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American Diabetes Association (ADA)
   71st Scientific Sessions, San Diego, CA
   June 24 to 28, 2011

   Twitter Buzz Analysis – June 24 to 28, 2011



   Tanmay Saraykar – Manager, Social Media Analytics                  www.pharmarc.com

© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.
Index

                Twitter Charts
                   –     Total Tweets
                   –     Momentum over 10 Days & Peaks
                   –     Roche Social Media Diabetes Summit, Engagement Activities, Buzz and Impact
                   –     #ADA2011 Trends – Most Active Accounts
                             • Sanofi Tweets and Content Classification
                             • Key Social Advocates from Diabetes Online Community
                             • Buzzed Physicians and Profiles
                Stories Shared on Twitter during the Conference, and Opportunities
                   –     Where are you from?
                   –     Video highlights
                   –     Big shift in prescription patterns for T2DM
                   –     Wal-Mart increased prices for branded diabetes drugs
                Competitor Intelligence
                   –     Companies Buzzed about during ADA Conference
                   –     Buzzed Drugs and Content
                   –     Sanofi Event – Dribble to Stop Diabetes
                   –     Outdoor Ads – Boehringer Ingleheim and Novo Nordisk



© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.                                   Slide 2
Twitter buzz during the ADA SciSessions conference was mainly
         around three Twitter hashtags


                                       Total Tweets                              #ADA2011: For the
    3,000                                                                        conference, released
                                                                                 by the ADA
                                                     2,555
    2,500                                                                        #dsma: Weekly twitter
                                                                                 chat, organized by
                                                                       2,141     DOC member
                                                                                 (diabetes online
    2,000                 1,878
                                                                                 community),
                                                                                 @DiabetesSocMed

    1,500
                                                                                 #dsummit: Roche
                                                                                 Diabetes Social Media
    1,000
                                                                                 Summit, Hard Rock
                                                                                 Café, San Diego, June
                                                                                 23, 2011
       500


            0
                     #ADA2011                       #dsma             #dsummit


© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.                                      Slide 3
Tweets with different hashtags peaked at different times before, during
         and after the ADA conference

      1,400                                                                            Daily Tweets                                                                  1,311 Tweets
                                                                                      1,147 Tweets                                                                 #dsma (Chat Day)
      1,200                                                                          Roche Diabetes
                                                                                      Social Media                                                                      #ADA2011
                                      894 Tweets                                         Summit
      1,000                                                                                                                                                             #dsma
                                   #dsma (Chat Day)
                                                                                                                                                                        #dsummit
         800
                                                                                                                                                                   #dsummit – peaked
                                                                                                                                                                   before the conference
         600                                                                                                     #ADA2011, official
                                                                                                                  hashtag for ADA                                  #ADA2011 – peaked
                                                                                                                    SciSessions                                    during the conference
         400
                                                                                                                                                                   #dsma – peaked
         200                                                                                                                                                       before and after the
                                                                                                                                                                   conference

             0
                                                                                         24-Jun-11
                       19-Jun-11


                                    20-Jun-11


                                                21-Jun-11


                                                             22-Jun-11


                                                                         23-Jun-11




                                                                                                     25-Jun-11


                                                                                                                   26-Jun-11


                                                                                                                               27-Jun-11


                                                                                                                                           28-Jun-11


                                                                                                                                                       29-Jun-11
© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.                                                                                                               Slide 4
Roche conducted the Diabetes Social Media Summit along the bylines
         of ADA conference

                                                                      Roche Online Social Media Summit

                                                                      Description – A power-packed get-together
                                                                      of 37 diabetes bloggers and “online
                                                                      influencers” during which all topics related
                                                                      to social media and diabetes advocacy
                                                                      were discussed

                                                                      Venue

                                                                      Hard Rock Café – Across from the
                                                                      convention center where ADA Scientific
                                                                      Session 2011 were held

                                                                      Also attended by:

 Topics Discussed:                                                    Isabella Platon – Head of
                                                                      Communications, International Diabetes
 •     Disconnection of IDC from other major advocacy                 Federation
       organizations from US and their hesitation in involving DOC
       (Diabetes Online Community) in their campaigns                 Jeffrey Brewer – CEO of JDRF (Juvenile
 •     Gaps in social media, next steps, how to reach out to          Diabetes Research Foundation)
       disconnected patients and healthcare care providers, future
       vision

© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.                                         Slide 5
Roche representatives presented and discussed various subjects with
         the diabetes online community

                                                                      “Social Media MAKES THINGS HAPPEN. Dan Kane VP of
                                                                      Mkting Roche #dsummit“

                                                                      Roche Marketing head at #dsummit : "We are trying to be genuine
                                                                      and real" Seems odd to have to keep sayin that...

                                                                      “@dLife: It's about more than just selling a product - from Roche
                                                                      #dsummit”
                                                                      Roche asks, "How is social media changing for people with
                                                                      #diabetes, and for the leaders in the diabetes community?" -
                                                                      #dsummit”
                                                                      Roche: "What is the next big thing that all companies should know
                                                                      to help better engage their customers (living with #diabetes)?
                                                                      #dsummit”

                                                                      Dan Kane says Roche Summit has never been about the product.
                                                                      So why? "To be a better company, we have to know you better"
                                                                      #dsummit
                                                                      #dsummit Dan Kane VP Marketing Roche on why roche does this
                                                                      summit. For a first timer clarifying their commitm… (cont)
                                                                      http://deck.ly/~vHJEv

                                                                      RT @saraknic: CDEs say that Roche is the company most
                                                                      interested in helping product behavior change. #dsummit

© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.                                                                   Slide 6
Analysis of sample of 100 tweets that mentioned Roche reveals
         significantly positive brand reputation for Roche

                                     Solicited  % Tweets               Expressed                 Some upcoming initiatives
                                  response from                          intent to               from Roche mentioned in the
                                      Roche                           attend Roche               Tweets
                                       6%                                  event
                                                                           17%                   •   Will launch #Diabetes
       Quoted Dan                                                                                    Heroes Program
        Kane, VP
       Marketing,                                                                                •   Will promote
         Roche                                                                                       #bestbetesblogs,
          17%                                                                   Mentioned a
                                                                                social media         nominations of June
                                                                                 initiative by       posts open until 28th June
                                                                                    Roche
                                                                                      10%




                                                                            Neutral
                                                                             17%
                         Praised
                         Roche's
                         Efforts
                          33%

© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.                                                      Slide 7
Members of the diabetes online community live-tweeted from the
         Roche event and praised Roche’s efforts

                                                         RT @D_Advocates: .@DiabetesSisters bridging the online-offline worlds
                                                         through their PODS meetups program, w the support of @roche_com
                                                         #dsummit

                                                         woot woot! Roche is going to help promote the #bestbetesblogs!! Nominations
                                                         of June posts open until the 28th :) #dsummit

