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Jim Joyce
                                                                                                     Chairman, CEO
                                                                                                     January 9, 2012

My presentation may contain predictions, estimates, and other forward looking statements that involve risks and uncertainties, including whether
and when our products are successfully developed and introduced, market acceptance of the Aethlon ADAPT™ system, the Hemopurifier® and
other product offerings, regulatory delays, manufacturing delays, and other risks detailed in our sec filings accessible at www. Sec.gov.
We create medical devices to address unmet
medical needs in cancer, infectious disease,
and other life-threatening conditions
The transition from development-stage
     to revenue-stage organization
Adaptive Dialysis-like Affinity Platform Technology
The intersection of medical device
technology and affinity drug mechanisms


                                Mabs

    Dialysis

                     ADAPT        Lectins


    Plasmapheresis           Aptamers
Target binding is
Effective target separation
                                 highly selective




 No target discrimination     Toxicity Limits Dosing
High specificity

Indiscriminate       ADAPT              Toxicity

                 Effective separation
The Hemopurifier®
An Aethlon ADAPT™ Therapy
Aethlon ADAPT™ therapies seamlessly integrate
into the infrastructure of dialysis and CRRT
machines located in hospitals in clinics worldwide
Aethlon ADAPT™ therapies provide access
       to the entire circulatory system



•  Rapid real-time access to single or
   multiple therapeutic targets in as
   little as 15 minutes

•  Adjunct to improve SOC therapy
   benefit without adding drug toxicity
   or interaction risks

•  Able to address targets beyond
   the reach of drugs
The future is home based therapy
The Aethlon Hemopurifier®


•  The lead Aethlon ADAPT™ treatment
   candidate

•    Broad-spectrum capture of viral
     pathogens and immunosuppressive
     exosomes underlying cancer and
     infectious disease

•    Compelling HCV & HIV/AIDS treatment
     outcomes in ESRD patient population
•  The Drug Industry

  •  Provides medical device pathway for affinity drug agents


  •  $5 million vs. $500 million


  •  Repurposes approved, clinical stage & previous clinical dropouts


•  Military & Government Health Agencies

  •  Seeking innovative therapeutic solutions
Viral Load Reduction by Drugs Alone

                            $!!"#


                             ,!"#


                             +!"#
!"#$%&'(")*+"+%,'("-.'/"




                             *!"#


                             )!"#


                             (!"#


                             '!"#


                             &!"#


                             %!"#


                             $!"#


                              !"#
                                    !#   $#   %#            &#    '#   (#   )#   *#

                                                   0%12"3/'456"
Viral Load Reduction by Hemopurifier Alone

                           $!!"#


                            ,!"#


                            +!"#
!"#$%&'(")*+"+%,'("-.'/"




                            *!"#


                            )!"#


                            (!"#


                            '!"#


                            &!"#


                            %!"#


                            $!"#


                             !"#
                                   !#   $#   %#            &#    '#   (#   )#   *#

                                                  0%12"3/'456"
Viral Load Reduction by Drugs and
                               Hemopurifier in Combination
                           $!!"#


                            ,!"#                                 -.#/0123#45#'607/89#         :0123#8;.<=#>0=/?@A=/#


                            +!"#
                                                                 :0123#B#45#'60#>0=/?@A=/#    :0123#8;.<=#.C3#
!"#$%&'(")*+"+%,'("-.'/"




                            *!"#


                            )!"#


                            (!"#


                            '!"#


                            &!"#


                            %!"#


                            $!"#


                             !"#
                                   !#   $#   %#            &#       '#                   (#             )#             *#

                                                  0%12"3/'456"
Comparasion to RVR Achievement
                   7000000




                   6000000




                   5000000
Viral Load ul/ml




                   4000000



                                                                                                       SOC Alone
                   3000000                                                                             SOC + Hemopurifier®




                   2000000




                   1000000




                        0
                       Day 1 Pre   3 post   7 post     D-10    D-14   D-17   D-21     D-24   30 post
                                                               Day
Contact

