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Md (surg) part1 nmj 2011 student

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Neuromuscular Physiology Prof. Vajira Weerasinghe Department of Physiology Faculty of Medicine University of Peradeniya
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Nerve conduction ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Membrane potential ,[object Object],[object Object],[object Object]
What are excitable tissues? ,[object Object]
[object Object],[object Object],[object Object],excitable neuron muscle Non-excitable Red cell GIT
Resting Membrane Potential ,[object Object],[object Object],[object Object],[object Object],[object Object]
Factors contributing to RMP ,[object Object],[object Object],[object Object],[object Object],[object Object]
Ionic channels ,[object Object],[object Object],[object Object],K + Na +
Na/K pump ,[object Object],[object Object],[object Object],3 Na + 2 K + ATP ADP
Action Potential (A.P.) ,[object Object],[object Object],[object Object],[object Object]
Depolarisation Repolarisation RMP Hyperpolarisation -90 +35
Physiological basis of AP ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Physiological basis of AP ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],outside inside outside inside -90 Threshold level +35 Na+ Na+ Na+ m gate h gate outside inside
[object Object],[object Object],[object Object],[object Object],[object Object],outside inside outside inside -90 At +35 K+ K+ n gate
Propagation of AP ,[object Object],[object Object],[object Object],[object Object]
Propagation of AP ,[object Object],[object Object],[object Object]
Propagation of AP ,[object Object],[object Object],[object Object]
AP propagation along myelinated nerves ,[object Object],[object Object]
AP propagation along myelinated nerves ,[object Object],[object Object],[object Object]
Membrane stabilisers ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
NMJ function ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Synapse ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
Presynaptic terminal (terminal knob, boutons, end-feet or synaptic knobs) ,[object Object],[object Object],Vesicles containing neurotransmitter (Ach)
Presynaptic terminal (terminal knob, boutons, end-feet or synaptic knobs) ,[object Object],[object Object],[object Object],[object Object]
Ca 2+ Ca 2+
[object Object],[object Object],Ach Na+ ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Ach release ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Ach vesicle docking ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Axoplasmic transport ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
NMJ blocking ,[object Object],[object Object]
Earliest known NMJ blocker - Curare ,[object Object],[object Object],[object Object],[object Object],[object Object]
Neuromuscular blocking agents ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Neuromuscular blocking agents ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Neuromuscular blocking agents ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
NMJ disorders ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
NMJ disorders ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Botulinum toxin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Video clip
Organophosphates ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Snake venom ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Myasthenia gravis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Muscle contraction ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Muscle contraction ,[object Object],[object Object]
Muscle contraction ,[object Object],[object Object],[object Object]
Ca++ Ca++
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Troponin Actin Myosin Tropomyosin ATP
Detachment Sliding Binding Ca 2+ Troponin Actin Myosin Tropomyosin Ca 2+ Myosin binding sites Ca 2+ Ca 2+
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slow & fast fibres ,[object Object],[object Object]
Slow twitch fibre (type I fibre) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Fast twitch fibre (type II fibre) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Md (surg) part1 nmj 2011 student