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PERAK	
   BIOTECHNOLOGY	
   STRATEGIC	
  
PLAN	
  AND	
  ACTION	
  PLAN	
  	
  
                                                                                   Contents	
  
	
  

A.	
   INTRODUCTION	
  .......................................................................................................................	
   4	
  

B.	
   Definition	
  and	
  Categories	
  of	
  Biotechnology	
  ...........................................................................	
   5	
  

C.	
              Biotechnology	
  and	
  Perak	
  ........................................................................................................	
   8	
  

         1.	
              Underlying	
  State	
  Policies	
  .....................................................................................................	
   8	
  

         2.	
              Perak	
  Biotechnology:	
  Strength	
  and	
  Challenges	
  ..................................................................	
   9	
  

         3.	
              Existing Biotechnology Initiatives in Perak	
  ......................................................................	
  11	
  

                  a.	
        Perak	
  Bio	
  .......................................................................................................................	
  11	
  

                  b.	
        Healthcare	
  biotechnology	
  .............................................................................................	
  13	
  

                  c.	
        Agriculture	
  biotechnology	
  .............................................................................................	
  14	
  

                  d.	
        Industrial and green biotechnology	
  ...............................................................................	
  16	
  

                  e.	
        Bioinformatics	
  ...............................................................................................................	
  17	
  

                  f.	
        Human Resource Development	
  .....................................................................................	
  17	
  

D.	
   Perak	
  Biotechnology	
  Strategic	
  Plan	
  
                                                  .......................................................................................	
  19	
  

         1.	
              Introduction	
  .......................................................................................................................	
  19	
  

         2.	
              Success Factor	
  ...................................................................................................................	
  20	
  

         3.	
              Policy Thrust	
  .....................................................................................................................	
  21	
  

E.	
              Perak	
  Biotechnology	
  Action	
  Plan	
  ..........................................................................................	
  25	
  

	
  

	
  

	
  


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                                                                  Table	
  of	
  Figures	
  
Figure	
  1:	
  Biotechnology	
  Focus	
  Areas	
  in	
  Malaysia	
  ...........................................................................	
   6	
  

Figure	
  2:	
  Biotechnology	
  Capacity	
  Building	
  2005-­‐10	
  ........................................................................	
   6	
  

Figure	
  3:	
  Creating	
  Business	
  2011-­‐2015	
  ...........................................................................................	
   7	
  

Figure	
  4:	
  Long	
  Term	
  Development	
  2016-­‐2020	
  
                                                          ................................................................................	
   7	
  

Figure	
  5:	
  Some	
  existing	
  biotech	
  activities	
  in	
  Perak	
  .......................................................................	
  11	
  

Figure	
  6:	
  Perak	
  Bio	
  Vision	
  and	
  Mission	
  .........................................................................................	
  12	
  

Figure	
  7:	
  Roles	
  of	
  Perak	
  Bio	
  
                                           ...........................................................................................................	
  12	
  

Figure	
  8:	
  Perak	
  Bio	
  Organisation	
  Structure	
  ...................................................................................	
  13	
  

Figure	
  9:	
  RAC	
  Aquaculture	
  in	
  Segari	
  ..............................................................................................	
  15	
  

Figure	
  10:	
  Biotechnology	
  Success	
  Factor	
  ......................................................................................	
  20	
  

Figure	
  11:	
  	
  Action	
  Plan	
  ..................................................................................................................	
  25	
  

Figure	
  12:	
  Individual	
  Success	
  Factors	
  ............................................................................................	
  27	
  

Figure	
  13:	
  Critical	
  Path	
  Analysis	
  Chart	
  
                                                      ...........................................................................................	
  28	
  

Figure	
  14:	
  Biotechnology	
  Clusters	
  in	
  Perak	
  ...................................................................................	
  30	
  

Figure	
  15:	
  Perak	
  CBioD	
  Initiatives	
  .................................................................................................	
  31	
  

Figure	
  16:	
  Formation	
  of	
  Specialised	
  Facilities	
  ...............................................................................	
  33	
  

Figure	
  17:	
  Advisory	
  Centre	
  ............................................................................................................	
  35	
  

Figure	
  18:	
  Perak	
  Hitech	
  Park	
  (Biotech)	
  
                                                     ..........................................................................................	
  37	
  

Figure	
  19:	
  Perak	
  Biotech	
  Park	
  Development	
  Structure	
  .................................................................	
  38	
  

Figure	
  20:	
  Development	
  Progress	
  of	
  Perak	
  Hitech	
  Park	
  ...............................................................	
  38	
  

Figure	
  21:	
  Basic	
  Concept	
  for	
  Perak	
  Biotech	
  Park	
  ..........................................................................	
  39	
  

Figure	
  22:	
  Main	
  milestones	
  of	
  Perak	
  Biotech	
  Park	
  Development	
  .................................................	
  40	
  

Figure	
  23:	
  Concept	
  for	
  Perak	
  Bio	
  HQ,	
  Incubators	
  and	
  PLSI	
  (based	
  on	
  Manchester	
  U)	
  .................	
  41	
  

Figure	
  24:	
  Value	
  Proposition	
  of	
  PLSI	
  .............................................................................................	
  46	
  


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Figure	
  25:	
  Vision	
  and	
  Missions	
  of	
  PLSI	
  ..........................................................................................	
  47	
  

Figure	
  26:	
  Perak	
  Hitech	
  Venture	
  Fund	
  ..........................................................................................	
  50	
  

	
  




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A.        INTRODUCTION	
  

1.        The main objectives of the creation of the Perak Biotechnology Strategic Plan and
          Perak Bio Business Plan include:
          a. To take stock of Perak’s position in biotechnology sector from the Malaysian
             and more perspective;
          b. To provide a broad based Strategic Plan on the development of biotechnology
             in Perak; and
          c. To provide a broad based and flexible action plan.
2.        Perak Biotechnology Strategic Plan will be guided by various State and National
          policies including the National Biotechnology Policy (NBP), the Malaysian Third
          Industrial Master Plan 3 (IMP3), Perak Maju 2015 Policy Statement, K Perak
          2010 Strategic Plan and Gagasan Perak Amanjaya.
3.        The Strategic Plan incorporates the followings:-
          a. The vision planning, strategic thrust and directions that is economically,
             socially, politically and environmentally viable;
          b. Identify the focus niche key areas with its competitive advantages; and
          c. An economic plan that is conducive to foster development of biotechnology
             industries in the State of Perak.




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B.                                                         Definition	
  and	
  Categories	
  of	
  Biotechnology	
  

1.                                                         Biotechnology has been in existence for centuries, long before the terminology
                                                           was even coined. Biotechnology can be categorised into classical and modern
                                                           biotechnology. While classical biotechnology is always referred to as the
                                                           production of useful products by living microorganisms such as the fermentation
                                                           process that produces beer or food items, modern biotechnology began in the
                                                           1970s with the research into genetic engineering based on the two basic
                                                           techniques of recombinant DNA technology (rDNA), hybridoma technology1 and
                                                           cell fusion technology.2
2.                                                         Biotechnology can be broadly defined as the use of living organisms to make a
                                                           product or run a process.3 Biotechnology also refers to any technological
                                                           application that uses biological systems, living organisms or derivatives to make
                                                           or modify products or processes for specific uses,4 or industries. Biotechnology is
                                                           as also defined as “the application of science and technology to living organisms,
                                                           as well as parts, products and models thereof, to alter living or non-living
                                                           materials for the production of knowledge, goods and services.”5
3.                                                         Biotechnology combines disciplines such as genetics, biochemistry, microbiology,
                                                           and cell biology and has been called the “technology of hope” for its ability to
                                                           improve the quality of life through advancements in food safety, health care,
                                                           industrial and environmental sustainability.6
4.                                                         Among the benefits of biotechnology are increased agriculture output, protection
                                                           of the environment and production of health care products.
5.                                                         Malaysia has identified several biotechnology focus areas, as shown in Figure 1
                                                           below:



	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
   	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  
1   S.N.   Cohen,   .,   A.   C.   Y.   Chang,   H.   W.   Boyer,   and   R.   B.   Helling,   ‘Construction   of   Biologically   Functional  
Bacterial  Plasmids  in  Vitro.’,  70  Proceedings  of  the  National  Academy  of  Sciences,  3240,  (1973).  
2  ATAS,  Biotechnology  and  Development:  expanding  the  capacity  to  produce  food,  Advanced  Technology  
Assessment  System,  Issue  9,  (New  York,  United  Nations,  1992).  
3  See  for  example  P.W.  Grubb,  Patents  for  Chemicals,  Pharmaceuticals  and  Biotechnology,  Fundamentals  of  
Global  Law,  Practice  and  Strategy,  (Oxford,  OUP  3rd  Ed.,  1999),  224.  
4  Convention  on  Biodiversity  (hereinafter  called  ‘CBD’),  Art.2.  
5  B.van  Beuzekom  and  A.  Arundel,  OECD  Biotechnology  Statistics  -­‐‑2006,  (Paris,  Organisation  for  Economic  
Cooperation  and  Development,  Paris,  2006),  7.  
6  A.  Kumar,  ‘Indian  Biotech  Bazaar,  A  Swot  Analysis,’  Biotechnol  J,  May  4:  2,  (5)  543-­‐‑535.  (2007).  



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                             Biotechnology Malaysia – Focus Areas

                                                                     Traditional
                                                                   Complementary
                                                                     Medicines


                                          New Agriculture                                    Value Added Products




                                          Food Supply                                             High Yield Crop

                                                               Agri Biotechnology

                                          Natural Substances                                    Nutraceutical



              Tropical Diseases                                      Bioinformatics                                    Microbes Technologies




       Contract Research                                         Contract Manufacturing                                                Bio Fuel
             CRO                                                          CMO


                             Healthcare Biotechnology                                         Industrial Biotechnology
                                                                                                                                     Green Chemistry
           Clinical Trials            Diagnostics &              Vaccines
                                        BioMedical                                     Bio Materials
                                       Instruments                                                           Enzymes/Catalyst




Figure	
  1:	
  Biotechnology	
  Focus	
  Areas	
  in	
  Malaysia

                The focus areas are within three broad categories namely agriculture
                biotechnology, healthcare biotechnology and industrial biotechnology.
6.              The policy encompasses 3 phases, namely capacity building (2005-2010), creating
                business out of science (2011-2015) and turning Malaysia into global player
                (2016-2020) as outlined in Figures 2, 3 and 4 below.

                                PHASE 1: SHORT TERM DEVELOPMENT (2005-2010)

                                          Action                                              Time Frame                                               Target

                             Establish first phase of the                             2005-2010                                       6 Commercial trophies by year 2010
                             Biotechnology Business
                                Agriculture
                                                                                                                                      Establish as regional centre of
                                • Enhance Agriculture                                 2005                                            excellence by year 2009
                                   Biotechnology Centre
                                                                                                                                      Establish as regional centre of
                                • Enhance Marine Biotechnology
                                                                                      2005                                            excellence by year 2010
                                   Centre

                                Healthcare
                                                                                                                                        Establish as regional CRO centre by
                                • CRO in Clinical Expertise                           2005-2008                                         year 2008
                                • CMO in Bio-Generics                                 2005-2009                                         Establish as regional CMO centre by
                                • Molecular Diagnostic for                                                                              year 2009
                                                                                      2005-2010
                                   infectious diseases
                                                                                      2006-2010                                         Commercialization by year 2010
                                • Vaccines for tropical diseases
                                                                                                                                        Commercialization by year 2010


                                Industry Biotechnology
                                                                                                                                        Generate early revenue for the
                                • Enzymes and Industrial                              2007-2008
                                                                                                                                        industry by year 2008
                                   chemicals




Figure	
  2:	
  Biotechnology	
  Capacity	
  Building	
  2005-­‐10




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             PHASE 11: MEDIUM TERM DEVELOPMENT (2011-2015)

                       Action                    Time Frame                            Target

       Establish second phase of the
       Biotechnology Business
                                                 2011-2015              One Key Transaction every 6 months
       Accelerator
         Agricultural Biotechnology
         • Development of Improved                                      Commercialization success by year
            Crops                                2011-2015              2015
         • Development of Research               2011-2015              Commercialization success by year
            Outsourcing Center                                          2015
                                                 2011-2015
         • Development of Natural
            Products                                                    Commercialization success by year
                                                                        2015
         Healthcare
         • Bio-Banking                           2009-2010              Bio Banking products to be
                                                                        commercialized by year 2012
         Industry Biotechnology                                         Develop a successful company for both local
         • Bio-Energy                           2011-2015               and export markets by year 2015
                                                2011-2015               Develop a successful company for both local
         •    Bio-Materials
                                                                        and export markets by year 2015
         •    Bioinformatics initiatives in                             Contribution towards success of at least 3
                                                 Starts in 2006         business accelerator projects by year
              support of 3 focus area
                                                                        2015




Figure	
  3:	
  Creating	
  Business	
  2011-­‐2015




             PHASE 111: LONG TERM DEVELOPMENT (2016-2020)

                          Action                      Time Frame                        Target




         Agricultural Biotechnology
         • Bio-pharming                               2016-2020              Commercialization
                                                                             success by year 2020
         Healthcare Biotechnology                                            Commercialization
         • Drug discovery                             2016-2020              success by year 2020

         Industry Biotechnology                                              Commercialization
                                                      2016-2020              success by year 2020
         • Manufacturing of bio-based
            products




Figure	
  4:	
  Long	
  Term	
  Development	
  2016-­‐2020




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C.        Biotechnology	
  and	
  Perak	
  
	
  

1.        Underlying	
  State	
  Policies	
  
	
  

1.        There are three major policies of the State of Perak which may be taken into
          account at this stage to assist Perak to develop its biotechnology sector. The two
          policies are Perak Maju 2015, KPerak 2010 and Gagasan Amanjaya.
2.        The Vision of Perak Maju 2015 is for Perak to become a developed state during
          2015 by focusing on state economic development, eradication of poverty and
          squatters. The mission of Perak Maju 2015 is to generate all sectors towards
          achieving key economic and social indicators to fulfil the criteria of developed
          state and increase citizens standard of living and quality of life through
          comfortable environment and healthy lifestyles.
3.        To achieve the KPerak 2010, the State Government has prepared three important
          knowledge development areas, namely the Knowledge Infrastructure (K-Infra),
          Knowledge Economy (K-Economy) and Knowledge Society (K-Society).
4.        The K-Economy thrust encompasses both existing and new economic sectors and
          this is not limited to ICT sector alone. Although the original strategy hinges on
          developing ICT as an industry as well as ICT as an enabler to spur new economic
          activities and enhance value-creation, biotechnology should also be included in
          the aim of K-economy. This is because the aim of K-economy under the KPerak
          2010 is to e-enable major industries by tapping the potential synergy from the
          interaction between new technologies and educated population within an enabling
          environment for the attainment of knowledge - based economies.
5.        Sustainable human capital development is a key component of K-Society. Perak
          has outlined a 5As strategy; consisting of Access (by providing equal access to PC
          and internet to the society), Awareness (by running awareness programme and
          engagement activities), Academy (by running basic and advanced ICT courses),
          Add Value (by enhancing community access points) and Adoption (by
          implementing commercial and social activities); to build confidence across
          different segments of the communities in embracing the ICT lifestyle by providing
          the people with access to technology, skills to use technology; and reason to
          continue using technology.
6.        In order to achieve a balanced and sustainable development, Perak has also
          launched the Gagasan Perak Amanjaya that has 7 specific thrusts namely:
          balanced development and distribution, community with skills, knowledge and
          integrity, state and government as a catalyst, social integration, participative and
          active younger generations, sustainable private sector development, and eco-
          friendly and sustainable development practices.

