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2004 North America Planning Meeting

                for

         Baxter BioScience
       January 21 – 24, 2004




                                      Page 1
2004 Create Demand and Build Momentum

    P. Mitsos               Presenter 2     Presenter 3           Presenter 4          Presenter 5    Presenter 6

                            Clinician          Insure                Sales             Homecare
    Patient                                                                                            Product
                           Engagement         Funding                POAs             Participation

T
     Viral Safety
A
C    Peer-to-Peer

T    DTP ADVATE
     Trial Offer Program
I
     CRM Marketing
     Campaign
C
S                                  Operations / Training / Global Marketing / Medical Affairs

                                             Measurements & Progress Tracking



                                                                                                              Page 2
Patient


          Stakeholder Champion
                P. Mitsos




                                 Page 3
Market Research Summary: Patient
 KEY FINDINGS

 HOW PATIENTS GAIN INFORMATION
 •  Patients become aware of ADVATE from their (N = 29) (MedPanel – Oct. ’03)
      – Doctor (31%)
      – Support groups (20.7%)
      – Internet research (17.2%)
    Conclusion: In line with our implementing a “See Your Doctor/Ask Your Doctor about ADVATE” call
    to action messaging strategy in our DTP efforts

 •   What patients “Want to Know” (MedPanel – Oct. ’03)
      – General Information is tied with “Is it right for me?” (27%)
      – As much information as possible (13%)

 •   In both the HHS (N = 200) and Caremark (n = 76) studies, the HTC/Physician was the most
     important way for patients to learn about a new product, followed by brochure, then website*

 •   Preferred Manner in which to Receive Information on Hemophilia A (Synovate Study - Topline)*
      – 54% from mail pieces, such as newsletters and brochures, journals, magazines, etc.

 •   Where are you finding additional information? (Synovate Study - Topline)
      – 40% from the internet
 *Note - Whereas in the Synovate Study, the majority of people (54%) preferred to learn
  about Hemophilia A from mail, in both the HHS and Caremark studies, HTC’s/physicians
  were the most important avenues for learning about new products.



                                                                                                      Page 4
Market Research Summary: Patient
KEY FINDINGS – (cont.)

COMBINED CAREMARK AND HHS PATIENT ANALYSIS (COMBINED N = 138)
•   29.0% Prophy; 41.3% On-demand
•   63.8% < age 19; 36.2% age 19+
•   % of Conversions to ADVATE rAHF-PFM from other Product:
     – 65.2% - Recombinate
     – 8.0% - FS
     – 4.3% - Refacto
     – 8.0% - PD (Hemofil M and Monoclate-P)
*Note – 90 out of 138 patients in both studies combined were on Recombinate




                                                                              Page 5
Market Research Summary: Patient
KEY FINDINGS – (cont.)

SAFETY
•   Safety is the #1 consideration when selecting a hemophilia product (HHS and Caremark studies)
    Conclusion: Future research should drill down as to whether patients/caregivers understand what a
    plasma/albumin-free therapy means to them, not just that it is “safe”. That is, probe them to
    determine if they understand why this is so important

DOCTOR VISITS
•  From Synovate Study (Topline), patients indicated that they visit their doctor, on average, every
   6.2 months
   Conclusion: DTP campaign needs to immediately drive office visits

AWARENESS OF HEMOPHILIA A PROGRAMS AND BAXTER FACTOR PROGRAMS
•  With regard to awareness of Hemophilia A Programs (Synovate Study - Topline)
    – 87% were aware of the Baxter Factor Program (N = 15)
    – 47%, however, were unable to name a hemophilia A program on an unaided basis
    Conclusion: Review current programs, which ones do we keep, which ones do we
    Discontinue. Also, we are more than likely branding our main DTP program under “Baxter Factor”

•   54% currently use/recommend the Baxter Factor Monthly Newsletter (Synovate Study - Topline)
    Conclusion: Should maintain regular communications via BF Monthly Newsletter, possibly revisit
    look/feel



                                                                                                        Page 6
Market Research Summary: Patient
KEY FINDINGS – (cont.)

AWARENESS OF HEMOPHILIA A PROGRAMS AND BAXTER FACTOR PROGRAMS – (cont.)

•   84% of those asked as to their level of experience with Hemophilia A were not aware of the NHF
    Sweepstakes (Synovate Study - Topline)

•   Among those responding to the question “What is perceived as the most valuable resource
    program?” (N = 13) (Synovate Study - Topline):
     – 39% mentioned Factor Assist
     – 23% mentioned NHF Sweepstakes

•   46% of patients surveyed indicated that they were not aware of HemophiliaGalaxy
    (N = 13) (Synovate Study - Topline)
    Impact – Important, because both the Trial Offer Program and CRM campaign are promoted here

ASKING FOR ADVATE rAHF-PFM
•  51% (HHS) and 42% (Caremark) indicated that they would ask their HCP for ADVATE rAHF-PFM
   when approved




                                                                                                     Page 7
Market Research Summary: Patient
 OTHER FINDINGS

 •   Awareness of convenience as a benefit is not high among both clinicians and patients (MedPanel –
     Oct. ’03)

 •   A 36% majority of patients (N = 25) cited plasma/albumin-free as the reason for switching to
     ADVATE rAHF-PFM (MedPanel – Oct. ’03)




                                                                                                        Page 8
Opportunities and Challenges: Patient
 Segments             Opportunities                           Challenges

 Patients vs.         • Establish ongoing relationship      • Contract for HealthInfo (Database) not
                        using CRM strategies with names       signed; therefore, database not yet cleaned
 Parents/Caregivers
                        on the database (mail,              • Obtaining breadth of response to our
                        e-strategies)                         questions over time, in order to eventually
                                                              develop targeted messaging
                      • By learning more about names on     • Ascertaining how best to reach names not on
                        the database over time, can           the database (Internet, Chapters – use a
                        develop increasingly targeted         response device - Leave-behind BRC/online
                        messaging and offers                  survey questions)
                                                            • From Synovate study, patients indicated that
                      • A high awareness of “The Baxter
                                                              they visit their doctor, on avg., every 6.2
                        Factor” exists, based on research
                                                              months
                        (87%).
                        CRM campaign likely to go under       - Conclusion: DTP campaign needs to drive
                        “The Baxter Factor” theme.            office visits
                                                            • Targeting them via HCC’s
                                                            • Identifying appropriate cut-off age for
                                                              children-directed vs. parent-directed
                                                              messaging (could be closer to 23, not 19)
                                                            • Constructing language that is patient-friendly
                                                              enough that is still legal




                                                                                                               Page 9
Opportunities and Challenges: Patient
 Segments               Opportunities                            Challenges

                        • More likely to respond to call to    • Establishing criteria for identifying correct
 Early Adopters           action motivating them to              adoption stage, and then develop targeted
                          see their doctor to talk about         messages appropriate for each stage
                          ADVATE rAHF-PFM                      • Correctly identifying this segment early
                        • Use them for testimonials and on       enough to capitalize on their very trait of
                          patient advisory councils              being early adopters
 Mid- and Late-         • Use other patient testimonials to    • Once defined, developing stronger
 Adopters                 aid in their adoption                  messaging and/or promotional incentives to
                                                                 get them to act

                        • Use them for testimonials and        • Keeping them on ADVATE (due to cost,
 Patients/CG’s of P’s
                          on patient advisory councils           insurance caps, competitive intrusion,
 on ADVATE
                        • Possible W-O-M                         inhibitor formation, possible supply issue)

 Patients/CG’s of P’s   • Stay with the integrity of Baxter,   • Getting them to switch; can’t antagonize them
 on Recombinate           but now fully eliminate risk of      • Using safety messaging appropriately
                          carrying unknown viruses or          • Eventual supply shortage of Recombinate could
                          infectious diseases                    be antagonizing
                        • Trial Offer Program                  • And, DB names that are identified as “highly
                                                                 loyal” Recombinate users could result in slower
                                                                 adoption

  Patients on other     • Stay with integrity of Baxter        • Getting them to switch therapies and still stay
  Baxter therapies      • Offer safety, peace of mind;           within the Baxter family
                          convenience, efficacy, supply        • Can’t antagonize them by inducing fear/anger
                        • Trial Offer Program                  • Alleviating insurance issues


                                                                                                                 Page 10
Opportunities and Challenges: Patient
 Segments           Opportunities                        Challenges


 Patients on non-   • Offer safety (peace of mind);    • Making them question their current therapy
 Baxter therapies     convenience, efficacy, supply    • Gaining their trust of Baxter
                    • Trial Offer Program              • Alleviating insurance issues
                                                       • Getting them to Try, Convert, Retain
                                                       • And, DB names that are identified as “highly
                                                         loyal” users of non-Baxter product could
                                                         result in slower adoption


