Pharm Metabolism Presentation

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charlseyking15

Video showing basic concepts of drug metabolism in the body

Gesundheit & Medizin

Metabolism
JOSIE KERBO, CASSANDRA GUTIERREZ, CHARLSEY KING

Why Is Metabolism Important For
Nurses?
•All individuals metabolize drugs differently due to genetic
differences, therefore, nurses should be aware that no two patients
are going to have identical responses to the same drug. We must be
knowledgeable about any potential side effects of each drug
throughout the lifespan and the appropriate actions to take in life
threatening situations.

References
•Alavijeh, M. S., Chishty, M., Qaiser, M. Z., & Palmer, A. M. (2005). Drug metabolism and
pharmacokinetics, the blood-brain barrier, and central nervous system drug discovery. NeuroRx, 2
(4), 554-571.
•Lehne, R. A. (2007). Pharmacology for nursing care. St. Louis, MO: Saunders Elsevier.
•Le, J. (2014, May). Drug Metabolism - Clinical Pharmacology - Merck Manuals Professional Edition.
Retrieved September 4, 2015, from http://merckmanuals.com/professional/clinical-
pharmacology/pharmacokinetics/drug-metabolism
•Pharmacokinetics Basics- Absorption, Distribution, Metabolism and Excretion | Notes |. (2011, April
9). Retrieved September 4, 2015, from
http://pharmaxchange.info/press/2011/04/pharmacokinetics-basics-absorption-distribution-
metabolism-and-excretion

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Main Post Pharmacokinetics and Pharmacodynamics As advanced practice nurses it is important that we understand pharmacokinetics and pharmacodynamics when caring for our patients. There are many factors to consider when prescribing medications because not one person is the same. Pharmacokinetics is the study of drug movement throughout the body, and has four basic processes: absorption, distribution, metabolism, and excretion (Rosenthal, 2021, p 13). Pharmacodynamics is the study of the biochemical and physiologic effects of drugs on the body and the molecular mechanisms by which those effects are produced (Rosenthal, 2021, p 22). In my experience I can not pinpoint one specific scenario in which pharmacokinetic and pharmacodynamic factors altered an anticipated response to a drug but multiple scenarios. I can think of things to consider when prescribing medications like their medical history, medications they take, whether prescribed or over the counter, compliance, genetics, age, race, and family history. Other things to consider is the patients liver function and renal function, which affect the drugs absorption and excretion rate. One class of drugs that comes to mind are chemotherapy medications. Not everyone has the same outcome with chemotherapeutic agents when treating cancers. Another class of medications are psychotropic medications, some psych medications work better for others and do not work at all for some. And one of the most common ailments hypertension, antihypertensive drugs that work for some and not others. Immunosuppressed, CHF, renal failure, liver failure patients and patients with multiple ailments on multiple medications, all have to be prescribed medications carefully because of possible polypharmacy and drug interactions. A-fib patients prescribed coumadin needing their PT/INR checked to make sure their coumadin is therapeutic, educating them not to eat green leafy vegetables or drink grapefruit juice. A patient’s genetics may play a role in whether the medication prescribed is going to work or not. It became evident in the 60’s that therapeutic doses of psychotropic medications vary markedly from person to person, with some patients failing to respond despite treatment with high dosages (Lerer, 2004, p158). Among many factors that may influence the drug response, hepatic function, and drug metabolism ae of great importance for nearly all medications used in psychiatry and even more importantly patient compliance with medication use (Lerer, 2004, p158). The CYP2D6 genetic polymorphism was discovered in late 1970’s and represents one of the most intensively studied monogenic variations in drug metabolism, approx. 7% of Caucasians are poor metabolizers of CYP2D6 substrates while the rest are considered as extensive metabolizers (Lerer, 2004, p160). CYP2D6 enzyme has particular significance for clinical psychiatry as it is involved in clearance of many psychotropic drugs such as tricyclic, antidepressants, selective.