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2.        Perak	
  Biotechnology:	
  Strength	
  and	
  Challenges	
  
	
  

7.        Biotechnology in Perak may take advantage of several other factors. Such factors
          include:
          a.         Perak is one of the mega-diversity states in Malaysia, which is itself a
                     mega-diversity country in the world. Measuring 21,005 km2, almost half of
                     Perak is covered with forests as much as 10,502km2 where by 95.6% of it
                     is Equatorial Rainforest and the remaining 4.4% is covered by mangrove
                     forests which may provide genetic resources for biotechnology related
                     activities. The Belum and Temenggor forest reserves, approximately of
                     130 years old, older than the Amazon and the Congo, form the second
                     largest remaining block of virgin forest in Peninsular Malaysia and the
                     largest example of the northern monsoonal Burmese-Thai forest vegetation
                     zone (Bamboo-Schima) in Malaysia.
          b.         The biodiversity can also be combined with the traditional knowledge that
                     may enhance competitiveness in the local and indigenous biotechnology
                     sectors. Traditional knowledge in Perak can be sourced from the various
                     ethnic groups such as the Malay, Chinese, Indian and also the Tribal
                     people. Perak Bio-Corporation has already started operation on this part.
          c.         The lower cost of industrial land and factory building compared to the
                     nearest neighbouring states such as Penang, Selangor and Kedah. The
                     selling price in Perak is between RM 5.00–17.00 per square foot compared
                     to RM 12.20–21.00 in Penang and RM 7.00–22.00 in Selangor. The quit
                     rent is also cheaper, that is a flat rate of RM 3,000.00 per hectare in Perak
                     compared to RM 1500.00–21,095.00 in Selangor. However, the property
                     price should not be the main selling factor as Perak has be able to portray
                     other advantages over other states in attracting those interested in
                     biotechnology.
          d.         Perak has clear objectives of becoming a developed state by 2015, which
                     is reflected in the KPerak and also Perak Maju targets. These two plans
                     will make Perak Government work hard to achieve the targets. For
                     example, the Perak Maju 2015 targets to have a GDP of RM68.43 billion
                     in 2020 from RM34.49 billion in 2010.
          e.         Biotechnology activities are already taking place in various parts in Perak.
                     For example, Perak has designated a Pharmaceutical Park in Seri Iskandar
                     and Biotechnology Park in Ipoh which has two existing pharmaceutical
                     factories. At the same time, there are research and teaching institutions that
                     provide teaching and research in the fields relating to biotechnology. Perak
                     may take advantage of the existence of universities such as University


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                     Tunku Abdul Rahman (UTAR) and University Teknologi Petronas (UTP)
                     to enhance the human capital development and research and development
                     activities.
8.        Despite the advantages above, development of the biotechnology sector in Perak
          faces several challenges:
          a.         Perak faces investment, capital and financial issues which are prevalent
                     anywhere in the world as biotechnology activities are highly capital
                     intensive, whilst at the same time requires highly skilled and
                     knowledgeable workers. Thus, Perak has to be able to find solutions to this
                     problem and Perak cannot rely on the Federal government alone. There is
                     not enough human capital to attend to specific requirement of
                     biotechnology. For example, not many experienced human resources with
                     experience in managing biotechnology business in the state of Perak. Such
                     people guide company growth and move products through the
                     commercialization process to the marketplace. These managers not only
                     have to design and direct the strategic product development plan and face
                     the technical and regulatory hurdles involved, but also have to manage
                     manufacturing, find funding and develop alliances for commercial success.
          b.         The State has to ensure that biotechnology activities not only bring wealth
                     and benefit to the main participants and investors, but also to bring the
                     benefit to as wide a community as possible, so that biotechnology will be
                     the catalyst to reduce poverty, to bring more income equality and to
                     enhance standards of living among the people across the different parts of
                     the state.
          c.         There is culture and innovation gap in biotechnology field in the state of
                     Perak. There are not enough biotechnology starts-up in the state of Perak.
                     Even if there are universities academics, many academics are embedded in
                     the academic mindset and not entrepreneurial in nature. Yet the success of
                     development requires a different set of skills and experience on the
                     commercial side. Lack of biotechnology activities also contributes to the
                     lack in innovation, causing the existence of innovation gap in the state as a
                     result of lack of research and development, technology development,
                     research expenditure and human capital development in the field.
          d.         In order to develop biotechnology commercial activities and to attract
                     investment, Perak has to compete with other states in Malaysia and other
                     countries in the region. Competition within Malaysia comes from more
                     matured biotechnology activities in Penang, Selangor and also through the
                     development of BioXcell in Iskandar Malaysia in Johore. Down south,
                     Singapore has become a world class biotechnology destination for
                     commercial and research development activities which attract large
                     multinational companies. Nevertheless, Perak may be able to compete by
                     leveraging on its main strength i.e. biodiversity.




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3.          Existing Biotechnology Initiatives in Perak




Figure	
  5:	
  Some	
  existing	
  biotech	
  activities	
  in	
  Perak

            	
  

 a.         Perak	
  Bio	
  


9.          Biotechnology initiative in Perak is led by Perak Bio Corporation Sdn Bhd (Perak
            Bio), a subsidiary of Perak State Development Corporation (PSDC). Perak Bio is
            being managed by Puan Rohati Shafie and assisted by Puan Petri Zawahair as the
            Project Manager.
10.         Perak Bio, being the lead agency responsible for the coordinated implementation
            of the Perak Biotechnology Strategic Plan and Action Plan will oversee the
            implementation of the Strategic Plan and the Action Plan. Perak Bio may have the
            following Vision and Missions:




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4
Figure	
  6:	
  Perak	
  Bio	
  Vision	
  and	
  Mission



1.          The role of Perak Bio includes:




            Figure	
  7:	
  Roles	
  of	
  Perak	
  Bio	
  




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                                                                                       BOARD OF DIRECTOR
                                                                                  Dato' Hamdi b Abu Bakar
                                                                       Tn Sayed Shariffuddin b Sayed Shamsuddin                               ADVISOR
                                                                                Tn Hj Sarjiddin b Ahmad Hanif                         Dato' Samsudin b Hashim
                                                                                     Pn Norhaslinda bt Dato' Ayob
                                                                                      En Mohamed Sani b Supi
                                                                                       En Zaffani b Azul Islami


                                                                                                    CEO
                                                                                                Rohati bt Shafie




                                                                                               ASSISTANT CEO
                                                                                                   Vacant



         Petri Zawahair bt Megat Ishak               Petri Zawahair bt Megat Ishak                                       MANAGER                                MANAGER
       OPERATION & SERVICES & MGMT                    INVESTMENT & PROJECT                                          BUSINESS DEVELOPMENT               FINANCE & ADMINISTRATION
       OF BIOD RESOURCES MANAGER                     DEVELOPMENT MANAGER                                                                                  & HUMAN RESOURCES


           ASSISTANT MANAGER                           ASSISTANT MANAGER                                             ASSISTANT MANAGER                    ASSISTANT MANAGER
                 Vacant                                      Vacant                                                        Vacant                               Vacant


                 EXECUTIVE                                   EXECUTIVE                                                   EXECUTIVE                              EXECUTIVE
                   Vacant                                      Vacant                                                      Vacant                                 Vacant


                                         CLERK                                                                                                CLERK
                                         Vacant                                                                                               Vacant

                                                                `
     BIO                     BIO                      BIO              BIODIVERSITY                 BIO MARINE               BIO                                ENVIRONMENTAL
   SERVICES              AGRICULTURE              HEALTH CARE          & TRADITIONAL                 ANIMAL &            INDUSTRIAL        BIOFUEL              (EM TECHNOLOGY)
                                                                        KNOWLEDGE                  AQUACULTURE




Figure	
  8:	
  Perak	
  Bio	
  Organisation	
  Structure



b.                 Healthcare	
  biotechnology	
  


2.                 In healthcare biotechnology, there is a 150 acre site of Seri Iskandar
                   Pharmaceutical Park in Seri Iskandar. Nevertheless there is low take up rate of the
                   spaces in the Pharmaceutical Park. One is the Idaman Pharma Manufacturing Sdn.
                   Bhd, (previously known as Safire Pharmaceuticals (M) Sdn. Bhd.) a bumiputra
                   owned manufacturing generic pharmaceutical products mainly for the government
                   contracts. Another occupant in the Seri Iskandar Pharmaceutical Park is
                   Pharmasafe, a healthcare products manufacturer (contact lense solution and the
                   like).
3.                 In addition, Hovid Research Sdn Bhd, a Bionexus Company is also involved in
                   the clinical research services, pre-clinical drug development, drug delivery
                   systems and its related services for pharmaceutical companies. Stem Life, a stem
                   cell based company with Bionexus Status is also having its branch in Ipoh.
4.                 Teleflex, a US medical device group with its headquarters in Philadelphia plans to
                   turn its manufacturing and research and development facility in Taiping into a hub
                   for its next generation medical devices.




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  c.      Agriculture	
  biotechnology	
  
	
  

5.        Many activities are also taking place in the agriculture and aquaculture sectors.
          Under the aquaculture sector, Perak has designated more than 26 areas as the
          aquaculture industrial zone (ZIA). Among the objectives of ZIA are to provide a
          supply of aquaculture products in order to balance the trade, to increase the
          income of small aquaculture entrepreneurs and workers to a minimum of RM3000
          per month, to ensure fish and fishery products are safe and of high quality, to
          increase the participation of private sectors in the ZIA, and to create an efficient
          aquaculture network.
6.        Among the high impact ZIAs in Perak are Rungkup, Hilir Perak (2,175 hectares)
          for salt water shrimps in ponds, Tasik Kenering (100 hectares) and Tasik
          Temenggor (100 hectares) acres both in Hulu Perak for the caged freshwater fish.
          In addition there are 100 hectares being gazetted as ZIA in Bukit Merah in the
          district of Kerian for arowana breeding. Among the ZIA already identified are
          Tasik Temenggor (200 ha, 1600 mt), Tasik Kenering (60 ha, 480 mt), Tasik
          Chenderoh (60 ha, 380 mt), Kayan and Lekir (451 ha, 7036 mt), Segari (77 ha,
          1200 mt, Pulau Mentagor (200ha, 8000 mt) and Lawan Kuda (122ha).
7.        Among areas identified for mining ponds are Batang Padang (900ha), Perak
          Tengah (100ha), Kuala Kangsar (35ha), Larut Matang (23ha) and Hulu Perak
          (40ha). The mud flats areas of Kerian (250ha), Larut Matang (950 ha), Manjung
          (115ha) and Hilir Perak (113 ha).
8.        The Fisheries Department plans hatcheries for fresh water fish (34 and 172 m
          fries), Udang Galah (4 and 20m fries), Sea Shrimp (47 and 938 m fries), sea water
          fish (8 and 19 m fries).
9.        The Department of Fisheries Perak runs several centres in Perak, such as the Pusat
          Penetasan Udang Galah Kampung Acheh, Pusat Ikan Hiasan Enggor, Pusat
          Teknologi Perikanan Kampung Acheh, Pusat Pengembangan Akuakultur Tapah
          and Pusat Pengembangan Akuakultur Banding.
10.       Under the Perak Maju 2015 strategic plan, the Fisheries Department plans to
          develop marine fisheries, aquaculture, fisheries produce processing and
          ornamental fish. To develop aquaculture business, the Fisheries Department plans
          to create Zone Industri Akuakulture (ZIA), redevelop mine ponds, mud plans and
          develop hatcheries for fish and shrimps. The Fisheries Department plans to have
          commercial, large scale, high technology and integrated development involving
          private sectors. The development process will take into account conservation
          objectives and sustainable use of resources with the aim of producing competitive,
          high quality and safe produces.
11.       In relation to the above, Perak Bio is also developing a 150 acres area through its
          JV company RAC Sdn Bhd in Segari and another 40 hectares area in Teluk


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            Senangin, both in the district of Manjung for aquaculture projects. The site in
            Segari will also be recognised as ZIA.