 All Patients       • Education of Lifetime Caps       • Lifetime Caps
                    • Patient Advocacy Workshops       • Cost Justification vs. Recombinate
                    • HCE Regional Advocacy Meetings   • Perception vs. Reality of Insurance Issues
                    • Factor Assist                    • Navigating Insurance During Therapy
                    • Conversion Roadmap                 Change
                    • Lifetime Cap Calculator
                    • ADVATE Pricing Justification




                                                                                                        Page 11
Critical Path: Patient
•   Currently, two key programs are targeted to patients and caregivers:
      – ADVATE Trial Offer Program
      – CRM
•   The critical path for targeting patients and caregivers on ADVATE Trial Offer Program via DTP efforts
    alone (not including initial rep/doc interactions) consists of:
      – Sending a one-way Teaser communication (“Be on the Lookout”) via web (on site and via email),
         direct mail off database, and at chapters, using a one-way communication device
      – Following-up the Teaser with the launch of the Advate Trial Offer Program:
             • DB - Focus initial targeted, personalized effort to existing names in the database
             • Web - Next, promote Trial Offer Program on hemophiliagalaxy.com and advate.com,
                leading to patient’s/caregiver’s obtaining reminder sheet to take into office, to see and talk
                to doctor about ADVATE rAHF-PFM
             • Chapters - Concurrently, promote ADVATE Trial Offer Program through chapters
             • Messaging – “Is it Right for You?”, based on findings from MedPanel
             • Call-to-Action - Messaging through all channels will include “See your Doctor” call-to-action
             • Doctor Visit - Should lead to receipt of Trial Rx Kit
             • BRC>>CRM - All participants in the ADVATE Trial Offer Program will receive their patient kit,
                including complimentary doses and an opportunity, via BRC, to request 5 additional Sharpies.
                Any names entered into the database via this BRC will then be rolled into the CRM program




                                                                                                            Page 12
Critical Path: Patient
•   The critical path for targeting patients and caregivers via CRM consists of:
      – Questionnaire – Send questionnaire under “Baxter Factor” banner to all names on the db, via mail
         and email, with incentive to complete it. De-dupe any names entered via the Trial Offer Program
         who have already received the questionnaire, thereby also entering the CRM stream
      – Dimensional direct mailer - Send to all names on DB, recruiting participants into the CRM program.
         Concurrently, assess incoming responses from survey, and begin to segment database.
      – Recruitment/Fulfillment - Follow-up dimensional direct mailer with series of waves of both direct
         mail and email tactics, including newsletters.
             • Invite/reward program participation
      – Cast-the-Net – Develop communications targeted to HCP’s, HTC’s, and HCC’s to reach people
         outside the database and recruit new members into the program.
      – Wave communications – Send to existing program members/names on the database
      – Online communication and education – Conduct various market surveys, provide e-Learning
         opportunities, and encourage audience feedback

•   Develop an ongoing dialog with our target audience – the meaning behind CRM:
     – All efforts are designed to:
          • Successively learn more about our target audience,
          • Build a relationship with them, and
          • Eventually convert them to ADVATE rAHF-PFM




                                                                                                        Page 13
Patient Programs
                                                  DTP
                                                                                      CRM
     Viral Safety      Peer-to-Peer         ADVATE Trial Offer
                                                                               Marketing Campaign
                                                Program


  Quarterly Packets                         Baxter rep talks to Doctor;        Survey sent to all names on db;
                      Advisory Board       DR. talks to patients, faxes Rx      For any Sample Kit recipients
    to Chapters                                    form to Boswell            identified, version the cover letter


                                            Boswell sends Trial Offer Kit       Dimensional Direct
   Bylined Articles    Presentations                 to Patient
                                                                                     Mailer

                                                     DTP Begins:
                                               HealthInfo sends Teaser               Recruitment/
    Presentations        Webcasts           followed by Patient Mailing to            Fulfillment
                                           names on DB (Letter, Reminder
                                                      Form, OE)

      Meetings        Teleconferences        Patient sees Dr.; Receives          Invite/Reward
                                             Trial Offer Kit (3-Dose Trial,
                                               ADVATE Sharpies Offer)         Program Participation

                                             BRC Responses from both                    Send
                                             streams added to database;
                                              Patient/CG gets Sharpies         Initial Education Kit

                                               HealthInfo sends survey         Ongoing Educational
                                                       to patient;
                                           Patient rolled into CRM program           Dialog


                          Measurements & Progress Tracking


                                                                                                                     Page 14
DTP ADVATE Trial Offer Program Flow
      Consumer receives initial
      mailing informing them of         Consumer (patient/
                                        caregiver) prompted        MD fills out supplied (from rep) 1st Rx
      ADVATE trial sample offer.
                                        to review need with        prescription form. Faxes to Boswell for
      (letter/trial promotional
                                        MD.                        fulfillment of ADVATE.
      sheet/PI/10 x 13 envelope).




                                      Patient receives ADVATE       Boswell receives Rx from MD and
                                      Trial Prescription and        prepares ADVATE Trial Package,
                                      GoPak.                        w/ADVATE GoPak.

      Patient responds to BRC
      w/Sharpies offer and opts in
      to receive further
      communication.
                                                                  HI determines if patient/caregiver is
                                         HI informs Jett to       current or a new contact point within
                                         Fulfill Sharpies Offer   database and assigns appropriate ID#s
                                                                  and codes record.

       CRM Communication Strategy
       A) Protect the Franchise
       B) Convert to ADVATE
       C) Retain ADVATE
       D) Keep within Baxter Family




      Segmentation of DB begins,                                    HI sends out 1st wave questionnaire to
      based upon initial              Questionnaire response        contact. Will send up to 4 total waves
      responses. Begin CRM            received and recorded by      until contact responds or is tagged as
      communication campaign.         HI from contact.              non-responder




                                                                                                             Page 15
DTP ADVATE Trial Offer Program
 Program Description
 • Integrated direct marketing campaign motivating hemophilia A families to ask their doctor about receiving a Trial Rx of
   ADVATE rAHF-PFM

 Marketing Communications Objectives
 • Market the ADVATE Trial Offer Program to all suitable names on the database(database has not yet been transferred) with
   mailing and online communications
 • Attain 20% response to our tactics among all current database names (e.g., 20% respond to mailing in 2004 = 560)
 • Convert app. 60% of respondents to the ADVATE Trial Offer Program direct campaign to ADVATE by 7/ 04 (60% x 560 =
   336). This equals 12% of names on DB)
 • Acquire app. 425 names (5% of 8500 mod-sev), outside of existing db, of newly diagnosed and existing hemophilia A patient
   families, through web promotions and chapter meeting tactics
 • Establish, maintain and build on a useable database for highly targeted communications

 Marketing Communications Strategies
 • “Is It Right for You?” messaging strategy (mailing, chapters, web); “Ask Your Doctor about ADVATE rAHF-PFM ” call-to-
    action
 • Invite ADVATE conversion candidates to a 1:1 Baxter BioScience relationship
 • Maintain ongoing dialogue between Baxter and new and existing DB names responding to initial trial offer mailing by
   delivering relevant, personalized information

 Audiences
 • Prior to launching trial offer program, will launch a Teaser campaign (“Be on the Lookout”) via mail, web (on site and via e-
   mail), and chapters (challenge - timing)
 • Focus initial targeted, personalized effort to existing names in the database
 • Follow efforts to names on database with tactics targeted to outside the db (Web promotions, Chapter Meetings, etc.)
 • Target audiences include Caregivers/Patients and Professionals (HTC’s, HCP’s, Physicians, Nurses, etc.)

                                                                                                                                   Page 16
DTP ADVATE Trial Offer Program
                         Integrated direct marketing campaign motivating hemophilia A families to ask their doctor about receiving a Trial Rx of ADVATE.
Campaign Description     Tactics include mailing directly to names on the database, and promoting Trial Offer Program on both advate.com and HG.com.
                         Utilize “Is it Right for You” messaging strategy in mailing and on web, and “Ask Your Doctor about ADVATE” call-to-action.

