Phenolic compounds can also be stable free radical compounds. 18:2n-6 -> 20:4n-6 ( Arachidonic acid) -> 2-prostaglandins, 2-thromboxane, 5-HPETE, leukotriene A4, leukotriene C4 act as local hormones for pain, swelling, inflammation, and platelet aggregation 18:3n-3 -> 20:5n-3 (EPA) -> 22:6n-3 (DHA) -> 3-prostaglandins, 3-thromboxane, 5-leukotrienes act as local hormones and are anti-inflammatory and anti-aggregative