2. OUTLINE
⢠INTRODUCTION
⢠RELEVANT ANATOMY
⢠TYPES OF PUD
⢠INDICATIONS FOR SURGICAL TREATMENT
⢠VARIOUS TREATMENT OPTIONS
⢠COMPLICATIONS OF TREATMENT
⢠PROGNOSIS
⢠CONCLUSION
⢠REFERENCES
3. INTRODUCTION
⢠Peptic ulcer disease is an ulcer caused by gastric acid or pepsin. These
secretions overwhelms the gastroduodenal mucosa and there is
colonization of the pyloric antrum by H. pylori.
⢠The treatment is principally medical. Surgery is indicated when ulcers
are refractory or become complicated.
6. RELEVANT PHYSIOLOGY
⢠There 3 glandular zones
ďCardiac > mucus cells and few
parietal cells
ďOxyntic(parietal)> (80% at fundus
and body) parietal cells secretes
HCL and intrinsic factor the chief
cells pepsinogen
ďPyloric gland> G-cells secrete
gastrin
Stimulant of Gastric secretion:
⢠Acetylcholine (vagus) --> G cells
and parietal cells
⢠Gastrin --> parietal cell and chief
cells
⢠Histamine (mast cells) ---> parietal
& chief cells
Phases :
⢠Cephalic - vagus
⢠Gastric - food
⢠Intestinal -chyme
7. CLASSIFICATION
Site
⢠Common sites are the
duodenum and
Gastric(stomach)
⢠Other sites;
ď§ lower end of oesophagus,
ď§ Meckelâs diverticulum with
ectopic gastric tissue,
ď§ jejunum in gastrojejunostomy.
Modify Johnsonâs classification
8. INDICATIONS FOR SURGERY
⢠Refractory ulcers
⢠Haemorrhage not responding to endoscopic treatment
⢠Gastric outlet obstruction
⢠Perforation
⢠Suspicious of Malignancy
9. SURGICAL OPTION
⢠VAGOTOMY
⢠Truncal and drainage
⢠Selective
⢠Highly selective
⢠Posterior vagotomy and anterior seromyotomy
⢠GASTRECTOMY
⢠Billroth I
⢠Billroth II
⢠Subtotal gastrectomy
⢠GRAHAMâS OMENTAL PATCH
⢠SUTURE LIGATION OF GASTRODUODENAL ARTERY
⢠UNDRER-RUNNING AN ULCER BASE
⢠After excision of the edge
⢠Vagotomy
11. ⢠Division of the vagus nerve remove the cephalic stimulus to oxyntic
cells; acid secretion reduce by 60%.
⢠Types;
⢠Truncal vagotomy and drainage
⢠Selective vagotomy
⢠Highly selective vagotomy
⢠Posterior Truncal vagotomy and anterior seromyotomy (Taylorâs)
12. Truncal vagotomy and drainage
⢠The 2 nerve trunks are divided below the diaphragm near the hiatus.
⢠The gastric tone and mobility are diminished and emptying delayed
⢠A drainage procedure is done to drain the stomach
⢠Drainage;
ďPyloroplasty; a longitudinal incision about 6cm long is made across the
pylorus at the mid anterior part to involve the adjacent part of the pyloric
antrum and duodenum. (Heineke-Mikuliez) other types are Finneyâs and
Jaboulay
ďGastrojejunostomy; the jejunum, about 15cm from the duodeno-jejunal
flexure is anastomose usually to the posterior wall of the stomach behind the
transverse colon
13. Selective vagotomy
⢠Vagotomy with sparing the hepatic branch of anterior vagus and the
coeliac branch of the posterior vagus.
⢠A drainage procedure is also performed
⢠Time consuming and it has being abandoned
⢠Recurrence rate is 10%
14. Highly selective
⢠It aims at denervating only the acid producing oxyntic gland sparing
nerve to the pyloric antrum(nerve of latarjet) such that drainage
procedure is not required.
⢠It is difficult to determine the exact area of denervation of oxyntic cell
⢠Recurrence rate is 10%
15. Taylorâs operation
⢠Seromyotomy- denervate the fundic parietal mass preserves nerve of
Latarget. The seromyotomy is done 6cm proximal to the pylorus and
1.5cm from the lesser curvature
16. Billroth I
Billroth I â partial gastrectomy gastro-duodenostomy end-to-end
Done for gastric ulcer in the antrum
18. Grahamâs patch
⢠Piece of omentum is used to
cover the perforation.
⢠3 or 4 interrupted sutures are
inserted through and through
along the long axis.
⢠Modified Grahamâs patch
19. SUTURE LIGATION OF GASTRODUODENAL ARTERY
⢠Pylorodedontomy
⢠Non-absorbable suture must
incorporate the artery proximal
and distal to the site of bleeding
⢠And the transverse pancreatic
branch
⢠Usually for massive bleeding
21. COMPLICATIONS
⢠Immediate
⢠Bleeding
⢠Gastric retention
⢠Dysphagia
⢠Leakage of duodenal stump
⢠Obstruction of the stoma
⢠Acute pancreatitis
⢠Late
⢠Dumping syndrome
⢠Diarrhoea
⢠Steatorhoea
⢠Enterogastric reflux
⢠Recurrent ulceration
⢠Iron deficiency anaemia
⢠Risk of colorectal and gastric tumours
⢠Weight loss
⢠Megaloblastic anaemia
⢠Osteomalacia
⢠Anastomotic ulcer
⢠Gastro-jejunocolic fistula
22. Prognosis
⢠Overall operative procedure gives satisfactory result in at least 80% of
patients
⢠Mortality of vagotomy and drainage is <1%
⢠Partial gastrectomy has overall mortality of 2%, 90% are satisfied with
result, 2% anastomotic ulceration and 5-10% dumping problems.
⢠Operative mortality for perforated DU is 7%
23. CONCLUSION
â˘Peptic ulcers requiring surgeries are complicated
and the patients present as emergency which
requires adequate resuscitation.
â˘Delay in presentation, diagnosis and treatment
increases morbidity and mortality
24. References
⢠E.A Badoe et al, âPrinciples and Practice of surgery including
pathology in the tropicsâ 4th edition, Assembly of God Literature
Center ltd, 2009
⢠Bailey and Loveâs âShort Practice of Surgeryâ 26th edition CRC press
Taylor and Francis group. 2013
⢠Farquharsonâs textbook of operative general surgery 9th edition
⢠SRBâs manual of surgery. 4th edition 2013.
⢠www.slideshare .net
Hinweis der Redaktion
Enterochromaffin-like cells ECL release histamine which stimulates the parietal cells to produce. Gastrin stimulates ECL cells