                         • Market the ADVATE Trial Offer Program to all suitable (patient/caregiver) names on the database(database has not yet been
                            transferred) with mailing and online communications
                         • Attain 20% response to our tactics among all current database names (e.g., 20% respond to mailing in 2004 = 560)
Marketing
                         • Convert app. 60% of respondents to ADVATE Trial Offer Program direct campaign to ADVATE by 7/ 04 (60% x 560 = 336). This
Communications
                           equals 12% of names on DB)
(Program) Objective(s)
                         • Acquire app. 425 names (5% of 8500 mod-sev), outside of existing db, of newly diagnosed and existing hemophilia A patient
                           families, through web promotions and chapter meeting tactics
                         • Establish, maintain and build on a useable database for highly targeted communications

                         • Utilize “Is it Right for You” messaging strategy in mailing, on web, and to chapters; “Ask Your Doctor about ADVATE” call-to-action
Marketing
                         • Invite ADVATE conversion candidates to a 1:1 Baxter BioScience relationship
Communications
                         • Maintain ongoing dialogue between Baxter and new and existing DB names responding to initial sampling mailing by delivering
Strategie(s)
                            relevant, personalized information. Also institute retention strategies for any of those identified as highly Recombinate-loyal.
                         •     Prior to DTP launch of Trial Offer Program, promote Teaser campaign (“Be on the Lookout”) in mail, on web, to chapters
Target                   •     Focus initial targeted, personalized efforts for ADVATE Trial Offer Program to existing patient/caregiver names in the database
                         •     In addition to names on database, use tactics targeted to outside the db (Web promotions, Chapter Meetings, HCC’s etc.)
Audience (Stakeholder)
                         •     Target audiences include Caregivers/Patients and, if possible,Professionals (HTC’s, HCP’s, Physicians, Nurses, etc.) Focus initial
                               efforts on existing names in the database
                         • “Be on the Lookout” Teaser on web,         • Patients and Caregivers get 1-way      • Audience sees doctor/receives ADVATE Trial Rx
                            emailed, mailed to DB, chapters            Teaser                                 • Audience responds to BRC and receives either
Vehicles &Channels/      • Trial Rx Kit - DB Names (P/CG)            • Patients and Caregivers off DB           5 Sharpies
Audience/Tactics         • Promote T.P. thru Chapters                • Chapters contact point
                                                                                                               • Drop DM survey upon receipt of BRC (CRM pgm)
                         • Promote Trial Pgm on advate.com            • Patients/CG’s/HCP’s on advate.
                            and hemophiliagalaxy.com                    com and hemophiliagalaxy.com          •Obtain additional insights; Est. ongoing dialog

Message(s)               See if ADVATE is “Right for You”. Talk to your Doctor to see if ADVATE is right for you, and participate in the Trial Offer Program.
                         Consent to Participate (offering             Receive Trial Advate Prescription & relevant
                         Self-reported information)                  information and incentives of value to you              Ask your doctor for ADVATE!
Calls to Action
                         • Attain 20% response to our tactics among all current database names (e.g., 20% respond to mailing in 2004 = 560)
                         • Convert app. 60% of resp. to ADVATE TOP direct campaign to ADVATE by 12/ 04 (60% x 560 = 336; Equals 12% db names)
Metrics                  • Acquire app. 425 names (5% of 8500 mod-sev), outside of existing db, of newly diagnosed and existing hemophilia A patient
                           families, through web promotions and chapter meeting tactics
Timeline                 • Feb. 23 – Teaser; March 15 - Drop mail for Trial Offer Pgm to DB names; Also promote Trial Offer Program on advate.com & hg.com

Costs ($000)             Advate Trial Offer Program uniquely, estimated at $40,000.

Project Status           In development; reviewing Patient-Friendly language in SOP 1/20/04; Conduct Research; Incorporate findings into copy; Drop mail
                                                                                                                                                                    Page 17
DTP ADVATE Trial Offer Program
Dec. ‘03 & Q1 - Q4 ‘04 Activity
                                                 Feb. „04
                Dec. „03 - Jan. 04                                         Mar. ‟04                   Apr. ‟04                   May‟04
                                          Launch Pgm to Docs/
                Design Program             Test DTP/DTP Teaser            DTP Launch               DTP Continues             Rolled into CRM

                                                                        Place Trial banner ad      Monitor response of        Monitor response of
   Web                                      Place Teaser Message       on advate.com. Offer          promotion on               promotion on
 (Mass - N/A)
                         N/A                (“Be on the Lookout”)      Reminder Sheet for pts.          web-site                   web-site

                                           SOP Approv./Test Patient    Trial Rx Kit at Chapters;
                 Design DTP Strategy        Friendly Lang./Incorpor.                                  Receive Trial Kits
  Patient/       for ADVATE Trial Pgm;    Findings/Obtain Final SOP/
                                                                        Send mailing to all DB     thru Rep/Doc comm.          Possibly continue
                                                                       names (Mailing>>Doc                                    promoting on web/
 Caregiver       Brainstorm Patient-Fr.        Drop Teaser to DB           Visit>>Trial Rx>>
                                                                                                      and through DTP
                                                                                                                                chapters/CRM
                 Lang.; Design Teaser            and Chapters                                       Efforts; Roll into CRM
                                                                         Possible BRC Return)


 Advocacy                TBD                        TBD                         TBD                        TBD                       TBD

                                           Reps introduce Program.                                  HTC’s will contact
    HTC                   N/A             Access phones HTC’ and
                                                                        Send mailer to HTC’s
                                                                                                   patients (see Patient/            N/A
                                                                       post Access phone call.
                                          sends mailing/pers. forms.                                Caregiver for April)



   HCC                   TBD                        TBD                         TBD                        TBD                       TBD


  Payor                  N/A                      N/A                           N/A                        N/A                       N/A

                                              Program Training;
                                                 Call on HTC’s;           TM Calls to HTC’s
   Sales         Sales Training           Provide names to Access             continue,                     N/A                     N/A
                                             for TM Calls to HTC’s      followed by mailings



    CSR                  N/A                 Program Training.          Ongoing monitoring
                                             Monitor TM calls.            of any TM calls.                  N/A                     N/A



                                                                                                                                              Page 18
CRM Marketing Campaign
 Program Description
 • Integrated direct marketing campaign motivating hemophilia A families to ask their doctor about ADVATE rAHF-PFM


 Marketing Communications Objectives
 • Identify all 2,800 (est.) names in the current database through various direct marketing tactics
 • Attain 30% response among total number of current database names to our tactics (e.g., 30% respond to survey, throughout year
   = 840)
 • Convert app. 60% of respondents to survey/CRM campaign to ADVATE by 12/ 04 (60% x 840 = 504). This equals 18% of
   names on DB)
 • Acquire app. 850 names (10% of 8500 mod-sev), outside of existing db, of newly diagnosed and existing hemophilia A patient
   families, through web promotions and chapter meeting tactics
 • Establish, maintain and build on a useable database for highly targeted communications

 Marketing Communications Strategies
 •   Identify and segment current database audience who are candidates for ADVATE conversion
 •   Invite ADVATE conversion candidates to a 1:1 Baxter BioScience relationship
 •   Maintain ongoing dialogue between new and existing DB names and Baxter by delivering relevant, personalized information
 •   Support patient advocacy and hemophilia community associations/groups as goodwill gesture
 •   Institute retention strategies for any people who are identified as being highly Recombinate-loyal

 Audiences
 • Focus initial efforts to existing names in the database
 • Follow efforts to names on database with tactics targeted to outside the db (Patient Advisory Council, Chapter Meetings, etc.)
 • Target audiences include Caregivers/Patients, Professionals (HTC’s, HCP’s, HCC’s, Physicians, Nurses, etc.), Advocacy
   Groups

                                                                                                                                    Page 19
CRM Marketing Campaign
                         Integrated direct marketing campaign motivating hemophilia families to ask their doctor about ADVATE. Tactics include conversion of
Campaign                 existing Recombinate and non-Baxter product users, as well as “cast the net” efforts through HTC’s, HCP’s, and providers. Key program
Description              strategy captures patient data to be used to update and establish a new patient/caregiver database (DB) for future targeted programs
                         promoting Baxter hemophilia products and services.

