How hair Loss takes place & Role of Nutraceutical

1. Medical Slides – Internal Circulation only
IDENSE
Dr. Praveen K Tavva
Medico Marketing

2. Medical Slides – Internal Circulation only
Hair
Physiology of hair growth (anagen, catagen, telogen)
Causes of Hair loss (Nutritional deficiencies)
Types of Hair loss
Androgenetic alopecia
Treatment
Pharmacotherapy (Minoxidil & Finasteride)
Oral Supplements: Neturacuticals

3. Medical Slides – Internal Circulation only
Types of Alopecia
Androgenetic Alopecia (AGA)
Alopecia Areata
Telogen effluvium
Cicatricial Alopecia
Traumatic alopecia

4. Medical Slides – Internal Circulation only
Epidemiology
Affects between 50 and 80% of men.
For men in their thirties, 30%
For men in their forties, 40% and so on until 80% of men are affected when 80 or
more years old
Hair loss is first observed in women in their late twenties to early forties, somewhat
later in age than first onset in men.
Unlike men the frequency of women affected does not continue to increase with
increasing age

5. Medical Slides – Internal Circulation only
Importance of Oral Supplements in Hair Loss
Nutritional deficiency may impact both hair
structure and hair growth
Effects on hair growth include acute telogen
effluvium (TE), a well-known effect of sudden
weight loss or decreased protein intake
Protein malnutrition can result in hair changes
that include hair thinning and hair loss
Less intake of Hair Vitamins like Biotin, Iron, Zinc,
Water soluble vitamins & other

6. Medical Slides – Internal Circulation only
Importance of Oral Supplements in Hair Loss
Proteins, vitamins and minerals contribute towards healthy hair
Lack of vitamins and micronutrients causes
 Slowing of growth of hair
 Dull hairs
 Easily broken hair
 Thinning of hair
Micronutrients are necessary for overall good body health and good body health is necessary for healthy
hair

7. Medical Slides – Internal Circulation only
 Follicle: Inadequate nutrition
 Hair Thinning
 Hair Damage
Importance of Oral Supplements in Hair Loss

8. Medical Slides – Internal Circulation only
Do Hair Supplements really work?
Oral supplements has the significant role in the Hair loss. Which is an evident by clinical
studies.
Randomized, double-blind, placebo-controlled study
In adult women with self-perceived thinning hair associated with poor diet, stress,
hormonal influences, or abnormal menstrual cycles
The daily administration of a proprietary nutritional supplement significantly increased
hair growth after 90 and 180 days. Self-perceived improvements after 90 days were
increased after 180 days of additional treatment, suggesting continued improvements may
occur with ongoing treatment
Ref: Glynis, A Double-blind, Placebo-controlled Study Evaluating the Efficacy of an Oral Supplement in Women with Self-perceived Thinning Hair, (J Clin Aesthet Dermatol. 2012;5(11):28–34.)

9. Medical Slides – Internal Circulation only
The use of a new oral supplement was
associated with a visible increase in hair
growth after 90 and 180 days

10. Medical Slides – Internal Circulation only

11. Medical Slides – Internal Circulation only
Idense Composition
Key Ingredients
Soy Protein Hydrolysate It contains Essential Amino Acids L-Glutamic Acid L-Aspartic Acid L-Leucine L-Arginine L-Lysine L-
Phenylalanine L-Serine L-Proline L-Valine L-Isoleucine L-Alanine L-Glycine L-Threonine L-
Tyrosine L-Histidine L-Tryptophan L-Cysteine DL-Methionine
Botanical Extracts Green Apple Extract
Green Tea Extract
Beta sitosterol
Vitamins Vitamin C Niacin Vitamin E Vitamin B5 Vitamin B6 Vitamin B1 Folic Acid Biotin Vitamin B12
Minerals Calcium
Magnesium
Iron
Zinc
Manganese
Copper
Selenium

12. Medical Slides – Internal Circulation only
Idense EVA Composition
Key Ingredients
Soy Protein Hydrolysate It contains Essential Amino Acids L-Glutamic Acid L-Aspartic Acid L-Leucine L-Arginine L-Lysine L-
Phenylalanine L-Serine L-Proline L-Valine L-Isoleucine L-Alanine L-Glycine L-Threonine L-
Tyrosine L-Histidine L-Tryptophan L-Cysteine DL-Methionine
Botanical Extracts Green Apple Extract
Green Tea Extract
Inositol
Vitamins Vitamin C Niacin Vitamin E Vitamin B5 Vitamin B6 Vitamin B1 Folic Acid Biotin Vitamin B12
Minerals Calcium
Magnesium
Iron
Zinc
Manganese
Copper
Selenium

13. Medical Slides – Internal Circulation only
Soy Protein Hydrolysate
Obtained from hydrolysis of Soy Protein
Complex of essential amino acids similar to natural keratin
Meet the essential requirements for hair growth
Benefits can be improved quality of keratin produced and hair repairing
effects

