The document provides an overview of rational therapeutics and clinical pharmacology. It discusses how clinical pharmacology aims to improve therapeutic decisions through a rational approach based on scientific principles. This involves understanding pharmacokinetics, how the body processes drugs, and pharmacodynamics, how drugs act on the body. The document outlines key concepts like dosage optimization to maximize efficacy while minimizing adverse effects based on an individual patient's needs, characteristics and treatment goals.

1. BASIC INTRAVENOUS THERAPY TRAINING PROGRAM CLINICAL PHARMACOLOGY Rational Therapeutics Pharmacokinetics Pharmacodynamics

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24. Concentration over Time C ½

29. Time to Peak Concentration

42. t ½ C ½

45. Area Under the Curve (AUC)

57. t ½ Pharmacokinetic parameters describing a typical plasma concentration time profile after an oral administration. C max , maximum concentration; t max , time to C max ; t ½ , half-life; AUC , area under the curve; MEC , minimum effective concentration; MTC , maximum tolerated concentration.

70. Drug Interactions Chart

72. Drug Interactions

73. Drug Interactions

74. Drug Interactions

76. Dr. Ronald Sanchez - Magbitang Thank You !