                         •Identify all 2,800 (est.) names in the current database through various direct marketing tactics
Marketing
                         •Attain 30% response among total number of current database names to our tactics (e.g., 30% respond to survey, throughout year = 840)
Communications
                         •Convert app. 60% of respondents to survey/CRM campaign to ADVATE by 12/ 04 (60% x 840 = 504). This equals 18% of names on DB)
(Program)                •Acquire app. 850 names (10% of 8500 mod-sev), outside of existing db, of newly diagnosed and existing hemophilia A patient families
Objective(s)             •Establish, maintain and build on a useable database for highly targeted communications

                         •Identify and segment current database audience who are candidates for ADVATE conversion
Marketing                •Invite ADVATE conversion candidates to a 1:1 Baxter BioScience relationship (related products/services)
Communications           •Maintain ongoing dialogue between new and existing DB names and Baxter by delivering relevant, personalized information
Strategie(s)             •Support patient advocacy and hemophilia community associations/groups as goodwill gesture
                         •Institute retention strategies for any people who are identified as being highly Recombinate-loyal
                         •     Focus initial efforts to existing names in the database
Target
                         •     Follow efforts to names on database with tactics targeted to outside the db (Patient Advisory Council, Chapter Meetings, etc.)
Audience (Stakeholder)
                         •     Target audiences include Caregivers/Patients, Professionals (HTC’s, HCP’s, HCC’s, Physicians, Nurses, etc.), Advocacy Groups
                         • DM and Online Questionnaire to           • Get a read on new DB              • Patient-specific survey, incent participation
                           all db names, inc.                        • Recruitment/Fulfillment           • Invite/reward program participation
                         • Dimensional Direct Mail                  • Patient/Caregiver/Prof            • Patient Loyalty Wave; Send ADVATE GoPak with first NL
Vehicles & Channels/
                         • Direct Mail Waves                                                               after recruitment kit; On-going dialogue leading to
Audience/Tactics
                                                                                                            ADVATE conversion
                         • DM Surveys                               •Patient/Caregiver                  • Build insight into demographics,psychographics
                         • Online Comm. & education                 • All                               • Market surveys, e-Learning,audience feedback
                         Participate in the Advancing the Dialog program and receive pertinent educational information that will help you and your family aspire
Message(s)               to a quality of life, however you define it.

                                                                                   Receive Trial Advate Prescription &
                         Consent to Participate (offering self-reported
Calls to Action          information)
                                                                                   relevant information and incentives of         Ask your doctor for ADVATE!
                                                                                   value to you 

                         Recruit prospects from current DB (2800 names) into Program with initial projected response of 30% (840); Cast net to potential new
Metrics                  prospects (8500 hemophilia A) – attain projected response of 10%, or, acquire 850 new names into DB

                         Q1: Build new DB architecture; Identify, segment current DB; Recruitment/fulfillment to new DB file, “Cast the net” to HCP’s, HTC’s, HCC’s,
Timeline                 Providers. Q2-4: Wave communications to program members, recruit new members; continuous online e-Learning, market research

Costs ($000)             App. $527,000 - November 2003 through October 2004 (12 mo.)

Project Status           Assessing proposed CRM campaign in relation to current Baxter Factor and other consumer/trade initiatives
                                                                                                                                                                       Page 20
CRM Marketing Campaign
Q1 - Q4 ‘04 Activity
             Dec. „03         Q1 „04                Q2 „04               Q3 „04               Q4 „04
             “Build”       “Awareness ”         “Interest/Trial”    “Desire/Convert”     “Desire/Convert”


  Mass          N/A              N/A                  N/A                 N/A                   N/A


 Patient/                  Complete DB Build;   Recruit, Educate,    Recruit, Educate,    Recruit, Educate,
                 N/A        Segmentation        Retain & Convert
Caregiver                   Questionnaire
                                                                     Retain & Convert     Retain & Convert



Advocacy        N/A        Establish Patient      Peer to Peer         Peer to Peer        Peer to Peer
                           Advisory Group       Communication         Communication       Communication


  HTC           N/A          Cast the Net         Cast the Net         Cast the Net         Cast the Net
                              E-Learning           E-Learning           E-Learning           E-Learning



  HCC       Cast the Net      Cast the Net       Cast the Net          Cast the Net
                                                                                            Cast the Net



 Payor          N/A              N/A                  N/A                  N/A                  N/A



  Sales         N/A              N/A                  N/A                  N/A                  N/A



                N/A              N/A                  N/A                  N/A                  N/A
  CSR



                                                                                                       Page 21
Metrics
Tactic             Metric                                     Rationale                                         Timeframe
                   • Attain 20% response to tactics among     • Though an aggressive message will be            • Begin tracking
                     all DB names (app. 560)                    pushed, Trial Offer Program will be available     response to DTP
DTP ADVATE Trial                                                                                                  tactics by April 15,
                   • Convert app. 60% of respondents to         only for a limited time
Program                                                                                                           2004, but possibly
                     ADVATE Trial Offer Program direct        • Though those who respond to mailing may
                     campaign to ADVATE by 7/04 (60% x                                                            3/15/04 for rep
                                                                visit their HCP, certain HCP’s may not be
                     560 = 336)                                                                                   initiatives
                                                                trial-offer friendly
                   • Acquire 5% of moderate-severe names      • This is a modest prediction of gaining only     • Convert 60% - 7/04
                     outside of DB (app. 425), of newly         names, not necessarily converts to
                     diagnosed and existing hemophilia A        ADVATE. Campaign will generate thought
                     patient families, through web                                                              • Acquire names
                                                                among patients and caregivers to consider
                     promotions and chapter meeting                                                               outside DB (app.
                                                                if ADVATE is right for them, and will appeal
                     tactics                                                                                      425) by 7/04
                                                                to their concern about safety

CRM Marketing      • Identify all 2,800 (est.) names in the   • An aggressive message of “Is it Right for       • Names acquired
Campaign             current database through various           You?” will be pushed for CRM, and a survey        through Trial Offer
                     direct marketing tactics                   will be sent up to four times to non-             will be rolled into
                   • Attain 30% response among total            responders, as a means to collect names.          CRM campaign by
                     number of current database names           Efforts to bring names into the db will also      4/15/04
                     to our tactics (e.g., 30% respond to       be made through web initiatives and             • Since names
                     survey, throughout year = 840)             chapter events. Because we have longer to         outside DB (app.
                   • Convert app. 60% of respondents to         program CRM efforts, which will be                425) are expected
                     survey/CRM campaign to ADVATE              ongoing, a larger response to the survey,         to be acquired via
                     by 12/ 04 (60% x 840 = 504). This          which is also going to all names on the db        Trial Offer Program
                     equals 18% of names on DB)                 (just as the Trial Offer Program was              by 7/04, they will go
                   • Acquire app. 850 names (10% of             dropped to all names on the db), a larger         into CRM efforts
                     8500 mod-sev), outside of existing         number of people responding to the survey       • By 7/04, acquire
                     db, of newly diagnosed and existing        is expected than the number of people             840 names in DB in
                     hemophilia A patient families              expected to respond to the Program.               response to initial,
                                                                                                                  4-wave survey


                                                                                                                                    Page 22
EXAMPLE FOR FUTURE PROJECT PLANNING
                      Do Not Fill Out
2004 Overall Timeline
                         NORTH AMERICA PFM LAUNCH PLAN: [ ENTER SECTION HERE ]
Progress Stage Key:         PLANNING              IN PROGRESS         COMPLETE
                                2     0     0      3                  PFM LAUNCH                          2     0     0     4
KEY MILESTONES                  Jan   Feb   Mar   Apr     May   Jun   Jul   Aug   Sep   Oct   Nov   Dec   Jan   Feb   Mar   Apr   May   Jun   Jul

STAGE 1: [ ENTER STAGE NAME ]

   Step   1
   Step   2
   Step   3
   Step   4
   Step   5

STAGE 2: [ ENTER STAGE NAME ]                           Enter “P” to make a cell a “Planning” stage,
                                                        Enter “I” to make a cell an “In Progress” stage, and
   Step   1                                             Enter “C” to make a cell a “Complete” stage
   Step   2
   Step   3
   Step   4
   Step   5

STAGE 3: [ ENTER STAGE NAME ]

   Step   1
   Step   2
   Step   3
   Step   4
   Step   5

STAGE 4: [ ENTER STAGE NAME ]

   Step   1
   Step   2
   Step   3
   Step   4
   Step   5



                                                                                                                                              Page 23
Critical Issues and Risks

 Critical Issue/Risk              Resolution                         Mitigation                          Contingency
• HCC’s - not as receptive        • Possible resolution via PMS      • If regular Trial Offer Program   • If HCC’s have no interest, will
  to getting word out/working        study, as opposed to regular      (not PMS) pursues, utilize reps,   not send anything from
   with Baxter to promote            Trial Offer Program               others to convince HCC’s to        HealthInfo
   ADVATE Trial Offer Program                                          mail materials to patients/CG’s


 • For both Trial Offer Program   • Need to get contract signed      • Work with attorneys to finalize • Mail DTP packet for Trial
   and CRM, contracts have not      by app. Jan. 31 in order to        contracts                         Program using the Jette
   yet been signed; therefore,      clean up data, and meet          • Use pronounced call-to-action     database (db will not be
   data has not yet been            various drop dates for Trial       of “see your doctor” on           cleaned/NCOA’d)
   transferred, nor reviewed.       Program and CRM                    Trial Offer Program targeted to • Use multiple channels (web, db,
                                                                       patients/caregivers               chapters, to broaden the net)