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Registered Dietitian Nutritionist David Wiss is an expert at food addiction. He has noticed that the classic eating disorder algorithm has been unsuccessful in integrating the latest research on food addiction into eating disorder treatment. In this presentation Mr. Wiss will review the literature and propose a model for incorporating food addiction into disordered eating. A new model will be proposed.

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Running head: PROJECT MILESTONE TWO 1. PROJECT MILESTONE TWO 6. Running head: FINAL PROJECT MILESTONE 3. Southern New Hampshire University January 6th, 2019 Research question: “Does self-disclosure of the therapist improve eating disorder treatment.” Hypothesis: Self-disclosure of the therapist improves eating disorder treatment. Information On Research The key variables for this research are self-disclosure of the therapist and eating disorder treatment. This research will focus on online research whereby participants will be recruited from an eating disorder charity database. The participants will be asked about the status of their condition and how they feel about having the disorder. The neutral condition will be that the therapists will disclose their sexuality and their feelings towards the patients’ conditions and personality (Marziliano, Pessin, Rosenfeld, & Breitbart, 2018). Process of Study The study will continue for two months with the therapists making contact with the participants once every week. These conditions will form the independent variables. The dependent variable would be participants continued to receive positive self-disclosures from the therapist leading to a greater level of patient self-disclosure, which lowered their shame, and encouraged the participants to continue with the treatment process. The participants will also be asked if they have been involved in any treatment before, and how they could describe their therapeutic alliance (Fuertes, Moore, & Ganley, 2018). A longitudinal study and the rate of drop-out will be used to gather more information about the participants. The collected data will then be analyzed in relation to the independent variables by the end of the study. One of the ethical issues, which will be looked into while conducting the study, is informed consent. Participants will be informed about the purpose of the research and will have the right to participate or not participate in it. Secondly, the research will ensure the privacy and confidentiality of every participant. Annotated Bibliography: Secrecy and concealment are typical behaviors in individuals with eating problems. In the article titled “ Self-Disclosure in eating disorders,” researchers examined women with greater related eating issues and determined whether or not, these women would be willing to disclose information. In this study, different types of disclosure were calculated considering the body appearance of the individual and to restrained eating. This article would benefit my research because it provides great information that will confirm my theory and test my hypothesis. Abstract 1. Those who suffer from eating disorders are very emotional beings. Often times, some may not feel a need to express their need to not eat foods. Many women become self-conscious about their weight and find it hard to share th.

