ImmunoCellular Investor Presentation

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IMUC is a clinical-stage company that is developing immune-based therapies for the treatment of brain and other cancers.

Business Technologie

January 2010 Manish Singh, PhD President and CEO OTC BB: IMUC.OB www.imuc.com

SEC Disclaimer Statement ,[object Object],January 2010

Cancer Stem Cells: Good Guys Turned Bad ,[object Object],[object Object],January 2010 Targeting CSCs may significantly delay or prevent disease recurrences. Normal Stem Cell mutations Cancer Stem Cell Mature Tissue Bulk Tumor Progenitor cells

Technology Overview: Utilizing Both Arms of Immune System ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],January 2010

ICT-107: Dendritic Cell-Based Vaccine Targeting Cancer Stem Cells and Tumor Associated Antigens January 2010 Antigens Tumor Expression CSC Expression gp100 Melanoma, brain cancer Trp-2 Melanoma and brain cancer High Her-2/neu Breast, ovarian cancer Medium MAGE-1 Melanoma, brain cancer AIM Breast, ovarian, colon, brain High IL-13aR2 Brain cancer

January 2010 Significant Improvement in Progression-Free Survival (Compared to Historical Controls Using Standard of Care) Radiation + Temozolomide* Radiation + Temozolomide +ICT-107 ,[object Object],[object Object]

Summary of Clinical Data: Progression-Free and Overall Survival January 2010 SOC = Standard of care (surgery + radiation + Temozolomide) Newly Diagnosed (16) SOC + ICT-107 Historical Control (SOC) Median PFS (months) 19.0 6.9 Median OS (months) > 21 14.2 % Survival at 12 months 94% 60% % Survival at 21 months 80% 30% Recurrent (3) Median OS (months) 30.5 7.0 (9.2 with Avastin+SOC)

ICT-121: Cancer Stem Cell Vaccine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],January 2010 Potential Blockbuster Product

Summary of Antibody Programs January 2010 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Value Creation Catalysts in Next 12 Months ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],January 2010

Management Team ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],January 2010

Key Opinion Leaders ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],January 2010

Financial Position and Capitalization ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],January 2010

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ImmunoCellular Investor Presentation

1. January 2010 Manish Singh, PhD President and CEO OTC BB: IMUC.OB www.imuc.com

6. ICT-107: Dendritic Cell-Based Vaccine Targeting Cancer Stem Cells and Tumor Associated Antigens January 2010 Antigens Tumor Expression CSC Expression gp100 Melanoma, brain cancer Trp-2 Melanoma and brain cancer High Her-2/neu Breast, ovarian cancer Medium MAGE-1 Melanoma, brain cancer AIM Breast, ovarian, colon, brain High IL-13aR2 Brain cancer

8. Summary of Clinical Data: Progression-Free and Overall Survival January 2010 SOC = Standard of care (surgery + radiation + Temozolomide) Newly Diagnosed (16) SOC + ICT-107 Historical Control (SOC) Median PFS (months) 19.0 6.9 Median OS (months) > 21 14.2 % Survival at 12 months 94% 60% % Survival at 21 months 80% 30% Recurrent (3) Median OS (months) 30.5 7.0 (9.2 with Avastin+SOC)

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ImmunoCellular Investor Presentation

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