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11/8/2012   we miss you dr!!   1
A.    Hypoglycemia
B.    Persistence Acidosis
C.    Hypokalemia
D.    Cerebral edema




11/8/2012               we miss you dr!!   2
    Hypoglycemia -glucose level <3.9 mmol/l
      (about 70 mg/dl)




11/8/2012              we miss you dr!!         3
    autonomic activation                 neuroglycopenia
     Trembling                        Difficulty in concentrating
     Rapid heart rate                 Irritability
     Palpitations                     Blurred double vision
     Sweating                         Disturbed colour vision
     Pallor                           Difficulty hearing
     Hunger / nausea                  Slurred speech
                                       Dizziness and unsteady gait
                                       Tiredness
                                       Nightmares
                                       Loss of consciousness
                                       Seizures




11/8/2012                we miss you dr!!                             4
i.     Mild hypoglycemia-Pt recognizes it &is
       able to Tx it.
ii.    Moderate hypoglycemia-child / parent is
       aware of &Tx with assistance .pt not able to
       support himself .
iii.   Severe hypoglycemia-when the patient either
       loses consciousness or has a convulsion.




11/8/2012               we miss you dr!!              5
    The Pt will have symptoms of moderate or
      severe hypoglycemia without the warning
      symptoms of mild hypoglycemia coming first.
     Mgt- adjusting target glucose values upwards,
      to avoid hypoglycemia for several weeks or
      months




11/8/2012              we miss you dr!!               6
I.     Feeding the child with rapid-acting CHO food.
       -severe symptoms
II.    IV glucose (10% glucose drip or 1ml/kg of 25%
       dextrose)
III.   IV, IM or subcutaneous glucagon (0.25 mg for
       small children; 0.5 mg for children up to 40-50
       kg).




11/8/2012                we miss you dr!!                7
1)    Teach the child and parents about The
      symptoms of hypoglycemia
2)    Remind them about what might cause
      hypoglycemia &Risk Factor assessment for
      hypoglycemia
3)     use MedicAlert identification bracelet or
      necklacee “I have diabetes”




11/8/2012               we miss you dr!!           8
    Clinically apparent Cerebral edema occurs in
      1-2% of children with DKA. It is a serious
      complication with a mortality of > 70%. Only
      15% recover without permanent damage.
     Typically it takes place 6-10 hours after
      initiation of treatment, often following a
      period of clinical improvement.




11/8/2012              we miss you dr!!              9
The mechanism of CE is not fully understood,
   but many factors have been implicated:
  rapid decline in serum osmolality with
   treatment.
  high initial corrected serum Na
   concentration.
  high initial serum glucose concentration.
  longer duration of symptoms prior to
   initiation of treatment.
  younger age.
  failure of serum Na to raise as serum glucose
   falls during treatment.
11/8/2012            we miss you dr!!              10
    Sx of ICP
     deterioration of level of consciousness
      Headache & Vomiting
     Papilledema & pupillary changes
      seizures & posturing
     Incontinence
     Change in vital signs -bradycardia &
      respiratory arrest when brain stem herniation
      takes place.

11/8/2012              we miss you dr!!               11
    Elevate the head of the bed
     Reduce the rate of fluid administration by 1/3
     Intubation/Hyperventilation
     Give mannitol 0.5-1 g/kg IV over20 minutes
      &repeat if there is no initial response in 30’-2hr.
      OR
     Hypertonic saline (3%), 5 ml/kg over 30’.
     Cranial CT to R/O IC cause of neurologic
      deterioration(thrombosis or haemorrhage)10%.

11/8/2012                we miss you dr!!               12
11/8/2012   we miss you dr!!   13
11/8/2012   we miss you dr!!   14
11/8/2012   we miss you dr!!   15

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pedatrics

  • 1. 11/8/2012 we miss you dr!! 1
  • 2. A. Hypoglycemia B. Persistence Acidosis C. Hypokalemia D. Cerebral edema 11/8/2012 we miss you dr!! 2
  • 3. Hypoglycemia -glucose level <3.9 mmol/l (about 70 mg/dl) 11/8/2012 we miss you dr!! 3
  • 4. autonomic activation  neuroglycopenia  Trembling  Difficulty in concentrating  Rapid heart rate  Irritability  Palpitations  Blurred double vision  Sweating  Disturbed colour vision  Pallor  Difficulty hearing  Hunger / nausea  Slurred speech  Dizziness and unsteady gait  Tiredness  Nightmares  Loss of consciousness  Seizures 11/8/2012 we miss you dr!! 4
  • 5. i. Mild hypoglycemia-Pt recognizes it &is able to Tx it. ii. Moderate hypoglycemia-child / parent is aware of &Tx with assistance .pt not able to support himself . iii. Severe hypoglycemia-when the patient either loses consciousness or has a convulsion. 11/8/2012 we miss you dr!! 5
  • 6. The Pt will have symptoms of moderate or severe hypoglycemia without the warning symptoms of mild hypoglycemia coming first.  Mgt- adjusting target glucose values upwards, to avoid hypoglycemia for several weeks or months 11/8/2012 we miss you dr!! 6
  • 7. I. Feeding the child with rapid-acting CHO food. -severe symptoms II. IV glucose (10% glucose drip or 1ml/kg of 25% dextrose) III. IV, IM or subcutaneous glucagon (0.25 mg for small children; 0.5 mg for children up to 40-50 kg). 11/8/2012 we miss you dr!! 7
  • 8. 1) Teach the child and parents about The symptoms of hypoglycemia 2) Remind them about what might cause hypoglycemia &Risk Factor assessment for hypoglycemia 3) use MedicAlert identification bracelet or necklacee “I have diabetes” 11/8/2012 we miss you dr!! 8
  • 9. Clinically apparent Cerebral edema occurs in 1-2% of children with DKA. It is a serious complication with a mortality of > 70%. Only 15% recover without permanent damage.  Typically it takes place 6-10 hours after initiation of treatment, often following a period of clinical improvement. 11/8/2012 we miss you dr!! 9
  • 10. The mechanism of CE is not fully understood, but many factors have been implicated:  rapid decline in serum osmolality with treatment.  high initial corrected serum Na concentration.  high initial serum glucose concentration.  longer duration of symptoms prior to initiation of treatment.  younger age.  failure of serum Na to raise as serum glucose falls during treatment. 11/8/2012 we miss you dr!! 10
  • 11. Sx of ICP  deterioration of level of consciousness  Headache & Vomiting  Papilledema & pupillary changes  seizures & posturing  Incontinence  Change in vital signs -bradycardia & respiratory arrest when brain stem herniation takes place. 11/8/2012 we miss you dr!! 11
  • 12. Elevate the head of the bed  Reduce the rate of fluid administration by 1/3  Intubation/Hyperventilation  Give mannitol 0.5-1 g/kg IV over20 minutes &repeat if there is no initial response in 30’-2hr. OR  Hypertonic saline (3%), 5 ml/kg over 30’.  Cranial CT to R/O IC cause of neurologic deterioration(thrombosis or haemorrhage)10%. 11/8/2012 we miss you dr!! 12
  • 13. 11/8/2012 we miss you dr!! 13
  • 14. 11/8/2012 we miss you dr!! 14
  • 15. 11/8/2012 we miss you dr!! 15