Figure	
  9:	
  RAC	
  Aquaculture	
  in	
  Segari



12.         Perak may benefit from the research and development conducted at the Veterinary
            Research Institute in Ipoh. It provides leadership in research into animal health
            and diseases of economic and zoonotic importance and serves as the national
            animal health reference centre. Established in 1948, it spearheads the research and
            development of novel vaccines and biologicals for veterinary use using local
            isolates. These vaccines are tested and proven for safety, efficacy and potency
            following USDA standards.
13.         There are several agriculture biotechnology activities already taken place in Perak.
            For example, there is plant tissue culture facility operated by Actinalpha Biotech
            Sdn Bhd in Kampar and Ipoh. In addition Klonsawit Agrocom, an Ipoh based
            company is also involved in palm oil cloning using the in vitro technique of tissue
            culture known as somatic embryogenesis.
14.         Perak has several research institutions capable of contributing to the development
            of agriculture biotechnology. One is the Pusat Pembangunan Komoditi Jabatan
            Pertanian in Titi Gantong, Bota, which is involved in the development of



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          horticulture. Another is the Pusat Penyelidikan dan Pembangunan, Lembaga Koko
          Malaysia, in Sungai Sumun, Perak.


d.        Industrial and green biotechnology
	
  

15.       Green biotechnology involves the production of environmental friendly products
          and processes using or contributing to biotechnology techniques. For example
          Wing-M Chemical Sdn Bhd has been producing biomass from palm oil kernels in
          Kanthan Industrial Estate in Ipoh for use mostly in the pottery industry as
          alternative to fossil fuel. In another development Sariyaa Sdn Bhd is also
          developing alternative fuel from bamboo based in Gerik Perak.
16.       In the field of green biotechnology, Enretech (M) Sdn Bhd, a Bionexus Company,
          a company related to Enretech in Australia, plans to have activities related to
          organic absorbents and soil treatment technologies using cotton and recycle
          cellulose materials which can be used in food, health and education.
17.       Related to Hovid, Bio-Fertilisers Sdn. Bhd, another Bionexus Company, is a
          biotechnology company specializing in the production and use of microorganisms
          in agriculture, horticulture, animal husbandry and aquaculture. Their products aim
          to improve the quality and yield of the relevant produce as well as to maintain
          their sustainability. The Company’s area of focus is research and development
          using microbes to:-
          a.         Remediate the environment (soil, water, waste) via bio-augmentation;
          b.         Control pathogens and pests using bio-pesticides;
          c.         Enhance plant and animal health, (hence better yield);
          d.         Improve the aesthetic quality of produce; and
          e.         Enhance sustainability
18.       Bio-Fertilizers Sdn. Bhd. is committed to formulate highly efficient and harmless
          products that will help reduce environment pollution yet able to maximize the
          returns from the land. The Company’s present line of products include plant
          growth promoting microbes (bio-fertilizer), soil and water remediation microbes
          also known as effective microorganisms, probiotics for aqua culture like
          photosynthetic bacteria (PSB) and other growth enhancing microorganisms for
          livestocks. Organisms like fungus that help to degrade organic wastes faster are
          also available. Pesticides, using microbes, for control of pests in agriculture are
          also being developed.




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19.       Another related activity is in the field of biofuel through Carotech Biovit, a
          Bionexus Company, a subsidiary of Carotech Berhad which is engaged in the
          processing and extracting of palm phytonutrients. Carotech Berhad is a Malaysia-
          based company engaged in the extraction and processing of nutrients from palm
          oil for the purpose of manufacturing and producing pharmaceutical, phytonutrient
          and oleochemical products. The Company principally operates in three
          geographical areas: Asia and Asia Pacific region; North and South America, and
          Europe.


 e.       Bioinformatics


20.       Bioinformatics is an inter-phase between information technology and
          biotechnology. There is no single definition of what is meant by bioinformatics.
          There are few definitions including “the backbone computational tools and
          databases that support genomic and related research, which broadly encompasses
          the study of DNA structure/function, gene expression and protein production/
          structure/ function”; “the application of information technologies and sciences to
          the organization, management, mining and use of life-sciences information” and
          “the application of information technologies to the processing of molecular
          biology datasets” (Bilateral and the Bioinformatics Industry Opportunity
          Taskforce 2002).
21.       At the moment there is no commercial activity involving bioinformatics in Perak
          although there could be some activities in research institutes such as the Institut
          Penyelidikan Veterinar and also at the Lembaga Koko.


   f.     Human Resource Development


22.       There are several institutes of higher education that can contribute towards human
          resource development in the field of biotechnology in Perak. One is Universiti
          Teknologi Petronas (UTP), based in Seri Iskandar. Although UTP is petroleum
          technology based, there are several clusters that could be of interest to
          biotechnology sector, such as Chemistry cluster, computer information systemand
          physic cluster. Another important institution of higher education is University
          Tunku Abdul Rahman (UTAR) in Kampar that has biotechnology related teaching
          and research activities.
23.       UTAR offers life science degree programmes covering biomedical science,
          biotechnology and biochemistry. The bachelor's honours degree in biochemistry
          touches on the study of molecular processes of life while programmes covering
          biotechnology and biomedical sciences are specialised programmes built on the


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          concepts of biochemistry. UTAR's Bachelor of Science (Hons) Biotechnology
          focuses on the fundamentals and applied aspects of biological sciences. The
          Bachelor of Science (Hons) Biomedical Science emphasises developing sound
          knowledge and analytical skills for use in the medical line and in clinical sciences.
          The three-year programmes provide students with theoretical knowledge and
          practical skills. One of the strongest features of UTAR's life science programme is
          its global appeal as students are not only taught core subjects but are also required
          to take elective subjects such as business, management, human relations, ethics,
          entrepreneurship and social issues. Students are also encouraged to intern after
          their second year of study. The firms include Sime Darby Technology, Vivantis,
          Sunway Medical Centre and Temasek LifeScience Laboratory Singapore.




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D.        Perak	
  Biotechnology	
  Strategic	
  Plan	
  

1.        Introduction
	
  

1.        Perak is challenged with minimal capital and managerial talent, insufficient
          infrastructure, and processes that impede commercialization of technology by
          private business. To be globally preeminent, Perak must:
          a.         Spark innovation and discovery by building networks among scientific and
                     research resources and those capable of developing new ideas.
          b.         Attract research and management talent that can drive formation of the
                     next generation of companies.
          c.         Encourage greater commercialization, so society and the state economy
                     can benefit sooner.
          d.         Respond to emerging societal, scientific and economic trends.
          e.         Provide a globally competitive environment and the perspective for
                     collaboration among institutional, scientific, entrepreneurial and public-
                     private institutions.
2.        Developing biotechnology business and attracting biotechnology investment is a
          massive task faced by the State of Perak.It is a norm that, investors would
          consider investing in a country or a location if:
          a.          they can lower costs through a lower cost work force and good external
                     supports (such as government incentives);
          b.         they can take advantage of the capital;
          c.         they can be closer to partners or clients and diversify risk by locating
                     another facility elsewhere. They would like to benefit from being close to
                     similar businesses and universities and research centres;
          d.         the biotechnology business may take advantage of any special technology,
                     such as a product that crosses industry boundaries (for example, a
                     therapeutic that works in conjunction with an optoelectronic device);
          e.         there is the level of infrastructure meeting company needs. Research,
                     development, and manufacturing all have different needs and different
                     levels of support. Smaller operations tend to need more support from a
                     structured business park because the size of their operation does not justify



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                       the expense of running their own utilities, for example. Larger operations
                       may be able to save money by contracting directly with outside providers.
3.         Thus, Perak requires policy thrusts that are able to meet the expectations of the
           investors and stakeholders in the biotechnology sector whilst at the same time
           fulfil the socio-economic needs of the people in the State.


2.         Success Factor


4.         Perak needs a clear Biotechnology Policy Thrusts, in tandem with and
           complements the National Biotechnology Policy in order to meet the following
           success factors:




Figure	
  10:	
  Biotechnology	
  Success	
  Factor	
  




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3.        Policy Thrust
	
  

5.        In order to meet the success factors, it is proposed that the state of Perak adopts
          the following policy thrusts:


Thrust One: Development and Acquisition of The Right Technologies
6.        Access to new technologies and scientific advancements is the foundation for
          innovation opportunities. Biotechnology industry relies on a large number of new
          discovery and enabling biotechnologies, which drive innovation and will be the
          source of future economic value. Most developed countries increase their
          investments and developing strategies in order to capitalize on innovation.
          Technologies in biotechnology area cover a wide range.
          a.         First, Perak has to identify home-grown technology in Perak, such as
                     traditional knowledge, or industrial technology, either being developed by
                     the local industry or through local centres of excellence. In addition it may
                     tap on proven technology developed by other Malaysian companies or
                     centres of excellence and those which may have being commercialized or
                     pre-commercialised. Using the concept of Public-Private Partnership and
                     Private Finance Initiative, Perak may encourage commercialisation and
                     creation of new business based on, and expansion of existing business
                     using, those technologies.
          b.         Secondly, the State may encourage foreign parties such as companies and
                     institutions to bring in new technologies that could be useful to enhance
                     biotechnology activities in the State. Foreign parties may invest directly on
                     their own, thus bringing in and utilising the technology on their own,
                     although this may not bring direct benefit in terms of local technology
                     development. To increase local understanding and uptake of foreign new
                     and useful technologies, local companies may be encouraged to acquire
                     those technologies either by direct purchase, licensing or forming joint
                     venture businesses. Nevertheless there must be genuine transfer of those
                     technologies.
          c.         Thirdly, there must be continuous support for local innovation and
                     research, development and design in biotechnology related activities.
                     Local innovation and R&D&D may take place either by formation of
                     R&D&D department in existing businesses or within local centres of
                     excellence. The State should also encourage joint collaboration between
                     industry and centres of excellence in order to encourage development of



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                     useful technologies expected by the public in addition to the development
                     of fundamental technologies.
          d.         Fourthly there must be strategic alliances between the private sector and
                     the public sector, between local and foreign parties and between industry
                     and centres of excellence. In order for Perak to compete with other states
                     and other countries in the region, Perak has to position itself clearly in the
                     field whilst at the same time creating strategic alliance within and without
                     Malaysia. The most important alliance is with Malaysian Biotechnology
                     Corporation but it does not stop there. The state may encourage the
                     development of state driven and private sector drive centres of excellence.
                     In order to promote biotechnology activities there must be Centres of
                     Excellence that is capable of providing research and development in the
                     areas identified by the stakeholders in various biotechnology fields. The
                     centres of excellence may also form strategic alliance as stated above.


Thrust Two: Leveraging on Niche Economic Areas


7.        To be competitive as a regional player, Perak has to be selective in what
          technology and business it needs depending on what it wants to leverage on. For
          Perak to move forward with biotechnology industry there is a need for strategic
          positioning of the state within the biotechnology industry in the country and the
          region.
          a.         First of all it needs to identify the focus areas of technology. It is suggested
                     that Perak concentrates on the following areas of biotechnology:
                     aquaculture, animal breeding, pharmaceutical and nutraceutical and
                     industrial biotechnology. In the support sectors, Perak may encourage
                     activities in logistics, biosafety, intellectual property protection and
                     management, diagnostics and research tools.
          b.         Secondly, Perak may also leverage on the availability of mega-biodiversity
                     for the development of technologies and for the research and development
                     and design and commercialisation efforts. Perak has to position itself as
                     the centre for biodiversity related research and production of
                     biotechnology products and services including those using traditional
                     knowledge.
          c.         Thirdly, the marine and aquaculture sector is one of the targets of Perak
                     Maju 2015 which targets among others marine fish, aquaculture, fish
                     processing and ornamental fish. Aquaculture and ornamental fish could be
                     the main targets of marine biotechnology. Based on the Perak Maju 2015,
                     ornamental fish would bring in sale value of RM49.5 million in 2010 and


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                     RM75 million in 2015. These values could be enhanced with the
                     application of biotechnology. It is also expected that aquaculture activities
                     would bring in RM950 million sale in 2010 and RM1,480 million sale in
                     2015 to the state. In addition, marine biotechnology may also assist in
                     conservation of the marine areas such as the mangrove trees, turtle
                     sanctuaries and other important sectors, which in turn helps to promote
                     tourism. Biotechnology may also be beneficial in boosting fish stocks and
                     able to assist in combating fish and prawn diseases.


Thrust Three: Development of Specialised Facilities


8.        The Perak Biotechnology Park may contain specialised facilities such as advance
          labs, shared state of the art equipment and advisory services. Another important
          facility is the existence of special biotechnology cluster or clusters in the State.
          One such cluster may be created at the Perak Hitech Park within the soon-to-be-
          developed Perak Biotechnology Park.


Thrust Four: Creation and Maintenance of Supportive Public Policy
9.        As envisaged in the National Biotechnology Policy, the Government of Perak is
          also committed to support biotechnology as an industry and all the stakeholders
          within biotechnology industry in the state with investor friendly policies.
10.       Perak may take advantage of different economic activities in different parts of the
          state to promote different biotechnology activities. For example, in the central
          region, the state may be able capitalise the former mining lands and lakes for agri-
          and aquaculture using biotechnology based techniques. The northern region which
          is part of the Royal Belum and Temenggor area can become the source of nature
          based biotechnology activities. The eastern region near Cameron Highlands also
          has the same advantage. The Western and coastal region may become the focus
          area for marine biotechnology activities.
11.       The state may also take advantage of the K Perak and ICT sector in promoting
          bioinformatics which is necessary in promoting biotechnology sectors. The
          advances of industrial and agriculture sector may also add to relevant activities in
          industrial biotechnology such as enzyme production and biofuel and biomass.


Thrust Five: Preparing For Educated Workforce




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12.       Human capital development is necessary to provide the required skills and
          expertise needed in ensuring the success of biotechnology industry in the state.
          Human capital development is not limited to formal classes but may also include
          continuous learning and skill upgrading classes and trainings.
13.       In addition to knowledge and expertise in fundamental science, a successful
          progression through the multiple phases of commercialization requires strong
          management teams with a combination of technical, financial, clinical, regulatory,
          business and marketing skills and experience. This includes experience in
          designing strategy and implementing product development plans, obtaining
          financing, manufacturing and marketing. Moreover, the business must have a
          global orientation, since generally a company cannot justify the investment
          needed to develop a product solely for the Malaysian market alone, but must gain
          access to the larger foreign markets such as Indonesia, China, the US and EU
          markets. This requires knowledge and experience in international regulatory
          requirements, commercialization practices and foreign business operations.
14.       The largest barrier to competitiveness is the availability of experienced senior
          management in commercial product development and company growth. Such
          people able to guide company growth and move products through the
          commercialization process to the marketplace. These managers not only have to
          design and direct the strategic product development plan and face the technical
          and regulatory hurdles involved, but also have to manage manufacturing, seek
          necessary funding and develop alliances for commercial success.


Thrust Six: Encouraging Foreign and Domestic Direct Investment and Capital
Formation.


15.       In order to encourage economic development, Perak has to rely on private sectors
          to kick start the activities in biotechnology, to be fully supported by the
          Government and Government linked companies (GLC). GLCs should also be
          encouraged to develop new breed of entrepreneurs who are technology savvy and
          able to handle the commercial risk in developing businesses based on
          biotechnology.
16.       The State or its GLC may want to take the lead in encouraging private sector
          driven financial infrastructure in order to increase private sector take up and
          investment in biotechnology. Providing access to capital may be necessary in
          addition to providing fiscal and other types of incentives to investors. The state
          through supports from Federal Government may also encourage strategic alliance
          with local banks and financial institutions and encourage the creation of Perak-
          centric venture capital companies. Strategic alliance may also be formed with
          foreign recognised and licensed capital providers.


