Henoch Schonlein Purpura

HENOCH-SCHÖNLEIN PURPURA Morning Report July 6, 2007 Sima Patel, MD

DEFINITION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

BACKGROUND ,[object Object],[object Object]

EPIDEMIOLOGY ,[object Object],[object Object],[object Object],[object Object],[object Object]

PATHOGENESIS ,[object Object],[object Object]

PRECIPITATING ANTIGENS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

PRECIPITATING ANTIGENS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

PRECIPITATING ANTIGENS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

PATHOLOGIC FEATURES ,[object Object]

Direct Immunofluorescence of skin biopsy. Granular IgA and C3 staining of cutaneous vasculature. http://www.medscape.com/viewarticle/459714

H & E stain of skin biopsy showing leukocytoclastic vasculitis with infiltration of neutrophils. http://www.medscape.com/viewarticle/459714

Skin biopsy: Leukocytoclastic vasculitis with mononuclear and polymorphonuclear cell infiltrates in the perivascular space ,[object Object]

Renal biopsy: sclerosis and fibrous crescents in the glomerulus. http://www.ndt-educational.org/nagycase.asp

http://www.ndt-educational.org/nagycase.asp Immunofluorescence: Glomerular deposits of IgA

CLINICAL FEATURES ,[object Object],[object Object],[object Object],[object Object],[object Object]

CLINICAL FEATURES ,[object Object],[object Object]

CLINICAL FINDINGS ,[object Object]

CLINICAL FEATURES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

DIAGNOSTIC EVALUATION ,[object Object],[object Object],[object Object],[object Object]

DIAGNOSIS ,[object Object],[object Object],[object Object]

MANAGEMENT ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

MANAGEMENT ,[object Object],[object Object],[object Object],[object Object],[object Object]

PROGNOSIS ,[object Object],[object Object],[object Object],[object Object],[object Object]

REFERENCES ,[object Object],[object Object],[object Object],[object Object],[object Object]

Henoch Schonlein Purpura

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Henoch Schonlein Purpura