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Emetic 
& 
Expectorants
By: Sahaya Asirvatham
Emetics
These  are  the  drugs  which  give  rise  to  forced 
regurgitation  (emesis)  by  which  the  contents  of 
the stomach get expelled through the oral cavity. 
They are very important in cases of  Poisoning. 
The emetics act by 2 types:
1. Locally acting emetics:  by local irritation of gastric 
mucosa. 
 e.g. Ammonium bicarbonate, Ipecacuanha 
     
2. Centrally acting emetics: directly on the Chemoreceptor 
 Trigger Zone (CTZ) in the floor of IV th ventricle in 
medulla
 e.g. Apomorphine & Morphine
Mechanism of action
        Cerebral Centers Affecting Vomiting
Uses of Emetics
  1.  Vomiting  is  primarily  considered  to  be  a  respiratory 
function, its ultimate result would cause the evacuation 
of the stomach thus emetics produces a reflux aaction by 
which  TOXIC  substances  gets  expelled  in  case  of 
poisoning.
2. Emetics are sometimes added to cough preparations in 
low  doses  to  stimulate  flow  of  respiratory  tract 
secretions.
 Salt water • Warm water – mild emetic • 2 spoonful
of common salt in 1 pint of warm water
 Mustard seed • 1 table spoonful ground mustard
seeds in half-pin of warm water • Strong coffee is
one of the best domestic stimulants, especially after
a narcotic poison
Natural Emetics
When not to use Emetics????
 In Corrosive poisoning – acid and alkali (why?)
 In CNS stimulant poisoning
 To unconscious patients
Expectorants
Expectorants are “Drugs that help in removing sputum
from the respiratory tract either by
 increasing the fluidity (or reducing the viscosity) of
sputum
Or
 increasing the volume of fluids that have to be
expelled from the respiratory tract by coughing.”
Classification of Expectorants
According the their mechanism of action… 
1) Sedative expectorant 
2) Stimulant expectorant 
Sedative Expectorants   
 These are stomach irritant expectorants which
are able to produce their effect through
stimulation of gastric reflexes.
e.g.
 Bitter drugs – Ipecac, Senega, Indian Squill
 Compounds – Antimony potassium tartrate,
Ammonium chloride, Sodium citrate, Potassium
iodide
 These are the expectorants which bring about a 
stimulation  of  the  secretory  cells  of  the 
respiratory tract directly or indirectly.
   Since  these  drugs  stimulate  secretion,  more 
fluid in respiratory tract and sputum is diluted.
  e.g.  ­  Eucalyptus,  lemon,  anise  ­  Active 
constituents of oil like terpine hydrate, anethole 
Stimulant Expectorants   
Emetic and  expectorant

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