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E.           Perak	
  Biotechnology	
  Action	
  Plan	
  

1.           The above mentioned Policy Thrusts will have to be implemented by the State of
             Perak through a special agency designated for this purpose, and this case it shall
             be the under the portfolio of Perak Bio Corporation Sdn Bhd.




                                                                                                         	
  
	
  

Figure	
  11:	
  	
  Action	
  Plan

2.           The Action Plan will have to take into account the above mentioned success
             factors (under the Strategic Plan) and the more detailed success factors for the
             individual Policy Thrust.




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Thrust                Success Factors                    Strengths/Weaknesses             Actions

Thrust 1 -            Funding for acquisition            (lack of capital)                Encourage PFI
Technology
                      Funding for R&D                    (lack of capital)                Encourage PFI, Federal support



                      Local participants                 (no clear participants)          Import HR from outside Perak

                                                                                          -

                      IP Protections                     Good IP system

                      Human Resource                     (lack of local talents)          Training, capacity building, Perak
                                                                                          Life Sciences Institute (PLSI)

Thrust 2 –            Technology – modern and            There are local                  Encourage further development
Niche Areas           traditional                        technologies,                    and R&D, contacts with
                                                         universities,                    Technofund
                                                         Technofund
                                                                                          Training
                      IP                                 Good system
                                                                                          Encourage PFI
                      Funding/Investment                 (Lack of capital)

                      R&D
                                                                                          Encourage PFI
                                                         (Need further R&D)

                      Raw Material
                                                                                          Develop raw material, contract
                                                         (Need further                    farming
                                                         enhancement)


                      Market                                                              Market study, promotion
                                                         (market unclear)


                      Logistic                                                            Need to provide specialised
                                                         IIP, Lumut (no                   facilities
                                                         specialised facility)
                                                                                          Training, capacity building, PLSI
                      Human Resource                     (lack, UTAR provides
                                                         some HR)

Thrust 3 –            Participants                       (lacking specialised             Create market to encourage
Specialised                                              facilities)                      participants
Facilities
                                                         (lacking experience)             Training, capacity building
                      Human Resource


                                                                                          Encourage PFI
                      Funding / Investment




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                       IP                                (lacking)

                       Market                            Good system                         -

                                                         (depends on industrial              Create capacity
                                                         development)

Thrust 4 –             Human Resource                    Some HR available                   Training, Capacity Building
Supportive
Public Policy          Clear investment approval         (lacking clear                      Prepare guidelines
                       policies                          guidelines)

Thrust 5-              Institutions                      (lacking apart from                 PLSI, Centres of Excellence
Educated                                                 UTAR and other states’
Workforce                                                facilities)

                       Human Resource                    (lacking professional,              Attract foreign and domestic staff
                                                         teaching staff)


                       Funding / Investment                                                  PFI
                                                         (lack)

                                                         Switzerland, China,
                       Partners                          Costa Rica, USA                     Finalise arrangement, licensing



                       Market                            Ready market

Thrust 6 –             Investment Promotion              Using Perak Invest,                 Continuous participation
Foreign and                                              MIDA, MATRADE,
Domestic                                                 private contacts
Direct
Investment,            Funding for investment            In contacts with banks,             Continuous promotion
Capital                promotion                         private equity, VCs
Formation                                                                                    Submission of project papers.




Figure	
  12:	
  Individual	
  Success	
  Factors

3.         The implementation of the various policy thrusts is outlined in the following
           Critical Path Analysis Chart:

Task                                                                       Earliest start Length                    Dependent..
       1. Setting	
  up	
  of	
  Perak	
  Bio	
                            Done	
                  -­‐	
           -­‐	
  
          a. Reorganisation	
  and	
  staffing	
                           Jan	
  2011	
           3	
  months	
   Finance	
  	
  
       2. Technology	
  Selection:	
  	
                                   	
                      	
               	
  
       a. Formation	
  of	
  standing	
  committee	
                       Nov	
  2010	
           1	
  month	
     Acceptance	
  



                                                                27

	
  
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  29.10.2010)	
  




       b.    Identify	
  home-­‐grown	
  technology	
                          Dec	
  2010	
     1	
  month	
         Standing	
  cmt	
  
       c.    Identify	
  regional	
  technology	
                              Dec	
  2010	
     2	
  months	
        Standing	
  cmt	
  
       d.    Identify	
  international	
  technology	
                         Dec	
  2010	
     2	
  months	
        Standing	
  cmt	
  
       e.    Strategic	
  alliances	
  on	
  technology	
                      Dec	
  2010	
     6	
  months	
        Partners	
  
       3. Niche	
  Business	
  areas	
                                         	
                	
                   	
  
       a. Selection	
  of	
  niche	
  areas	
                                  Dec	
  2010	
     1	
  month	
         Standing	
  cmt	
  
       b. Identification	
  of	
  existing	
  business	
  for	
                Dec	
  2010	
                          	
  
          expansion	
                                                          	
                                     	
  
       c. Identification	
  of	
  potential	
  investors	
                     Dec	
  2010	
                          	
  
       d. Identification	
  of	
  required	
  infrastructure	
                 Dec	
  2010	
                          	
  
       e. Entrepreneur	
  Development	
                                        Dec	
  2010	
                          Focus	
  Group	
  
       f. Identification	
  of	
  raw	
  material	
  and	
  suppliers	
        Dec	
  2010	
  
       4. Development	
  of	
  specialised	
  facilities	
                    	
                 	
                   	
  
       a. Logistic	
  –	
  Transportation	
  and	
  Storage	
  facilities	
   June	
  2010	
     1	
  year	
          Businesses	
  
       b. Advisory	
  Centre	
                                                Dec	
  2010	
      3	
  months	
        Partner	
  
       c. Biosafety	
  and	
  Biosecurity	
                                   Nov	
  2010	
      6	
  months	
        PFI	
  partner,	
  	
  
          	
                                                                  	
                 	
                   expertise	
  
       d. Standards	
  and	
  Certification	
                                 Dec	
  2010	
      6	
  months	
        Partner	
  
       e. ICT	
  and	
  Data	
  Centre	
                                      Dec	
  2010	
      6	
  months	
        K	
  Perak/PEO	
  
       f. Biotechnology	
  Park	
                                             Jan	
  2011	
      1-­‐2	
  years	
     Approval,	
  
                                                                                                                      market,	
  
                                                                                                                      squatters	
  
       5. Supportive	
  Policies	
                                             	
                	
              	
  
       a. Investment	
  Policy	
                                               Nov	
  2010	
     2	
  months	
   	
  
       b. Biodiversity	
  Management	
  Centre	
                               Jan	
  2011	
     3	
  months	
   Exco,	
  Taman	
  
	
                                                                                                               Negeri	
  
       6. Educated	
  Workforce	
                                              	
                	
                   	
  
       a. Perak	
  Life	
  Sciences	
  Institute	
                             Dec	
  2010	
     7	
  months	
        Location,	
  
          	
                                                                   	
                	
                   Finance,	
  License	
  
       b. Aquaculture	
  Centre	
  of	
  Excellence	
                          Jan	
  2011	
     7	
  months	
        Location,	
  
          	
                                                                   	
                	
                   Finance	
  
       c. Strategic	
  alliance	
                                              Jan	
  2011	
     6	
  months	
        Partners	
  
       7. Foreign	
  and	
  Domestic	
  Direct	
  Investment	
                 	
                	
             	
  
       a. Domestic	
  promotional	
  activities	
                              Nov	
  2010	
     Continuous	
   Finance,	
  alliance	
  
       b. Foreign	
  promotion	
                                               Nov	
  2010	
     Continuous	
  	
  Finance,	
  alliance	
  
       8. Capital	
  Formation	
                                               	
                	
              	
  
       a. Venture	
  Capital	
  Management	
                                   Nov	
  2010	
     6	
  months	
   Partner,	
  license	
  
       b. Alliances	
  with	
  banks/financial	
  institutions	
               Nov	
  2010	
     6	
  months	
   Partner	
  
Figure	
  13:	
  Critical	
  Path	
  Analysis	
  Chart	
  

Thrust 1: Development and Acquisition of The Right Technology
4.           To implement this policy thrust, Perak Bio will have to work with all parties and
             stakeholders in the value chain and must not work in isolation. The right set of
             technologies depends upon the creation of niche activities which will utilise the


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  29.10.2010)	
  




          relevant broad areas of technology. Upon finding the right set of niche, Perak may
          proceed to create various clusters in various parts of the state. At the same time
          the right of set of technologies may be identified by the industry players or in the
          opposite case to be identified by Perak Bio to be proposed to industry players.
5.        For the purpose of identifying and acquiring technologies, Perak Bio may form a
          standing committee consisting of representatives of industry players in the state;
          representatives from Perak Life Sciences Institute and its associated organisations;
          representatives from universities in the State and from other parts of Malaysia and
          eminent persons.
6.        Funding for the acquisition of technologies and the development of home-grown
          technologies may be acquired through the relevant industry with the support from
          Federal agencies such as Malaysian Biotechnology Corporation, Malaysian
          Ministry of Science, Technology and Innovations and Malaysian Technology
          Development Corporation. At the same time the industrial player may also
          contribute towards the cost of research and development and design of the
          relevant technology.
7.        Acquisition of Platform Technologies: Perak Bio should also encourage the
          acquisition of platform technologies with the right business model. At the same
          time, coupled with local technologies, Perak may need to grow local players to be
          positioned as key global players in agriculture sector. For example, Multiple
          Micro-organism Symbiosis Technology (MSF) which can be applied in enzyme-
          based health product. The acquisition of Supercritical Fluid platform technology
          will enable large scale extraction of novel bioactive compounds or APIs with high
          purity and uniformity for the purpose of scale up commercialisation. In order to
          capitalize on the new opportunities arising from the increasing investments in
          research, technology transfer from universities to commercial development must
          be timely and efficient. This includes protecting and strengthening patents and IP,
          testing proof-of-principle and assessing the market. The transfer process might
          result in new start-up companies or simply out-licensing, but the research entity
          must have adequately protected its discoveries through patents and know-how to
          justify commercialization.
Thrust 2: Leveraging on Niche Areas
8.        The development of biotechnology in the State of Perak will have to be based on
          certain clusters leveraging on the strength and uniqueness of the State whilst
          avoiding areas that may have disadvantages.
9.        It is suggested that Perak creates three niche clusters, concentrating on
          biodiversity related activities, agriculture and healthcare and services.




                                                                29

	
  
Private	
  and	
  Confidential	
  –	
  Limited	
  Circulation	
  (WTI	
  Consulting	
  29.10.2010)	
  




Figure	
  14:	
  Biotechnology	
  Clusters	
  in	
  Perak

10.        One of the niche areas that could be implemented is to capitalise on the existence
           of large and unique biodiversity as a basis for biotechnology activities. The state
           may encourage clinical and bio pharmaceutical activities, ranging from the
           research and development to the commercialisation of finished products.
11.        Another angle is to develop biotechnology activities from traditional knowledge.
           Traditional knowledge in herbal and medicinal plants, and a treasure trove of flora
           and fauna which remains largely unexplored shall be economically developed
           such as to encourage discovery of novel and bioactive compounds from natural
           resources that can be extracted, formulated, developed and commercialised for use
           in ethnic herbal products, food ingredients, functional food, cosmeceuticals,
           nutraceuticals and botanical drugs.
12.        The biodiversity combined with the traditional knowledge may enhance
           competitiveness in the local and indigenous biotechnology sectors. Traditional
           knowledge in Perak can be sourced from the various ethnic groups such as the
           Malay, Chinese, Indian and also the Tribal people. There is no single definition of
           the term “traditional knowledge”. According to WIPO, traditional knowledge is a
           multifaceted concept that encompasses several components. What characterizes
           traditional knowledge is the fact that, generally, it is not produced systematically,


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            but in accordance with the individual or collective creators' responses to and
            interaction with their cultural environment. In addition, traditional knowledge, as
            representative of cultural values, is generally held collectively. According to
            WIPO, contrary to common perception traditional knowledge is not necessarily
            ancient.
13.         One must recognise that there is an abundance of economic opportunities from the
            working of and with traditional knowledge. There are several segments of
            biotechnology sectors that could be of interest to traditional knowledge holders to
            innovate further. Examples of such areas are in the area of Traditional Medicine
            (TM) and Complementary Alternative Medicine (CAM). One of the sub-sectors of
            the TM and CAM is the supply of medicinal plants, botanical drug products and
            raw materials. The World Bank reports trade in medicinal plants, botanical drug
            products and raw materials is growing at an annual growth rate between 5 and 15
            percent. Pharmaceutical companies have shown interest in natural product drug
            development and discovery and this is an area where traditional knowledge
            holders may want to work or collaborate with these companies.
14.         Perak will implement the CBioD initiative that leverages biodiversity as catalyst
            for various economic activities, resulting in more business opportunities not only
            in core biotechnology sectors but also in related activities such as media content
            and eco-tourism.




