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“ INCREASED PROTHROMBIN, APOLIPOPROTEIN A-IV, AND HAPTOGLOBIN IN THE CEREBROESPINAL FLUID OF PATIENTS WITH HUNTINGTON´S DISEASE.” Yen-Chu Huang . Maria Camila Montufar Pantoja Heyly Milena Ortega III SEMESTER 2011 UNIVERSIDAD PONTIFICIA BOLIVARIANA
GENERAL OBJETIVE ,[object Object]
INTRODUCTION ,[object Object],[object Object]
PROTHROMBIN ,[object Object],[object Object],[object Object],Tromboplastina Ca++ Xa Va
APOLIPOPROTEIN AIV (APO AIV) ,[object Object],[object Object],[object Object],[object Object]
HAPTOGLOBIN ,[object Object],[object Object],[object Object],[object Object]
HUNITNGTON  DISEASE - HD ,[object Object],[object Object]
MATERIALES Y METODOS ,[object Object],[object Object],[object Object],[object Object],[object Object],PREPARACION DE LAS MUESTRAS
 
ELECTROFORESIS DE DOS DIMENSIONES (2-DE ) ,[object Object],[object Object],[object Object],[object Object]
DIGESTION EL GEL ,[object Object],[object Object],[object Object],[object Object],[object Object]
ESPECTROMETRIA DE MASA ,[object Object],[object Object],[object Object]
WESTERN BLOT ,[object Object],[object Object],[object Object],[object Object]
ELISA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
RESULTADOS ,[object Object]
[object Object],RESULTADOS
[object Object],RESULTADOS
DISCUSSION AUTOR OPINION YES NO Bjorkqvist M. The mutant huntingtin may enchance the ability of microglia to produce proinflamatory mediators (IL-6, IL-8 and TNF-a) and contribute to neurodegeneration in HD. Djoussé L. In HD, weigth loss is a characteristic feature in advanced as well early stage. Fang Q, Strand  In proteome analyses several the neuronal proteins were found to be reduced Underwood BR A serum metabolic profile indicative of a pro-catabolic phenotype in early HD
CONCLUTIONS ,[object Object],[object Object]
CONCLUTIONS ,[object Object],[object Object]
MAPA CONCEPTUAL
 
BIBLIOGRAFIA ,[object Object],[object Object],[object Object]

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Seminario molecular

  • 1. “ INCREASED PROTHROMBIN, APOLIPOPROTEIN A-IV, AND HAPTOGLOBIN IN THE CEREBROESPINAL FLUID OF PATIENTS WITH HUNTINGTON´S DISEASE.” Yen-Chu Huang . Maria Camila Montufar Pantoja Heyly Milena Ortega III SEMESTER 2011 UNIVERSIDAD PONTIFICIA BOLIVARIANA
  • 2.
  • 3.
  • 4.
  • 5.
  • 6.
  • 7.
  • 8.
  • 9.  
  • 10.
  • 11.
  • 12.
  • 13.
  • 14.
  • 15.
  • 16.
  • 17.
  • 18. DISCUSSION AUTOR OPINION YES NO Bjorkqvist M. The mutant huntingtin may enchance the ability of microglia to produce proinflamatory mediators (IL-6, IL-8 and TNF-a) and contribute to neurodegeneration in HD. Djoussé L. In HD, weigth loss is a characteristic feature in advanced as well early stage. Fang Q, Strand In proteome analyses several the neuronal proteins were found to be reduced Underwood BR A serum metabolic profile indicative of a pro-catabolic phenotype in early HD
  • 19.
  • 20.
  • 22.  
  • 23.