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NAME: PATRICIA HENTOSH, Sc.D.
ADDRESS: 410 Delaware Avenue, Unit 301
Norfolk, VA 23508
757 622-3421 (home), 816 695-3070 (cell)
phentosh@dphpartners.com
EDUCATION:
Sc.D. Harvard University, School of Public Health
Boston, Massachusetts (Cancer Biology, Radiation Biology)
S.M. Harvard University, School of Public Health
Boston, Massachusetts (Cancer Biology, Radiation Biology)
B.S. Ohio State University
Columbus, Ohio (Zoology)
EXPERIENCE:
2014-present Member, DPH and Partners, LLC–Academic, Medical & Legal Consulting
2008-2013 Director, Molecular Diagnostics Certificate Program, Department of Medical Laboratory &
Radiation Sciences (now called Medical Diagnostic & Translational Sciences), Old Dominion
University, Norfolk, VA
6/06-01/07 Interim Associate Dean of Research, College of Health Sciences, Old Dominion University
2006-2013 Professor, Department of Medical Laboratory & Radiation Sciences, Old Dominion University,
Norfolk, VA
2000-05 Professor and Chairperson, Department of Pharmacology, Kansas City University of Medicine &
Biosciences (formerly University of Health Sciences), Kansas City, MO
1995-99 Associate Professor, Department of Cellular and Molecular Pharmacology, Finch University of
Health Sciences-Chicago Medical School (now Rosalind Franklin University of Medicine and
Science), North Chicago, IL
1998 Feb-Mar Visiting Scientist, Department of Biochemistry and Biophysics, University of California-San
Francisco, San Francisco, CA
1990-94 Assistant Professor, Department of Pharmacology and Molecular Biology, Finch University of
Health Sciences-Chicago Medical School, North Chicago, IL
1988-90 Research Associate, Department of Biochemical and Clinical Pharmacology, St. Jude Children's
Research Hospital, Memphis, TN
1984-87 Postdoctoral Fellow, Eleanor Roosevelt Institute for Cancer Research, University of Colorado
Health Sciences Center, Denver, CO
TEACHING:
Old Dominion University, Formal Courses:
2009-13 Sp MLRS 600 Advanced Clinical Applications of Molecular Diagnostics (3 cr); Course
Director and Instructor
2009-13 Sp MLRS 601 Advanced Molecular Diagnostics Laboratory (3 cr); Course Director and
Instructor
2013 Sp MLRS 898 Research- Doctoral student Pete Mollica (3 cr)

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2007-12 Fa MLRS 400/500 Principles of Molecular Pathology & Clinical Diagnostics (3 cr); Course
Director and Instructor
2007-12 Fa MLRS 401/501 Molecular Diagnostics Laboratory (3 cr); Course Director and Instructor
2012 Fa MLRS 898 Research- Doctoral student Pete Mollica (3 cr)
2012 Su MLRS 898 Research- doctoral student Pete Mollica (6 cr)
2012 Su BIOL 497 Undergraduate Research-Kevin Stroop (3 cr)
2010 -12 Fa MLRS 805 Fundamentals of Cancer Biology (3 cr); Course Director and Instructor
(New graduate level course presented Fall semester, 2010)
2012 Sp MLRS 898 Research- Doctoral student Tabetha Sundin (3 cr)
2012 Sp MLRS 898 Research- Doctoral student Peter Mollica (3 cr)
2012 Sp BIOL 497 Independent Study- Undergraduate student Kevin Stroop (3 cr)
2011 Fa MLRS 898 Research- Doctoral student Tabetha Sundin (6 cr)
2011 Fa MLRS 814 Molecular Laboratory Rotation-Doctoral student Haley Thrift (2 cr)
2011 Fa MEDT 497 Undergraduate Research—Peter Mollica (3 cr)
2011 Su MLRS 898 Research- doctoral student Tabetha Sundin (6 cr)
2011 Sp MLRS 895 Topics in Personalized Medicine (1 cr); Course Director and Instructor
(New graduate level course presented Spring semester, 2011)
2011 Sp BIOL 898 Research- doctoral student Tabetha Sundin (3 cr)
2010 Fa MLRS 668 Internship in Molecular Diagnostics (3 cr); Instructor, 1 student
2010 Fa BIOL 898 Research- doctoral student Tabetha Sundin (3 cr)
2010 Su MLRS 668 Internship in Molecular Diagnostics (3 cr); Instructor, 3 students
(New Molecular Diagnostics internship initiated Summer semester, 2010)
2010 Su BIOL 898 Research- doctoral student Tabetha Sundin (6 cr)
2010 Sp BIOL 898 Research- doctoral student Tabetha Sundin (3 cr)
2010 Sp ME 895 Tissue Engineering and Fabrication Independent Study- doctoral student
Hrishikesh Phadke (3 cr)
2008 Sp Presenter and organizer, grant writing workshop entitled “Writing Successful Research
Proposals” (Eastern Virginia Medical School/ODU co-sponsors) (May)