                                                         Closing: It's awesome that Roche is reaching out to the community and
                                                         getting opinions from some of us who represent ALL OF US. #dsma

                                                         RT @dLife: Roche is working to be more real, more direct and more
                                                         supportive to patients with #diabetes. #dsummit

                                                         RT @betizuka: Accu-Check Cash Card is here! Test strips prescriptions for
                                                         less. Good job, Roche! #dsummit

                                                         @woodonwheels @lifewithtype1 @tmana I think Roche picked a pretty great
                                                         group of people to represent our community! :) #dsummit

                                                         Closing: Love you all and thanks for representing us so well! Proud of Roche
                                                         and other companies for embracing us! #dsma

                                                         Proud of Roche and other companies for embracing the online D-community!
                                                         #dsma Ahem, Ahem to the others still waiting... CC: @mod4acure


© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.                                                              Slide 8
Encouragement from Roche to the diabetes online community
         resonated positively in the diabetes blogosphere
                                                                                       @RotoTok says “you guys are
                                                                      Following: 486   just beginning to understand
                                                                                       how powerful you are when
                                                                      Followers: 390   you come together and work
                                                                                       on an idea” #dsummit (To
                                                                                       Diabetes Online Community at
                                                                                       the summit)


                                                                                       One of my favorite people to
                                                                                       visit with is Bennet from Your
                                                                                       Diabetes May Vary. Two of his
                                                                                       four kids live with type 1
                                                                                       diabetes, and he lives with
                                                                                       type 2 diabetes. He said that
                                                                                       one of the biggest things
                                                                                       Roche gives us is something I
                                                                                       know I didn’t fully appreciate;
                                                                                       the opportunity to get to know
                                                                                       each other better. He didn’t
                                                                                       mean Roche and the
                                                                                       attendees, although that is
                                                                                       valuable too. What he meant
                                                                                       was US getting to know US
                                                                                       better. Thank you Roche.


© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.                                             Slide 9
Analysis for #ADA2011 – Official Twitter Hashtag Released by ADA



                                                                     #ADA2011
       500                                                                                                                                                Total Tweets –
                                                                                              462
       450                                                                                                                                                1,878
                                                                                                          403
       400

       350                                                                                                            322
       300                                                                        291

       250

       200

       150                                                           120                                                          129

       100
                                 39                      43                                                                                   39
         50                                  29
                      1
            0
                                             21-Jun-11




                                                                                                          26-Jun-11
                     19-Jun-11


                                 20-Jun-11




                                                         22-Jun-11


                                                                      23-Jun-11


                                                                                  24-Jun-11


                                                                                              25-Jun-11




                                                                                                                      27-Jun-11


                                                                                                                                  28-Jun-11


                                                                                                                                              29-Jun-11
© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.                                                                                                  Slide 10
The top 20 most active Twitter accounts during the conference includes
         Sanofi Aventis high up in the list
                                                                             No. of Tweets
           OmniPodNA                                                                                                                 89
        MiriamETucker                                                                                     56
       Diabetes_sanofi                                                                                    56
        iam_spartacus                                                                                50
           deb_ruppert                                                                              49
                 NDEP                                                                         44
        endocrinologia                                                                        44
      CureT1Diabetes                                                                     41
        synchealthcare                                                                 39
             askmanny                                                             36
      AmDiabetesVols                                                            34
          diabetesdaily                                                    31
     AmDiabetesAssn                                                       30                              Diabetes_Sanofi was the only corporate
        BirdWingPress                                                   28                                account among the 25 most active twitter
    1stRManagedCare                                                     28                                accounts
        ClinEndoNews                                               22
             diabeteshf                                          20
     SciSessions2011                                      16
           MarkHarmel                                     16
          InsulinFairies                                  16
         DeliciousBuzz                                    16
       Diabetic_Iz_Me                                    15
              cme_doc                                    15
         DiabetesMine                                   14
        DiabetesLiving                                  14
                                 0             10             20        30         40              50      60      70       80      90      100


© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.                                                                         Slide 11
Sanofi’s Twitter account was far more active as compared to those of
         other companies competing in the diabetes space

                                                              # of tweets by companies
      60
                        56                Sanofi has, by far the most
                                          active corporate Twitter Account
                                          during ADA
      50



      40



      30



      20


                                                  11
      10                                                                   7
                                                                                        4             4
                                                                                                                    2
        0
             Diabetes_sanofi novonordisktbl                           boehringerus   SanofiUS   AstraZenecaUS   Boehringer

© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.                                                          Slide 12
Content classification of tweets from Sanofi account reveals variety of
         activities
                                                                                             Examples
                                               Tweets                 Asking for
                                                                      response/              Retweeting others: RT @iam_spartacus:
                                                                       General               Heard someone from Dublin ask a question to
                                                                         16%                 a presenter from Japan. Diabetes knows no
                                                                                             borders. #ada2011
                                                                                             Asking for response: What's been your
                                                                                             favorite part of #ADA2011 so far?
                                                                                          Dispersing ideas data/helping diabetics:
                                                                                          Need to train more educators and have them
                                                                              Dispersing effectively prepared to make a difference.
Retweeting                                                                    ideas/data, #ADA2011
  others                                                                        helping
   47%                                                                         diabetics Inviting for a Sanofi Event: Come meet
                                                                                 16%      former @NBA basketball player Chris Dudley
                                                                                          at the Dribble to Stop Diabetes (DTSD) event
                                                                                          at #ADA2011 Sails Pavilion
                                                                                             Promoting Sanofi blog: Check out the latest
                                                                                             Discuss #Diabetes #dblog post recapping
                                                                                             Day 1 of #ADA2011 http://ow.ly/5qepv
                                                                            Inviting for a
                                                                               Sanofi        Total tweets - 60
                                                     Promoting                  Event
                                                     Sanofi blog                 12%
                                                        9%

© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.                                                             Slide 13
Most Active Twitter Accounts during Conference –
         Key Social Advocates from Diabetes Online Community
                                                                            No. of Tweets
          OmniPodNA                                                                                                           89
       MiriamETucker                                                                                     56
      Diabetes_sanofi                                                                                    56
       iam_spartacus                                                                                50
          deb_ruppert                                                                              49
                NDEP                                                                         44
       endocrinologia                                                                        44
     CureT1Diabetes                                                                     41
       synchealthcare                                                                 39
            askmanny                                                             36
     AmDiabetesVols                                                            34                 Manny Hernandez (DOC)
         diabetesdaily                                                    31
    AmDiabetesAssn                                                       30
       BirdWingPress                                                   28
   1stRManagedCare                                                     28
       ClinEndoNews                                               22
            diabeteshf                                          20
    SciSessions2011                                      16                                        Cherise Shockley (DOC)
          MarkHarmel                                     16
         InsulinFairies                                  16
        DeliciousBuzz                                    16
      Diabetic_Iz_Me                                    15
             cme_doc                                    15
        DiabetesMine                                   14
       DiabetesLiving                                  14
                                0             10            20         30         40              50      60    70      80   90    100


© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.                                                                Slide 14
KSAs – Key Social Advocates Examples

             Cherise Shockley
                                                                      Manny Hernandez




© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.                     Slide 15
Key Social Advocate for diabetes – Ms. Cherise Shockley

                                                                                     Activity Profile
                                                                                     Diabetes Social Media Advocacy –
                                                                                     Online community that chats weekly on
                                                                                     Twitter
                                                                                     Twitter Followers – 1,380


                                               Founder Profile                       Topics for DSMA Blog Carnival

                                               Founder - Cherise Shockley, Type 1    •   June 2011 – Troubleshooting
                                               diabetic                                  Diabetes

                                               Blog - Own - http://diabetic-iz-      •   May 2011 – Type Awesome –
                                               me.com/                                   People who support PWDs
                                               Featured Diabetes Blogger –
                                               www.diabetesdaily.com (Estimated      •   April 2011 – Life Stages with
                                               monthly page view – 610,000)              Diabetes

                                               Moderator - (#dsma) Diabetes Social   •   March 2011 – Exercise does a
                                               Media Advocacy Twitter Chat               body good

                                               Participant – Diabetes Annual Blog    •   Feb 2011 – The most awesome
                                               Week, May 2011                            thing I have ever done inspite of
                                                                                         diabetes
                                               Organizer – DSMA Blog Carnival
                                               (2011)
© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.                                                      Slide 16
Key social advocate for diabetes - Manny Hernandez, Berkley, CA

                                                                                                Type 1 diabetic since 2001
                                                                                                Non Profit Leader
                                                                                                Social Media Author
                                                                                                Consultant
                                                                                                Passionate Diabetes Advocate

                                                                                                Significant Contributor to the
                                                                                                Diabetes Hand Awareness
                                                                                                Program
   Twitter -                           Founder                                                  tudiabetes.org
   @askmanny                                                                                    Estudiabetes.org
   Tweets – 24,547                                                                              A community of people
   Following – 602                                                                              touched by diabetes, run
   Followers – 6,125                                                                            by the diabetes hands
   Listed – 528                                                                                 foundation

                                                    App – TuAnalyse is an application jointly developed by Tudiabetes.org and
                                                    Children’s Hospital Boston

                                                    Mission – To empower people touched by diabetes to track, share and
                                                    compare their health information for research advancing diabetes care and
                                                    public health response

                                                    Function – Recording and sharing the measure of diabetes patients

© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.                                                              Slide 17
Doctors/physicians were quoted in the tweets by attendees of the
         conference

                                  Doctors/Physicians – No. of Mentions
             Dr. Bill Polonsky                                                                           19
     Dr. Doug Throckmorton                                                                          14
     Dr. Steven E. Kahn, MD                                                                    12
           Dr. Trevor Orchard                                                             10
                     Dr. Albright                                                     9
                   Dr. W. Ward                                                    8
                       Dr. Tuttle                                                 8
                   Dr. T. Danne                                               7
          Dr. Aaron Kowalski                                              6
                    Dr. D. Elleri                                         6
           Dr. Bill Tamborlane                                        5
               Dr. Satish Garg                                  4
                    Dr. S. Heller                          3
              Dr. Henry Anhalt                             3
    Dr. Judith E. Fradkin, MD                              3
                 Dr Faustman                           2
               Dr. R. Frykberg                         2
             Dr. Daniel Lorber                         2
              Dr. Ron Tamler                       1
                     Dr. Skyler                    1
       Dr. Johnny Ludvigsson                       1
                   Dr. Irl Hirsch                  1
                                            0                    5                    10            15   20

© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.                                           Slide 18
Dr. William Polonsky, PhD, CDE
                                                                             Dr. William Polonsky
                                                                             gives practical
                                                                             advice for dealing
                                                                             with the emotional
                                      Founder/Pres.                          side of diabetes.
                                      Behavioral                             This segment aired
                                      Diabetes                               Jan. 27, 2008, and is
                                      Institute                              sponsored by Accu-
                                                                             Chek. (Roche)
                                                                                                     Author –
   Dr. Polonsky, PhD, CDE
                                                                                                     Diabetes
   • Associate Clinical Professor in Psychiatry at the University of California,
                                                                                                     Burnout -
       San Diego
                                                                                                     What to Do
   • PhD in clinical psychology from Yale University
                                                                                                     When You
   • Served as Chairman of the National Certification Board for Diabetes
                                                                                                     Can’t Take it
       Educators, Senior Psychologist at the Joslin Diabetes Center in Boston,
                                                                                                     Anymore, a
       and Instructor in Psychiatry at Harvard Medical School
                                                                                                     book for
   • He is an active researcher in behavioral diabetes, with his most recent
                                                                                                     patients
       projects focusing on the utility of home blood glucose monitoring in type 2
                                                                                                     published by
       diabetes, the emotional and behavioral consequences of being diagnosed
                                                                                                     the American
       with diabetes, and the value of diabetes self-management support training
                                                                                                     Diabetes
       for health care professionals
                                                                                                     Association
   • Dr. Polonsky has served on the editorial boards of Diabetes Care, Diabetes
       Forecast, Clinical Diabetes, Diabetes Self-Management and Diabetes
       Health

© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.                                        Slide 19
Dr. Doug Throckmorton, US FDA
                                                        Douglas Throckmorton, M.D.
                                                        Deputy Director, Center for Drug Evaluation and Research (CDER)
                                                        U.S. Food and Drug Administration (FDA)

                                                        Dr. Throckmorton joined FDA in 1997 and has been acting Deputy
                                                        Director of CDER since May 2004.

                                                        Dr. Throckmorton is Board-certified in Internal Medicine and Nephrology,
                                                        having received his training at the University of Nebraska Medical
                                                        School, Case Western Reserve University and Yale University. Prior to
                                                        coming to the FDA, he practiced medicine at the Medical College of
                                                        Georgia in Augusta, Georgia.