 • Structuring patient-friendly   • Held a Brainstorming Session       • Conducting Market Research      • If next SOP on messaging
   messaging that appeals to        on 1/13. Received comments           in February to test messaging     results in still “unfriendly”
   both Legal, Marketing, and       in SOP on notes. Language          • Need to resubmit findings to      language, conduct another
   the Consumers                    is still not very patient-friendly   SOP again                         session with additional Baxter
                                                                                                           individuals and HealthInfo

• Based on Synovate study,        • Promote on both advate.com • Using an integrated                     • Will promote both the
  though n=only 13, 46% of          and on hg.com, which only      campaign of mail, one-way               Trial Offer Program and CRM
  patients surveyed indicated       drives people to advate.com.   communications off web,                 Program on both hemophila-
  that they are not aware of        Once at advate.com,            direct marketing off web,               galaxy.com and advate.com
  hemophiliagalaxy.com, and         patients/caregivers can        and chapters, the rather low
  this campaign promotes, tho       request for reminder form to   awareness of HG will be
  only in part, both the Trial      be sent to them directly via   buttressed by its still high
  Program and the CRM               email, which they bring to doc visitor rate, and targeting
  program on hg.com.                                               names both on and off the
                                                                   db thru other channels


                                                                                                                                       Page 24
Critical Issues and Risks

 Critical Issue/Risk                 Resolution                          Mitigation                             Contingency

 • Bad E-Mail addresses on           • Clean up email addresses         • Jill Felbein, contractor, is re-      • Will wait to market via email
   Siebel. Also, need to ascer-                                           reviewing addresses and                 until addresses are sufficiently
   tain how we’re going to                                                alerting reps to which ones             cleaned up
   use Siebel information at                                              need cleaning.                        • If we decide to provide
   HealthInfo.                                                          • Meeting will also be held               HealthInfo with a copy of
                                                                          among M. Donges, J. Felbein,            portions of Siebel
                                                                          C. Ping, HealthInfo, and P.             information, updates to
                                                                          Mitsos to review status of              email addresses and other
                                                                          emails and how we plan to               contact information should
                                                                          utilize Siebel info in CRM efforts.     be sent to HealthInfo on a
                                                                                                                  monthly basis,

 • DB names that are identified      • Establish a patient advisory      • Identify and segment names           • Until patient advisory council
   as highly loyal other-product       council that includes former        on DB                                  is formed, use testimonials
   users (Recombinate, other           highly loyal Recombinate          • Establish appropriate patient          and incorporate opportuni-
   Baxter product, non-Baxter          users converted to ADVATE           advisory council                       ties for peer-to-peer dialog
   product) could result in slower     to serve as springboard for                                                in other direct channels (web,
   adoption to ADVATE                  peer-to-peer communica-                                                    newsletter, etc.)
                                       tions, to aid in converting to
                                       ADVATE




