Kawasaki disease
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definition ,cause ,presentation ,criteria ,diagnosis
![Prof. Dr. Saad S Al Ani Senior Pediatric Consultant Head of Pediatric Department Khorfakkan Hospital, Sharjah, UAE [email_address] Kawasaki disease](https://image.slidesharecdn.com/kawasakidisease1-110404152027-phpapp01/85/Kawasaki-disease-1-320.jpg)
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Kawasaki disease
- 1. Prof. Dr. Saad S Al Ani Senior Pediatric Consultant Head of Pediatric Department Khorfakkan Hospital, Sharjah, UAE [email_address] Kawasaki disease
- 8. Pathogenesis Severe vasculitis Edema of endothelial and smooth muscle cells Intense inflammatory infiltration of the vascular wall Weakens, resulting in dilatation or aneurysm formation Thrombi Fibrosis, intimal proliferation, stenosis
- 9. Pathogenesis (cont.) An inflammatory infiltrate in * myocardium * upper respiratory tract * pancreas *Kidney * biliary tract
- 29. Thank you
Hinweis der Redaktion
- including aneurysms, with the potential for the development of: 1. coronary artery thrombosis or stenosis 2. myocardial infarction 3. aneurysm rupture 4. sudden death .
- *by polymorphonuclear cells but rapidly changing to macrophages, lymphocytes (which are mostly CD8 T cells), and plasma cells * * inflammation involves all three layers of the vascular wall, with destruction of the internal elastic lamina. *In the healing phase, the lesion becomes progressively fibrotic, with marked intimal proliferation, which may result in stenotic occlusion of the vessel over time.
- *by polymorphonuclear cells but rapidly changing to macrophages, lymphocytes (which are mostly CD8 T cells), and plasma cells * * inflammation involves all three layers of the vascular wall, with destruction of the internal elastic lamina. *In the healing phase, the lesion becomes progressively fibrotic, with marked intimal proliferation, which may result in stenotic occlusion of the vessel over time.