                                                    Quotes from the Conference (that mentioned Dr. Throckmorton)
 Dr. Douglas Throckmorton
 Internal Medicine,                                 •     2008 guidance on diabetes drugs didn't kill development #ADA2011
 Nephrology                                         •     There were 63 investigational new drug applications between Jan. 1, 2006
                                                          and Nov. 30, 2008
                                                    •     Since Dec. 1, 2008, there have been 70 NID applications for diabetes drugs
                                                    •     There's no evidence of a decline in diabetes IND applicants since CV
                                                          guidance was released
                                                    •     The complexity of #diabetes drug development is worth remembering. Each
                                                          patient is unique
                                                    •     FDA takes the efficient development and appropriate use of medical
                                                          treatments for diabetes seriously

© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.                                                                Slide 20
Analysis of various stories/news shared on Twitter reveals buzz on
         various topics – No single story stands out

   Story shared on Twitter                                                              # (Re)Tweeted

   The Role of Vitamin D in Type 1 and Type 2 #Diabetes                                         21

   Act on Diabetes NOW! An inspiring call-to-action from the Pres. of @IntDiabetesFed           18

   Where are you from?                                                                          17

   Scientific Sessions Update: Carbs, Protein or Calories?                                      16

   Video highlights from the 71st Scientific Sessions                                           16

   National Diabetes Fact Sheet                                                                 16

   Cardiovascular Disease Risks Appear Early in Girls with Type 1 #Diabetes                     16

   Advances in Type 1 Treatment                                                                 16

   Chris Dudley at the Dribble to Stop Diabetes event - Sponsored by Sanofi Aventis             15

   Live Long with Type 1: An update from our Scientific Sessions!                               13

   Big Shift Seen in Prescription Patterns for Type 2 #Diabetes.                                10

   Behind the Scenes of the World's Largest #Diabetes Meeting                                   10

   Action Shot: Red Rider Alexis Pollak shows off her cycling skills                            10


© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.                                     Slide 21
Analysis of various stories/news shared on Twitter reveals buzz on
         various topics – No single story stands out

   Story shared on Twitter                                                                   # (Re) Tweeted

   Progress on the Artificial Pancreas                                                             10

   Data for newly approved Boehringer Ingelheim/Lilly type 2 #diabetes treatment                    9

   Life For a Child program growing from keeping kids alive to keeping them healthy.                9

   Pts drinking > 2 diet sodas/ day saw a 2x increase in waist circumference over 9 years.          9

   Cellnovo patch pump has cell PDA, uploads data to net automatically. Has pedometer to            9
   know when you're active.
   Diabetes Product Updates                                                                         9

   Screening and Early Intervention are Key                                                         8

   Continuous Glucose Monitoring in the Youngest Patients                                           8

   Diabetes Prevention is Cost Effective                                                            8

   Prevention Program for Native American Youth                                                     7

   Depression is what causes the complications                                                      7

   Wal-Mart hikes branded diabetes drug prices-study                                                6

   Merck retro study: Risk of CVD events 23% higher in elder #diabetes ptts started on              5
   sulfonylureas vs. metformin.

© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.                                     Slide 22
The activities around the conference presented several opportunities
         for engaging attendees

                                                                      A global map
                                                                      with pins to point
                                                                      out “Where are
                                                                      you from?”


                                                                      52% of the
                                                                      attendees are
                                                                      from outside
                                                                      USA


                                                                      Opportunity
                                                                      Sponsoring this
                                                                      board would
                                                                      have been a
                                                                      great way to
                                                                      generate brand
                                                                      awareness




© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.               Slide 23
Live coverage through video or live tweets received high attention
   online – great resource of information for those who couldn’t attend

                                                                      Dr. Steven E Kahn, MD,
                                                                      Puget Sound Health
                                                                      Care System – Reports
                                                                      on future direction of
                                                                      treatments of diabetes
                                                                      and obesity as reported   Opportunity
                                                                      at 71st Scientific
                                                                                                Proactively reporting
                                                                      Sessions in San Diego
                                                                                                events and summary of
                                                                                                presentations directly
                                                                                                from event draw
                                                                                                significant real time
                                                                                                attention and buzz (Dr.
                                                                                                Kahn and Miriam
                                                                                                Tucker, as in the
                                                                                                examples shown)
                                                                      Twitter
                                                                                                Sanofi also posted daily
                                                                      Tweets – 9,068
                                                                                                reports of activities on
                                                                      Followers – 3,227
                                                                                                their blog
                                                                      ADA SciSessions
                                                                      Tweeted – 56 times
                                                                      Retweeted – 105 times




© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.                                               Slide 24
Stories and Engagement Opportunities – Big shift in prescription
         patters for type 2 diabetes mellitus

                                                                      Data Source: A study of 7,846 patients
                                                                      with type 2 diabetes at the Joslin
                                                                      Diabetes Center, Boston, who had
                                                                      9,178 new prescriptions for
                                                                      rosiglitazone, pioglitazone, and other
                                                                      agents from 2001-2010.

                                                                          Findings - Relative proportion
                                                                            of prescriptions for T2DM
                                                                              Year 2005      Year 2010
                                                                                                          80%

                                                                        44%          50%
   Using Electronic Health Records to track prescribing
   patterns – Rise of novel type 2 diabetes drugs noted after                             18%
                                                                              2%                     6%
   2007 - At the annual scientific sessions of the American
   Diabetes Association, Dr. Sanjeev N. Mehta presented               rosiglitazone pioglitazone     other
   findings from a study of electronic medical records at Joslin                                   medications
   Diabetes Center, Boston, that evaluated 10-year
   prescribing patterns for rosiglitazone and pioglitazone, as        Opportunity
   well as uptake of novel drug classes (categorized as
                                                                      Identifying researchers, subject matter
   "other") approved between 2001 and 2010. The "other"
                                                                      experts, KOLs, etc. In this example, Dr.
   group consisted of amylin analogs, GLP-1 analogs, DPP-IV
                                                                      Mehta is a Pediatric Endocrinologist and
   inhibitors, and bile acid sequestrants. Insulin use was not
                                                                      an Instructor in Medicine, Harvard
   studied, nor were medications introduced prior to 2001.
                                                                      Medical School
                                                                                                                 Slide 25
© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.                                              Slide 25
Interesting study on the retail pricing of diabetes drugs in the US was
         presented - Wal-Mart hikes branded diabetes drugs prices

                                                                      Study by - Dr. Ronald Tamler, an endocrinologist at New York's
                                                                      Mount Sinai Medical Center, and co-author of the price study


                                                                      Overall findings – Industry
                                                                      Prices for generic diabetes       Prices for brand-name
                                                                      drugs (2008-2010)                 diabetes drugs (2008-2010)



                                                                                                                        113%
                                                                                      58%


                                                                              Price increase for 10 most prescribed
                                                                                  diabetes drugs - 2008 to 2010
                                                                             35%
                                                                                                32%

   Shared on                                                                                                      21%

   Twitter – 104 times
   LinkedIn – 7
   Facebook Recommendations – 70
                                                                            K-Mart           Wal-Mart         Industry-Avg.
© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.                                                            Slide 26
As for the most mentioned company in Tweets by attendees or DOC,
         Sanofi was a clear winner