Jim Joyce
Chairman, CEO
8910 University Center Lane
San Diego, California 92122
858.459.7800 x301
jj@aethlonmedical.com

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01 09-12+biotech+showcase+presentation(1)

  • 1. Jim Joyce Chairman, CEO January 9, 2012 My presentation may contain predictions, estimates, and other forward looking statements that involve risks and uncertainties, including whether and when our products are successfully developed and introduced, market acceptance of the Aethlon ADAPT™ system, the Hemopurifier® and other product offerings, regulatory delays, manufacturing delays, and other risks detailed in our sec filings accessible at www. Sec.gov.
  • 2. We create medical devices to address unmet medical needs in cancer, infectious disease, and other life-threatening conditions
  • 3. The transition from development-stage to revenue-stage organization
  • 4.
  • 5. Adaptive Dialysis-like Affinity Platform Technology
  • 6. The intersection of medical device technology and affinity drug mechanisms Mabs Dialysis ADAPT Lectins Plasmapheresis Aptamers
  • 7. Target binding is Effective target separation highly selective No target discrimination Toxicity Limits Dosing
  • 8. High specificity Indiscriminate ADAPT Toxicity Effective separation
  • 10. Aethlon ADAPT™ therapies seamlessly integrate into the infrastructure of dialysis and CRRT machines located in hospitals in clinics worldwide
  • 11. Aethlon ADAPT™ therapies provide access to the entire circulatory system •  Rapid real-time access to single or multiple therapeutic targets in as little as 15 minutes •  Adjunct to improve SOC therapy benefit without adding drug toxicity or interaction risks •  Able to address targets beyond the reach of drugs
  • 12. The future is home based therapy
  • 13.
  • 14.
  • 15.
  • 16.
  • 17.
  • 18. The Aethlon Hemopurifier® •  The lead Aethlon ADAPT™ treatment candidate •  Broad-spectrum capture of viral pathogens and immunosuppressive exosomes underlying cancer and infectious disease •  Compelling HCV & HIV/AIDS treatment outcomes in ESRD patient population
  • 19.
  • 20.
  • 21.
  • 22. •  The Drug Industry •  Provides medical device pathway for affinity drug agents •  $5 million vs. $500 million •  Repurposes approved, clinical stage & previous clinical dropouts •  Military & Government Health Agencies •  Seeking innovative therapeutic solutions
  • 23.
  • 24.
  • 25.
  • 26. Viral Load Reduction by Drugs Alone $!!"# ,!"# +!"# !"#$%&'(")*+"+%,'("-.'/" *!"# )!"# (!"# '!"# &!"# %!"# $!"# !"# !# $# %# &# '# (# )# *# 0%12"3/'456"
  • 27. Viral Load Reduction by Hemopurifier Alone $!!"# ,!"# +!"# !"#$%&'(")*+"+%,'("-.'/" *!"# )!"# (!"# '!"# &!"# %!"# $!"# !"# !# $# %# &# '# (# )# *# 0%12"3/'456"
  • 28. Viral Load Reduction by Drugs and Hemopurifier in Combination $!!"# ,!"# -.#/0123#45#'607/89# :0123#8;.<=#>0=/?@A=/# +!"# :0123#B#45#'60#>0=/?@A=/# :0123#8;.<=#.C3# !"#$%&'(")*+"+%,'("-.'/" *!"# )!"# (!"# '!"# &!"# %!"# $!"# !"# !# $# %# &# '# (# )# *# 0%12"3/'456"
  • 29. Comparasion to RVR Achievement 7000000 6000000 5000000 Viral Load ul/ml 4000000 SOC Alone 3000000 SOC + Hemopurifier® 2000000 1000000 0 Day 1 Pre 3 post 7 post D-10 D-14 D-17 D-21 D-24 30 post Day
  • 30.
  • 31.
  • 32. Contact Jim Joyce Chairman, CEO 8910 University Center Lane San Diego, California 92122 858.459.7800 x301 jj@aethlonmedical.com