Appetite stimulant and

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Energy intake > Energy expenditure stored as adipose Appetite Satiety Absorption Metabolic rate Thermogenesis Physical action

Genetic Factors Energy expenditure ↓ Environmental Factors Energy intake ↑ Neuroendocrine regulation OBESITY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Central NPY Cocaine Agouti related peptide Amphetamine Dopamine Histamine Noradrenaline Peripheral Gherlin Leptin Dynorphin Insulin

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Appetite stimulant and

1.

2. Energy intake > Energy expenditure stored as adipose Appetite Satiety Absorption Metabolic rate Thermogenesis Physical action

3.

4.

5. Central NPY Cocaine Agouti related peptide Amphetamine Dopamine Histamine Noradrenaline Peripheral Gherlin Leptin Dynorphin Insulin

6.

7.