Awesomesauce is a creative digital marketing agency that brews Awesomeness in your marketing initiatives. We love design, technology, innovation and hearing from people. The company has been set up by a team of social media enthusiasts motivated to make a dent in the universe by changing the perception of agency work and providing end-to-end solutions.
Pe parcursul celor două zile de atelier, cursanții, pregătiți să colecționeze sfaturi pe care apoi să le aplice în practică, vor descoperi cu uimire că nu trebuie să învețe nimic, ci doar să aleagă să trăiască altfel.
La cererea publicului, vom organiza mai multe sesiuni, dintre care primele două în datele de
15 – 16 Martie 2014 – Sâmbătă și Duminică și
9 – 10 Aprilie 2014 – Miercuri și Joi
Locurile sunt limitate.
Awesomesauce is a creative digital marketing agency that brews Awesomeness in your marketing initiatives. We love design, technology, innovation and hearing from people. The company has been set up by a team of social media enthusiasts motivated to make a dent in the universe by changing the perception of agency work and providing end-to-end solutions.
Pe parcursul celor două zile de atelier, cursanții, pregătiți să colecționeze sfaturi pe care apoi să le aplice în practică, vor descoperi cu uimire că nu trebuie să învețe nimic, ci doar să aleagă să trăiască altfel.
La cererea publicului, vom organiza mai multe sesiuni, dintre care primele două în datele de
15 – 16 Martie 2014 – Sâmbătă și Duminică și
9 – 10 Aprilie 2014 – Miercuri și Joi
Locurile sunt limitate.
Cambridge Institute is of the leading Institute in India offering specialised foreign language training, along with translation and interpretation services. We are providing Corporate Training to various premier companies successfully for years together.
Our institute offers language courses in French, Spanish, German, Chinese, Russian, Arabic and Japanese along with fluent English course which will be taught at 7 different levels. Well equipped with well groomed professional trainers, language training is given with the aid of Audio Visuals for better learning and understanding.
Population-Based Pharmacokinetic Modeling of Vancomycin in Children with Rena...Mawaya Tanaka
Background: Vancomycin dosing to achieve the area-under-the-curve to
minimum inhibitory concentration (AUC/MIC) target of ≥ 400 in children with
renal insufficiency is unknown. Our objectives were to compare vancomycin
clearance (CL) and initial dosing in children with normal and impaired renal
function.
Methods: Using a matched case-control study in subjects ≥ 3 months old
who received vancomycin ≥ 48 hr, we performed population-based modeling
with empiric Bayesian post-hoc individual parameter estimations and Monte
Carlo simulations. Cases, defined by baseline serum creatinine (SCr) ≥ 0.9 mg/
dL, were matched 1:1 to controls by age and weight.
Results: Analysis included 63 matched pairs with 319 serum
concentrations. Mean age (± SD) was 13 ± 6 yr and weight, 51 ± 25 kg. Mean
baseline SCr was 0.6 ± 0.2 mg/dL for controls, and 1.3 ± 0.5 for cases. Age,
SCr, and weight were independent covariates for CL. Final model parameters
and inter-subject variability (ISV) were: CL(L/hr) = 0.235*Weight0.75*(0.64/
SCr)0.497*(ln(DOL)/8.6)1.19 ISV=39%, where DOL is day of life. Target AUC/MIC
≥ 400 was achieved in 80% of cases at vancomycin 45 mg/kg/day, but required
60 mg/kg/day for controls. Drug CL improved in 87% of cases due to recovery
of renal function.
Conclusion: Due to reduced drug CL, a less frequent dosing at 15 mg/kg
every 8 hr (i.e., 45 mg/kg/day) is appropriate for children with renal impairment.
Close monitoring of renal function and drug concentrations is prudent to ensure
adequate drug exposure, especially in those with renal impairment since
recovery of renal function may occur during therapy.
The first generation of “GPH Single Shear Off Technology” allowed precision and consistent contact force with which the conductor is installed into the barrel of the mechanical connector providing:
• a simple and fail safe solution without use of special tools
• a connection that guaranteed the correct contact force within the barrel by shearing off the hexagon head at the correct torque level every time
• optimized contact regardless of the cable type or make-up e.g. solid, stranded, compacted, round or sector
• suitability for a wide cross sectional range of conductors
The second generation of “GPH Double Shear Off Technology” using an Allen Key for a 2 Step installation providing suitability for a wider cross sectional range of conductors. Further development for medium voltage applications required reduction of “excess length” of shear off bolts.
The third generation of “GPH Multi Share Off Bolt Technology” once again improved the technical performance. This design was patented in 1998 and is used in all GPH M- and C - Series products. Market demand, to reduce stock cost, drove the need to widen the cross section range. This brought new challenges into the design of mechanical connectors when considering the minimum and maximum range of a particular shear bolt and the management of excess length of the shear bolt itself. It is physically intuitive that small cross sections should be connected with lower forces than larger ones. Exposing small conductors to high contact forces causes inevitable partial cross section reduction.
Raumschall Entkopplung mit vollflexiblen Lüftungsrohren der WesterQuadro Warengruppe zum Vorderwand- und Deckeneinbau bei gleichzeitig niedriger Raumhöhe geeignet. Dämpfung und Packungsdicke sind variabel.
