The National Toxicology Program (NTP)’s Nonneoplastic Lesion Atlas is a valuable, web-based resource with thousands of high-quality, enlargeable images, diagnostic guidelines, and preferred NTP terminology for numerous nonneoplastic rodent lesions. The atlas will be used by the NTP and its many pathology partners to standardize lesion diagnosis, terminology, and the way lesions are recorded in NTP studies. The goal is to improve the consistency and accuracy of the diagnosis of nonneoplastic lesions between pathologists and laboratories to improve the organization and utility of the NTP’s nonneoplastic lesion database and, ultimately, our understanding of nonneoplastic lesions. The NTP Nonneoplastic Lesion Atlas is a living document that complements the INHAND publications. In fact, one of the aims of the atlas is to align the NTP terminology with that of the INHAND publications as much as possible. The atlas is also a useful training tool for pathology residents and can be used by any organization to improve their own nonneoplastic lesion database. A total of 56 organs organized into 13 organ systems will be included in the completed project. The atlas is free to the public at http://ntp.niehs.nih.gov/nnl.

1. U.S. Department of Health and Human Services
The National Toxicology Program Nonneoplastic Lesion Atlas
ESTP BERLIN 2014
Mark F. Cesta1, David E. Malarkey1, Ronald A. Herbert1, Amy Brix2, Melvin H. Hamlin, II2,
Emily Singletary2, Gabrielle A. Willson2, and Robert C. Sills1
1Division of the National Toxicology Program, National Institute of Environmental Health
Sciences, North Carolina, USA; 2Experimental Pathology Laboratories, Inc., North Carolina, USA
The National Toxicology Program (NTP)’s Nonneoplastic Lesion Atlas is a valuable, web-based resource with thousands of high-quality, enlargeable images, diag-nostic
guidelines, and preferred NTP terminology for numerous nonneoplastic rodent lesions. The atlas will be used by the NTP and its many pathology partners to
standardize lesion diagnosis, terminology, and the way lesions are recorded in NTP studies. The goal is to improve the consistency and accuracy of the diagnosis of
nonneoplastic lesions between pathologists and laboratories to improve the organization and utility of the NTP’s nonneoplastic lesion database and, ultimately, our
understanding of nonneoplastic lesions. The NTP Nonneoplastic Lesion Atlas is a living document that complements the INHAND publications. In fact, one of the aims
of the atlas is to align the NTP terminology with that of the INHAND publications as much as possible. The atlas is also a useful training tool for pathology residents
and can be used by any organization to improve their own nonneoplastic lesion database. A total of 56 organs organized into 13 organ systems will be included in
the completed project. The atlas is free to the public at http://ntp.niehs.nih.gov/nnl.
Purpose
Goal
Key Features
Impact
Acknowledgments
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Images
Option
Image Only
Option
Text Only
Option
To document the NTP’s diagnostic strategy and guidelines
for nonneoplastic lesions
To improve the quality (e.g., consistency, organization, and
functionality) of the NTP nonneoplastic lesion database
Poster designed and created by
David A. Sabio
• 1000’s of high-quality, enlargeable images
• Recommendations for NTP terminology and diagnostic
strategy for nonneoplastic lesions
• Uses INHAND terminology whenever possible
• Covers rat and mouse nonneoplastic lesions:
* Background lesions
* Common treatment-related lesions
* Nonneoplastic proliferative lesions
* Lesions from acute, subchronic, and chronic studies
• 56 organs in 13 organ systems represented
• Updatable
• Searchable
• Downloadable
• Available free of charge to toxicologists, pathologists,
and other scientists around the world
• Expedite and simplify NTP nonneoplastic lesion
database searches
• Facilitate comparative morphologic and molecular
studies
• Allow generation of nonneoplastic historical control
data
http://ntp.niehs.nih.gov/nnl
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