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Investigation of the effects of Simvastatin and other statin drugs on gut Microbiome with regards to clinical obesity ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Outline ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],Investigation of the effects of Simvastatin and other statin drugs on gut Microbiome with regards to clinical obesity
Investigation of the effects of Simvastatin and other statin drugs on gut Microbiome with regards to clinical obesity ,[object Object],[object Object],[object Object]
Hypothesis ,[object Object],[object Object],[object Object]
Methods ,[object Object],[object Object]
Results ,[object Object],[object Object],[object Object]
R s R S S Fimicute Clostridium sordellii See Fig. 3 and comments. R: Resistant, little or no zone of inhibition; S: susceptible, clear zone of inhibition; s: slightly susceptible, hazy zone of inhibtion S S S S S Fungi Candida albicans R R R R R Enterobacteria E. aerogenes R R R R R Enterobacteria S. marcescens R R s R R Enterobacteria K. pneumoniae R R s s s Fimicute S. epidemidis R R S S S Enterobacteria E. coli R R S S S Fimicute S. aureus  (MRSA&MSSA) s S S S S Enterobacteria P. mirabilis R S S S S Fimicute B. subtilis Crestor Lovastatin Lipitor Fluvastatin Zocor Taxonomic group Species Table 1. Variable susceptibilities of bacterial species to individual statins by agar-based assay
Bacillus subtilis Zocor Lovastatin Lovastatin (1:10) Zocor  (1:10) Fluvastatin Fluvastatin (1:10)
Clostridium sordellii   Zocor Lovastatin Lovastatin (1:10) Zocor  (1:10) Fluvastatin Fluvastatin (1:10)
Clostridium sordellii Crestor DMSO Act.Buffer Crestor  (1:10) Lipitor Lipitor (1:10)
 
Future Experiments ,[object Object]
Conclusion ,[object Object],[object Object],[object Object]

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Statins Talk 2009

  • 1.
  • 2.
  • 3.
  • 4.
  • 5.
  • 6.
  • 7.
  • 8. R s R S S Fimicute Clostridium sordellii See Fig. 3 and comments. R: Resistant, little or no zone of inhibition; S: susceptible, clear zone of inhibition; s: slightly susceptible, hazy zone of inhibtion S S S S S Fungi Candida albicans R R R R R Enterobacteria E. aerogenes R R R R R Enterobacteria S. marcescens R R s R R Enterobacteria K. pneumoniae R R s s s Fimicute S. epidemidis R R S S S Enterobacteria E. coli R R S S S Fimicute S. aureus (MRSA&MSSA) s S S S S Enterobacteria P. mirabilis R S S S S Fimicute B. subtilis Crestor Lovastatin Lipitor Fluvastatin Zocor Taxonomic group Species Table 1. Variable susceptibilities of bacterial species to individual statins by agar-based assay
  • 9. Bacillus subtilis Zocor Lovastatin Lovastatin (1:10) Zocor (1:10) Fluvastatin Fluvastatin (1:10)
  • 10. Clostridium sordellii Zocor Lovastatin Lovastatin (1:10) Zocor (1:10) Fluvastatin Fluvastatin (1:10)
  • 11. Clostridium sordellii Crestor DMSO Act.Buffer Crestor (1:10) Lipitor Lipitor (1:10)
  • 12.  
  • 13.
  • 14.