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Complications of Nephrotic syndrome
Introduction ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Introduction ,[object Object],[object Object]
Complications nephrotic syndrome  ,[object Object],[object Object],[object Object],[object Object]
 
Nephrotic Oedema ,[object Object],[object Object],[object Object]
Nephrotic Oedema-  Underfill (classical) theory ,[object Object]
Nephrotic Oedema-  Underfill (classical) theory ,[object Object],[object Object],[object Object],[object Object],[object Object]
Nephrotic Oedema- Arguments against Underfill (classical) theory ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Nephrotic Oedema- Overfill theory ,[object Object]
Nephrotic Oedema- treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Nephrotic Oedema- treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Nephrotic Oedema- treatment ,[object Object],[object Object],[object Object],[object Object],[object Object]
Infection
Infections in nephrotic patients  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Primary peritonitis  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Primary peritonitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cellulitis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Other infections ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pathogenesis of infections ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Alternative complement pathway ,[object Object],[object Object],[object Object],[object Object],[object Object]
Alternative complement pathway ,[object Object],[object Object]
Pathogenesis of infections ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Thromboembolic complications
Thromboembolic complications ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Commonest presentation ,[object Object],[object Object],[object Object],[object Object],[object Object]
Concentrations of proteins important in coagulation in the nephrotic syndrome in relation to molecular weight  Reduced  54,000  α  1  -Antitrypsin  Raised–normal  65,000  Protein C  Normal–reduced  68,000  Antithrombin III  Normal–reduced  70,000  α  2  -Antiplasmin  Normal–reduced  75,000  Protein S  Normal–reduced  81,000  Plasminogen  Raised  840,000  α  1  -Macroglobulin  Regulator proteins  Normal–reduced  55,400  Factor IX  Normal–reduced  56,000  Factor X  Normal–reduced  72,000  Factor II (prothrombin)  Normal–reduced  79,000  Factor XII  Normal–reduced  160,000  Factor XI  Raised–normal  200,000  Factor VII  Raised  330,000  Factor I (fibrinogen)  Raised  350,000  Factor V  Raised  840,000  Von Willebrand factor  Zymogens and cofactors  Concentration in nephrotic plasma  MW (Da)  Protein
Physical Factors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Alterations in zymogen (enzyme precursors) and cofactors ,[object Object],[object Object],[object Object]
Alterations in fibrinolytic, regulator proteins and platlet function ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Alterations in fibrinolytic, regulator proteins and platlet function ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Summary :- ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Role of drugs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Peripheral venous thrombosis and PE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Arterial Thrombosis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Renal Vein Thrombosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Renal Vein Thrombosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Renal Vein Thrombosis- Prognosis ,[object Object],[object Object],[object Object]
Treatment/prevention of thromboembolic events ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Prevention ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Should we anticoagulate asymptomatic DVT? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Prophylactic anticoagulation in nephrotic patients? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Lipid abnormalities
Hyperlipidaemia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hyperlipidaemia ,[object Object],[object Object],[object Object]
Hyperlipidaemia- Pathogenesis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hyperlipidaemia- Pathogenesis ,[object Object],[object Object]
Hyperlipidaemia- consequences  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hyperlipidaemia- treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hyperlipidaemia- treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Acute Renal Failure in Nephrotic Syndrome, Hein, NDT 2001 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Acute Renal Failure in Nephrotic Syndrome- Pathology ,[object Object],[object Object],[object Object],[object Object]
Acute Renal Failure in Nephrotic Syndrome ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Others ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 

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  • 28. Concentrations of proteins important in coagulation in the nephrotic syndrome in relation to molecular weight Reduced 54,000 α 1 -Antitrypsin Raised–normal 65,000 Protein C Normal–reduced 68,000 Antithrombin III Normal–reduced 70,000 α 2 -Antiplasmin Normal–reduced 75,000 Protein S Normal–reduced 81,000 Plasminogen Raised 840,000 α 1 -Macroglobulin Regulator proteins Normal–reduced 55,400 Factor IX Normal–reduced 56,000 Factor X Normal–reduced 72,000 Factor II (prothrombin) Normal–reduced 79,000 Factor XII Normal–reduced 160,000 Factor XI Raised–normal 200,000 Factor VII Raised 330,000 Factor I (fibrinogen) Raised 350,000 Factor V Raised 840,000 Von Willebrand factor Zymogens and cofactors Concentration in nephrotic plasma MW (Da) Protein
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