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Screening of antihypertensive agents

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Kanthlal SK
Kanthlal SK
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[object Object],[object Object],SCREENING OF AGENTS S.K.LAL Ist M.Pharm Dept. PHARMACOLOGY JKKMMRF KPM
What is Hypertension ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
ACE INHIBITION IN RAS ,[object Object],Inactive Angiotensin -I Active Angiotensin -II ACE
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
In vivo models GOLDBALT HYPERTENSION (2 Kidney 1 Clip Method) ,[object Object],[object Object],[object Object],[object Object],ACUTE HYPERTENSION
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CHRONIC RENAL HYPERTENSION (1 Kidney- I -Clip Method) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
TAIL CUFF METHOD (Blood Pressure in Conscious rats) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
SALT- SENSITIVE DAHL RATS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
ANGIOTENSIN - II ANTAGONISM ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
ATIHYPERTENSIVE & VASODILATIOR ACTIVITY IN GANGLION BLOCKED ANG II SUPPORTED RATS . ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
IN VITRO MODELS MONOCROTALINE INDUCED HYPERTENSION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
ACE INHIBITION IN ISOLATED GUINEA PIG ILEUM ANGIOTENSIN CONVERTING ENZYME 1. Inactive Angiotensin I Active Angiotensin II 2. Active Peptide Bradykinin Inactive products A ctivity of Angiotensin II ACE Inhibition Activity of Bradykinin The Guinea Pig Ileum responds powerfully for both Angiotensin II, and Bradykinin.
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
β 1 SYMPATHOLYTIC ACTIVITY IN GUENIA PIG ATRIA ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
OBSERVATION Higher conc. of ISP is necessary to attain same response (potentation and ionotropy). The increase in the frequency and ionotropy is reduced at same ISP Conc. added before. β1 receptor blocking activity
Left atrium (Electricaly stimulated) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Screening of antihypertensive agents

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  • 21. ACE INHIBITION IN ISOLATED GUINEA PIG ILEUM ANGIOTENSIN CONVERTING ENZYME 1. Inactive Angiotensin I Active Angiotensin II 2. Active Peptide Bradykinin Inactive products A ctivity of Angiotensin II ACE Inhibition Activity of Bradykinin The Guinea Pig Ileum responds powerfully for both Angiotensin II, and Bradykinin.
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  • 25. OBSERVATION Higher conc. of ISP is necessary to attain same response (potentation and ionotropy). The increase in the frequency and ionotropy is reduced at same ISP Conc. added before. β1 receptor blocking activity
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