Figure	
  15:	
  Perak	
  CBioD	
  Initiatives



15.         One area that could also be developed as a support to the biotechnology activities
            is the concept of “research tourism” where researchers in biotechnology and

                                                                31

	
  
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  Confidential	
  –	
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          bioprospecting activities are provided with proper facilities and granted access for
          their research.
16.       Another area where Perak may start any related CBioD activity is the creation of
          bioinformatics centre for the protection data relating to biodiversity in Perak and
          promoting economic activities through commercialisation of the data. The
          bioinformatics centre will be an interphase between Perak Bio, Perak E-
          Organisation and K-Perak.
17.       Marine Biotechnology and Aquaculture: The marine aquaculture sector is one
          of the targets of Perak Maju 2015 which targets among others marine fish,
          aquaculture, fish processing and ornamental fish. Aquaculture and ornamental fish
          could be the main targets of marine biotechnology. Based on the Perak Maju
          2015, ornamental fish would bring in sale value of RM49.5 million in 2010 and
          RM75 million in 2015. These values could be further enhanced with the proper
          utilisation of biotechnology. It is also expected that aquaculture activities would
          bring in RM950 million sale in 2010 and RM1,480 million sale in 2015. In
          addition, marine biotechnology may also assist in conservation of the marine areas
          such as the mangrove trees, turtle sanctuaries and other important sectors, which
          then will be able to assist in promoting tourism. Biotechnology may also be used
          to increase fish stocks and assist in combating fish and prawn diseases. It is
          proposed that more companies be encouraged to enter the marine and aquaculture
          segment, particularly in the fish, seaweed and algae sub-segments.
18.       Agriculture: Focus will also be on producing high end crop, seeds and tissue
          culture. The state can also encourage development of contract planting. In animal,
          the use of assisted reproductive techniques and the production of animal feed and
          vaccines should continue thereby improving productivity in the livestock segment.
          In addition, the way forward is to develop multiplier farms to ensure the
          continuous supply of selected animals from nucleus farms to commercial farms. In
          addition there has to be use of biotechnology techniques such as effective
          microbes, growth regulators to assist better productivity. The Northern Corridor
          Investment Authority (NCIA) and the Veterinary Department plan develop a 1000
          acre site in Pondok Tanjung, Selama as an integrated animal industry centre
          including the application of artificial insemination and the production of animal
          vaccines.
19.       Agriculture based Industrial and Green Biotechnology: Accelerate
          development of technology for effective implementation of green chemistry
          initiatives. Perak can take advantage of its bamboo and palm oil for continuous
          production of biomass and biofuel. Some of the key barriers to the development of
          the industrial biotechnology sector are the lack of know-how and experience in the
          scaling-up process, limited production capacity and efficiency of infrastructure
          and the high costs of setting up commercial scale facilities. As part of the
          initiative to support the development of industrial biotechnology sector, the set up



                                                                32

	
  
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           of shared facilities for outsourcing services is equally critical given the amount of
           investment required to set up such facilities.
20.        Human and Animal Healthcare: Perak may also want to position itself as a
           centre for outsourcing and clinical research, with some logistical expertise. In this
           field, Perak needs to leverage on the Pharmaceutical Park in Seri Iskandar and the
           planned Biotechnology Park in Ipoh to develop CMO and CRO in healthcare. At
           the same time there is a need to find a niche in production such as the production
           of production tool, diagnostic equipment and research tools. There is also a need
           to leverage on existing and future centres of excellence to develop the necessary
           experience, knowledge and infrastructure are present to support the CROs. In
           order to effectively implement the specific actions identified to develop the
           various segments, it is proposed that a public-private partnership (PPP) model be
           adopted through strategic partnerships and collaborations. It is important in this
           field to attract foreign direct investment into Perak and this has to be done through
           aggressive and clever positioning of Perak as a preferred destination in health care
           biotechnology.


Thrust 3: Formation of Specialised Facilities
21.        The formation of specialised services may consist of the following activities:




Figure	
  16:	
  Formation	
  of	
  Specialised	
  Facilities

22.        Support Across Value Chain

                                                                33

	
  
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          a.         For the production of raw materials and finish products, the State may
                     encourage the formation of support services within the value chain such as
                     specialist transport systems which cater for specialist products such as
                     insulated containers, fast, punctual and safe delivery of products to nearby
                     airports, ports and Ipoh Inland Port. The state may also encourage the
                     formation of specialised storage facilities at the relevant sites to be shared
                     between small biotechnology industry players. This will reduce cost and at
                     the same time increased investor’s confidence.
23.       Advisory Centre
          a.         Perak Bio may also facilitate the formation of advisory centres providing
                     legal, intellectual property, commercialisation and international advisory
                     services. Perak may take the lead in providing support to biotechnology
                     industry through the design, set up and manage the proposed Advisory
                     Centre for Biotechnology Law, Regulations and Commercialisation. The
                     Advisory Centre aims to assist in building a successful and flourishing
                     bioscience base in Malaysia by providing stakeholders such as investors
                     and inventors who are involved in research and development and
                     commercialisation of biotechnology products and services with a one-stop
                     shop for legal and regulatory advice.
          b.         It is recognised that researchers at universities and people in small
                     business often have bright ideas about new or improved products, services
                     or processes. Research has shown that innovation, when properly
                     managed, can produce a higher rate of return than many other forms of
                     investment. There are several key issues faced by people who are involved
                     bioscience businesses, especially during the development stage such as:
                     i.         How to define and protect intellectual property;
                     ii.        Identifying the right staff for growth plans; recruiting them and
                                keeping them;
                     iii.       Access to finance sources that understand the long product
                                development lead time to commercially beneficial production;
                     iv.        Identification and contracting of appropriate premises and
                                facilities;
                     v.         Successful generation of revenue creating opportunities during
                                early stages of business operation; and
                     vi.        Clear definition of market potential and route to market.
          c.         It is also recognised that only a very small number of inventions make
                     money in the marketplace. At the same time significant regulatory
                     impediments often exist to the introduction of new products. Depending on

                                                                34

	
  
Perak biotechnology masterplan-8th
Perak biotechnology masterplan-8th
Perak biotechnology masterplan-8th
Perak biotechnology masterplan-8th
Perak biotechnology masterplan-8th
Perak biotechnology masterplan-8th
Perak biotechnology masterplan-8th
Perak biotechnology masterplan-8th
Perak biotechnology masterplan-8th
Perak biotechnology masterplan-8th
Perak biotechnology masterplan-8th
Perak biotechnology masterplan-8th
Perak biotechnology masterplan-8th
Perak biotechnology masterplan-8th
Perak biotechnology masterplan-8th
Perak biotechnology masterplan-8th
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Perak biotechnology masterplan-8th

