7. O-254: ICSI IN INFERTILE MEN WITH TREATED AND UNTREATED VARICOCELE Esteves, Oliveira & Bertolla – Brazil; ASRM 2009 Results: Clinical Pregnancy Frequency of Clinical Pregnancy *Pearson’s Chi-square test Logistic Regression of Group 1 on Group 2 with Clinical Pregnancy as Dependent Variable Group 1 (N=80; Treated) Group 2 (N=162; Untreated) P-value * Clinical Pregnancy N (%) 48 (60.0) 73 (45.0) 0.03 Group 1 P-value Odds-ratio 95% CI for OR Lower Upper Clinical Pregnancy 0.04 1.69 1.00 2.84
242 infertile men were included, divided in 2 groups: In group 1, Eighty men had a prior successful microsurgical subinguinal varicocelectomy (all of them performed by the same urologist); and in Group 2, 162 men had any grade of clinical varicocele at the time of ICSI. For group 1, semen analysis results were compared before and after surgery. Clinical pregnancy rates were compared between groups, and a logistic regression analysis was performed to verify if surgical correction of the varicoceles increased the odds of obtaining a clinical pregnancy or decreased the odds of miscarriage occurence.
Clinical pregnancy rates after ICSI were significantly higher (60%) in the treated group. Moreover, the chance of obtaining a clinical pregnancy was increased by 69% if the varicocele had been treated before ICSI, as shown by the logistic regression.