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NEW PROTEIN STRUCTURE 
COULD HELP TREAT 
ALZHEIMER´S, RELATED 
DISEASES AND WHEN 
TEMPERATURES GET COLD, 
NEWLY-DISCOVERED 
PROCESS HELPS FRUIT 
FLIES COPE. 
MANUELA VALENCIA BOTERO 
Medicine Student 
3rd Semester 
UPB
FOLDING
INTRODUCTION 
• Today the molecular biology is the 
starting point to know the form which 
difference pathology work in the 
human's body. 
• The amyloid disease are each time 
most frequently because part of a 
process that pass in all bodies. 
• A one gen in the drosophila permit 
maintain the temperature in blood-cold 
animals.
NEW PROTEIN STRUCTURE 
COULD HELP TREAT 
ALZHEIMER´S, 
RELATED DISEASES. 
Date: 
July 28, 2014. 
Source: 
University of 
Washington
NEW PROTEIN STRUCTURE 
COULD HELP TREAT ALZHEIMER´S, 
RELATED DISEASES. 
In the all bodies which age, 
some proteins change the 
normal state to abnormally 
folded, and accumulate in 
some tissues, but does not 
happen quickly. 
This are 
nominated 
amyloid fibrils.
NEW PROTEIN STRUCTURE 
COULD HELP TREAT ALZHEIMER´S, 
RELATED DISEASES. 
The amyloids fibrils 
possibly pass to a toxic 
state quickly and 
produce the amyloids 
diseases. 
The amyloids diseases 
include Parkinson's, 
Alzheimer's, heart 
disease and type 2 
diabetes.
NEW PROTEIN STRUCTURE 
COULD HELP TREAT ALZHEIMER´S, 
RELATED DISEASES. 
The researchers found a 
one peptide nominate 
“"alpha sheet“. This is able 
to stop the passage the 
active protein to toxic 
protein. 
This will produce the 
decrease of the effects of 
these diseases or at least 
progress and accurate 
diagnosis of disease
NEW PROTEIN STRUCTURE 
COULD HELP TREAT ALZHEIMER´S, 
RELATED DISEASES. 
Each step in the research is 
a progress in search of the 
solution of the disease, and 
in this case the hope of a 
better quality of life for 
patients. 
The accurate diagnosis of 
the disease will do to better 
treatment and thus avoid 
treating these diseases to 
be widespread.
WHEN TEMPERATURES 
GET COLD, NEWLY 
DISCOVERED PROCESS 
HELPS FRUIT FLIES 
COPE. 
Dat e: 
July 21, 2014. 
Source: 
University of Rochester
WHEN TEMPERATURES GET COLD, 
NEWLY DISCOVERED PROCESS HELPS 
FRUIT FLIES COPE. 
The blood-cold animals 
does not have a 
mechanism to regulate 
its corporal temperature 
In this extreme 
temperature the cells are 
stressed and some 
biological processes in 
the cell are slowed down 
more than others.
WHEN TEMPERATURES GET COLD, 
NEWLY DISCOVERED PROCESS HELPS 
FRUIT FLIES COPE. 
A researchers discover the 
internal mechanisms of 
the egg cell of the fruit fly, 
known as Drosophila. 
The productions of proteins 
is a fundamental process in 
the cells, a type of assembly 
line carries raw materials 
from the nucleus to the 
posterior end of the egg cell 
where the proteins are 
synthesized
WHEN TEMPERATURES GET COLD, 
NEWLY DISCOVERED PROCESS HELPS 
FRUIT FLIES COPE. 
When temperatures 
drop, the rate at which 
the proteins are built is 
slow significantly more 
than the rate at which 
the raw materials are 
delivered 
A protein nominated 
“klar” decreases the rate 
at which proteins are 
delivered, to be 
proportional 
conduction and 
production. 
A one of the protein that are 
syntethized denominate “oskar”, It is 
essential to put the tail in the right 
place. 
Only when Klar was 
present did the fruit fly 
develop properly
WHEN TEMPERATURES GET COLD, 
NEWLY DISCOVERED PROCESS HELPS 
FRUIT FLIES COPE. 
This study demonstrates that 
humans do not possess the 
same mechanism but if a 
similar, and perhaps could be 
used for places where the 
temperature is extreme.
Medical utility
Medical utility 
The discovery of the protein from 
the gene that synthesizes makes it 
easier to correct disorders 
permanently or used for genetic 
manipulation. 
Detect the exact spot that develops 
a disease makes the research is 
successful, allowing the 
development of new techniques 
and drugs that promote the exact 
need of the patient.
Medical utility 
More and more diseases and 
modes of resistance arise, 
which is why research should 
be increasingly demanding, 
and go beyond. 
Animals are often the starting 
point and experiment to reach 
breakthroughs, and no matter 
what species is, any discovery 
can be a big step for medicine.
Medical utility 
The disease that has no solution will always be catastrophic from anywhere 
display, but how are you arise when solutions becomes easier to treat patients 
even from the psychological aspect. 
Although the investigation from the outset not have a medical use to future 
development of these can promote strides for humanity, including the 
discovery of this gene or the protein that maintains a coordinated certain 
temperature control may eventually be used in medicine and to be a benefit. 
Even I would say that researchers are 
the chaperone of medicine.
BIBLIOGRAPHY 
•SCIENCE DAILY. New protein structure could help treat 
Alzheimer's related diseases 
•SCIENCE DAILY. When temperatures get cold, newly— 
discovered process helps fruit flies cope. 