                                                                                                                                              Page 25

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  • 1. 2004 North America Planning Meeting for Baxter BioScience January 21 – 24, 2004 Page 1
  • 2. 2004 Create Demand and Build Momentum P. Mitsos Presenter 2 Presenter 3 Presenter 4 Presenter 5 Presenter 6 Clinician Insure Sales Homecare Patient Product Engagement Funding POAs Participation T Viral Safety A C Peer-to-Peer T DTP ADVATE Trial Offer Program I CRM Marketing Campaign C S Operations / Training / Global Marketing / Medical Affairs Measurements & Progress Tracking Page 2
  • 3. Patient Stakeholder Champion P. Mitsos Page 3
  • 4. Market Research Summary: Patient KEY FINDINGS HOW PATIENTS GAIN INFORMATION • Patients become aware of ADVATE from their (N = 29) (MedPanel – Oct. ’03) – Doctor (31%) – Support groups (20.7%) – Internet research (17.2%) Conclusion: In line with our implementing a “See Your Doctor/Ask Your Doctor about ADVATE” call to action messaging strategy in our DTP efforts • What patients “Want to Know” (MedPanel – Oct. ’03) – General Information is tied with “Is it right for me?” (27%) – As much information as possible (13%) • In both the HHS (N = 200) and Caremark (n = 76) studies, the HTC/Physician was the most important way for patients to learn about a new product, followed by brochure, then website* • Preferred Manner in which to Receive Information on Hemophilia A (Synovate Study - Topline)* – 54% from mail pieces, such as newsletters and brochures, journals, magazines, etc. • Where are you finding additional information? (Synovate Study - Topline) – 40% from the internet *Note - Whereas in the Synovate Study, the majority of people (54%) preferred to learn about Hemophilia A from mail, in both the HHS and Caremark studies, HTC’s/physicians were the most important avenues for learning about new products. Page 4
  • 5. Market Research Summary: Patient KEY FINDINGS – (cont.) COMBINED CAREMARK AND HHS PATIENT ANALYSIS (COMBINED N = 138) • 29.0% Prophy; 41.3% On-demand • 63.8% < age 19; 36.2% age 19+ • % of Conversions to ADVATE rAHF-PFM from other Product: – 65.2% - Recombinate – 8.0% - FS – 4.3% - Refacto – 8.0% - PD (Hemofil M and Monoclate-P) *Note – 90 out of 138 patients in both studies combined were on Recombinate Page 5
  • 6. Market Research Summary: Patient KEY FINDINGS – (cont.) SAFETY • Safety is the #1 consideration when selecting a hemophilia product (HHS and Caremark studies) Conclusion: Future research should drill down as to whether patients/caregivers understand what a plasma/albumin-free therapy means to them, not just that it is “safe”. That is, probe them to determine if they understand why this is so important DOCTOR VISITS • From Synovate Study (Topline), patients indicated that they visit their doctor, on average, every 6.2 months Conclusion: DTP campaign needs to immediately drive office visits AWARENESS OF HEMOPHILIA A PROGRAMS AND BAXTER FACTOR PROGRAMS • With regard to awareness of Hemophilia A Programs (Synovate Study - Topline) – 87% were aware of the Baxter Factor Program (N = 15) – 47%, however, were unable to name a hemophilia A program on an unaided basis Conclusion: Review current programs, which ones do we keep, which ones do we Discontinue. Also, we are more than likely branding our main DTP program under “Baxter Factor” • 54% currently use/recommend the Baxter Factor Monthly Newsletter (Synovate Study - Topline) Conclusion: Should maintain regular communications via BF Monthly Newsletter, possibly revisit look/feel Page 6
  • 7. Market Research Summary: Patient KEY FINDINGS – (cont.) AWARENESS OF HEMOPHILIA A PROGRAMS AND BAXTER FACTOR PROGRAMS – (cont.) • 84% of those asked as to their level of experience with Hemophilia A were not aware of the NHF Sweepstakes (Synovate Study - Topline) • Among those responding to the question “What is perceived as the most valuable resource program?” (N = 13) (Synovate Study - Topline): – 39% mentioned Factor Assist – 23% mentioned NHF Sweepstakes • 46% of patients surveyed indicated that they were not aware of HemophiliaGalaxy (N = 13) (Synovate Study - Topline) Impact – Important, because both the Trial Offer Program and CRM campaign are promoted here ASKING FOR ADVATE rAHF-PFM • 51% (HHS) and 42% (Caremark) indicated that they would ask their HCP for ADVATE rAHF-PFM when approved Page 7
  • 8. Market Research Summary: Patient OTHER FINDINGS • Awareness of convenience as a benefit is not high among both clinicians and patients (MedPanel – Oct. ’03) • A 36% majority of patients (N = 25) cited plasma/albumin-free as the reason for switching to ADVATE rAHF-PFM (MedPanel – Oct. ’03) Page 8
  • 9. Opportunities and Challenges: Patient Segments Opportunities Challenges Patients vs. • Establish ongoing relationship • Contract for HealthInfo (Database) not using CRM strategies with names signed; therefore, database not yet cleaned Parents/Caregivers on the database (mail, • Obtaining breadth of response to our e-strategies) questions over time, in order to eventually develop targeted messaging • By learning more about names on • Ascertaining how best to reach names not on the database over time, can the database (Internet, Chapters – use a develop increasingly targeted response device - Leave-behind BRC/online messaging and offers survey questions) • From Synovate study, patients indicated that • A high awareness of “The Baxter they visit their doctor, on avg., every 6.2 Factor” exists, based on research months (87%). CRM campaign likely to go under - Conclusion: DTP campaign needs to drive “The Baxter Factor” theme. office visits • Targeting them via HCC’s • Identifying appropriate cut-off age for children-directed vs. parent-directed messaging (could be closer to 23, not 19) • Constructing language that is patient-friendly enough that is still legal Page 9
  • 10. Opportunities and Challenges: Patient Segments Opportunities Challenges • More likely to respond to call to • Establishing criteria for identifying correct Early Adopters action motivating them to adoption stage, and then develop targeted see their doctor to talk about messages appropriate for each stage ADVATE rAHF-PFM • Correctly identifying this segment early • Use them for testimonials and on enough to capitalize on their very trait of patient advisory councils being early adopters Mid- and Late- • Use other patient testimonials to • Once defined, developing stronger Adopters aid in their adoption messaging and/or promotional incentives to get them to act • Use them for testimonials and • Keeping them on ADVATE (due to cost, Patients/CG’s of P’s on patient advisory councils insurance caps, competitive intrusion, on ADVATE • Possible W-O-M inhibitor formation, possible supply issue) Patients/CG’s of P’s • Stay with the integrity of Baxter, • Getting them to switch; can’t antagonize them on Recombinate but now fully eliminate risk of • Using safety messaging appropriately carrying unknown viruses or • Eventual supply shortage of Recombinate could infectious diseases be antagonizing • Trial Offer Program • And, DB names that are identified as “highly loyal” Recombinate users could result in slower adoption Patients on other • Stay with integrity of Baxter • Getting them to switch therapies and still stay Baxter therapies • Offer safety, peace of mind; within the Baxter family convenience, efficacy, supply • Can’t antagonize them by inducing fear/anger • Trial Offer Program • Alleviating insurance issues Page 10
  • 11. Opportunities and Challenges: Patient Segments Opportunities Challenges Patients on non- • Offer safety (peace of mind); • Making them question their current therapy Baxter therapies convenience, efficacy, supply • Gaining their trust of Baxter • Trial Offer Program • Alleviating insurance issues • Getting them to Try, Convert, Retain • And, DB names that are identified as “highly loyal” users of non-Baxter product could result in slower adoption All Patients • Education of Lifetime Caps • Lifetime Caps • Patient Advocacy Workshops • Cost Justification vs. Recombinate • HCE Regional Advocacy Meetings • Perception vs. Reality of Insurance Issues • Factor Assist • Navigating Insurance During Therapy • Conversion Roadmap Change • Lifetime Cap Calculator • ADVATE Pricing Justification Page 11
  • 12. Critical Path: Patient • Currently, two key programs are targeted to patients and caregivers: – ADVATE Trial Offer Program – CRM • The critical path for targeting patients and caregivers on ADVATE Trial Offer Program via DTP efforts alone (not including initial rep/doc interactions) consists of: – Sending a one-way Teaser communication (“Be on the Lookout”) via web (on site and via email), direct mail off database, and at chapters, using a one-way communication device – Following-up the Teaser with the launch of the Advate Trial Offer Program: • DB - Focus initial targeted, personalized effort to existing names in the database • Web - Next, promote Trial Offer Program on hemophiliagalaxy.com and advate.com, leading to patient’s/caregiver’s obtaining reminder sheet to take into office, to see and talk to doctor about ADVATE rAHF-PFM • Chapters - Concurrently, promote ADVATE Trial Offer Program through chapters • Messaging – “Is it Right for You?”, based on findings from MedPanel • Call-to-Action - Messaging through all channels will include “See your Doctor” call-to-action • Doctor Visit - Should lead to receipt of Trial Rx Kit • BRC>>CRM - All participants in the ADVATE Trial Offer Program will receive their patient kit, including complimentary doses and an opportunity, via BRC, to request 5 additional Sharpies. Any names entered into the database via this BRC will then be rolled into the CRM program Page 12
  • 13. Critical Path: Patient • The critical path for targeting patients and caregivers via CRM consists of: – Questionnaire – Send questionnaire under “Baxter Factor” banner to all names on the db, via mail and email, with incentive to complete it. De-dupe any names entered via the Trial Offer Program who have already received the questionnaire, thereby also entering the CRM stream – Dimensional direct mailer - Send to all names on DB, recruiting participants into the CRM program. Concurrently, assess incoming responses from survey, and begin to segment database. – Recruitment/Fulfillment - Follow-up dimensional direct mailer with series of waves of both direct mail and email tactics, including newsletters. • Invite/reward program participation – Cast-the-Net – Develop communications targeted to HCP’s, HTC’s, and HCC’s to reach people outside the database and recruit new members into the program. – Wave communications – Send to existing program members/names on the database – Online communication and education – Conduct various market surveys, provide e-Learning opportunities, and encourage audience feedback • Develop an ongoing dialog with our target audience – the meaning behind CRM: – All efforts are designed to: • Successively learn more about our target audience, • Build a relationship with them, and • Eventually convert them to ADVATE rAHF-PFM Page 13
