The antigen-antibody reaction is a specific chemical interaction between antibodies produced by B cells and antigens, forming the basis of antibody-mediated immunity. Each antibody can only bind to a specific antigen at the antibody binding site on the antigen known as the epitope. There are three main types of antigen-antibody reactions: precipitation, agglutination, and complement fixation. The reaction is highly specific, non-covalent, and reversible. It has applications in determining blood groups, detecting proteins, and characterizing immunodeficiency diseases.