Voet, Donald; Voet, Judith. voet bioquímica. 3. Ed. Buenos 
Aires. Editorial medica panamericana. 2006. Páginas 318-321
NEW PROTEIN STRUCTURE COULD HELP TREAT ALZHEIMER´S, RELATED DISEASES AND WHEN TEMPERATURES GET COLD, NEWLY-DISCOVERED PROCESS HELPS FRUIT FLIES COPE.

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NEW PROTEIN STRUCTURE COULD HELP TREAT ALZHEIMER´S, RELATED DISEASES AND WHEN TEMPERATURES GET COLD, NEWLY-DISCOVERED PROCESS HELPS FRUIT FLIES COPE.

  • 1. NEW PROTEIN STRUCTURE COULD HELP TREAT ALZHEIMER´S, RELATED DISEASES AND WHEN TEMPERATURES GET COLD, NEWLY-DISCOVERED PROCESS HELPS FRUIT FLIES COPE. MANUELA VALENCIA BOTERO Medicine Student 3rd Semester UPB
  • 3.
  • 4. INTRODUCTION • Today the molecular biology is the starting point to know the form which difference pathology work in the human's body. • The amyloid disease are each time most frequently because part of a process that pass in all bodies. • A one gen in the drosophila permit maintain the temperature in blood-cold animals.
  • 5. NEW PROTEIN STRUCTURE COULD HELP TREAT ALZHEIMER´S, RELATED DISEASES. Date: July 28, 2014. Source: University of Washington
  • 6. NEW PROTEIN STRUCTURE COULD HELP TREAT ALZHEIMER´S, RELATED DISEASES. In the all bodies which age, some proteins change the normal state to abnormally folded, and accumulate in some tissues, but does not happen quickly. This are nominated amyloid fibrils.
  • 7. NEW PROTEIN STRUCTURE COULD HELP TREAT ALZHEIMER´S, RELATED DISEASES. The amyloids fibrils possibly pass to a toxic state quickly and produce the amyloids diseases. The amyloids diseases include Parkinson's, Alzheimer's, heart disease and type 2 diabetes.
  • 8. NEW PROTEIN STRUCTURE COULD HELP TREAT ALZHEIMER´S, RELATED DISEASES. The researchers found a one peptide nominate “"alpha sheet“. This is able to stop the passage the active protein to toxic protein. This will produce the decrease of the effects of these diseases or at least progress and accurate diagnosis of disease
  • 9. NEW PROTEIN STRUCTURE COULD HELP TREAT ALZHEIMER´S, RELATED DISEASES. Each step in the research is a progress in search of the solution of the disease, and in this case the hope of a better quality of life for patients. The accurate diagnosis of the disease will do to better treatment and thus avoid treating these diseases to be widespread.
  • 10. WHEN TEMPERATURES GET COLD, NEWLY DISCOVERED PROCESS HELPS FRUIT FLIES COPE. Dat e: July 21, 2014. Source: University of Rochester
  • 11. WHEN TEMPERATURES GET COLD, NEWLY DISCOVERED PROCESS HELPS FRUIT FLIES COPE. The blood-cold animals does not have a mechanism to regulate its corporal temperature In this extreme temperature the cells are stressed and some biological processes in the cell are slowed down more than others.
  • 12. WHEN TEMPERATURES GET COLD, NEWLY DISCOVERED PROCESS HELPS FRUIT FLIES COPE. A researchers discover the internal mechanisms of the egg cell of the fruit fly, known as Drosophila. The productions of proteins is a fundamental process in the cells, a type of assembly line carries raw materials from the nucleus to the posterior end of the egg cell where the proteins are synthesized
  • 13. WHEN TEMPERATURES GET COLD, NEWLY DISCOVERED PROCESS HELPS FRUIT FLIES COPE. When temperatures drop, the rate at which the proteins are built is slow significantly more than the rate at which the raw materials are delivered A protein nominated “klar” decreases the rate at which proteins are delivered, to be proportional conduction and production. A one of the protein that are syntethized denominate “oskar”, It is essential to put the tail in the right place. Only when Klar was present did the fruit fly develop properly
  • 14. WHEN TEMPERATURES GET COLD, NEWLY DISCOVERED PROCESS HELPS FRUIT FLIES COPE. This study demonstrates that humans do not possess the same mechanism but if a similar, and perhaps could be used for places where the temperature is extreme.
  • 16. Medical utility The discovery of the protein from the gene that synthesizes makes it easier to correct disorders permanently or used for genetic manipulation. Detect the exact spot that develops a disease makes the research is successful, allowing the development of new techniques and drugs that promote the exact need of the patient.
  • 17. Medical utility More and more diseases and modes of resistance arise, which is why research should be increasingly demanding, and go beyond. Animals are often the starting point and experiment to reach breakthroughs, and no matter what species is, any discovery can be a big step for medicine.
  • 18. Medical utility The disease that has no solution will always be catastrophic from anywhere display, but how are you arise when solutions becomes easier to treat patients even from the psychological aspect. Although the investigation from the outset not have a medical use to future development of these can promote strides for humanity, including the discovery of this gene or the protein that maintains a coordinated certain temperature control may eventually be used in medicine and to be a benefit. Even I would say that researchers are the chaperone of medicine.
  • 19. BIBLIOGRAPHY •SCIENCE DAILY. New protein structure could help treat Alzheimer's related diseases •SCIENCE DAILY. When temperatures get cold, newly— discovered process helps fruit flies cope. Voet, Donald; Voet, Judith. voet bioquímica. 3. Ed. Buenos Aires. Editorial medica panamericana. 2006. Páginas 318-321