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Membrane Biology
Plasma Membrane Structure and Function

• The plasma membrane separates the internal
  environment of the cell from its surroundings.
• The plasma membrane is a phospholipid
  bilayer with embedded proteins.
• The plasma membrane has a fluid consistency
  and a mosaic pattern of embedded proteins.
Fluid-mosaic model of membrane structure
• Cells live in fluid environments, with
  water inside and outside the cell.
• Hydrophilic (water-loving) polar heads of
  the phospholipid molecules lie on the
  outward-facing surfaces of the plasma
  membrane.
• Hydrophobic (water-fearing) nonpolar
  tails extend to the interior of the plasma
  membrane.
• Plasma membrane proteins may be
  peripheral proteins or integral proteins.
• Aside from phospholipid, cholesterol is
  another lipid in animal plasma
  membranes; related steroids are found in
  plants.
• Cholesterol strengthens the plasma
  membrane.
Functions of membrane proteins
• Membrane proteins have a variety of
  functions.
• Some help to transport materials across the
  membrane.
• Others receive specific molecules, such as
  hormones.
• Still other membrane proteins function as
  enzymes.
Channel protein
Carrier protein
Cell recognition protein
Receptor protein
The Permeability of the Plasma Membrane

• The plasma membrane is differentially
  permeable.
• Macromolecules cannot pass through because
  of size, and tiny charged molecules do not
  pass through the nonpolar interior of the
  membrane.
• Small, uncharged molecules pass through the
  membrane, following their concentration
  gradient.
How molecules cross the plasma
         membrane
• Movement of materials across a membrane
  may be passive or active.
• Passive transport does not use chemical
  energy; diffusion and facilitated transport are
  both passive.
• Active transport requires chemical energy and
  usually a carrier protein.
• Exocytosis and endocytosis transport
  macromolecules across plasma membranes
  using vesicle formation, which requires
  energy.
Diffusion and Osmosis
• Diffusion is the passive movement of
  molecules from a higher to a lower
  concentration until equilibrium is
  reached.
• Gases move through plasma membranes
  by diffusion.
Process of diffusion
Membrane biology
Membrane biology

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Membrane biology

  • 2. Plasma Membrane Structure and Function • The plasma membrane separates the internal environment of the cell from its surroundings. • The plasma membrane is a phospholipid bilayer with embedded proteins. • The plasma membrane has a fluid consistency and a mosaic pattern of embedded proteins.
  • 3. Fluid-mosaic model of membrane structure
  • 4. • Cells live in fluid environments, with water inside and outside the cell. • Hydrophilic (water-loving) polar heads of the phospholipid molecules lie on the outward-facing surfaces of the plasma membrane. • Hydrophobic (water-fearing) nonpolar tails extend to the interior of the plasma membrane.
  • 5. • Plasma membrane proteins may be peripheral proteins or integral proteins. • Aside from phospholipid, cholesterol is another lipid in animal plasma membranes; related steroids are found in plants. • Cholesterol strengthens the plasma membrane.
  • 6. Functions of membrane proteins • Membrane proteins have a variety of functions. • Some help to transport materials across the membrane. • Others receive specific molecules, such as hormones. • Still other membrane proteins function as enzymes.
  • 11. The Permeability of the Plasma Membrane • The plasma membrane is differentially permeable. • Macromolecules cannot pass through because of size, and tiny charged molecules do not pass through the nonpolar interior of the membrane. • Small, uncharged molecules pass through the membrane, following their concentration gradient.
  • 12. How molecules cross the plasma membrane
  • 13. • Movement of materials across a membrane may be passive or active. • Passive transport does not use chemical energy; diffusion and facilitated transport are both passive. • Active transport requires chemical energy and usually a carrier protein. • Exocytosis and endocytosis transport macromolecules across plasma membranes using vesicle formation, which requires energy.
  • 14. Diffusion and Osmosis • Diffusion is the passive movement of molecules from a higher to a lower concentration until equilibrium is reached. • Gases move through plasma membranes by diffusion.