                                                                      # mentioned in tweets
100
                      77
  80
  60
  40
                                                    21
  20                                                                      15
                                                                                         8                5                 2
    0
                   Sanofi                    Boehringer                   Lilly    Novo Nordisk         Abbott           Roche
                                             Ingelheim
           Actively                       Data for newly approved                  Liraglutide -    Donated to       Note: Not
           engaged the                    Boehringer Ingleheim/Lilly type          sustained        ADA San          much buzz
           diabetes                       2 #diabetes treatment                    weight loss at   Diego, for       with
           community at                   presented – New Phase III data           56 weeks in      being the host   #ADA2011,
           ADA                            and pooled analysis for                  non-diabetic,    city of          but ample
                                          linagliptin show improved blood          obese            SciSessions,     activity around
           Organized                      sugar control in adults with type        individuals      2011             #dsummit,
           event “Dribble                 2 diabetes when used alone                                                 Roche
           for diabetes”                  and with metformin                       Sponsored                         Diabetes
                                                                                   ADA@5K,                           Social Media
           Tweeted ideas                                                           morning walk                      Summit
           – Diabetes                                                              on San Diego
           Midwives                                                                Waterfront
© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.                                                             Slide 27
Although relatively low, there was some buzz around metformin and
         dapagliflozin

   Metformin (18)
   •     Some poor countries have such high taxes on insulin and metformin that at-cost product is completely
         unaffordable after taxes
   •     Metformin costs a fraction of a cent to produce
   •     Merck retro study: Risk of CVD events 23% higher in elderly #diabetes patients started on sulfonylureas
         vs. metformin
   •     Starting Elderly #Diabetes Patients on Metformin May Reduce Cardiovascular Disease Risk
   •     Risk-benefit assessment of anti-diabetic drugs shows metformin as most efficacious
   •     Is Afressa by $MNKD the simplest approval that FDA made complex? Risk-benefit more tolerable than
         Avandia or metformin
   •     Long-term cost effectiveness evaluation of DPP and DPPOS gives resounding thumbs up to use of
         metformin
   •     Reusing lancets; forgetting metformin doses; blowing a good carb intake week with a night out with the
         girls
   •     Metformin decided to turn on me and ruin my insides. On week 2 of titration. Any thoughts?

   Dapagliflozin (2)
   •     Dapagliflozin Effective at 102 Weeks, but Drug Poses Breast and Bladder Cancer Risk
   •     Dapagliflozin non-inferior to metformin in lowering A1c, superior in lowering FPG, weight. Sig more UTI,
         genital infects in women




© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.                                          Slide 28
CI – Sanofi Event – Dribble to Stop Diabetes – A diabetes awareness
         initiative with NBA players, sponsored by Sanofi




                                                Sanofi Aventis – Dribble to     Dennis Ubraniak from Sanofi
                                                Stop Diabetes event with        USA at the event, contributing
                                                former NBA Player, Chris        to YMCA San Diego County
                                                Dudley at Sails Pavilion, San   on behalf of the partnership
                                                Diego, CA




© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.                                              Slide 29
CI – Outdoor Advertising –
         Boehringer Ingleheim and Novo Nordisk

                                                                      Outdoor Ads for –
                                                                      Tradjenta (Linagliptin)




                                                                      Novo Nordisk –
                                                                      Levemir Pen




© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.                             Slide 30
For further information on this document, please contact:



         Tanmay Saraykar
         Manager, Social Media Analytics
         +91 7829909766
         tanmay.saraykar@pharmarc.com


         Corporate Headquarters                                       Europe                              USA
         PharmARC Analytic Solutions Pvt. Ltd.                        PharmARC Consulting Services GmbH   PharmARC Inc.
         Mercury 2B Block, 6th Floor                                  Blumenrain 16                       100 Overlook Center
         Prestige Technology Park                                     4051 Basel                          2nd Floor, Princeton, NJ 08540
         Sarjapur – Marathahalli Outer Ring Road                      Switzerland                         USA
         Bangalore 560 103, India

         T +91 (80) 4123 8900                                         T +41 (61) 261 8900                 T +1 (609) 450 1880
         F +91 (80) 4123 8999                                         F +41 (61) 261 8901                 F +1 (609) 895 2666




© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.                                                                        Slide 31

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American Diabetes Association Scientific Sessions Twitter Buzz Analysis by PharmARC