  • 1. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   PERAK   BIOTECHNOLOGY   STRATEGIC   PLAN  AND  ACTION  PLAN     Contents     A.   INTRODUCTION  .......................................................................................................................   4   B.   Definition  and  Categories  of  Biotechnology  ...........................................................................   5   C.   Biotechnology  and  Perak  ........................................................................................................   8   1.   Underlying  State  Policies  .....................................................................................................   8   2.   Perak  Biotechnology:  Strength  and  Challenges  ..................................................................   9   3.   Existing Biotechnology Initiatives in Perak  ......................................................................  11   a.   Perak  Bio  .......................................................................................................................  11   b.   Healthcare  biotechnology  .............................................................................................  13   c.   Agriculture  biotechnology  .............................................................................................  14   d.   Industrial and green biotechnology  ...............................................................................  16   e.   Bioinformatics  ...............................................................................................................  17   f.   Human Resource Development  .....................................................................................  17   D.   Perak  Biotechnology  Strategic  Plan   .......................................................................................  19   1.   Introduction  .......................................................................................................................  19   2.   Success Factor  ...................................................................................................................  20   3.   Policy Thrust  .....................................................................................................................  21   E.   Perak  Biotechnology  Action  Plan  ..........................................................................................  25         1  
  • 2. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   Table  of  Figures   Figure  1:  Biotechnology  Focus  Areas  in  Malaysia  ...........................................................................   6   Figure  2:  Biotechnology  Capacity  Building  2005-­‐10  ........................................................................   6   Figure  3:  Creating  Business  2011-­‐2015  ...........................................................................................   7   Figure  4:  Long  Term  Development  2016-­‐2020   ................................................................................   7   Figure  5:  Some  existing  biotech  activities  in  Perak  .......................................................................  11   Figure  6:  Perak  Bio  Vision  and  Mission  .........................................................................................  12   Figure  7:  Roles  of  Perak  Bio   ...........................................................................................................  12   Figure  8:  Perak  Bio  Organisation  Structure  ...................................................................................  13   Figure  9:  RAC  Aquaculture  in  Segari  ..............................................................................................  15   Figure  10:  Biotechnology  Success  Factor  ......................................................................................  20   Figure  11:    Action  Plan  ..................................................................................................................  25   Figure  12:  Individual  Success  Factors  ............................................................................................  27   Figure  13:  Critical  Path  Analysis  Chart   ...........................................................................................  28   Figure  14:  Biotechnology  Clusters  in  Perak  ...................................................................................  30   Figure  15:  Perak  CBioD  Initiatives  .................................................................................................  31   Figure  16:  Formation  of  Specialised  Facilities  ...............................................................................  33   Figure  17:  Advisory  Centre  ............................................................................................................  35   Figure  18:  Perak  Hitech  Park  (Biotech)   ..........................................................................................  37   Figure  19:  Perak  Biotech  Park  Development  Structure  .................................................................  38   Figure  20:  Development  Progress  of  Perak  Hitech  Park  ...............................................................  38   Figure  21:  Basic  Concept  for  Perak  Biotech  Park  ..........................................................................  39   Figure  22:  Main  milestones  of  Perak  Biotech  Park  Development  .................................................  40   Figure  23:  Concept  for  Perak  Bio  HQ,  Incubators  and  PLSI  (based  on  Manchester  U)  .................  41   Figure  24:  Value  Proposition  of  PLSI  .............................................................................................  46   2  
  • 3. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   Figure  25:  Vision  and  Missions  of  PLSI  ..........................................................................................  47   Figure  26:  Perak  Hitech  Venture  Fund  ..........................................................................................  50     3  
  • 4. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)     A. INTRODUCTION   1. The main objectives of the creation of the Perak Biotechnology Strategic Plan and Perak Bio Business Plan include: a. To take stock of Perak’s position in biotechnology sector from the Malaysian and more perspective; b. To provide a broad based Strategic Plan on the development of biotechnology in Perak; and c. To provide a broad based and flexible action plan. 2. Perak Biotechnology Strategic Plan will be guided by various State and National policies including the National Biotechnology Policy (NBP), the Malaysian Third Industrial Master Plan 3 (IMP3), Perak Maju 2015 Policy Statement, K Perak 2010 Strategic Plan and Gagasan Perak Amanjaya. 3. The Strategic Plan incorporates the followings:- a. The vision planning, strategic thrust and directions that is economically, socially, politically and environmentally viable; b. Identify the focus niche key areas with its competitive advantages; and c. An economic plan that is conducive to foster development of biotechnology industries in the State of Perak. 4  
  • 5. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   B. Definition  and  Categories  of  Biotechnology   1. Biotechnology has been in existence for centuries, long before the terminology was even coined. Biotechnology can be categorised into classical and modern biotechnology. While classical biotechnology is always referred to as the production of useful products by living microorganisms such as the fermentation process that produces beer or food items, modern biotechnology began in the 1970s with the research into genetic engineering based on the two basic techniques of recombinant DNA technology (rDNA), hybridoma technology1 and cell fusion technology.2 2. Biotechnology can be broadly defined as the use of living organisms to make a product or run a process.3 Biotechnology also refers to any technological application that uses biological systems, living organisms or derivatives to make or modify products or processes for specific uses,4 or industries. Biotechnology is as also defined as “the application of science and technology to living organisms, as well as parts, products and models thereof, to alter living or non-living materials for the production of knowledge, goods and services.”5 3. Biotechnology combines disciplines such as genetics, biochemistry, microbiology, and cell biology and has been called the “technology of hope” for its ability to improve the quality of life through advancements in food safety, health care, industrial and environmental sustainability.6 4. Among the benefits of biotechnology are increased agriculture output, protection of the environment and production of health care products. 5. Malaysia has identified several biotechnology focus areas, as shown in Figure 1 below:                                                                                                                         1   S.N.   Cohen,   .,   A.   C.   Y.   Chang,   H.   W.   Boyer,   and   R.   B.   Helling,   ‘Construction   of   Biologically   Functional   Bacterial  Plasmids  in  Vitro.’,  70  Proceedings  of  the  National  Academy  of  Sciences,  3240,  (1973).   2  ATAS,  Biotechnology  and  Development:  expanding  the  capacity  to  produce  food,  Advanced  Technology   Assessment  System,  Issue  9,  (New  York,  United  Nations,  1992).   3  See  for  example  P.W.  Grubb,  Patents  for  Chemicals,  Pharmaceuticals  and  Biotechnology,  Fundamentals  of   Global  Law,  Practice  and  Strategy,  (Oxford,  OUP  3rd  Ed.,  1999),  224.   4  Convention  on  Biodiversity  (hereinafter  called  ‘CBD’),  Art.2.   5  B.van  Beuzekom  and  A.  Arundel,  OECD  Biotechnology  Statistics  -­‐‑2006,  (Paris,  Organisation  for  Economic   Cooperation  and  Development,  Paris,  2006),  7.   6  A.  Kumar,  ‘Indian  Biotech  Bazaar,  A  Swot  Analysis,’  Biotechnol  J,  May  4:  2,  (5)  543-­‐‑535.  (2007).   5  
  • 6. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   Biotechnology Malaysia – Focus Areas Traditional Complementary Medicines New Agriculture Value Added Products Food Supply High Yield Crop Agri Biotechnology Natural Substances Nutraceutical Tropical Diseases Bioinformatics Microbes Technologies Contract Research Contract Manufacturing Bio Fuel CRO CMO Healthcare Biotechnology Industrial Biotechnology Green Chemistry Clinical Trials Diagnostics & Vaccines BioMedical Bio Materials Instruments Enzymes/Catalyst Figure  1:  Biotechnology  Focus  Areas  in  Malaysia The focus areas are within three broad categories namely agriculture biotechnology, healthcare biotechnology and industrial biotechnology. 6. The policy encompasses 3 phases, namely capacity building (2005-2010), creating business out of science (2011-2015) and turning Malaysia into global player (2016-2020) as outlined in Figures 2, 3 and 4 below. PHASE 1: SHORT TERM DEVELOPMENT (2005-2010) Action Time Frame Target Establish first phase of the 2005-2010 6 Commercial trophies by year 2010 Biotechnology Business Agriculture Establish as regional centre of • Enhance Agriculture 2005 excellence by year 2009 Biotechnology Centre Establish as regional centre of • Enhance Marine Biotechnology 2005 excellence by year 2010 Centre Healthcare Establish as regional CRO centre by • CRO in Clinical Expertise 2005-2008 year 2008 • CMO in Bio-Generics 2005-2009 Establish as regional CMO centre by • Molecular Diagnostic for year 2009 2005-2010 infectious diseases 2006-2010 Commercialization by year 2010 • Vaccines for tropical diseases Commercialization by year 2010 Industry Biotechnology Generate early revenue for the • Enzymes and Industrial 2007-2008 industry by year 2008 chemicals Figure  2:  Biotechnology  Capacity  Building  2005-­‐10 6  
  • 7. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   PHASE 11: MEDIUM TERM DEVELOPMENT (2011-2015) Action Time Frame Target Establish second phase of the Biotechnology Business 2011-2015 One Key Transaction every 6 months Accelerator Agricultural Biotechnology • Development of Improved Commercialization success by year Crops 2011-2015 2015 • Development of Research 2011-2015 Commercialization success by year Outsourcing Center 2015 2011-2015 • Development of Natural Products Commercialization success by year 2015 Healthcare • Bio-Banking 2009-2010 Bio Banking products to be commercialized by year 2012 Industry Biotechnology Develop a successful company for both local • Bio-Energy 2011-2015 and export markets by year 2015 2011-2015 Develop a successful company for both local • Bio-Materials and export markets by year 2015 • Bioinformatics initiatives in Contribution towards success of at least 3 Starts in 2006 business accelerator projects by year support of 3 focus area 2015 Figure  3:  Creating  Business  2011-­‐2015 PHASE 111: LONG TERM DEVELOPMENT (2016-2020) Action Time Frame Target Agricultural Biotechnology • Bio-pharming 2016-2020 Commercialization success by year 2020 Healthcare Biotechnology Commercialization • Drug discovery 2016-2020 success by year 2020 Industry Biotechnology Commercialization 2016-2020 success by year 2020 • Manufacturing of bio-based products Figure  4:  Long  Term  Development  2016-­‐2020 7  
  • 8. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   C. Biotechnology  and  Perak     1. Underlying  State  Policies     1. There are three major policies of the State of Perak which may be taken into account at this stage to assist Perak to develop its biotechnology sector. The two policies are Perak Maju 2015, KPerak 2010 and Gagasan Amanjaya. 2. The Vision of Perak Maju 2015 is for Perak to become a developed state during 2015 by focusing on state economic development, eradication of poverty and squatters. The mission of Perak Maju 2015 is to generate all sectors towards achieving key economic and social indicators to fulfil the criteria of developed state and increase citizens standard of living and quality of life through comfortable environment and healthy lifestyles. 3. To achieve the KPerak 2010, the State Government has prepared three important knowledge development areas, namely the Knowledge Infrastructure (K-Infra), Knowledge Economy (K-Economy) and Knowledge Society (K-Society). 4. The K-Economy thrust encompasses both existing and new economic sectors and this is not limited to ICT sector alone. Although the original strategy hinges on developing ICT as an industry as well as ICT as an enabler to spur new economic activities and enhance value-creation, biotechnology should also be included in the aim of K-economy. This is because the aim of K-economy under the KPerak 2010 is to e-enable major industries by tapping the potential synergy from the interaction between new technologies and educated population within an enabling environment for the attainment of knowledge - based economies. 5. Sustainable human capital development is a key component of K-Society. Perak has outlined a 5As strategy; consisting of Access (by providing equal access to PC and internet to the society), Awareness (by running awareness programme and engagement activities), Academy (by running basic and advanced ICT courses), Add Value (by enhancing community access points) and Adoption (by implementing commercial and social activities); to build confidence across different segments of the communities in embracing the ICT lifestyle by providing the people with access to technology, skills to use technology; and reason to continue using technology. 6. In order to achieve a balanced and sustainable development, Perak has also launched the Gagasan Perak Amanjaya that has 7 specific thrusts namely: balanced development and distribution, community with skills, knowledge and integrity, state and government as a catalyst, social integration, participative and active younger generations, sustainable private sector development, and eco- friendly and sustainable development practices. 8  
  • 9. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   2. Perak  Biotechnology:  Strength  and  Challenges     7. Biotechnology in Perak may take advantage of several other factors. Such factors include: a. Perak is one of the mega-diversity states in Malaysia, which is itself a mega-diversity country in the world. Measuring 21,005 km2, almost half of Perak is covered with forests as much as 10,502km2 where by 95.6% of it is Equatorial Rainforest and the remaining 4.4% is covered by mangrove forests which may provide genetic resources for biotechnology related activities. The Belum and Temenggor forest reserves, approximately of 130 years old, older than the Amazon and the Congo, form the second largest remaining block of virgin forest in Peninsular Malaysia and the largest example of the northern monsoonal Burmese-Thai forest vegetation zone (Bamboo-Schima) in Malaysia. b. The biodiversity can also be combined with the traditional knowledge that may enhance competitiveness in the local and indigenous biotechnology sectors. Traditional knowledge in Perak can be sourced from the various ethnic groups such as the Malay, Chinese, Indian and also the Tribal people. Perak Bio-Corporation has already started operation on this part. c. The lower cost of industrial land and factory building compared to the nearest neighbouring states such as Penang, Selangor and Kedah. The selling price in Perak is between RM 5.00–17.00 per square foot compared to RM 12.20–21.00 in Penang and RM 7.00–22.00 in Selangor. The quit rent is also cheaper, that is a flat rate of RM 3,000.00 per hectare in Perak compared to RM 1500.00–21,095.00 in Selangor. However, the property price should not be the main selling factor as Perak has be able to portray other advantages over other states in attracting those interested in biotechnology. d. Perak has clear objectives of becoming a developed state by 2015, which is reflected in the KPerak and also Perak Maju targets. These two plans will make Perak Government work hard to achieve the targets. For example, the Perak Maju 2015 targets to have a GDP of RM68.43 billion in 2020 from RM34.49 billion in 2010. e. Biotechnology activities are already taking place in various parts in Perak. For example, Perak has designated a Pharmaceutical Park in Seri Iskandar and Biotechnology Park in Ipoh which has two existing pharmaceutical factories. At the same time, there are research and teaching institutions that provide teaching and research in the fields relating to biotechnology. Perak may take advantage of the existence of universities such as University 9  
  • 10. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   Tunku Abdul Rahman (UTAR) and University Teknologi Petronas (UTP) to enhance the human capital development and research and development activities. 8. Despite the advantages above, development of the biotechnology sector in Perak faces several challenges: a. Perak faces investment, capital and financial issues which are prevalent anywhere in the world as biotechnology activities are highly capital intensive, whilst at the same time requires highly skilled and knowledgeable workers. Thus, Perak has to be able to find solutions to this problem and Perak cannot rely on the Federal government alone. There is not enough human capital to attend to specific requirement of biotechnology. For example, not many experienced human resources with experience in managing biotechnology business in the state of Perak. Such people guide company growth and move products through the commercialization process to the marketplace. These managers not only have to design and direct the strategic product development plan and face the technical and regulatory hurdles involved, but also have to manage manufacturing, find funding and develop alliances for commercial success. b. The State has to ensure that biotechnology activities not only bring wealth and benefit to the main participants and investors, but also to bring the benefit to as wide a community as possible, so that biotechnology will be the catalyst to reduce poverty, to bring more income equality and to enhance standards of living among the people across the different parts of the state. c. There is culture and innovation gap in biotechnology field in the state of Perak. There are not enough biotechnology starts-up in the state of Perak. Even if there are universities academics, many academics are embedded in the academic mindset and not entrepreneurial in nature. Yet the success of development requires a different set of skills and experience on the commercial side. Lack of biotechnology activities also contributes to the lack in innovation, causing the existence of innovation gap in the state as a result of lack of research and development, technology development, research expenditure and human capital development in the field. d. In order to develop biotechnology commercial activities and to attract investment, Perak has to compete with other states in Malaysia and other countries in the region. Competition within Malaysia comes from more matured biotechnology activities in Penang, Selangor and also through the development of BioXcell in Iskandar Malaysia in Johore. Down south, Singapore has become a world class biotechnology destination for commercial and research development activities which attract large multinational companies. Nevertheless, Perak may be able to compete by leveraging on its main strength i.e. biodiversity. 10  