  • 14. Patient Programs DTP CRM Viral Safety Peer-to-Peer ADVATE Trial Offer Marketing Campaign Program Quarterly Packets Baxter rep talks to Doctor; Survey sent to all names on db; Advisory Board DR. talks to patients, faxes Rx For any Sample Kit recipients to Chapters form to Boswell identified, version the cover letter Boswell sends Trial Offer Kit Dimensional Direct Bylined Articles Presentations to Patient Mailer DTP Begins: HealthInfo sends Teaser Recruitment/ Presentations Webcasts followed by Patient Mailing to Fulfillment names on DB (Letter, Reminder Form, OE) Meetings Teleconferences Patient sees Dr.; Receives Invite/Reward Trial Offer Kit (3-Dose Trial, ADVATE Sharpies Offer) Program Participation BRC Responses from both Send streams added to database; Patient/CG gets Sharpies Initial Education Kit HealthInfo sends survey Ongoing Educational to patient; Patient rolled into CRM program Dialog Measurements & Progress Tracking Page 14
  • 15. DTP ADVATE Trial Offer Program Flow Consumer receives initial mailing informing them of Consumer (patient/ caregiver) prompted MD fills out supplied (from rep) 1st Rx ADVATE trial sample offer. to review need with prescription form. Faxes to Boswell for (letter/trial promotional MD. fulfillment of ADVATE. sheet/PI/10 x 13 envelope). Patient receives ADVATE Boswell receives Rx from MD and Trial Prescription and prepares ADVATE Trial Package, GoPak. w/ADVATE GoPak. Patient responds to BRC w/Sharpies offer and opts in to receive further communication. HI determines if patient/caregiver is HI informs Jett to current or a new contact point within Fulfill Sharpies Offer database and assigns appropriate ID#s and codes record. CRM Communication Strategy A) Protect the Franchise B) Convert to ADVATE C) Retain ADVATE D) Keep within Baxter Family Segmentation of DB begins, HI sends out 1st wave questionnaire to based upon initial Questionnaire response contact. Will send up to 4 total waves responses. Begin CRM received and recorded by until contact responds or is tagged as communication campaign. HI from contact. non-responder Page 15
  • 16. DTP ADVATE Trial Offer Program Program Description • Integrated direct marketing campaign motivating hemophilia A families to ask their doctor about receiving a Trial Rx of ADVATE rAHF-PFM Marketing Communications Objectives • Market the ADVATE Trial Offer Program to all suitable names on the database(database has not yet been transferred) with mailing and online communications • Attain 20% response to our tactics among all current database names (e.g., 20% respond to mailing in 2004 = 560) • Convert app. 60% of respondents to the ADVATE Trial Offer Program direct campaign to ADVATE by 7/ 04 (60% x 560 = 336). This equals 12% of names on DB) • Acquire app. 425 names (5% of 8500 mod-sev), outside of existing db, of newly diagnosed and existing hemophilia A patient families, through web promotions and chapter meeting tactics • Establish, maintain and build on a useable database for highly targeted communications Marketing Communications Strategies • “Is It Right for You?” messaging strategy (mailing, chapters, web); “Ask Your Doctor about ADVATE rAHF-PFM ” call-to- action • Invite ADVATE conversion candidates to a 1:1 Baxter BioScience relationship • Maintain ongoing dialogue between Baxter and new and existing DB names responding to initial trial offer mailing by delivering relevant, personalized information Audiences • Prior to launching trial offer program, will launch a Teaser campaign (“Be on the Lookout”) via mail, web (on site and via e- mail), and chapters (challenge - timing) • Focus initial targeted, personalized effort to existing names in the database • Follow efforts to names on database with tactics targeted to outside the db (Web promotions, Chapter Meetings, etc.) • Target audiences include Caregivers/Patients and Professionals (HTC’s, HCP’s, Physicians, Nurses, etc.) Page 16
  • 17. DTP ADVATE Trial Offer Program Integrated direct marketing campaign motivating hemophilia A families to ask their doctor about receiving a Trial Rx of ADVATE. Campaign Description Tactics include mailing directly to names on the database, and promoting Trial Offer Program on both advate.com and HG.com. Utilize “Is it Right for You” messaging strategy in mailing and on web, and “Ask Your Doctor about ADVATE” call-to-action. • Market the ADVATE Trial Offer Program to all suitable (patient/caregiver) names on the database(database has not yet been transferred) with mailing and online communications • Attain 20% response to our tactics among all current database names (e.g., 20% respond to mailing in 2004 = 560) Marketing • Convert app. 60% of respondents to ADVATE Trial Offer Program direct campaign to ADVATE by 7/ 04 (60% x 560 = 336). This Communications equals 12% of names on DB) (Program) Objective(s) • Acquire app. 425 names (5% of 8500 mod-sev), outside of existing db, of newly diagnosed and existing hemophilia A patient families, through web promotions and chapter meeting tactics • Establish, maintain and build on a useable database for highly targeted communications • Utilize “Is it Right for You” messaging strategy in mailing, on web, and to chapters; “Ask Your Doctor about ADVATE” call-to-action Marketing • Invite ADVATE conversion candidates to a 1:1 Baxter BioScience relationship Communications • Maintain ongoing dialogue between Baxter and new and existing DB names responding to initial sampling mailing by delivering Strategie(s) relevant, personalized information. Also institute retention strategies for any of those identified as highly Recombinate-loyal. • Prior to DTP launch of Trial Offer Program, promote Teaser campaign (“Be on the Lookout”) in mail, on web, to chapters Target • Focus initial targeted, personalized efforts for ADVATE Trial Offer Program to existing patient/caregiver names in the database • In addition to names on database, use tactics targeted to outside the db (Web promotions, Chapter Meetings, HCC’s etc.) Audience (Stakeholder) • Target audiences include Caregivers/Patients and, if possible,Professionals (HTC’s, HCP’s, Physicians, Nurses, etc.) Focus initial efforts on existing names in the database • “Be on the Lookout” Teaser on web, • Patients and Caregivers get 1-way • Audience sees doctor/receives ADVATE Trial Rx emailed, mailed to DB, chapters Teaser • Audience responds to BRC and receives either Vehicles &Channels/ • Trial Rx Kit - DB Names (P/CG)  • Patients and Caregivers off DB 5 Sharpies Audience/Tactics • Promote T.P. thru Chapters  • Chapters contact point • Drop DM survey upon receipt of BRC (CRM pgm) • Promote Trial Pgm on advate.com • Patients/CG’s/HCP’s on advate. and hemophiliagalaxy.com  com and hemophiliagalaxy.com •Obtain additional insights; Est. ongoing dialog Message(s) See if ADVATE is “Right for You”. Talk to your Doctor to see if ADVATE is right for you, and participate in the Trial Offer Program. Consent to Participate (offering Receive Trial Advate Prescription & relevant Self-reported information) information and incentives of value to you  Ask your doctor for ADVATE! Calls to Action • Attain 20% response to our tactics among all current database names (e.g., 20% respond to mailing in 2004 = 560) • Convert app. 60% of resp. to ADVATE TOP direct campaign to ADVATE by 12/ 04 (60% x 560 = 336; Equals 12% db names) Metrics • Acquire app. 425 names (5% of 8500 mod-sev), outside of existing db, of newly diagnosed and existing hemophilia A patient families, through web promotions and chapter meeting tactics Timeline • Feb. 23 – Teaser; March 15 - Drop mail for Trial Offer Pgm to DB names; Also promote Trial Offer Program on advate.com & hg.com Costs ($000) Advate Trial Offer Program uniquely, estimated at $40,000. Project Status In development; reviewing Patient-Friendly language in SOP 1/20/04; Conduct Research; Incorporate findings into copy; Drop mail Page 17
  • 18. DTP ADVATE Trial Offer Program Dec. ‘03 & Q1 - Q4 ‘04 Activity Feb. „04 Dec. „03 - Jan. 04 Mar. ‟04 Apr. ‟04 May‟04 Launch Pgm to Docs/ Design Program Test DTP/DTP Teaser DTP Launch DTP Continues Rolled into CRM Place Trial banner ad Monitor response of Monitor response of Web Place Teaser Message on advate.com. Offer promotion on promotion on (Mass - N/A) N/A (“Be on the Lookout”) Reminder Sheet for pts. web-site web-site SOP Approv./Test Patient Trial Rx Kit at Chapters; Design DTP Strategy Friendly Lang./Incorpor. Receive Trial Kits Patient/ for ADVATE Trial Pgm; Findings/Obtain Final SOP/ Send mailing to all DB thru Rep/Doc comm. Possibly continue names (Mailing>>Doc promoting on web/ Caregiver Brainstorm Patient-Fr. Drop Teaser to DB Visit>>Trial Rx>> and through DTP chapters/CRM Lang.; Design Teaser and Chapters Efforts; Roll into CRM Possible BRC Return) Advocacy TBD TBD TBD TBD TBD Reps introduce Program. HTC’s will contact HTC N/A Access phones HTC’ and Send mailer to HTC’s patients (see Patient/ N/A post Access phone call. sends mailing/pers. forms. Caregiver for April) HCC TBD TBD TBD TBD TBD Payor N/A N/A N/A N/A N/A Program Training; Call on HTC’s; TM Calls to HTC’s Sales Sales Training Provide names to Access continue, N/A N/A for TM Calls to HTC’s followed by mailings CSR N/A Program Training. Ongoing monitoring Monitor TM calls. of any TM calls. N/A N/A Page 18
  • 19. CRM Marketing Campaign Program Description • Integrated direct marketing campaign motivating hemophilia A families to ask their doctor about ADVATE rAHF-PFM Marketing Communications Objectives • Identify all 2,800 (est.) names in the current database through various direct marketing tactics • Attain 30% response among total number of current database names to our tactics (e.g., 30% respond to survey, throughout year = 840) • Convert app. 60% of respondents to survey/CRM campaign to ADVATE by 12/ 04 (60% x 840 = 504). This equals 18% of names on DB) • Acquire app. 850 names (10% of 8500 mod-sev), outside of existing db, of newly diagnosed and existing hemophilia A patient families, through web promotions and chapter meeting tactics • Establish, maintain and build on a useable database for highly targeted communications Marketing Communications Strategies • Identify and segment current database audience who are candidates for ADVATE conversion • Invite ADVATE conversion candidates to a 1:1 Baxter BioScience relationship • Maintain ongoing dialogue between new and existing DB names and Baxter by delivering relevant, personalized information • Support patient advocacy and hemophilia community associations/groups as goodwill gesture • Institute retention strategies for any people who are identified as being highly Recombinate-loyal Audiences • Focus initial efforts to existing names in the database • Follow efforts to names on database with tactics targeted to outside the db (Patient Advisory Council, Chapter Meetings, etc.) • Target audiences include Caregivers/Patients, Professionals (HTC’s, HCP’s, HCC’s, Physicians, Nurses, etc.), Advocacy Groups Page 19
