2. About Us
CD Bioparticles is a high-tech company integrating professional R&D, production,
and sales, providing customized solutions for the development and production of
drug delivery systems (DDS) and new medical materials.
CD Bioparticles has strong technical strength and a high-level research team to
develop and produce high-quality polyethylene glycol (PEG) derivatives, which are
FDA-approved polymers for use in biomedical products. PEGylation is a chemical
modification process that connects PEGylated active derivatives to therapeutic
protein/peptide drugs or drug delivery systems. It is an advanced pharmaceutical
molecular modification and drug delivery technology in the world. Our facility is
ISO9001 and ISO13485 certified, and is operating according to ICH Q7A guidelines
to produce PEG derivatives for pharmaceutical companies.
A fully certified high purity polydisperse and monodisperse PEG derivatives. These
PEG derivatives have been widely used in bioconjugation, antibody-drug conjugates
(ADCs) therapeutic, drug delivery, medical materials, diagnostics field, etc.
• High purity pharmaceutical PEG derivatives with an extensive variety of
functional groups
• Providing custom PEG derivatives in milligram to hundreds of kilograms or greater
with GMP standard manufacturing capability
• Custom analytical test methods for customized PEG derivatives in order to adjust
our testing to best fit your needs
• Instant expert scientific support
Today we offer you:
4. 4 www.cd-bioparticles.net
PEG can be divided into monodisperse PEG and polydisperse PEG. Monodispersed
PEG are homogeneous polymers and have a single molecular weight, while
Polydisperse PEG are heterogeneous and contain polymer chains of unequal length.
Thus the polydisperse PEG molecular weight is not a single value—the polymer
exists as a distribution of chain lengths and molecular weights.
Polydisperse PEGs are very useful in the development of PEGylated protein drugs,
helping to increase drug half-life and lower clearance rates. For example, poly PEG
in PEGylated lipid nanoparticles has been used in COVID-19 mRNA vaccines and
gained international attention. PEG lipids have been widely applied to improve the
circulation time of liposome-encapsulated (LNP) drugs and reduce nonspecific
uptake.
Features
• Diverse product structure
• Rich in substitution
• High substitution rate of end group
- Polydisperse PEG Derivatives
6. 6 www.cd-bioparticles.net
Monodisperse PEG products are typically organic compounds with molecular
weights less than 1000. The monodisperse of PEGs may play a role in the
development of safe and effective PEGylated small-molecule drugs, which can
confer flexibility, anticoagulation, anti-macrophage phagocytosis, etc. to the
modified biomolecules. Currently, monodisperse PEGs are used in many fields,
including nanotechnology, drug release, pharmaceutical industry, and biomedical
research.
In drug delivery, PEG can be used as a linker for antibody-drug conjugates (ADCs)
or as a surface coating on nanoparticles to improve systemic drug delivery.
Previous studies have found that the incorporation of monodisperse PEG into
small molecule drugs can increase the solubility and molecular weight of the drug,
thereby prolonging the half-life of the drug in vivo, while reducing the steric
hindrance and binding effects generated when the protein is modified by high-
molecular PEG.
- Monodisperse PEG Derivatives
Product Name
Structural
Formula
CAS No. Structural Formula
HO-PEG1-
CH2CH2COOtBu
C9H18O4 671802-00-9
H2N-PEG2-
CH2CH2COOtBu
C11H23NO4 756525-95-8
N3-PEG3-
OH2CH2COONHS Ester
C13H20N4O7 1245718-89-1
N3-PEG4-OH C8H17N3O4 86770-67-4
N3-PEG6-CH2COOH C14H27O8N3 880129-82-8
N3-PEG10-CH2CH2NH2 C22H46O10N4 912849-73-1
7. www.cd-bioparticles.net
- Monodisperse PEG Derivatives
Product Name
Structural
Formula
CAS No. Structural Formula
Fmoc-NH-PEG5-
CH2CH2COOH
C28H37NO9 882847-32-7
Boc-NH-PEG3-
CH2CH2COOH
C14H27NO7 1347750-75-7
N3-PEG6-CH2CO2-NHS C18H30N4O14 --
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