  • 11. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   3. Existing Biotechnology Initiatives in Perak Figure  5:  Some  existing  biotech  activities  in  Perak   a. Perak  Bio   9. Biotechnology initiative in Perak is led by Perak Bio Corporation Sdn Bhd (Perak Bio), a subsidiary of Perak State Development Corporation (PSDC). Perak Bio is being managed by Puan Rohati Shafie and assisted by Puan Petri Zawahair as the Project Manager. 10. Perak Bio, being the lead agency responsible for the coordinated implementation of the Perak Biotechnology Strategic Plan and Action Plan will oversee the implementation of the Strategic Plan and the Action Plan. Perak Bio may have the following Vision and Missions: 11  
  • 12. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   4 Figure  6:  Perak  Bio  Vision  and  Mission 1. The role of Perak Bio includes: Figure  7:  Roles  of  Perak  Bio   12  
  • 13. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   BOARD OF DIRECTOR Dato' Hamdi b Abu Bakar Tn Sayed Shariffuddin b Sayed Shamsuddin ADVISOR Tn Hj Sarjiddin b Ahmad Hanif Dato' Samsudin b Hashim Pn Norhaslinda bt Dato' Ayob En Mohamed Sani b Supi En Zaffani b Azul Islami CEO Rohati bt Shafie ASSISTANT CEO Vacant Petri Zawahair bt Megat Ishak Petri Zawahair bt Megat Ishak MANAGER MANAGER OPERATION & SERVICES & MGMT INVESTMENT & PROJECT BUSINESS DEVELOPMENT FINANCE & ADMINISTRATION OF BIOD RESOURCES MANAGER DEVELOPMENT MANAGER & HUMAN RESOURCES ASSISTANT MANAGER ASSISTANT MANAGER ASSISTANT MANAGER ASSISTANT MANAGER Vacant Vacant Vacant Vacant EXECUTIVE EXECUTIVE EXECUTIVE EXECUTIVE Vacant Vacant Vacant Vacant CLERK CLERK Vacant Vacant ` BIO BIO BIO BIODIVERSITY BIO MARINE BIO ENVIRONMENTAL SERVICES AGRICULTURE HEALTH CARE & TRADITIONAL ANIMAL & INDUSTRIAL BIOFUEL (EM TECHNOLOGY) KNOWLEDGE AQUACULTURE Figure  8:  Perak  Bio  Organisation  Structure b. Healthcare  biotechnology   2. In healthcare biotechnology, there is a 150 acre site of Seri Iskandar Pharmaceutical Park in Seri Iskandar. Nevertheless there is low take up rate of the spaces in the Pharmaceutical Park. One is the Idaman Pharma Manufacturing Sdn. Bhd, (previously known as Safire Pharmaceuticals (M) Sdn. Bhd.) a bumiputra owned manufacturing generic pharmaceutical products mainly for the government contracts. Another occupant in the Seri Iskandar Pharmaceutical Park is Pharmasafe, a healthcare products manufacturer (contact lense solution and the like). 3. In addition, Hovid Research Sdn Bhd, a Bionexus Company is also involved in the clinical research services, pre-clinical drug development, drug delivery systems and its related services for pharmaceutical companies. Stem Life, a stem cell based company with Bionexus Status is also having its branch in Ipoh. 4. Teleflex, a US medical device group with its headquarters in Philadelphia plans to turn its manufacturing and research and development facility in Taiping into a hub for its next generation medical devices. 13  
  • 14. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   c. Agriculture  biotechnology     5. Many activities are also taking place in the agriculture and aquaculture sectors. Under the aquaculture sector, Perak has designated more than 26 areas as the aquaculture industrial zone (ZIA). Among the objectives of ZIA are to provide a supply of aquaculture products in order to balance the trade, to increase the income of small aquaculture entrepreneurs and workers to a minimum of RM3000 per month, to ensure fish and fishery products are safe and of high quality, to increase the participation of private sectors in the ZIA, and to create an efficient aquaculture network. 6. Among the high impact ZIAs in Perak are Rungkup, Hilir Perak (2,175 hectares) for salt water shrimps in ponds, Tasik Kenering (100 hectares) and Tasik Temenggor (100 hectares) acres both in Hulu Perak for the caged freshwater fish. In addition there are 100 hectares being gazetted as ZIA in Bukit Merah in the district of Kerian for arowana breeding. Among the ZIA already identified are Tasik Temenggor (200 ha, 1600 mt), Tasik Kenering (60 ha, 480 mt), Tasik Chenderoh (60 ha, 380 mt), Kayan and Lekir (451 ha, 7036 mt), Segari (77 ha, 1200 mt, Pulau Mentagor (200ha, 8000 mt) and Lawan Kuda (122ha). 7. Among areas identified for mining ponds are Batang Padang (900ha), Perak Tengah (100ha), Kuala Kangsar (35ha), Larut Matang (23ha) and Hulu Perak (40ha). The mud flats areas of Kerian (250ha), Larut Matang (950 ha), Manjung (115ha) and Hilir Perak (113 ha). 8. The Fisheries Department plans hatcheries for fresh water fish (34 and 172 m fries), Udang Galah (4 and 20m fries), Sea Shrimp (47 and 938 m fries), sea water fish (8 and 19 m fries). 9. The Department of Fisheries Perak runs several centres in Perak, such as the Pusat Penetasan Udang Galah Kampung Acheh, Pusat Ikan Hiasan Enggor, Pusat Teknologi Perikanan Kampung Acheh, Pusat Pengembangan Akuakultur Tapah and Pusat Pengembangan Akuakultur Banding. 10. Under the Perak Maju 2015 strategic plan, the Fisheries Department plans to develop marine fisheries, aquaculture, fisheries produce processing and ornamental fish. To develop aquaculture business, the Fisheries Department plans to create Zone Industri Akuakulture (ZIA), redevelop mine ponds, mud plans and develop hatcheries for fish and shrimps. The Fisheries Department plans to have commercial, large scale, high technology and integrated development involving private sectors. The development process will take into account conservation objectives and sustainable use of resources with the aim of producing competitive, high quality and safe produces. 11. In relation to the above, Perak Bio is also developing a 150 acres area through its JV company RAC Sdn Bhd in Segari and another 40 hectares area in Teluk 14  
  • 15. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   Senangin, both in the district of Manjung for aquaculture projects. The site in Segari will also be recognised as ZIA. Figure  9:  RAC  Aquaculture  in  Segari 12. Perak may benefit from the research and development conducted at the Veterinary Research Institute in Ipoh. It provides leadership in research into animal health and diseases of economic and zoonotic importance and serves as the national animal health reference centre. Established in 1948, it spearheads the research and development of novel vaccines and biologicals for veterinary use using local isolates. These vaccines are tested and proven for safety, efficacy and potency following USDA standards. 13. There are several agriculture biotechnology activities already taken place in Perak. For example, there is plant tissue culture facility operated by Actinalpha Biotech Sdn Bhd in Kampar and Ipoh. In addition Klonsawit Agrocom, an Ipoh based company is also involved in palm oil cloning using the in vitro technique of tissue culture known as somatic embryogenesis. 14. Perak has several research institutions capable of contributing to the development of agriculture biotechnology. One is the Pusat Pembangunan Komoditi Jabatan Pertanian in Titi Gantong, Bota, which is involved in the development of 15  
  • 16. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   horticulture. Another is the Pusat Penyelidikan dan Pembangunan, Lembaga Koko Malaysia, in Sungai Sumun, Perak. d. Industrial and green biotechnology   15. Green biotechnology involves the production of environmental friendly products and processes using or contributing to biotechnology techniques. For example Wing-M Chemical Sdn Bhd has been producing biomass from palm oil kernels in Kanthan Industrial Estate in Ipoh for use mostly in the pottery industry as alternative to fossil fuel. In another development Sariyaa Sdn Bhd is also developing alternative fuel from bamboo based in Gerik Perak. 16. In the field of green biotechnology, Enretech (M) Sdn Bhd, a Bionexus Company, a company related to Enretech in Australia, plans to have activities related to organic absorbents and soil treatment technologies using cotton and recycle cellulose materials which can be used in food, health and education. 17. Related to Hovid, Bio-Fertilisers Sdn. Bhd, another Bionexus Company, is a biotechnology company specializing in the production and use of microorganisms in agriculture, horticulture, animal husbandry and aquaculture. Their products aim to improve the quality and yield of the relevant produce as well as to maintain their sustainability. The Company’s area of focus is research and development using microbes to:- a. Remediate the environment (soil, water, waste) via bio-augmentation; b. Control pathogens and pests using bio-pesticides; c. Enhance plant and animal health, (hence better yield); d. Improve the aesthetic quality of produce; and e. Enhance sustainability 18. Bio-Fertilizers Sdn. Bhd. is committed to formulate highly efficient and harmless products that will help reduce environment pollution yet able to maximize the returns from the land. The Company’s present line of products include plant growth promoting microbes (bio-fertilizer), soil and water remediation microbes also known as effective microorganisms, probiotics for aqua culture like photosynthetic bacteria (PSB) and other growth enhancing microorganisms for livestocks. Organisms like fungus that help to degrade organic wastes faster are also available. Pesticides, using microbes, for control of pests in agriculture are also being developed. 16  
  • 17. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   19. Another related activity is in the field of biofuel through Carotech Biovit, a Bionexus Company, a subsidiary of Carotech Berhad which is engaged in the processing and extracting of palm phytonutrients. Carotech Berhad is a Malaysia- based company engaged in the extraction and processing of nutrients from palm oil for the purpose of manufacturing and producing pharmaceutical, phytonutrient and oleochemical products. The Company principally operates in three geographical areas: Asia and Asia Pacific region; North and South America, and Europe. e. Bioinformatics 20. Bioinformatics is an inter-phase between information technology and biotechnology. There is no single definition of what is meant by bioinformatics. There are few definitions including “the backbone computational tools and databases that support genomic and related research, which broadly encompasses the study of DNA structure/function, gene expression and protein production/ structure/ function”; “the application of information technologies and sciences to the organization, management, mining and use of life-sciences information” and “the application of information technologies to the processing of molecular biology datasets” (Bilateral and the Bioinformatics Industry Opportunity Taskforce 2002). 21. At the moment there is no commercial activity involving bioinformatics in Perak although there could be some activities in research institutes such as the Institut Penyelidikan Veterinar and also at the Lembaga Koko. f. Human Resource Development 22. There are several institutes of higher education that can contribute towards human resource development in the field of biotechnology in Perak. One is Universiti Teknologi Petronas (UTP), based in Seri Iskandar. Although UTP is petroleum technology based, there are several clusters that could be of interest to biotechnology sector, such as Chemistry cluster, computer information systemand physic cluster. Another important institution of higher education is University Tunku Abdul Rahman (UTAR) in Kampar that has biotechnology related teaching and research activities. 23. UTAR offers life science degree programmes covering biomedical science, biotechnology and biochemistry. The bachelor's honours degree in biochemistry touches on the study of molecular processes of life while programmes covering biotechnology and biomedical sciences are specialised programmes built on the 17  
  • 18. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   concepts of biochemistry. UTAR's Bachelor of Science (Hons) Biotechnology focuses on the fundamentals and applied aspects of biological sciences. The Bachelor of Science (Hons) Biomedical Science emphasises developing sound knowledge and analytical skills for use in the medical line and in clinical sciences. The three-year programmes provide students with theoretical knowledge and practical skills. One of the strongest features of UTAR's life science programme is its global appeal as students are not only taught core subjects but are also required to take elective subjects such as business, management, human relations, ethics, entrepreneurship and social issues. Students are also encouraged to intern after their second year of study. The firms include Sime Darby Technology, Vivantis, Sunway Medical Centre and Temasek LifeScience Laboratory Singapore. 18  
  • 19. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   D. Perak  Biotechnology  Strategic  Plan   1. Introduction   1. Perak is challenged with minimal capital and managerial talent, insufficient infrastructure, and processes that impede commercialization of technology by private business. To be globally preeminent, Perak must: a. Spark innovation and discovery by building networks among scientific and research resources and those capable of developing new ideas. b. Attract research and management talent that can drive formation of the next generation of companies. c. Encourage greater commercialization, so society and the state economy can benefit sooner. d. Respond to emerging societal, scientific and economic trends. e. Provide a globally competitive environment and the perspective for collaboration among institutional, scientific, entrepreneurial and public- private institutions. 2. Developing biotechnology business and attracting biotechnology investment is a massive task faced by the State of Perak.It is a norm that, investors would consider investing in a country or a location if: a. they can lower costs through a lower cost work force and good external supports (such as government incentives); b. they can take advantage of the capital; c. they can be closer to partners or clients and diversify risk by locating another facility elsewhere. They would like to benefit from being close to similar businesses and universities and research centres; d. the biotechnology business may take advantage of any special technology, such as a product that crosses industry boundaries (for example, a therapeutic that works in conjunction with an optoelectronic device); e. there is the level of infrastructure meeting company needs. Research, development, and manufacturing all have different needs and different levels of support. Smaller operations tend to need more support from a structured business park because the size of their operation does not justify 19  
  • 20. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   the expense of running their own utilities, for example. Larger operations may be able to save money by contracting directly with outside providers. 3. Thus, Perak requires policy thrusts that are able to meet the expectations of the investors and stakeholders in the biotechnology sector whilst at the same time fulfil the socio-economic needs of the people in the State. 2. Success Factor 4. Perak needs a clear Biotechnology Policy Thrusts, in tandem with and complements the National Biotechnology Policy in order to meet the following success factors: Figure  10:  Biotechnology  Success  Factor   20  
  • 21. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)     3. Policy Thrust   5. In order to meet the success factors, it is proposed that the state of Perak adopts the following policy thrusts: Thrust One: Development and Acquisition of The Right Technologies 6. Access to new technologies and scientific advancements is the foundation for innovation opportunities. Biotechnology industry relies on a large number of new discovery and enabling biotechnologies, which drive innovation and will be the source of future economic value. Most developed countries increase their investments and developing strategies in order to capitalize on innovation. Technologies in biotechnology area cover a wide range. a. First, Perak has to identify home-grown technology in Perak, such as traditional knowledge, or industrial technology, either being developed by the local industry or through local centres of excellence. In addition it may tap on proven technology developed by other Malaysian companies or centres of excellence and those which may have being commercialized or pre-commercialised. Using the concept of Public-Private Partnership and Private Finance Initiative, Perak may encourage commercialisation and creation of new business based on, and expansion of existing business using, those technologies. b. Secondly, the State may encourage foreign parties such as companies and institutions to bring in new technologies that could be useful to enhance biotechnology activities in the State. Foreign parties may invest directly on their own, thus bringing in and utilising the technology on their own, although this may not bring direct benefit in terms of local technology development. To increase local understanding and uptake of foreign new and useful technologies, local companies may be encouraged to acquire those technologies either by direct purchase, licensing or forming joint venture businesses. Nevertheless there must be genuine transfer of those technologies. c. Thirdly, there must be continuous support for local innovation and research, development and design in biotechnology related activities. Local innovation and R&D&D may take place either by formation of R&D&D department in existing businesses or within local centres of excellence. The State should also encourage joint collaboration between industry and centres of excellence in order to encourage development of 21  
  • 22. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   useful technologies expected by the public in addition to the development of fundamental technologies. d. Fourthly there must be strategic alliances between the private sector and the public sector, between local and foreign parties and between industry and centres of excellence. In order for Perak to compete with other states and other countries in the region, Perak has to position itself clearly in the field whilst at the same time creating strategic alliance within and without Malaysia. The most important alliance is with Malaysian Biotechnology Corporation but it does not stop there. The state may encourage the development of state driven and private sector drive centres of excellence. In order to promote biotechnology activities there must be Centres of Excellence that is capable of providing research and development in the areas identified by the stakeholders in various biotechnology fields. The centres of excellence may also form strategic alliance as stated above. Thrust Two: Leveraging on Niche Economic Areas 7. To be competitive as a regional player, Perak has to be selective in what technology and business it needs depending on what it wants to leverage on. For Perak to move forward with biotechnology industry there is a need for strategic positioning of the state within the biotechnology industry in the country and the region. a. First of all it needs to identify the focus areas of technology. It is suggested that Perak concentrates on the following areas of biotechnology: aquaculture, animal breeding, pharmaceutical and nutraceutical and industrial biotechnology. In the support sectors, Perak may encourage activities in logistics, biosafety, intellectual property protection and management, diagnostics and research tools. b. Secondly, Perak may also leverage on the availability of mega-biodiversity for the development of technologies and for the research and development and design and commercialisation efforts. Perak has to position itself as the centre for biodiversity related research and production of biotechnology products and services including those using traditional knowledge. c. Thirdly, the marine and aquaculture sector is one of the targets of Perak Maju 2015 which targets among others marine fish, aquaculture, fish processing and ornamental fish. Aquaculture and ornamental fish could be the main targets of marine biotechnology. Based on the Perak Maju 2015, ornamental fish would bring in sale value of RM49.5 million in 2010 and 22  
  • 23. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   RM75 million in 2015. These values could be enhanced with the application of biotechnology. It is also expected that aquaculture activities would bring in RM950 million sale in 2010 and RM1,480 million sale in 2015 to the state. In addition, marine biotechnology may also assist in conservation of the marine areas such as the mangrove trees, turtle sanctuaries and other important sectors, which in turn helps to promote tourism. Biotechnology may also be beneficial in boosting fish stocks and able to assist in combating fish and prawn diseases. Thrust Three: Development of Specialised Facilities 8. The Perak Biotechnology Park may contain specialised facilities such as advance labs, shared state of the art equipment and advisory services. Another important facility is the existence of special biotechnology cluster or clusters in the State. One such cluster may be created at the Perak Hitech Park within the soon-to-be- developed Perak Biotechnology Park. Thrust Four: Creation and Maintenance of Supportive Public Policy 9. As envisaged in the National Biotechnology Policy, the Government of Perak is also committed to support biotechnology as an industry and all the stakeholders within biotechnology industry in the state with investor friendly policies. 10. Perak may take advantage of different economic activities in different parts of the state to promote different biotechnology activities. For example, in the central region, the state may be able capitalise the former mining lands and lakes for agri- and aquaculture using biotechnology based techniques. The northern region which is part of the Royal Belum and Temenggor area can become the source of nature based biotechnology activities. The eastern region near Cameron Highlands also has the same advantage. The Western and coastal region may become the focus area for marine biotechnology activities. 11. The state may also take advantage of the K Perak and ICT sector in promoting bioinformatics which is necessary in promoting biotechnology sectors. The advances of industrial and agriculture sector may also add to relevant activities in industrial biotechnology such as enzyme production and biofuel and biomass. Thrust Five: Preparing For Educated Workforce 23  
