Every day, there is something new that may or may not have an impact on our daily practice. In this talk , we want to highlight some of these new developments
6. Progesterone & Preterm labor
Mainly for prevention of preterm labor
But still there are many preterm labor
Liable to cerebral palsy and delayed neural
development
12. DNA sequencing
⢠Rapidly evolving
⢠Allow genetic diagnosis of diseases
⢠Allow prediction for disease later in life
⢠Determine human genome in details
Now Next generation Sequencer
13. Work flow of conventional versus second-
generation sequencing
14. 1. Prepare genomic DNA
2. Attach DNA to surface
3. Bridge amplification
4. Fragement become
double stranded
5. Denature the double
stranded molecules
6. Complete amplification
⢠Illumina
⢠ABI SOLiD
⢠Roche 454
⢠HeliScope
What is next-generation sequencing ?
15. 7. Determine first base
8. Image first base
9. Determine second base
10. Image second base
11. Sequence reads over
multiple cycles
12. Align data.
1 billion bases per
run, 1% of the cost
of capillary-based
method.
20. Spindle transfer !!!!!
⢠spindle-chromosomal complex transfer
⢠taking nuclear DNA from an egg cell and
transferring that DNA into another egg cell,
leaving the defective mitochondrial DNA
behind
⢠For genetic disease
⢠Safety?????? Gene therapy
25. Corifolitropin alfa
⢠Long acting FSH
⢠Under the name of Elonva
⢠Single shot
⢠Contraindicated with PCOS
⢠Not self administered
⢠Not cheaper
28. DNG in endometriosis
⢠no glucocorticoid
⢠no antimineralocorticoid activity.
⢠no antiestrogenic activity
⢠due to DNG's low gonadotropic activity, E2
levels are not decreased to zero, in contrast to
treatments with gonadotropin-releasing
hormone (GnRH) analogues.
29. COC
⢠This maintenance beneficial E2 effects is
of particular importance for the general
tolerability of the first contraceptive pill
to use E2V instead of EE
⢠safer??
30. Ulipristal acetate & Fibroids
⢠oral selective progesterone receptor
modulator (SPRM) that has successfully
completed phase III clinical trials.
⢠licensed in Western Europe
⢠has shown efficacy with a significant reduction
in uterine bleeding, fibroid volume, and
improved quality of life
⢠low side effects unlike (GnRH) agonists.