Elektromechanische und digitale potentiometerConrad
Ein Potentiometer (kurz Poti) ist ein elektrisches Widerstandsbauelement, dessen Widerstandswerte mechanisch (durch Drehen oder Verschieben) veränderbar sind. Es hat mindestens zwei Anschlüsse und wird vorwiegend als stetig einstellbarer Spannungsteiler eingesetzt. Der Spannungsteiler besteht aus einem elektrisch nicht leitenden Träger, auf dem ein Widerstandsmaterial aufgebracht ist, zwei Anschlüssen an den beiden Enden des Widerstandselements und einem beweglichen Gleitkontakt (auch als Schleifer bezeichnet), der den festen Gesamtwiderstand elektrisch in zwei entgegen gesetzte Teilwiderstände aufteilt. Je nach äußerer Beschaltung ergibt sich entweder ein verstellbarer Widerstand, ein verstellbarer Spannungsabgriff (Spannungsteiler) oder – bei nennenswerter Belastung am Ausgang – ein so genannter belasteter Spannungsteiler. Nur bei der Schaltung als Spannungsteiler liegt jedoch die namens gebende Potentiometerschaltung vor; dabei wird eine Spannung (Potentialdifferenz) durch den Drehwinkel eines (Präzisions-) Potentiometers dargestellt.
Cambridge Institute is of the leading Institute in India offering specialised foreign language training, along with translation and interpretation services. We are providing Corporate Training to various premier companies successfully for years together.
Our institute offers language courses in French, Spanish, German, Chinese, Russian, Arabic and Japanese along with fluent English course which will be taught at 7 different levels. Well equipped with well groomed professional trainers, language training is given with the aid of Audio Visuals for better learning and understanding.
Population-Based Pharmacokinetic Modeling of Vancomycin in Children with Rena...Mawaya Tanaka
Background: Vancomycin dosing to achieve the area-under-the-curve to
minimum inhibitory concentration (AUC/MIC) target of ≥ 400 in children with
renal insufficiency is unknown. Our objectives were to compare vancomycin
clearance (CL) and initial dosing in children with normal and impaired renal
function.
Methods: Using a matched case-control study in subjects ≥ 3 months old
who received vancomycin ≥ 48 hr, we performed population-based modeling
with empiric Bayesian post-hoc individual parameter estimations and Monte
Carlo simulations. Cases, defined by baseline serum creatinine (SCr) ≥ 0.9 mg/
dL, were matched 1:1 to controls by age and weight.
Results: Analysis included 63 matched pairs with 319 serum
concentrations. Mean age (± SD) was 13 ± 6 yr and weight, 51 ± 25 kg. Mean
baseline SCr was 0.6 ± 0.2 mg/dL for controls, and 1.3 ± 0.5 for cases. Age,
SCr, and weight were independent covariates for CL. Final model parameters
and inter-subject variability (ISV) were: CL(L/hr) = 0.235*Weight0.75*(0.64/
SCr)0.497*(ln(DOL)/8.6)1.19 ISV=39%, where DOL is day of life. Target AUC/MIC
≥ 400 was achieved in 80% of cases at vancomycin 45 mg/kg/day, but required
60 mg/kg/day for controls. Drug CL improved in 87% of cases due to recovery
of renal function.
Conclusion: Due to reduced drug CL, a less frequent dosing at 15 mg/kg
every 8 hr (i.e., 45 mg/kg/day) is appropriate for children with renal impairment.
Close monitoring of renal function and drug concentrations is prudent to ensure
adequate drug exposure, especially in those with renal impairment since
recovery of renal function may occur during therapy.
The first generation of “GPH Single Shear Off Technology” allowed precision and consistent contact force with which the conductor is installed into the barrel of the mechanical connector providing:
• a simple and fail safe solution without use of special tools
• a connection that guaranteed the correct contact force within the barrel by shearing off the hexagon head at the correct torque level every time
• optimized contact regardless of the cable type or make-up e.g. solid, stranded, compacted, round or sector
• suitability for a wide cross sectional range of conductors
The second generation of “GPH Double Shear Off Technology” using an Allen Key for a 2 Step installation providing suitability for a wider cross sectional range of conductors. Further development for medium voltage applications required reduction of “excess length” of shear off bolts.
The third generation of “GPH Multi Share Off Bolt Technology” once again improved the technical performance. This design was patented in 1998 and is used in all GPH M- and C - Series products. Market demand, to reduce stock cost, drove the need to widen the cross section range. This brought new challenges into the design of mechanical connectors when considering the minimum and maximum range of a particular shear bolt and the management of excess length of the shear bolt itself. It is physically intuitive that small cross sections should be connected with lower forces than larger ones. Exposing small conductors to high contact forces causes inevitable partial cross section reduction.
Raumschall Entkopplung mit vollflexiblen Lüftungsrohren der WesterQuadro Warengruppe zum Vorderwand- und Deckeneinbau bei gleichzeitig niedriger Raumhöhe geeignet. Dämpfung und Packungsdicke sind variabel.
Elektromechanische und digitale potentiometerConrad
Ein Potentiometer (kurz Poti) ist ein elektrisches Widerstandsbauelement, dessen Widerstandswerte mechanisch (durch Drehen oder Verschieben) veränderbar sind. Es hat mindestens zwei Anschlüsse und wird vorwiegend als stetig einstellbarer Spannungsteiler eingesetzt. Der Spannungsteiler besteht aus einem elektrisch nicht leitenden Träger, auf dem ein Widerstandsmaterial aufgebracht ist, zwei Anschlüssen an den beiden Enden des Widerstandselements und einem beweglichen Gleitkontakt (auch als Schleifer bezeichnet), der den festen Gesamtwiderstand elektrisch in zwei entgegen gesetzte Teilwiderstände aufteilt. Je nach äußerer Beschaltung ergibt sich entweder ein verstellbarer Widerstand, ein verstellbarer Spannungsabgriff (Spannungsteiler) oder – bei nennenswerter Belastung am Ausgang – ein so genannter belasteter Spannungsteiler. Nur bei der Schaltung als Spannungsteiler liegt jedoch die namens gebende Potentiometerschaltung vor; dabei wird eine Spannung (Potentialdifferenz) durch den Drehwinkel eines (Präzisions-) Potentiometers dargestellt.