  • 20. CRM Marketing Campaign Integrated direct marketing campaign motivating hemophilia families to ask their doctor about ADVATE. Tactics include conversion of Campaign existing Recombinate and non-Baxter product users, as well as “cast the net” efforts through HTC’s, HCP’s, and providers. Key program Description strategy captures patient data to be used to update and establish a new patient/caregiver database (DB) for future targeted programs promoting Baxter hemophilia products and services. •Identify all 2,800 (est.) names in the current database through various direct marketing tactics Marketing •Attain 30% response among total number of current database names to our tactics (e.g., 30% respond to survey, throughout year = 840) Communications •Convert app. 60% of respondents to survey/CRM campaign to ADVATE by 12/ 04 (60% x 840 = 504). This equals 18% of names on DB) (Program) •Acquire app. 850 names (10% of 8500 mod-sev), outside of existing db, of newly diagnosed and existing hemophilia A patient families Objective(s) •Establish, maintain and build on a useable database for highly targeted communications •Identify and segment current database audience who are candidates for ADVATE conversion Marketing •Invite ADVATE conversion candidates to a 1:1 Baxter BioScience relationship (related products/services) Communications •Maintain ongoing dialogue between new and existing DB names and Baxter by delivering relevant, personalized information Strategie(s) •Support patient advocacy and hemophilia community associations/groups as goodwill gesture •Institute retention strategies for any people who are identified as being highly Recombinate-loyal • Focus initial efforts to existing names in the database Target • Follow efforts to names on database with tactics targeted to outside the db (Patient Advisory Council, Chapter Meetings, etc.) Audience (Stakeholder) • Target audiences include Caregivers/Patients, Professionals (HTC’s, HCP’s, HCC’s, Physicians, Nurses, etc.), Advocacy Groups • DM and Online Questionnaire to • Get a read on new DB  • Patient-specific survey, incent participation all db names, inc. • Recruitment/Fulfillment  • Invite/reward program participation • Dimensional Direct Mail  • Patient/Caregiver/Prof  • Patient Loyalty Wave; Send ADVATE GoPak with first NL Vehicles & Channels/ • Direct Mail Waves  after recruitment kit; On-going dialogue leading to Audience/Tactics ADVATE conversion • DM Surveys  •Patient/Caregiver  • Build insight into demographics,psychographics • Online Comm. & education • All  • Market surveys, e-Learning,audience feedback Participate in the Advancing the Dialog program and receive pertinent educational information that will help you and your family aspire Message(s) to a quality of life, however you define it. Receive Trial Advate Prescription & Consent to Participate (offering self-reported Calls to Action information) relevant information and incentives of Ask your doctor for ADVATE! value to you  Recruit prospects from current DB (2800 names) into Program with initial projected response of 30% (840); Cast net to potential new Metrics prospects (8500 hemophilia A) – attain projected response of 10%, or, acquire 850 new names into DB Q1: Build new DB architecture; Identify, segment current DB; Recruitment/fulfillment to new DB file, “Cast the net” to HCP’s, HTC’s, HCC’s, Timeline Providers. Q2-4: Wave communications to program members, recruit new members; continuous online e-Learning, market research Costs ($000) App. $527,000 - November 2003 through October 2004 (12 mo.) Project Status Assessing proposed CRM campaign in relation to current Baxter Factor and other consumer/trade initiatives Page 20
  • 21. CRM Marketing Campaign Q1 - Q4 ‘04 Activity Dec. „03 Q1 „04 Q2 „04 Q3 „04 Q4 „04 “Build” “Awareness ” “Interest/Trial” “Desire/Convert” “Desire/Convert” Mass N/A N/A N/A N/A N/A Patient/ Complete DB Build; Recruit, Educate, Recruit, Educate, Recruit, Educate, N/A Segmentation Retain & Convert Caregiver Questionnaire Retain & Convert Retain & Convert Advocacy N/A Establish Patient Peer to Peer Peer to Peer Peer to Peer Advisory Group Communication Communication Communication HTC N/A Cast the Net Cast the Net Cast the Net Cast the Net E-Learning E-Learning E-Learning E-Learning HCC Cast the Net Cast the Net Cast the Net Cast the Net Cast the Net Payor N/A N/A N/A N/A N/A Sales N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A CSR Page 21
  • 22. Metrics Tactic Metric Rationale Timeframe • Attain 20% response to tactics among • Though an aggressive message will be • Begin tracking all DB names (app. 560) pushed, Trial Offer Program will be available response to DTP DTP ADVATE Trial tactics by April 15, • Convert app. 60% of respondents to only for a limited time Program 2004, but possibly ADVATE Trial Offer Program direct • Though those who respond to mailing may campaign to ADVATE by 7/04 (60% x 3/15/04 for rep visit their HCP, certain HCP’s may not be 560 = 336) initiatives trial-offer friendly • Acquire 5% of moderate-severe names • This is a modest prediction of gaining only • Convert 60% - 7/04 outside of DB (app. 425), of newly names, not necessarily converts to diagnosed and existing hemophilia A ADVATE. Campaign will generate thought patient families, through web • Acquire names among patients and caregivers to consider promotions and chapter meeting outside DB (app. if ADVATE is right for them, and will appeal tactics 425) by 7/04 to their concern about safety CRM Marketing • Identify all 2,800 (est.) names in the • An aggressive message of “Is it Right for • Names acquired Campaign current database through various You?” will be pushed for CRM, and a survey through Trial Offer direct marketing tactics will be sent up to four times to non- will be rolled into • Attain 30% response among total responders, as a means to collect names. CRM campaign by number of current database names Efforts to bring names into the db will also 4/15/04 to our tactics (e.g., 30% respond to be made through web initiatives and • Since names survey, throughout year = 840) chapter events. Because we have longer to outside DB (app. • Convert app. 60% of respondents to program CRM efforts, which will be 425) are expected survey/CRM campaign to ADVATE ongoing, a larger response to the survey, to be acquired via by 12/ 04 (60% x 840 = 504). This which is also going to all names on the db Trial Offer Program equals 18% of names on DB) (just as the Trial Offer Program was by 7/04, they will go • Acquire app. 850 names (10% of dropped to all names on the db), a larger into CRM efforts 8500 mod-sev), outside of existing number of people responding to the survey • By 7/04, acquire db, of newly diagnosed and existing is expected than the number of people 840 names in DB in hemophilia A patient families expected to respond to the Program. response to initial, 4-wave survey Page 22
  • 23. EXAMPLE FOR FUTURE PROJECT PLANNING Do Not Fill Out 2004 Overall Timeline NORTH AMERICA PFM LAUNCH PLAN: [ ENTER SECTION HERE ] Progress Stage Key: PLANNING IN PROGRESS COMPLETE 2 0 0 3 PFM LAUNCH 2 0 0 4 KEY MILESTONES Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec Jan Feb Mar Apr May Jun Jul STAGE 1: [ ENTER STAGE NAME ] Step 1 Step 2 Step 3 Step 4 Step 5 STAGE 2: [ ENTER STAGE NAME ] Enter “P” to make a cell a “Planning” stage, Enter “I” to make a cell an “In Progress” stage, and Step 1 Enter “C” to make a cell a “Complete” stage Step 2 Step 3 Step 4 Step 5 STAGE 3: [ ENTER STAGE NAME ] Step 1 Step 2 Step 3 Step 4 Step 5 STAGE 4: [ ENTER STAGE NAME ] Step 1 Step 2 Step 3 Step 4 Step 5 Page 23
  • 24. Critical Issues and Risks Critical Issue/Risk Resolution Mitigation Contingency • HCC’s - not as receptive • Possible resolution via PMS • If regular Trial Offer Program • If HCC’s have no interest, will to getting word out/working study, as opposed to regular (not PMS) pursues, utilize reps, not send anything from with Baxter to promote Trial Offer Program others to convince HCC’s to HealthInfo ADVATE Trial Offer Program mail materials to patients/CG’s • For both Trial Offer Program • Need to get contract signed • Work with attorneys to finalize • Mail DTP packet for Trial and CRM, contracts have not by app. Jan. 31 in order to contracts Program using the Jette yet been signed; therefore, clean up data, and meet • Use pronounced call-to-action database (db will not be data has not yet been various drop dates for Trial of “see your doctor” on cleaned/NCOA’d) transferred, nor reviewed. Program and CRM Trial Offer Program targeted to • Use multiple channels (web, db, patients/caregivers chapters, to broaden the net) • Structuring patient-friendly • Held a Brainstorming Session • Conducting Market Research • If next SOP on messaging messaging that appeals to on 1/13. Received comments in February to test messaging results in still “unfriendly” both Legal, Marketing, and in SOP on notes. Language • Need to resubmit findings to language, conduct another the Consumers is still not very patient-friendly SOP again session with additional Baxter individuals and HealthInfo • Based on Synovate study, • Promote on both advate.com • Using an integrated • Will promote both the though n=only 13, 46% of and on hg.com, which only campaign of mail, one-way Trial Offer Program and CRM patients surveyed indicated drives people to advate.com. communications off web, Program on both hemophila- that they are not aware of Once at advate.com, direct marketing off web, galaxy.com and advate.com hemophiliagalaxy.com, and patients/caregivers can and chapters, the rather low this campaign promotes, tho request for reminder form to awareness of HG will be only in part, both the Trial be sent to them directly via buttressed by its still high Program and the CRM email, which they bring to doc visitor rate, and targeting program on hg.com. names both on and off the db thru other channels Page 24
  • 25. Critical Issues and Risks Critical Issue/Risk Resolution Mitigation Contingency • Bad E-Mail addresses on • Clean up email addresses • Jill Felbein, contractor, is re- • Will wait to market via email Siebel. Also, need to ascer- reviewing addresses and until addresses are sufficiently tain how we’re going to alerting reps to which ones cleaned up use Siebel information at need cleaning. • If we decide to provide HealthInfo. • Meeting will also be held HealthInfo with a copy of among M. Donges, J. Felbein, portions of Siebel C. Ping, HealthInfo, and P. information, updates to Mitsos to review status of email addresses and other emails and how we plan to contact information should utilize Siebel info in CRM efforts. be sent to HealthInfo on a monthly basis, • DB names that are identified • Establish a patient advisory • Identify and segment names • Until patient advisory council as highly loyal other-product council that includes former on DB is formed, use testimonials users (Recombinate, other highly loyal Recombinate • Establish appropriate patient and incorporate opportuni- Baxter product, non-Baxter users converted to ADVATE advisory council ties for peer-to-peer dialog product) could result in slower to serve as springboard for in other direct channels (web, adoption to ADVATE peer-to-peer communica- newsletter, etc.) tions, to aid in converting to ADVATE Page 25