1. Partnerships in drug discovery and
development for diseases of the
developing world
Ken Duncan
BioDundee, Dundee
29 May, 2013
2. 2
TOPICS
1. Introduction to the work of the Bill &
Melinda Gates Foundation
2. Drug discovery portfolio
3. Importance of partnerships in TB drug
discovery and development
3. 3
TOPICS
1. Introduction to the work of the Bill &
Melinda Gates Foundation
2. Drug discovery portfolio
3. Importance of partnerships in TB drug
discovery and development
5. Our History
Bill and Melinda
read an article
about rotavirus
They officially
create the
foundation
Warren Buffett
decides to
give Berkshire
Hathaway stock
1998 2000 2006 2008
Bill joins Melinda
full-time at the
foundation
6. $36.4 billion
Asset trust endowment
$26 billion
Grants Since inception
1,100
Employees worldwide
$3.4 billion
2012 grants payments
$31.3 billion
Warren Buffet pledge
Headquarters: Seattle
Offices: London, Washington DC
Country Offices: China, India
Country Representatives:
Ethiopia, South Africa, Nigeria
Reach & Presence
7. What We Focus On
What are
the areas
of greatest
need?
Where can
we have
the greatest
impact?
9. 2011 Grants Paid Summary
For the year ended December 31, 2011. Amount in thousands.
(by Program Area)
Global Health $1,977,507
Global Development $667,780
United States Program $486,917
Operations/Non-Program Grants $48,466
Strategic Media Partnerships $18,379
Policy & Government Affairs $9,117
10. Integrated Approach for Global Health
VACCINES
VECTOR CONTROL
SANITATION
FAMILY HEALTH
DRUGS
DIAGNOSTICS
11. How Our Strategies Align
All strategies seek
transformational change.
All strategies rely on partners and
grantees to carry out the work.
All strategies emphasize
technology.
12. TOPICS
1. Introduction to the work of the Bill &
Melinda Gates Foundation
2. Drug discovery portfolio
3. Importance of partnerships in TB drug
discovery and development
19. Grantees and partners
Target Lead Candidate
Lead
Optimisation
Target
validation
Pre-clinical Clinical
Development
Lead
Identification
Target
identification
Product Development Partnerships
Academia, Institutes
Pharma
Biotech
20. TOPICS
1. Introduction to the work of the Bill &
Melinda Gates Foundation
2. Drug discovery portfolio
3. Importance of partnerships in TB drug
discovery and development
21. TB treatment today
6-24 months
Multiple drugs
Isoniazid
Rifampicin
Pyrazinamide
Ethambutol
Complexity: DOTS
Safety, drug-drug interactions
The World needs a
shorter, safer drug
regimen
23. Importance of Partnerships
Target Lead Candidate
Lead
Optimisation
Target
validation
Pre-clinical Clinical
Development
Lead
Identification
Target
identification
TBDA
CPTR
26. TBDA
Next generation therapy
Goal:
A new first line drug regimen
that works in one month or less
Problem:
Few new drug candidates, little
diversity
Solution:
An integrated cross-industry-
academia discovery partnership
Challenge:
27. TBDA
The TBDA is a groundbreaking partnership between seven pharmaceutical companies and
six research institutions collaborating on early TB drug discovery
The TB Drug Accelerator
How it works…
Company
Compound
Libraries
Collaborative Discovery Research 5 new preclinical
candidates
2016
1 month regimen
proof of concept
2021
• Hit and Lead Generation
• Target Identification
• Lead Optimization
Research Institutions: Pharmaceutical Companies: With support from:
28. TBDA
The TBDA is a New Paradigm For Drug Discovery
The TBDA offers a new approach that addresses many of the bottlenecks in the way TB
drugs are currently developed
ONLY THE BEST CANDIDATES ADVANCE
Early
Collaboration
Avoid
Redundancy
Data
Sharing
Maximize
Efficiency
Overcome
Competitive
Barriers
Companies Work
on Each Other’s
Compounds
29. TBDA
• Partnerships such as the TBDA show how industry and others can work
together in new ways to support global health innovation
• The TBDA model could be applied to other disease areas that lack incentives
for research or require combination drug therapies
The TBDA Offers a Model for
Other Initiatives
31. All Rights Reserved. Bill & Melinda Gates Foundation is a registered trademark in the United States and other countries.
Learn More
www.GatesFoundation.org
www.ImpatientOptimists.org
BillandMelindaGatesFoundation
@GatesFoundation
Hinweis der Redaktion
Broken up talk into three sections
Broken up talk into three sections
The Bill & Melinda Gates Foundation is a private foundation. The family decided to invest their resource to make their beliefs a reality , ALL LIVES NO MATTER WHERE THEY ARE BEING LIVED HAVE EQUAL VALUE. TRANSITION - This belief is the building blocks of our work.