14. Medical Slides – Internal Circulation only
Role of Amino Acids
L-Cysteine - most important amino acid for hair growth
One of the major amino acid present in human hair and is key constituents of
Protein Hydrolysate
Aids proper hair growth and stimulates new growth
Powerful antioxidant that protects the hair from the sun and its radiation
Helps to keep the hair from damage
bonds with other protein in the hair shaft and increase the diameter of the hair
shaft

15. Medical Slides – Internal Circulation only
Iron & L-Lysine
Depletion of the Iron levels in the body and suboptimal intake of the essential
amino acid L-lysine.
Correction of these imbalances stops the excessive hair loss and returns the hair
back to its normal
It plays a key role in iron and zinc absorption which is essential for maintaining the
hair growth and vitality

16. Medical Slides – Internal Circulation only
Zinc
Essential cofactor of several enzymes and transcription factors
Over 300 enzymes require zinc for their activation and nearly 2000 transcription
factors require zinc for gene expression
Alopecia is one of many consequences associated with zinc deficiency
Evidence of efficacy of zinc supplementation in hair loss
In one case report, a child with alopecia due to zinc deficiency was administered a zinc
supplement and her hair loss stopped in three weeks
Karashima, et al. study with five patients having zinc deficiency-related telogen
effluvium improved when treated with oral zinc administration in all patients
Ref: Skinmed. 2007;6:199–200; Dermatologic Therapy 2012; 210–213.

17. Medical Slides – Internal Circulation only
Implications of Zinc Deficiency
Zinc Deficiency can lead to TE- Thin, White and Brittle Hair
• The administration of Zinc for Zinc related deficiency
may recover appropriate activities of metalloenzymes,
hedgehog signalling, and immunomodulation, all of
which are required for normal control of hair growth
cycle.
Ref: Jerome Nriagu. Zinc Deficiency in Human Health. Elseivier 2007. Sourced from
http://www.extranet.elsevier.com/homepage_about/mrwd/nvrn/Zinc%20Deficiency%20in%20Humans.pdf. Accessed on 29.12.2012

18. Medical Slides – Internal Circulation only
Selenium
• Component of selenoproteins like glutathione peroxidase (protects cells from
oxidative damage)
• Aids in hair growth and prevention of dandruff
• Selenium compounds kill a fungus present on the scalp called Malassezia,
which sheds dry skin fragments.

19. Medical Slides – Internal Circulation only
Selenium & Zinc on Hair
Many dermatologists recommend zinc and
selenium for hair loss
Selenium along with zinc helps to optimize
the use of proteins and hormones and
thereby help to produce more hair
 Selenium supplement can also be used in
combination to treat many conditions like
gray hair

20. Medical Slides – Internal Circulation only
Biotin on Hair
• Biotin is a proven hair growth vitamin
and is known to prevent excessive
hair loss

21. Medical Slides – Internal Circulation only
Folic Acid on Hair
Folic acid is a vital vitamin for air
follicle cell division & growth
Folic acid is a well accepted
essential ingredient in nourishing
hair
Folic Acid deficiency may contribute to decreased hair-follicle cell division and growth
Ref:: http://www.cdph.ca.gov/HealthInfo/healthyliving/childfamily/Documents/MO-NUPAFolicAcidandFolate. pdf. Accessed on 17.12.12.

22. Medical Slides – Internal Circulation only
Pantothenic Acid on Hair Loss
Vitamin B5 works as a Humectant.
It improves the water content & elasticity of hair
Enhance the Hair Vitality

23. Medical Slides – Internal Circulation only
Beta Sitosterol
It is a systemic DHT blocker
Beta sitosterol is a plant sterol that contributes to lowering the amount of
DHT in the bloodstream

24. Medical Slides – Internal Circulation only
Green Apple Extract
Rich in all the minerals like potassium, magnesium, calcium and copper,
Green Apple Extract nourishes the scalp.
It also contains procyanidin which encourages healthy hair growth. It
thickens the hair and gives volume.

25. Medical Slides – Internal Circulation only
Green Tea Extract
The epigallocatechin gallate (EGCG) in green tea may prevent hair loss by
inhibiting the activity of hormones that induce hair loss and promoting hair
regrowth by stimulating hair follicles.

26. Medical Slides – Internal Circulation only
MOA - Idense
Inhibits DHT
Stimulating Hair Follicles
Hair Thickening
Vasodilation
Stimulating Hair Follicles
Beta Sitosterol
Vitamins & Minerals
Green Apple Extract
Green Tea Extract &
Amino Acids
Green Tea Extract
Soy Protein Hydrolysate
Improves Keratin

27. Medical Slides – Internal Circulation only
MOA – Idense EVA
Inhibits DHT
Stimulating Hair Follicles
Hair Thickening
Vasodilation
Stimulating Hair Follicles
Inositol
Vitamins & Minerals
Green Apple Extract
& Inositol
Green Tea Extract &
Amino Acids
Green Tea Extract
Soy Protein Hydrolysate
Improves Keratin

28. Medical Slides – Internal Circulation only
Clinical Evidence

29. Medical Slides – Internal Circulation only
Clinical Evidence
Pre Treatment Improvement in hair
quality, density after
4 months of
nutritional therapy
Take Home Message
Nutritional supplements are very vital in hair growth

30. Medical Slides – Internal Circulation only
Thank You