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Hello Dr. Professor, Topic I choose: Arthritis There are many types of arthritis, but in my paper will be writing about the most common one “Osteoarthritis”. Thank you, SEC TION I Pathophysiology: Background and Overview, 1 CHAPTER 1 Introduction to Pathophysiology, 1 CHAPTER 2 Fluid, Electrolyte, and Acid-Base Imbalances, 14 CHAPTER 3 Introduction to Basic Pharmacology and Other Common Therapies, 40 CHAPTER 4 Pain, 53 SEC TION I I Defense/Protective Mechanisms, 65 CHAPTER 5 Inflammation and Healing, 65 CHAPTER 6 Infection, 88 CHAPTER 7 Immunity, 114 SEC TION I I I Pathophysiology of Body Systems, 142 CHAPTER 8 Skin Disorders, 142 CHAPTER 9 Musculoskeletal System Disorders, 161 CHAPTER 10 Blood and Circulatory System Disorders, 184 CHAPTER 11 Lymphatic System Disorders, 213 CHAPTER 12 Cardiovascular System Disorders, 223 CHAPTER 13 Respiratory System Disorders, 272 CHAPTER 14 Nervous System Disorders, 325 CHAPTER 15 Disorders of the Eyes, Ears, and Other Sensory Organs, 385 CHAPTER 16 Endocrine System Disorders, 400 CHAPTER 17 Digestive System Disorders, 427 CHAPTER 18 Urinary System Disorders, 488 CHAPTER 19 Reproductive System Disorders, 514 SEC TION I V Factors Contributing to Pathophysiology, 545 CHAPTER 20 Neoplasms and Cancer, 545 CHAPTER 21 Congenital and Genetic Disorders, 565 CHAPTER 22 Complications of Pregnancy, 579 CHAPTER 23 Complications of Adolescence, 588 CHAPTER 24 Complications of Aging, 597 Section V Environmental Factors and Pathophysiology, 606 CHAPTER 25 Immobility and Associated Problems, 606 CHAPTER 26 Stress and Associated Problems, 611 CHAPTER 27 Substance Abuse and Associated Problems, 617 CHAPTER 28 Environmental Hazards and Associated Problems, 624 Appendices, 631 Glossary, 654 Index, 663 GOULD'S Pathophysiology for the Health Professions SIXTH EDITION Evolve Student Resources for Gould’s Pathophysiology for the Health Professions, Sixth Edition, include the following: t� "OJNBUJPOT� t� "OTXFS�,FZ�GPS�4UVEZ�2VFTUJPOT�JO�UIF�CPPL� Activate the complete learning experience that comes with each textbook purchase by registering at http://evolve.elsevier.com/Hubert/Goulds/ YOU’VE JUST PURCHASED MORE THAN A TEXTBOOK! REGISTER TODAY! You can now purchase Elsevier products on Evolve! Go to evolve.elsevier.com/html/shop-promo.html to search and browse for products. 2015v1.0 GOULD’S Pathophysiology for the Health Professions SIXTH EDITION Robert J. Hubert, BS Laboratory Coordinator Iowa State University Department of Animal Sciences Ames, Iowa Karin C. VanMeter, PhD Independent Consultant, Biomedical Sciences Ames, Iowa 3251 Riverport Lane St. Louis, Missouri 63043 GOULD’S PATHOPHYSIOLOGY FOR THE HEALTH PROFESSIONS, SIXTH EDITION ISBN: 978-0-323-41442-5 Copyright © 2018, 2014, 2011, 2006, 2002, 1997 by Saunders, an imprint of Elsevier Inc. No part of this publication may be reproduced or transmitted in any form ...

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Week 4 School resources Grand Theories Theories can be classified based on their levels of abstraction. The scope of grand theories is very broad and, therefore, they don't lend themselves easily to application and testing. Grand theories are less abstract than conceptual models, but the concepts that compose them are still relatively abstract and general, and the relationships cannot be tested empirically (Fawcett, 1995)1. Let's begin our exploration of grand theories with Sr. Callista Roy's adaptation model. The principal premise behind this model is that individuals are adaptive systems that cope with change through adaptation, and nursing helps to facilitate this adaptation of individuals during health and illness. Middle Range Theories Middle-range theories originate from grand theories. They are less abstract and comparatively more focused and narrower in scope, which implies that they are made up of concepts and propositions that are testable. The development of the concept of caring as the central concept to nursing gave rise to several theories focused on caring. The most prominent of these caring theories is Madeleine Leininger's theory of culture care. Madeleine Leininger: Culture Care: Diversity and Universality Theory Culture plays an important role in every healthcare setting. Integrating culture with care is an effective way of guiding thought processes, actions, and decisions within that culture. Leininger's theory takes into account the cultural beliefs and values of individuals and groups to provide satisfying and culturally congruent nursing care. Culture exhibits both diversity and universality. While diversity includes different ways of practicing care, universality refers to the common elements in care. While adopting this model, it is important to incorporate cultural differences into nursing assessments, interventions, and care plans. The culture care theory stresses the importance of cultural care and the need to be sensitive to the role of culture in health and healing. Consider this case. A South East Asian female patient admitted to a U.S. hospital for gynecological complaints felt that she was in a hostile healthcare environment, in the midst of caregivers who were not friendly or sensitive to her needs. Everything, starting from the admission procedure, routine questioning, and physical assessment to the diet she was served, sent out negative signals to the patient. Had the attending nursing and other healthcare professionals been sensitive to her cultural differences and taken the trouble to make her feel comfortable, this turn of events could easily have been avoided. Culturally competent nurses can create positive environments where patients feel accepted and their cultural norms, beliefs, and practices are respected. This model is relevant to education, research and practice. Education Research Practice Leininger's model is helpful to nurse educators to teach the importance of transcultural nursing to stud ...

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