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[object Object],[object Object],[object Object],Effect of hydrate formation on dissolution profile of theophylline  (A common problem in wet granulation) Theophylline (TP)
PRE-TEST ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
THESIS STATEMENT  ,[object Object]
Hydrates-A PIT ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Hydrate Formation in Theophylline
SEM ANALYSIS ( MORPHOLOGICAL CHANGE DURING  ANHYDRATE  MONOHYDRATE ) (Anhydrate theophylline) (Monohydrate theophylline)
“ EXPECTED ” DISSOLUTION PROFILE  OF THEOPHYLLINE ,[object Object],[object Object],[object Object],[object Object]
FIGURE 1. DISSOLUTION PROFILES OF UNPROCESSED AND PROCESSED ANHYDROUS THEOPHYLLINE SAMPLES: STEP 1 ( ● ), STEP 2 ( ♦ ), AND STEP 3 ( ■ ). THESE ARE DESCRIBED IN SCHEME 1. ( REF :DEBNATH S, SURYANARAYANAN R. INFLUENCE OF PROCESSING-INDUCED PHASE TRANSFORMATIONS ON THE DISSOLUTION OF THEOPHYLLINE TABLETS. AAPS PHARMSCITECH. 2004; 5(1) Step 1 Step 2 Step 3
ACTUAL DISSOLUTION PROFILE ,[object Object],[object Object],[object Object],[object Object]
CASE STUDY ,[object Object],[object Object]
How we can determine the Hydrate formation in theophylline? ,[object Object],[object Object],[object Object]
NIR SPECTROSCOPY METHOD ,[object Object],[object Object],[object Object]
[object Object],[object Object]
CRITICAL ISSUES ,[object Object],[object Object],[object Object],[object Object]
RAMAN SPECTROSCOPY ,[object Object],[object Object],[object Object],[object Object]
Comparision of NIR and Raman spectra AT has distinct peaks at 1664 and 1707 cm -1  and MT has a distinct peak at 1686 cm -1 ,  NIR spectra of AT and MT from 1100 to 1850 nm.
Waterfall Plot of NIR and Raman Effect
Summary :  Advantage of Raman Over NIR Spectroscopy ,[object Object],[object Object],[object Object]
CONCLUSION ,[object Object]
POST SEMINAR QUESTION ,[object Object]
 
THANK  YOU

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Effect Of Hydrate Formation (A Common Problem In Wet Granulation)

  • 1.
  • 2.
  • 3.
  • 4.
  • 5.  
  • 6. Hydrate Formation in Theophylline
  • 7. SEM ANALYSIS ( MORPHOLOGICAL CHANGE DURING ANHYDRATE MONOHYDRATE ) (Anhydrate theophylline) (Monohydrate theophylline)
  • 8.
  • 9. FIGURE 1. DISSOLUTION PROFILES OF UNPROCESSED AND PROCESSED ANHYDROUS THEOPHYLLINE SAMPLES: STEP 1 ( ● ), STEP 2 ( ♦ ), AND STEP 3 ( ■ ). THESE ARE DESCRIBED IN SCHEME 1. ( REF :DEBNATH S, SURYANARAYANAN R. INFLUENCE OF PROCESSING-INDUCED PHASE TRANSFORMATIONS ON THE DISSOLUTION OF THEOPHYLLINE TABLETS. AAPS PHARMSCITECH. 2004; 5(1) Step 1 Step 2 Step 3
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  • 17. Comparision of NIR and Raman spectra AT has distinct peaks at 1664 and 1707 cm -1 and MT has a distinct peak at 1686 cm -1 , NIR spectra of AT and MT from 1100 to 1850 nm.
  • 18. Waterfall Plot of NIR and Raman Effect
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