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A 4 Year Trial Of Tiotropium In Chronic Obstructive Pulmonary Disease

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Bassel Ericsoussi, MD
Bassel Ericsoussi, MD
Gesundheit & Medizin
1 von 20
A 4-Year Trial of Tiotropium in Chronic Obstructive Pulmonary Disease Donald P. Tashkin, M.D., Bartolome Celli, M.D., Stephen Senn, Ph.D., Deborah Burkhart, B.S.N., Steven Kesten, M.D., Shailendra Menjoge, Ph.D., Marc Decramer, M.D., Ph.D., for the UPLIFT Study Investigators Bassel Ericsoussi, PG-Y3 Internal Medicine Advocate Christ Medical Center N Engl J Med Volume 359(15):1543-1554 October 9, 2008
Background ,[object Object],[object Object],[object Object],[object Object]
What do we know about Tiotropium? ,[object Object],[object Object],[object Object],[object Object]
Study Overview ,[object Object],[object Object],[object Object]
Study Design ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Study Design (cont.) ,[object Object],[object Object],[object Object]
Patients ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Procedures ,[object Object],[object Object],[object Object],[object Object]
Results Study Population ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
Baseline characteristics and concomitant use of respiratory medications were similar in the two study groups > 45 yr At least 10 packs-yr Moderate to very severe Moderate Severe Very severe According to criteria of the Global Initiative for Chronic Obstructive Lung Disease (GOLD)
[object Object],[object Object],More than 90% of patients were receiving respiratory medications at baseline
Rate of Decline in Lung Function ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],87 to 103 ml 47 to 65 ml (P<0.001).
In the tiotropium group, FVC significantly improved before and after bronchodilation
[object Object],[object Object],[object Object],[object Object],2.3 to 3.3 units, P<0.001 But clinically not significant (< 4 units) Health-Related Quality of Life
Exacerbations ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],Mortality
Adverse Events ,[object Object],[object Object],[object Object],[object Object],RR < 1, favorable for Tiotropium P < 0.05
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Discussion/Conclusion

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A 4 Year Trial Of Tiotropium In Chronic Obstructive Pulmonary Disease

  • 1. A 4-Year Trial of Tiotropium in Chronic Obstructive Pulmonary Disease Donald P. Tashkin, M.D., Bartolome Celli, M.D., Stephen Senn, Ph.D., Deborah Burkhart, B.S.N., Steven Kesten, M.D., Shailendra Menjoge, Ph.D., Marc Decramer, M.D., Ph.D., for the UPLIFT Study Investigators Bassel Ericsoussi, PG-Y3 Internal Medicine Advocate Christ Medical Center N Engl J Med Volume 359(15):1543-1554 October 9, 2008
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  • 11. Baseline characteristics and concomitant use of respiratory medications were similar in the two study groups > 45 yr At least 10 packs-yr Moderate to very severe Moderate Severe Very severe According to criteria of the Global Initiative for Chronic Obstructive Lung Disease (GOLD)
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  • 15. In the tiotropium group, FVC significantly improved before and after bronchodilation
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