Mentored or Trained Under My Direct
Laboratory Supervision
• 2009-2012 – Alexandra Friedman – Formerly Student/Technician, Currently Nurse Practitioner
• 2010-2012 – Benjamin Kaffenberger MD– Formerly Medical Student, Currently Assistant Professor,
Dermatology, The Ohio State University Wexner Medical Center
• 2010-2014 – Elizabeth Erwin MD –Infectious Diseases and Allergy and Immunology at Nationwide
Children’s Hospital; Associate Professor of Pediatrics at The Ohio State University College of Medicine
• 2011-2012 – Saduf Ullah MD – Formerly Medical Student, Currently Resident, Wright State University
Boonshoft School of Medicine
• 2012-2014 – Michael Bruss – Formerly Student/Technician, Currently Medical Student at University of
Pikeville Kentucky, College of Osteopathic Medicine
• 2014-2016 – Saba Aqel – Formerly Undergraduate Student in Biomedical Sciences, Currently
Research Associate at The Ohio State University Division of Infectious Disease

11. • 2014– 2015 Kendra Jones – Currently Undergraduate Student in Biomedical Engineering, The Ohio
State University
• 2014-Present – Jeffrey Hampton – Currently a Research Assistant in our laboratory
• 2014 – 2015 – Maya Gotsatsenko – Formerly Undergraduate Student in Biomedical Sciences,
Currently an MBA Student at Ohio University
• 2014 – 2015 – Lucila Marino Claverie MD – Visiting Clinician/Researcher in our laboratory from
Buenos Aires, Argentina; Department of Rheumatology, Hospital Bernardino Rivadavia
• 2015-Present – Juhi Sharma – Currently Undergraduate Student, The Ohio State University
• 2016-Present – Misha Mobeen – Currently Undergraduate Student, The Ohio State University
• 2016-Present – Evelyn Thomas – Currently Undergraduate Student, The Ohio State University
• 2014-Present – Giancarlo Valiente – Currently a third year MD/PhD candidate in the Biomedical
Research Program in the Ohio State College of Medicine and active researcher in the lab
H. Research Support
Current
• Midwest strategic pharma-academic research consortium 01/17 – 01/19
Title: Global RNA analysis of extracellular vesicles to identify diagnostic biomarkers and
discover novel therapeutic targets in rheumatoid arthritis
My Role: Research Scientist
Principal investigator: Wael N. Jarjour, MD
• AstraZeneca (Ardea Biosciences, Inc.) 01/16 – 01/18
Title: Does exercise suppress systemic inflammation in a gout mouse model?
My Role: Co-Principal Investigator
Co-Principal investigator: Naomi Schlesinger, MD (Chief of Rheumatology, Rutgers University)
• Stefanie Spielman Research Award For Breast Medical Oncology 11/16 – 11/18
Title: Translational Mouse Model for Aromatase Inhibitor-Induced Arthralgias
My Role: Co-Principal Investigator
Co-Principal investigators: Wael N. Jarjour, MD; Maryam Lustberg, MD; Racquel Reinbolt, MD
• Center for Integrative Health and Wellness (Wexner Medical Center) 10/15 – 04/17
Title: S.M.I.L.E. Stress Modification Influencing Lupus with Exercise: Using Tai Chi to explore
the effects of daily moderate exercise and stress reduction in systemic lupus erythematosus
My Role: Co-Principal Investigator
Co-Principal investigator: Wael N. Jarjour, MD
• Alliance for Lupus Research 04/15 – 04/18
Title: Regulation of T Follicular Helper Cells in Systemic Lupus Erythematosus by Cbl-b
My Role: Research Scientist
Co-Principal investigator: Wael N. Jarjour, MD

12. • NIH 12/14 – 11/19
Title: MITF: Regulating Osteoclast Gene Expression and Function
My Role: Research Scientist
Co-Principal investigator: Wael N. Jarjour, MD
• NIH Small Business Innovation Research 07/15 – 04/18
Title: Clinical and Commercial Development of Manocept in Rheumatoid Arthritis
My Role: Research Scientist / Clinical Research Coordinator
Principal investigator: Wael N. Jarjour, MD
• Navidea Biopharmaceuticals, Inc. 06/13 – ongoing/present
Title: Developing NAVRA-Manocept-Cy3 as a novel imaging agent for rheumatoid arthritis
My Role: Research Scientist / Clinical Research Coordinator
Principal investigator: Wael N. Jarjour, MD
Previous
• Richmond Eye and Ear Foundation 05/08 – 06/11
Title: Do Regulatory T cells play a role in the pathogenesis of human Sjögren’s syndrome?
My Role: Post Doctoral Research Scientist / Clinical Research Coordinator
Principal investigator: Wael N. Jarjour, MD
• NIH 04/02 – 12/ 09
Title: Studies of estrogen receptors in autoimmunity
My Role: Post Doctoral Research Scientist / Clinical Research Coordinator
Principal investigator: Wael N. Jarjour, MD
• NIH 06/02 - 06/07
Title: Role of Multiple EDG Receptors in Glioma Cell Growth
My Role: Graduate Research Associate
Principal investigator: James Van Brocklyn, PhD
I. Volunteer and Fundraising Activities
• Ohio State University Wexner Medical Center Wellness Ambassador/Innovator
o Institute initiatives in my department and promote health and wellness in my division
• Ohio State University Wexner Medical Center Ross Heart Hospital—Wellness Series
o Active volunteer in health and wellness initiatives on campus
o Raise money and participate in the Ross Heart Hospital Triathlon annually
• Colon Cancer Alliance—Columbus Capital City Half-Marathon
o Raise funds to donate to this organization through Colon Cancer Alliance team by running the
Columbus City Half-Marathon annually
• Ohio State University Wexner Medical Center, James Cancer Hospital—Pelotonia
o Active volunteer and fundraiser annually
• High Point Elementary School—Parent Volunteer
o Active volunteer at my daughters’ school

13. J. Online Professional Profiles
LinkedIn: https://www.linkedin.com/profile/view?id=29373123&trk=nav_responsive_tab_profile
ResearchGate: https://www.researchgate.net/profile/Nicholas_Young4?ev=hdr_xprf
Google+: https://plus.google.com/u/0/100739220235129072100/about