More than a decade ago, Bill and Melinda read a newspaper article about the millions of children dying each year in poor countries from diseases that most people in the United States don’t have to worry about. One disease in particular—rotavirus—caught their attention. It was killing half a million children a year. They’d never even heard of rotavirus. They thought that that figure might be a typo. In 2006, Warren Buffett surprised them with a pledge of most of his shares in Berkshire Hathaway, doubling the foundation’s annual grantmaking and potential impact. In 2008,Bill made his transition from Microsoft, joining Melinda in a full-time role at the foundation. The foundation was established on Bill’s and Melinda’s passion to address some of the inequities in the world, with the premise that all lives, no matter where they are being lived, have equal value
Total 2012 Grant Payments: $3.4 billion (figure includes other direct charitable contributions of $234 million)Asset Trust Endowment: $36.4 billion (as of December, 31, 2012)Remaining Warren Buffet Pledge: $31.3 billion
To be successful, we have to focus on a set of problems. To do that, we ask two key questions.
Work divided into 3 main areasUS programs: education,libraries, and Pacific NWGlobal Development:Agricultural Development; Financial Services for the Poor; Water, Sanitation & Hygiene; Special InitiativesGlobal Health:harnesses advances in science and technology to save lives in poor countriesfocus on the health problems that have a major impact in developing countries but get too little attention and funding. Where proven tools exist, we support sustainable ways to improve their delivery. Where they don’t, we invest in research and development of new interventions, such as vaccines, drugs, and diagnostics. we allocate about half of our resources to our work in global health, a quarter to our work in the United States, and another quarter to our work in global development
To give you a sense of our scale and how we allocate these funds:Our endowment (as of Dec. 31, 2012) is $36.4 billion. We now employee over 1,100 people, and each year we give out about $3.4 billion in grants as of last year.This chart illustrates where our grants were made in 2011. You can see that Global Health received about 63 percent of our grantee funds with investments of more than $1.98 billion. Global Development grantees received $668 million while U.S. Program grantees received $487 million—about 21 percent and 16 percent of total program-related grants, respectively. While we are the largest charitable foundation in the world, we know that our money is a drop in the bucket compared to what is needed to solve these problems. For example, California’s public education annual budget is $57 billion annually. So, we see our funding as catalytic; we leverage our funds to bring even more funding and attention to issues.Recently, Bill and Melinda accelerated the timeline to sunset the foundation. Formerly 50 years, all resources will now be spent within 20 years of their deaths.
Summary of Changes with the Global ProgramsThat’s why we decided to create a new Global Programs structure to encourage a more integrated approach to our work. Program teams focused on areas ranging from agricultural development to vaccines are now working together more closely on the discovery and delivery of health and development innovations that will meet the many needs of the people we serve.Our goal is to maximize discovery and delivery in global health and development, as well as increase the relevance and impact of our in-country work. Working across Global Programs and engaging grantees and partners alike will increase our local-country insight—which ultimately helps us achieve greater results in the countries where we work and where the most intensive need exists.Integrated ApproachOur new Global Programs structure aims to meet the many needs of the people we serve:Agricultural Development - Helping poor farm families to grow and sell more food reduces hunger and poverty.Family Planning - Family planning can significantly improve the health and welfare of women and their families.Nutrition - Proper nutrition during pregnancy and in early childhood improves children's health and the quality of their lives for years to come.Malaria - Access to drugs and tools to prevent and treat malaria have saved and improved the lives of millions of families around the world.Vaccines - Vaccines work to save and improve lives and protect children for a lifetime.Sanitation - Improved sanitation increases productivity, reduces healthcare costs, and prevents illness, disability, and early death.
All of our strategies seek enduring, transformational change in people’s lives by discovering tools and approaches that can achieve results on a broad scale.All of our strategies rely on partners and grantees to carry out the work in the field.All of our strategies make use of technology to advance our work—whether it’s online learning tools that help students progress at their own pace, GPS mapping technology to help vaccination teams in the field, or new contraceptive technologies that are cheaper and easier for women to use.
Broken up talk into three sections
Broken up talk into three sections
Current TB regimens drive down bacterial levels quickly, but require months of treatment to rid the body of all TB……The only way to overcome this persistence is through ashorter, more effective regimen
Bill and Melinda Gates started the foundation because they believe every person should have the chance to live a healthy and productive life. This belief underlies all of the foundation’s work to reduce hunger, poverty, and disease around the globe.
