This document discusses structural genomics and its goals of determining the 3D structures of large numbers of gene products to identify novel protein folds and sequences. It describes methods for structural determination including de novo and modeling based approaches. Specific proteome projects on Thermotoga maritima and Mycobacterium tuberculosis are mentioned. The objectives of structural genomics are outlined as providing structural information to aid research, experimental design, identification of new structure-based medicines, and development of better therapeutics.