  • 1. American Diabetes Association (ADA) 71st Scientific Sessions, San Diego, CA June 24 to 28, 2011 Twitter Buzz Analysis – June 24 to 28, 2011 Tanmay Saraykar – Manager, Social Media Analytics www.pharmarc.com © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.
  • 2. Index  Twitter Charts – Total Tweets – Momentum over 10 Days & Peaks – Roche Social Media Diabetes Summit, Engagement Activities, Buzz and Impact – #ADA2011 Trends – Most Active Accounts • Sanofi Tweets and Content Classification • Key Social Advocates from Diabetes Online Community • Buzzed Physicians and Profiles  Stories Shared on Twitter during the Conference, and Opportunities – Where are you from? – Video highlights – Big shift in prescription patterns for T2DM – Wal-Mart increased prices for branded diabetes drugs  Competitor Intelligence – Companies Buzzed about during ADA Conference – Buzzed Drugs and Content – Sanofi Event – Dribble to Stop Diabetes – Outdoor Ads – Boehringer Ingleheim and Novo Nordisk © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 2
  • 3. Twitter buzz during the ADA SciSessions conference was mainly around three Twitter hashtags Total Tweets #ADA2011: For the 3,000 conference, released by the ADA 2,555 2,500 #dsma: Weekly twitter chat, organized by 2,141 DOC member (diabetes online 2,000 1,878 community), @DiabetesSocMed 1,500 #dsummit: Roche Diabetes Social Media 1,000 Summit, Hard Rock Café, San Diego, June 23, 2011 500 0 #ADA2011 #dsma #dsummit © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 3
  • 4. Tweets with different hashtags peaked at different times before, during and after the ADA conference 1,400 Daily Tweets 1,311 Tweets 1,147 Tweets #dsma (Chat Day) 1,200 Roche Diabetes Social Media #ADA2011 894 Tweets Summit 1,000 #dsma #dsma (Chat Day) #dsummit 800 #dsummit – peaked before the conference 600 #ADA2011, official hashtag for ADA #ADA2011 – peaked SciSessions during the conference 400 #dsma – peaked 200 before and after the conference 0 24-Jun-11 19-Jun-11 20-Jun-11 21-Jun-11 22-Jun-11 23-Jun-11 25-Jun-11 26-Jun-11 27-Jun-11 28-Jun-11 29-Jun-11 © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 4
  • 5. Roche conducted the Diabetes Social Media Summit along the bylines of ADA conference Roche Online Social Media Summit Description – A power-packed get-together of 37 diabetes bloggers and “online influencers” during which all topics related to social media and diabetes advocacy were discussed Venue Hard Rock Café – Across from the convention center where ADA Scientific Session 2011 were held Also attended by: Topics Discussed: Isabella Platon – Head of Communications, International Diabetes • Disconnection of IDC from other major advocacy Federation organizations from US and their hesitation in involving DOC (Diabetes Online Community) in their campaigns Jeffrey Brewer – CEO of JDRF (Juvenile • Gaps in social media, next steps, how to reach out to Diabetes Research Foundation) disconnected patients and healthcare care providers, future vision © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 5
  • 6. Roche representatives presented and discussed various subjects with the diabetes online community “Social Media MAKES THINGS HAPPEN. Dan Kane VP of Mkting Roche #dsummit“ Roche Marketing head at #dsummit : "We are trying to be genuine and real" Seems odd to have to keep sayin that... “@dLife: It's about more than just selling a product - from Roche #dsummit” Roche asks, "How is social media changing for people with #diabetes, and for the leaders in the diabetes community?" - #dsummit” Roche: "What is the next big thing that all companies should know to help better engage their customers (living with #diabetes)? #dsummit” Dan Kane says Roche Summit has never been about the product. So why? "To be a better company, we have to know you better" #dsummit #dsummit Dan Kane VP Marketing Roche on why roche does this summit. For a first timer clarifying their commitm… (cont) http://deck.ly/~vHJEv RT @saraknic: CDEs say that Roche is the company most interested in helping product behavior change. #dsummit © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 6
  • 7. Analysis of sample of 100 tweets that mentioned Roche reveals significantly positive brand reputation for Roche Solicited % Tweets Expressed Some upcoming initiatives response from intent to from Roche mentioned in the Roche attend Roche Tweets 6% event 17% • Will launch #Diabetes Quoted Dan Heroes Program Kane, VP Marketing, • Will promote Roche #bestbetesblogs, 17% Mentioned a social media nominations of June initiative by posts open until 28th June Roche 10% Neutral 17% Praised Roche's Efforts 33% © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 7
  • 8. Members of the diabetes online community live-tweeted from the Roche event and praised Roche’s efforts RT @D_Advocates: .@DiabetesSisters bridging the online-offline worlds through their PODS meetups program, w the support of @roche_com #dsummit woot woot! Roche is going to help promote the #bestbetesblogs!! Nominations of June posts open until the 28th :) #dsummit Closing: It's awesome that Roche is reaching out to the community and getting opinions from some of us who represent ALL OF US. #dsma RT @dLife: Roche is working to be more real, more direct and more supportive to patients with #diabetes. #dsummit RT @betizuka: Accu-Check Cash Card is here! Test strips prescriptions for less. Good job, Roche! #dsummit @woodonwheels @lifewithtype1 @tmana I think Roche picked a pretty great group of people to represent our community! :) #dsummit Closing: Love you all and thanks for representing us so well! Proud of Roche and other companies for embracing us! #dsma Proud of Roche and other companies for embracing the online D-community! #dsma Ahem, Ahem to the others still waiting... CC: @mod4acure © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 8
  • 9. Encouragement from Roche to the diabetes online community resonated positively in the diabetes blogosphere @RotoTok says “you guys are Following: 486 just beginning to understand how powerful you are when Followers: 390 you come together and work on an idea” #dsummit (To Diabetes Online Community at the summit) One of my favorite people to visit with is Bennet from Your Diabetes May Vary. Two of his four kids live with type 1 diabetes, and he lives with type 2 diabetes. He said that one of the biggest things Roche gives us is something I know I didn’t fully appreciate; the opportunity to get to know each other better. He didn’t mean Roche and the attendees, although that is valuable too. What he meant was US getting to know US better. Thank you Roche. © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 9
  • 10. Analysis for #ADA2011 – Official Twitter Hashtag Released by ADA #ADA2011 500 Total Tweets – 462 450 1,878 403 400 350 322 300 291 250 200 150 120 129 100 39 43 39 50 29 1 0 21-Jun-11 26-Jun-11 19-Jun-11 20-Jun-11 22-Jun-11 23-Jun-11 24-Jun-11 25-Jun-11 27-Jun-11 28-Jun-11 29-Jun-11 © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 10
  • 11. The top 20 most active Twitter accounts during the conference includes Sanofi Aventis high up in the list No. of Tweets OmniPodNA 89 MiriamETucker 56 Diabetes_sanofi 56 iam_spartacus 50 deb_ruppert 49 NDEP 44 endocrinologia 44 CureT1Diabetes 41 synchealthcare 39 askmanny 36 AmDiabetesVols 34 diabetesdaily 31 AmDiabetesAssn 30 Diabetes_Sanofi was the only corporate BirdWingPress 28 account among the 25 most active twitter 1stRManagedCare 28 accounts ClinEndoNews 22 diabeteshf 20 SciSessions2011 16 MarkHarmel 16 InsulinFairies 16 DeliciousBuzz 16 Diabetic_Iz_Me 15 cme_doc 15 DiabetesMine 14 DiabetesLiving 14 0 10 20 30 40 50 60 70 80 90 100 © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 11
