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HISTORY AND NEW DEVELOPMENTS IN THE BANFF CLASSIFICATION OF ALLOGRAFT PATHOLOGY Kim Solez, M.D.
Goals and Objectives ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Transplantation in Resource-limited Settings. ,[object Object],[object Object],[object Object],[object Object]
A PROBLEM LOOMING ,[object Object],[object Object],[object Object],[object Object]
Background – The Banff Classification ,[object Object],[object Object],[object Object],[object Object]
Background – The Banff Classification ,[object Object],[object Object],[object Object]
The Banff Schema was first developed by a  group of  pathologists, nephrologists, and  transplant surgeons at a meeting in Banff Canada  August 2-4, 1991. The Banff Schema was first developed by a  group of  pathologists, nephrologists, and  transplant surgeons at a meeting in Banff Canada  August 2-4, 1991. It has continued to evolve through  meetings every two years  and has  become the worldwide  standard for  interpretation of transplant biopsies.
BANFF CLASSIFICATION STANDARD FOR TRANSPLANT BIOPSY INTERPRETATION ,[object Object],[object Object]
GENOMICS VERSUS TRADITIONAL PATHOLOGY. A FOOT FIRMLY PLANTED IN BOTH CAMPS BUT IT SEEMS OK! ,[object Object],[object Object],[object Object],[object Object],[object Object],Affymetrix GeneChip® probe array.  Image courtesy of Affymetrix.
BANFF CONFERENCES ON ALLOGRAFT PATHOLOGY 1991-?
BANFF CLASSIFICATION: MILESTONES  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Isolated v-lesion Group IHC Quality Assurance Group Glomerular Lesion Scoring Group Polyoma Virus Nephropathy Staging Group Fibrosis Scoring Group Developing an organizational structure for the Banff process  Establishment of Banff Histopathology Training Courses Evidence-based and Self-organized  Banff Process Figure 1. Established Working Groups in August 2009 to address some of the unsolved issues in  transplantation, and to contribute quality assurance and improvement in transplantation pathology
DIAGNOSTIC CATEGORIES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
LESION SCORING (0-3+) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
FUTURE BANFF MEETINGS: ,[object Object],[object Object],[object Object],[object Object],[object Object]
GLOBAL CONSENSUS GENERATION WHILE MAINTAINING INTELLECTUAL FREEDOM.
LIKE THE MOSH PIT AT A GREAT ROCK CONCERT.  NO PARTNER, THE ULTIMATE IN INDIVIDUALITY, DANGEROUS, BUT WHEN THE MUSIC IS GOOD EVERYONE DANCES IN SYNC AND LIFE IS GOOD!
HOW TO DANCE IN SYNCH IN A WAY THAT IS PRACTICAL AND BENEFITS THE DEVELOPING WORLD!
Polys in peritubular capillaries in antibody-mediated rejection.
 
 
NEED A PROGRAMATIC APPROACH TO PATHOLOGY IN LIMITED RESOURCES AREAS.  NOT PRACTICAL TO LEAVE IT ON A PERSONAL FAVOR BASIS. DONATION OF EQUIPMENT. TRAINING OF MEDICAL AND TECHNICAL PERSONNEL.
FUNDRAISING APPROACHES AND IDEA GENERATION TO SOLVE THE PROBLEM OF HOW TO MEET PATHOLOGY STANDARDS IN THE DEVELOPING WORLD IS SOMETHING WE SHOULD ALL BE INVOLVED IN.  THE NEXT FRONTIER IN MEDICAL HUMANITARIAN WORK!
GOVERNANCE STRUCTURE – UNTIL NOW WE HAVE HAD NONE BEYOND DRS. RACUSEN AND SOLEZ.
Thought of creating non-profit Alberta company:  Banff Allograft Pathology Training Courses Ltd.  to provide formal corporate structure for Banff training courses.  Board of Directors of 12 people, half of whom are from Alberta.  Six year terms which can be renewed. Officers, Secretary-Treasurer etc. If this worked could expand it to other facets of Banff meetings and consensus process.  In many ways high quality education is the key to ensuring a positive future!  Decided against this. For now only structure will still be the benign guiding hand of Drs. Solez and Racusen as has been the case for past twenty years.

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HISTORY AND NEW DEVELOPMENTS IN THE BANFF CLASSIFICATION

  • 1. HISTORY AND NEW DEVELOPMENTS IN THE BANFF CLASSIFICATION OF ALLOGRAFT PATHOLOGY Kim Solez, M.D.
  • 2.
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  • 7. The Banff Schema was first developed by a group of pathologists, nephrologists, and transplant surgeons at a meeting in Banff Canada August 2-4, 1991. The Banff Schema was first developed by a group of pathologists, nephrologists, and transplant surgeons at a meeting in Banff Canada August 2-4, 1991. It has continued to evolve through meetings every two years and has become the worldwide standard for interpretation of transplant biopsies.
  • 8.
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  • 10. BANFF CONFERENCES ON ALLOGRAFT PATHOLOGY 1991-?
  • 11.
  • 12. Isolated v-lesion Group IHC Quality Assurance Group Glomerular Lesion Scoring Group Polyoma Virus Nephropathy Staging Group Fibrosis Scoring Group Developing an organizational structure for the Banff process Establishment of Banff Histopathology Training Courses Evidence-based and Self-organized Banff Process Figure 1. Established Working Groups in August 2009 to address some of the unsolved issues in transplantation, and to contribute quality assurance and improvement in transplantation pathology
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  • 16. GLOBAL CONSENSUS GENERATION WHILE MAINTAINING INTELLECTUAL FREEDOM.
  • 17. LIKE THE MOSH PIT AT A GREAT ROCK CONCERT. NO PARTNER, THE ULTIMATE IN INDIVIDUALITY, DANGEROUS, BUT WHEN THE MUSIC IS GOOD EVERYONE DANCES IN SYNC AND LIFE IS GOOD!
  • 18. HOW TO DANCE IN SYNCH IN A WAY THAT IS PRACTICAL AND BENEFITS THE DEVELOPING WORLD!
  • 19. Polys in peritubular capillaries in antibody-mediated rejection.
  • 20.  
  • 21.  
  • 22. NEED A PROGRAMATIC APPROACH TO PATHOLOGY IN LIMITED RESOURCES AREAS. NOT PRACTICAL TO LEAVE IT ON A PERSONAL FAVOR BASIS. DONATION OF EQUIPMENT. TRAINING OF MEDICAL AND TECHNICAL PERSONNEL.
  • 23. FUNDRAISING APPROACHES AND IDEA GENERATION TO SOLVE THE PROBLEM OF HOW TO MEET PATHOLOGY STANDARDS IN THE DEVELOPING WORLD IS SOMETHING WE SHOULD ALL BE INVOLVED IN. THE NEXT FRONTIER IN MEDICAL HUMANITARIAN WORK!
  • 24. GOVERNANCE STRUCTURE – UNTIL NOW WE HAVE HAD NONE BEYOND DRS. RACUSEN AND SOLEZ.
  • 25. Thought of creating non-profit Alberta company: Banff Allograft Pathology Training Courses Ltd. to provide formal corporate structure for Banff training courses. Board of Directors of 12 people, half of whom are from Alberta. Six year terms which can be renewed. Officers, Secretary-Treasurer etc. If this worked could expand it to other facets of Banff meetings and consensus process. In many ways high quality education is the key to ensuring a positive future! Decided against this. For now only structure will still be the benign guiding hand of Drs. Solez and Racusen as has been the case for past twenty years.