  • 24. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   12. Human capital development is necessary to provide the required skills and expertise needed in ensuring the success of biotechnology industry in the state. Human capital development is not limited to formal classes but may also include continuous learning and skill upgrading classes and trainings. 13. In addition to knowledge and expertise in fundamental science, a successful progression through the multiple phases of commercialization requires strong management teams with a combination of technical, financial, clinical, regulatory, business and marketing skills and experience. This includes experience in designing strategy and implementing product development plans, obtaining financing, manufacturing and marketing. Moreover, the business must have a global orientation, since generally a company cannot justify the investment needed to develop a product solely for the Malaysian market alone, but must gain access to the larger foreign markets such as Indonesia, China, the US and EU markets. This requires knowledge and experience in international regulatory requirements, commercialization practices and foreign business operations. 14. The largest barrier to competitiveness is the availability of experienced senior management in commercial product development and company growth. Such people able to guide company growth and move products through the commercialization process to the marketplace. These managers not only have to design and direct the strategic product development plan and face the technical and regulatory hurdles involved, but also have to manage manufacturing, seek necessary funding and develop alliances for commercial success. Thrust Six: Encouraging Foreign and Domestic Direct Investment and Capital Formation. 15. In order to encourage economic development, Perak has to rely on private sectors to kick start the activities in biotechnology, to be fully supported by the Government and Government linked companies (GLC). GLCs should also be encouraged to develop new breed of entrepreneurs who are technology savvy and able to handle the commercial risk in developing businesses based on biotechnology. 16. The State or its GLC may want to take the lead in encouraging private sector driven financial infrastructure in order to increase private sector take up and investment in biotechnology. Providing access to capital may be necessary in addition to providing fiscal and other types of incentives to investors. The state through supports from Federal Government may also encourage strategic alliance with local banks and financial institutions and encourage the creation of Perak- centric venture capital companies. Strategic alliance may also be formed with foreign recognised and licensed capital providers. 24  
  • 25. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   E. Perak  Biotechnology  Action  Plan   1. The above mentioned Policy Thrusts will have to be implemented by the State of Perak through a special agency designated for this purpose, and this case it shall be the under the portfolio of Perak Bio Corporation Sdn Bhd.     Figure  11:    Action  Plan 2. The Action Plan will have to take into account the above mentioned success factors (under the Strategic Plan) and the more detailed success factors for the individual Policy Thrust. 25  
  • 26. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   Thrust Success Factors Strengths/Weaknesses Actions Thrust 1 - Funding for acquisition (lack of capital) Encourage PFI Technology Funding for R&D (lack of capital) Encourage PFI, Federal support Local participants (no clear participants) Import HR from outside Perak - IP Protections Good IP system Human Resource (lack of local talents) Training, capacity building, Perak Life Sciences Institute (PLSI) Thrust 2 – Technology – modern and There are local Encourage further development Niche Areas traditional technologies, and R&D, contacts with universities, Technofund Technofund Training IP Good system Encourage PFI Funding/Investment (Lack of capital) R&D Encourage PFI (Need further R&D) Raw Material Develop raw material, contract (Need further farming enhancement) Market Market study, promotion (market unclear) Logistic Need to provide specialised IIP, Lumut (no facilities specialised facility) Training, capacity building, PLSI Human Resource (lack, UTAR provides some HR) Thrust 3 – Participants (lacking specialised Create market to encourage Specialised facilities) participants Facilities (lacking experience) Training, capacity building Human Resource Encourage PFI Funding / Investment 26  
  • 27. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   IP (lacking) Market Good system - (depends on industrial Create capacity development) Thrust 4 – Human Resource Some HR available Training, Capacity Building Supportive Public Policy Clear investment approval (lacking clear Prepare guidelines policies guidelines) Thrust 5- Institutions (lacking apart from PLSI, Centres of Excellence Educated UTAR and other states’ Workforce facilities) Human Resource (lacking professional, Attract foreign and domestic staff teaching staff) Funding / Investment PFI (lack) Switzerland, China, Partners Costa Rica, USA Finalise arrangement, licensing Market Ready market Thrust 6 – Investment Promotion Using Perak Invest, Continuous participation Foreign and MIDA, MATRADE, Domestic private contacts Direct Investment, Funding for investment In contacts with banks, Continuous promotion Capital promotion private equity, VCs Formation Submission of project papers. Figure  12:  Individual  Success  Factors 3. The implementation of the various policy thrusts is outlined in the following Critical Path Analysis Chart: Task Earliest start Length Dependent.. 1. Setting  up  of  Perak  Bio   Done   -­‐   -­‐   a. Reorganisation  and  staffing   Jan  2011   3  months   Finance     2. Technology  Selection:           a. Formation  of  standing  committee   Nov  2010   1  month   Acceptance   27  
  • 28. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   b. Identify  home-­‐grown  technology   Dec  2010   1  month   Standing  cmt   c. Identify  regional  technology   Dec  2010   2  months   Standing  cmt   d. Identify  international  technology   Dec  2010   2  months   Standing  cmt   e. Strategic  alliances  on  technology   Dec  2010   6  months   Partners   3. Niche  Business  areas         a. Selection  of  niche  areas   Dec  2010   1  month   Standing  cmt   b. Identification  of  existing  business  for   Dec  2010     expansion       c. Identification  of  potential  investors   Dec  2010     d. Identification  of  required  infrastructure   Dec  2010     e. Entrepreneur  Development   Dec  2010   Focus  Group   f. Identification  of  raw  material  and  suppliers   Dec  2010   4. Development  of  specialised  facilities         a. Logistic  –  Transportation  and  Storage  facilities   June  2010   1  year   Businesses   b. Advisory  Centre   Dec  2010   3  months   Partner   c. Biosafety  and  Biosecurity   Nov  2010   6  months   PFI  partner,           expertise   d. Standards  and  Certification   Dec  2010   6  months   Partner   e. ICT  and  Data  Centre   Dec  2010   6  months   K  Perak/PEO   f. Biotechnology  Park   Jan  2011   1-­‐2  years   Approval,   market,   squatters   5. Supportive  Policies         a. Investment  Policy   Nov  2010   2  months     b. Biodiversity  Management  Centre   Jan  2011   3  months   Exco,  Taman     Negeri   6. Educated  Workforce         a. Perak  Life  Sciences  Institute   Dec  2010   7  months   Location,         Finance,  License   b. Aquaculture  Centre  of  Excellence   Jan  2011   7  months   Location,         Finance   c. Strategic  alliance   Jan  2011   6  months   Partners   7. Foreign  and  Domestic  Direct  Investment         a. Domestic  promotional  activities   Nov  2010   Continuous   Finance,  alliance   b. Foreign  promotion   Nov  2010   Continuous    Finance,  alliance   8. Capital  Formation         a. Venture  Capital  Management   Nov  2010   6  months   Partner,  license   b. Alliances  with  banks/financial  institutions   Nov  2010   6  months   Partner   Figure  13:  Critical  Path  Analysis  Chart   Thrust 1: Development and Acquisition of The Right Technology 4. To implement this policy thrust, Perak Bio will have to work with all parties and stakeholders in the value chain and must not work in isolation. The right set of technologies depends upon the creation of niche activities which will utilise the 28  
  • 29. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   relevant broad areas of technology. Upon finding the right set of niche, Perak may proceed to create various clusters in various parts of the state. At the same time the right of set of technologies may be identified by the industry players or in the opposite case to be identified by Perak Bio to be proposed to industry players. 5. For the purpose of identifying and acquiring technologies, Perak Bio may form a standing committee consisting of representatives of industry players in the state; representatives from Perak Life Sciences Institute and its associated organisations; representatives from universities in the State and from other parts of Malaysia and eminent persons. 6. Funding for the acquisition of technologies and the development of home-grown technologies may be acquired through the relevant industry with the support from Federal agencies such as Malaysian Biotechnology Corporation, Malaysian Ministry of Science, Technology and Innovations and Malaysian Technology Development Corporation. At the same time the industrial player may also contribute towards the cost of research and development and design of the relevant technology. 7. Acquisition of Platform Technologies: Perak Bio should also encourage the acquisition of platform technologies with the right business model. At the same time, coupled with local technologies, Perak may need to grow local players to be positioned as key global players in agriculture sector. For example, Multiple Micro-organism Symbiosis Technology (MSF) which can be applied in enzyme- based health product. The acquisition of Supercritical Fluid platform technology will enable large scale extraction of novel bioactive compounds or APIs with high purity and uniformity for the purpose of scale up commercialisation. In order to capitalize on the new opportunities arising from the increasing investments in research, technology transfer from universities to commercial development must be timely and efficient. This includes protecting and strengthening patents and IP, testing proof-of-principle and assessing the market. The transfer process might result in new start-up companies or simply out-licensing, but the research entity must have adequately protected its discoveries through patents and know-how to justify commercialization. Thrust 2: Leveraging on Niche Areas 8. The development of biotechnology in the State of Perak will have to be based on certain clusters leveraging on the strength and uniqueness of the State whilst avoiding areas that may have disadvantages. 9. It is suggested that Perak creates three niche clusters, concentrating on biodiversity related activities, agriculture and healthcare and services. 29  
  • 30. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   Figure  14:  Biotechnology  Clusters  in  Perak 10. One of the niche areas that could be implemented is to capitalise on the existence of large and unique biodiversity as a basis for biotechnology activities. The state may encourage clinical and bio pharmaceutical activities, ranging from the research and development to the commercialisation of finished products. 11. Another angle is to develop biotechnology activities from traditional knowledge. Traditional knowledge in herbal and medicinal plants, and a treasure trove of flora and fauna which remains largely unexplored shall be economically developed such as to encourage discovery of novel and bioactive compounds from natural resources that can be extracted, formulated, developed and commercialised for use in ethnic herbal products, food ingredients, functional food, cosmeceuticals, nutraceuticals and botanical drugs. 12. The biodiversity combined with the traditional knowledge may enhance competitiveness in the local and indigenous biotechnology sectors. Traditional knowledge in Perak can be sourced from the various ethnic groups such as the Malay, Chinese, Indian and also the Tribal people. There is no single definition of the term “traditional knowledge”. According to WIPO, traditional knowledge is a multifaceted concept that encompasses several components. What characterizes traditional knowledge is the fact that, generally, it is not produced systematically, 30  
  • 31. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   but in accordance with the individual or collective creators' responses to and interaction with their cultural environment. In addition, traditional knowledge, as representative of cultural values, is generally held collectively. According to WIPO, contrary to common perception traditional knowledge is not necessarily ancient. 13. One must recognise that there is an abundance of economic opportunities from the working of and with traditional knowledge. There are several segments of biotechnology sectors that could be of interest to traditional knowledge holders to innovate further. Examples of such areas are in the area of Traditional Medicine (TM) and Complementary Alternative Medicine (CAM). One of the sub-sectors of the TM and CAM is the supply of medicinal plants, botanical drug products and raw materials. The World Bank reports trade in medicinal plants, botanical drug products and raw materials is growing at an annual growth rate between 5 and 15 percent. Pharmaceutical companies have shown interest in natural product drug development and discovery and this is an area where traditional knowledge holders may want to work or collaborate with these companies. 14. Perak will implement the CBioD initiative that leverages biodiversity as catalyst for various economic activities, resulting in more business opportunities not only in core biotechnology sectors but also in related activities such as media content and eco-tourism. Figure  15:  Perak  CBioD  Initiatives 15. One area that could also be developed as a support to the biotechnology activities is the concept of “research tourism” where researchers in biotechnology and 31  
  • 32. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   bioprospecting activities are provided with proper facilities and granted access for their research. 16. Another area where Perak may start any related CBioD activity is the creation of bioinformatics centre for the protection data relating to biodiversity in Perak and promoting economic activities through commercialisation of the data. The bioinformatics centre will be an interphase between Perak Bio, Perak E- Organisation and K-Perak. 17. Marine Biotechnology and Aquaculture: The marine aquaculture sector is one of the targets of Perak Maju 2015 which targets among others marine fish, aquaculture, fish processing and ornamental fish. Aquaculture and ornamental fish could be the main targets of marine biotechnology. Based on the Perak Maju 2015, ornamental fish would bring in sale value of RM49.5 million in 2010 and RM75 million in 2015. These values could be further enhanced with the proper utilisation of biotechnology. It is also expected that aquaculture activities would bring in RM950 million sale in 2010 and RM1,480 million sale in 2015. In addition, marine biotechnology may also assist in conservation of the marine areas such as the mangrove trees, turtle sanctuaries and other important sectors, which then will be able to assist in promoting tourism. Biotechnology may also be used to increase fish stocks and assist in combating fish and prawn diseases. It is proposed that more companies be encouraged to enter the marine and aquaculture segment, particularly in the fish, seaweed and algae sub-segments. 18. Agriculture: Focus will also be on producing high end crop, seeds and tissue culture. The state can also encourage development of contract planting. In animal, the use of assisted reproductive techniques and the production of animal feed and vaccines should continue thereby improving productivity in the livestock segment. In addition, the way forward is to develop multiplier farms to ensure the continuous supply of selected animals from nucleus farms to commercial farms. In addition there has to be use of biotechnology techniques such as effective microbes, growth regulators to assist better productivity. The Northern Corridor Investment Authority (NCIA) and the Veterinary Department plan develop a 1000 acre site in Pondok Tanjung, Selama as an integrated animal industry centre including the application of artificial insemination and the production of animal vaccines. 19. Agriculture based Industrial and Green Biotechnology: Accelerate development of technology for effective implementation of green chemistry initiatives. Perak can take advantage of its bamboo and palm oil for continuous production of biomass and biofuel. Some of the key barriers to the development of the industrial biotechnology sector are the lack of know-how and experience in the scaling-up process, limited production capacity and efficiency of infrastructure and the high costs of setting up commercial scale facilities. As part of the initiative to support the development of industrial biotechnology sector, the set up 32  
  • 33. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   of shared facilities for outsourcing services is equally critical given the amount of investment required to set up such facilities. 20. Human and Animal Healthcare: Perak may also want to position itself as a centre for outsourcing and clinical research, with some logistical expertise. In this field, Perak needs to leverage on the Pharmaceutical Park in Seri Iskandar and the planned Biotechnology Park in Ipoh to develop CMO and CRO in healthcare. At the same time there is a need to find a niche in production such as the production of production tool, diagnostic equipment and research tools. There is also a need to leverage on existing and future centres of excellence to develop the necessary experience, knowledge and infrastructure are present to support the CROs. In order to effectively implement the specific actions identified to develop the various segments, it is proposed that a public-private partnership (PPP) model be adopted through strategic partnerships and collaborations. It is important in this field to attract foreign direct investment into Perak and this has to be done through aggressive and clever positioning of Perak as a preferred destination in health care biotechnology. Thrust 3: Formation of Specialised Facilities 21. The formation of specialised services may consist of the following activities: Figure  16:  Formation  of  Specialised  Facilities 22. Support Across Value Chain 33  
  • 34. Private  and  Confidential  –  Limited  Circulation  (WTI  Consulting  29.10.2010)   a. For the production of raw materials and finish products, the State may encourage the formation of support services within the value chain such as specialist transport systems which cater for specialist products such as insulated containers, fast, punctual and safe delivery of products to nearby airports, ports and Ipoh Inland Port. The state may also encourage the formation of specialised storage facilities at the relevant sites to be shared between small biotechnology industry players. This will reduce cost and at the same time increased investor’s confidence. 23. Advisory Centre a. Perak Bio may also facilitate the formation of advisory centres providing legal, intellectual property, commercialisation and international advisory services. Perak may take the lead in providing support to biotechnology industry through the design, set up and manage the proposed Advisory Centre for Biotechnology Law, Regulations and Commercialisation. The Advisory Centre aims to assist in building a successful and flourishing bioscience base in Malaysia by providing stakeholders such as investors and inventors who are involved in research and development and commercialisation of biotechnology products and services with a one-stop shop for legal and regulatory advice. b. It is recognised that researchers at universities and people in small business often have bright ideas about new or improved products, services or processes. Research has shown that innovation, when properly managed, can produce a higher rate of return than many other forms of investment. There are several key issues faced by people who are involved bioscience businesses, especially during the development stage such as: i. How to define and protect intellectual property; ii. Identifying the right staff for growth plans; recruiting them and keeping them; iii. Access to finance sources that understand the long product development lead time to commercially beneficial production; iv. Identification and contracting of appropriate premises and facilities; v. Successful generation of revenue creating opportunities during early stages of business operation; and vi. Clear definition of market potential and route to market. c. It is also recognised that only a very small number of inventions make money in the marketplace. At the same time significant regulatory impediments often exist to the introduction of new products. Depending on 34