  • 12. Sanofi’s Twitter account was far more active as compared to those of other companies competing in the diabetes space # of tweets by companies 60 56 Sanofi has, by far the most active corporate Twitter Account during ADA 50 40 30 20 11 10 7 4 4 2 0 Diabetes_sanofi novonordisktbl boehringerus SanofiUS AstraZenecaUS Boehringer © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 12
  • 13. Content classification of tweets from Sanofi account reveals variety of activities Examples Tweets Asking for response/ Retweeting others: RT @iam_spartacus: General Heard someone from Dublin ask a question to 16% a presenter from Japan. Diabetes knows no borders. #ada2011 Asking for response: What's been your favorite part of #ADA2011 so far? Dispersing ideas data/helping diabetics: Need to train more educators and have them Dispersing effectively prepared to make a difference. Retweeting ideas/data, #ADA2011 others helping 47% diabetics Inviting for a Sanofi Event: Come meet 16% former @NBA basketball player Chris Dudley at the Dribble to Stop Diabetes (DTSD) event at #ADA2011 Sails Pavilion Promoting Sanofi blog: Check out the latest Discuss #Diabetes #dblog post recapping Day 1 of #ADA2011 http://ow.ly/5qepv Inviting for a Sanofi Total tweets - 60 Promoting Event Sanofi blog 12% 9% © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 13
  • 14. Most Active Twitter Accounts during Conference – Key Social Advocates from Diabetes Online Community No. of Tweets OmniPodNA 89 MiriamETucker 56 Diabetes_sanofi 56 iam_spartacus 50 deb_ruppert 49 NDEP 44 endocrinologia 44 CureT1Diabetes 41 synchealthcare 39 askmanny 36 AmDiabetesVols 34 Manny Hernandez (DOC) diabetesdaily 31 AmDiabetesAssn 30 BirdWingPress 28 1stRManagedCare 28 ClinEndoNews 22 diabeteshf 20 SciSessions2011 16 Cherise Shockley (DOC) MarkHarmel 16 InsulinFairies 16 DeliciousBuzz 16 Diabetic_Iz_Me 15 cme_doc 15 DiabetesMine 14 DiabetesLiving 14 0 10 20 30 40 50 60 70 80 90 100 © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 14
  • 15. KSAs – Key Social Advocates Examples Cherise Shockley Manny Hernandez © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 15
  • 16. Key Social Advocate for diabetes – Ms. Cherise Shockley Activity Profile Diabetes Social Media Advocacy – Online community that chats weekly on Twitter Twitter Followers – 1,380 Founder Profile Topics for DSMA Blog Carnival Founder - Cherise Shockley, Type 1 • June 2011 – Troubleshooting diabetic Diabetes Blog - Own - http://diabetic-iz- • May 2011 – Type Awesome – me.com/ People who support PWDs Featured Diabetes Blogger – www.diabetesdaily.com (Estimated • April 2011 – Life Stages with monthly page view – 610,000) Diabetes Moderator - (#dsma) Diabetes Social • March 2011 – Exercise does a Media Advocacy Twitter Chat body good Participant – Diabetes Annual Blog • Feb 2011 – The most awesome Week, May 2011 thing I have ever done inspite of diabetes Organizer – DSMA Blog Carnival (2011) © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 16
  • 17. Key social advocate for diabetes - Manny Hernandez, Berkley, CA Type 1 diabetic since 2001 Non Profit Leader Social Media Author Consultant Passionate Diabetes Advocate Significant Contributor to the Diabetes Hand Awareness Program Twitter - Founder tudiabetes.org @askmanny Estudiabetes.org Tweets – 24,547 A community of people Following – 602 touched by diabetes, run Followers – 6,125 by the diabetes hands Listed – 528 foundation App – TuAnalyse is an application jointly developed by Tudiabetes.org and Children’s Hospital Boston Mission – To empower people touched by diabetes to track, share and compare their health information for research advancing diabetes care and public health response Function – Recording and sharing the measure of diabetes patients © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 17
  • 18. Doctors/physicians were quoted in the tweets by attendees of the conference Doctors/Physicians – No. of Mentions Dr. Bill Polonsky 19 Dr. Doug Throckmorton 14 Dr. Steven E. Kahn, MD 12 Dr. Trevor Orchard 10 Dr. Albright 9 Dr. W. Ward 8 Dr. Tuttle 8 Dr. T. Danne 7 Dr. Aaron Kowalski 6 Dr. D. Elleri 6 Dr. Bill Tamborlane 5 Dr. Satish Garg 4 Dr. S. Heller 3 Dr. Henry Anhalt 3 Dr. Judith E. Fradkin, MD 3 Dr Faustman 2 Dr. R. Frykberg 2 Dr. Daniel Lorber 2 Dr. Ron Tamler 1 Dr. Skyler 1 Dr. Johnny Ludvigsson 1 Dr. Irl Hirsch 1 0 5 10 15 20 © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 18
  • 19. Dr. William Polonsky, PhD, CDE Dr. William Polonsky gives practical advice for dealing with the emotional Founder/Pres. side of diabetes. Behavioral This segment aired Diabetes Jan. 27, 2008, and is Institute sponsored by Accu- Chek. (Roche) Author – Dr. Polonsky, PhD, CDE Diabetes • Associate Clinical Professor in Psychiatry at the University of California, Burnout - San Diego What to Do • PhD in clinical psychology from Yale University When You • Served as Chairman of the National Certification Board for Diabetes Can’t Take it Educators, Senior Psychologist at the Joslin Diabetes Center in Boston, Anymore, a and Instructor in Psychiatry at Harvard Medical School book for • He is an active researcher in behavioral diabetes, with his most recent patients projects focusing on the utility of home blood glucose monitoring in type 2 published by diabetes, the emotional and behavioral consequences of being diagnosed the American with diabetes, and the value of diabetes self-management support training Diabetes for health care professionals Association • Dr. Polonsky has served on the editorial boards of Diabetes Care, Diabetes Forecast, Clinical Diabetes, Diabetes Self-Management and Diabetes Health © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 19
  • 20. Dr. Doug Throckmorton, US FDA Douglas Throckmorton, M.D. Deputy Director, Center for Drug Evaluation and Research (CDER) U.S. Food and Drug Administration (FDA) Dr. Throckmorton joined FDA in 1997 and has been acting Deputy Director of CDER since May 2004. Dr. Throckmorton is Board-certified in Internal Medicine and Nephrology, having received his training at the University of Nebraska Medical School, Case Western Reserve University and Yale University. Prior to coming to the FDA, he practiced medicine at the Medical College of Georgia in Augusta, Georgia. Quotes from the Conference (that mentioned Dr. Throckmorton) Dr. Douglas Throckmorton Internal Medicine, • 2008 guidance on diabetes drugs didn't kill development #ADA2011 Nephrology • There were 63 investigational new drug applications between Jan. 1, 2006 and Nov. 30, 2008 • Since Dec. 1, 2008, there have been 70 NID applications for diabetes drugs • There's no evidence of a decline in diabetes IND applicants since CV guidance was released • The complexity of #diabetes drug development is worth remembering. Each patient is unique • FDA takes the efficient development and appropriate use of medical treatments for diabetes seriously © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 20
  • 21. Analysis of various stories/news shared on Twitter reveals buzz on various topics – No single story stands out Story shared on Twitter # (Re)Tweeted The Role of Vitamin D in Type 1 and Type 2 #Diabetes 21 Act on Diabetes NOW! An inspiring call-to-action from the Pres. of @IntDiabetesFed 18 Where are you from? 17 Scientific Sessions Update: Carbs, Protein or Calories? 16 Video highlights from the 71st Scientific Sessions 16 National Diabetes Fact Sheet 16 Cardiovascular Disease Risks Appear Early in Girls with Type 1 #Diabetes 16 Advances in Type 1 Treatment 16 Chris Dudley at the Dribble to Stop Diabetes event - Sponsored by Sanofi Aventis 15 Live Long with Type 1: An update from our Scientific Sessions! 13 Big Shift Seen in Prescription Patterns for Type 2 #Diabetes. 10 Behind the Scenes of the World's Largest #Diabetes Meeting 10 Action Shot: Red Rider Alexis Pollak shows off her cycling skills 10 © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 21
  • 22. Analysis of various stories/news shared on Twitter reveals buzz on various topics – No single story stands out Story shared on Twitter # (Re) Tweeted Progress on the Artificial Pancreas 10 Data for newly approved Boehringer Ingelheim/Lilly type 2 #diabetes treatment 9 Life For a Child program growing from keeping kids alive to keeping them healthy. 9 Pts drinking > 2 diet sodas/ day saw a 2x increase in waist circumference over 9 years. 9 Cellnovo patch pump has cell PDA, uploads data to net automatically. Has pedometer to 9 know when you're active. Diabetes Product Updates 9 Screening and Early Intervention are Key 8 Continuous Glucose Monitoring in the Youngest Patients 8 Diabetes Prevention is Cost Effective 8 Prevention Program for Native American Youth 7 Depression is what causes the complications 7 Wal-Mart hikes branded diabetes drug prices-study 6 Merck retro study: Risk of CVD events 23% higher in elder #diabetes ptts started on 5 sulfonylureas vs. metformin. © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 22
  • 23. The activities around the conference presented several opportunities for engaging attendees A global map with pins to point out “Where are you from?” 52% of the attendees are from outside USA Opportunity Sponsoring this board would have been a great way to generate brand awareness © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 23
  • 24. Live coverage through video or live tweets received high attention online – great resource of information for those who couldn’t attend Dr. Steven E Kahn, MD, Puget Sound Health Care System – Reports on future direction of treatments of diabetes and obesity as reported Opportunity at 71st Scientific Proactively reporting Sessions in San Diego events and summary of presentations directly from event draw significant real time attention and buzz (Dr. Kahn and Miriam Tucker, as in the examples shown) Twitter Sanofi also posted daily Tweets – 9,068 reports of activities on Followers – 3,227 their blog ADA SciSessions Tweeted – 56 times Retweeted – 105 times © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 24
  • 25. Stories and Engagement Opportunities – Big shift in prescription patters for type 2 diabetes mellitus Data Source: A study of 7,846 patients with type 2 diabetes at the Joslin Diabetes Center, Boston, who had 9,178 new prescriptions for rosiglitazone, pioglitazone, and other agents from 2001-2010. Findings - Relative proportion of prescriptions for T2DM Year 2005 Year 2010 80% 44% 50% Using Electronic Health Records to track prescribing patterns – Rise of novel type 2 diabetes drugs noted after 18% 2% 6% 2007 - At the annual scientific sessions of the American Diabetes Association, Dr. Sanjeev N. Mehta presented rosiglitazone pioglitazone other findings from a study of electronic medical records at Joslin medications Diabetes Center, Boston, that evaluated 10-year prescribing patterns for rosiglitazone and pioglitazone, as Opportunity well as uptake of novel drug classes (categorized as Identifying researchers, subject matter "other") approved between 2001 and 2010. The "other" experts, KOLs, etc. In this example, Dr. group consisted of amylin analogs, GLP-1 analogs, DPP-IV Mehta is a Pediatric Endocrinologist and inhibitors, and bile acid sequestrants. Insulin use was not an Instructor in Medicine, Harvard studied, nor were medications introduced prior to 2001. Medical School Slide 25 © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 25
  • 26. Interesting study on the retail pricing of diabetes drugs in the US was presented - Wal-Mart hikes branded diabetes drugs prices Study by - Dr. Ronald Tamler, an endocrinologist at New York's Mount Sinai Medical Center, and co-author of the price study Overall findings – Industry Prices for generic diabetes Prices for brand-name drugs (2008-2010) diabetes drugs (2008-2010) 113% 58% Price increase for 10 most prescribed diabetes drugs - 2008 to 2010 35% 32% Shared on 21% Twitter – 104 times LinkedIn – 7 Facebook Recommendations – 70 K-Mart Wal-Mart Industry-Avg. © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 26
  • 27. As for the most mentioned company in Tweets by attendees or DOC, Sanofi was a clear winner # mentioned in tweets 100 77 80 60 40 21 20 15 8 5 2 0 Sanofi Boehringer Lilly Novo Nordisk Abbott Roche Ingelheim Actively Data for newly approved Liraglutide - Donated to Note: Not engaged the Boehringer Ingleheim/Lilly type sustained ADA San much buzz diabetes 2 #diabetes treatment weight loss at Diego, for with community at presented – New Phase III data 56 weeks in being the host #ADA2011, ADA and pooled analysis for non-diabetic, city of but ample linagliptin show improved blood obese SciSessions, activity around Organized sugar control in adults with type individuals 2011 #dsummit, event “Dribble 2 diabetes when used alone Roche for diabetes” and with metformin Sponsored Diabetes ADA@5K, Social Media Tweeted ideas morning walk Summit – Diabetes on San Diego Midwives Waterfront © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 27
  • 28. Although relatively low, there was some buzz around metformin and dapagliflozin Metformin (18) • Some poor countries have such high taxes on insulin and metformin that at-cost product is completely unaffordable after taxes • Metformin costs a fraction of a cent to produce • Merck retro study: Risk of CVD events 23% higher in elderly #diabetes patients started on sulfonylureas vs. metformin • Starting Elderly #Diabetes Patients on Metformin May Reduce Cardiovascular Disease Risk • Risk-benefit assessment of anti-diabetic drugs shows metformin as most efficacious • Is Afressa by $MNKD the simplest approval that FDA made complex? Risk-benefit more tolerable than Avandia or metformin • Long-term cost effectiveness evaluation of DPP and DPPOS gives resounding thumbs up to use of metformin • Reusing lancets; forgetting metformin doses; blowing a good carb intake week with a night out with the girls • Metformin decided to turn on me and ruin my insides. On week 2 of titration. Any thoughts? Dapagliflozin (2) • Dapagliflozin Effective at 102 Weeks, but Drug Poses Breast and Bladder Cancer Risk • Dapagliflozin non-inferior to metformin in lowering A1c, superior in lowering FPG, weight. Sig more UTI, genital infects in women © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 28
  • 29. CI – Sanofi Event – Dribble to Stop Diabetes – A diabetes awareness initiative with NBA players, sponsored by Sanofi Sanofi Aventis – Dribble to Dennis Ubraniak from Sanofi Stop Diabetes event with USA at the event, contributing former NBA Player, Chris to YMCA San Diego County Dudley at Sails Pavilion, San on behalf of the partnership Diego, CA © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 29
  • 30. CI – Outdoor Advertising – Boehringer Ingleheim and Novo Nordisk Outdoor Ads for – Tradjenta (Linagliptin) Novo Nordisk – Levemir Pen © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 30
  • 31. For further information on this document, please contact: Tanmay Saraykar Manager, Social Media Analytics +91 7829909766 tanmay.saraykar@pharmarc.com Corporate Headquarters Europe USA PharmARC Analytic Solutions Pvt. Ltd. PharmARC Consulting Services GmbH PharmARC Inc. Mercury 2B Block, 6th Floor Blumenrain 16 100 Overlook Center Prestige Technology Park 4051 Basel 2nd Floor, Princeton, NJ 08540 Sarjapur – Marathahalli Outer Ring Road Switzerland USA Bangalore 560 103, India T +91 (80) 4123 8900 T +41 (61) 261 8900 T +1 (609) 450 1880 F +91 (80) 4123 8999 F +41 (61) 261 8901 F +1 (609) 895 2666 © PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 31