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2006 Presenter and organizer, grant writing workshop entitled “Developing Strategies for a
Successful Health Sciences Grant Submission” (Old Dominion University) (3 day
workshop, October)
Guest Lectures—ODU
2006-12 Fa Taught two lab classes entitled “PCR Methods”, MEDT 325 Clinical Instrumentation
Methods (Undergraduate course)
2011 Fa Taught one class on “Principles of PCR”, CYTO 415 Abnormal Gynecological Cytology
(Undergraduate course)
2008-11 Fa Taught one class (2 hr) entitled “Organizing and Designing a Logical Research Study”,
MEDT 440 Statistical Applications and Data Analysis in the Clinical Laboratory
(Undergraduate course)
2010 Sp Designed and co-taught two lab classes entitled “Multiplex PCR Detection of MRSA”,
MEDT 319 Medical Bacteriology Methods (Undergraduate course)
2010 Sp Taught one class entitled “Biomedical Research Opportunities in the College of Health
Sciences”, HLSC 889 (Graduate course)
2009 Sp Taught one class entitled “DNA Sequencing Methods and Capillary Electrophoresis”,
MEDT 351 Clinical Biochemistry (Undergraduate course)
Guest Lectures—Other
Philadelphia-College of Osteopathic Medicine, Atlanta, GA Campus (Visiting Professor):
2006 Fa Medical Biochemistry 6 contact hrs (~85 students)
Old Dominion University, Student / Faculty Advising
Undergraduate/High School Students Mentored--Research:
Kevin Stroop (Advisor, independent study class, spring & summer semesters 2012)
Peter Mollica (Advisor, independent study class, fall semester 2011)
Sterling Thomas (Advisor, 2006)
Graduate/Medical Students Mentored--Research:
Tabetha Sundin (Thesis Advisor, Old Dominion University Doctoral Student in Biology, 2009-
2012)
Peter Mollica (Advisor, Old Dominion University Doctoral Student in Biology 2012-2013)
Kathy Hilsinger-Walliser (Advisor, Old Dominion University Doctoral Student in Biology, 2011-
2013)
Donica H. Thrift (Advisor, Old Dominion University Doctoral Student in Biology, 2011-2012)
Elizabeth Poyner (Advisor, Old Dominion University Master’s Student in Biology, 2010-2013)
Hrishikesh Phadke (Mentor, Independent study – Old Dominion University Doctoral Student in
Mechanical Engineering, 2010)
Dawn Curran (Thesis Committee Member, Old Dominion University Master’s Student in
Biology, 2009-2010)

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Melanie Sloan (Thesis Committee Member, Old Dominion University Doctoral Student in
Biomedical Sciences, 2009-2012)
Liang Yu (Thesis Committee Member, Old Dominion University Doctoral Student in Biomedical
Sciences, 2007-2011)
Faculty Members Mentored--Research:
Thuraya Al Mansoori, Ph.D. (Fulbright Scholar from University of Bahrain), 2007
Graduate Students Mentored—Scholastics:
E. Polychronopoulos, Doctoral student in Health Services Research, HLSC 809, 2007
Teaching Prior to ODU:
Kansas City University of Medicine and Biosciences:
2000-2005 Medical Pharmacology 26 contact hrs/yr (Course Director, ~430
students/yr)
2000-2005 Cancer, Acquired Genetic Changes 1 contact hr/yr (~230 students)
Chicago Medical School:
1991-1999 Medical Pharmacology 7 contact hrs/yr (~200 students)
1991-1998 Molecular Biology of Cancer 22 contact hrs/2 yr (Course Director, 10
doctoral students)
1991-1999 Advanced Molecular Biology 3 contact hrs/yr (~20 doctoral students)
1995-1996 Human Disease, Genetics and Beyond 2 contact hrs/yr
1996 Molecular Basis of Disease 2 contact hrs/yr (~10 doctoral/med students)
1996-1999 Physician Assistant Pharmacology 3 contact hrs/yr (~50 students)
Student Advising Prior to ODU:
Undergraduate/High School Students Mentored--Research:
Chicago Medical School
Katie Good–Lake Forest High School Student, Summer Laboratory Rotation (6/97-9/97; 7/98-8/98)
William Hartman–Lake Forest College, Senior Thesis Advisor (6/93-6/94, received Honors)
Thesis title: "Expression of the gadd45 gene via lovastatin-induced growth arrest".
Graduate/Medical Students Mentored--Research:
Kansas City University of Medicine and Biosciences / University of Health Sciences (UHS)
Samuel Moore (Summer Research Fellow and Medical Student, Received KCUMB/UHS
Excellence in Biomedical Research Fellowship, 5/04-7/04)
James Lawrenzi (Summer Research Fellow and Medical Student, Received UHS Excellence in
Biomedical Research Fellowship, 6/02-8/02; 6/03-8/03)
Joyce M. Savage (Medical Student Research Fellow, 8/02-12/03)
Norman Huang (Summer Research Fellow and Medical Student, Received UHS Excellence in
Biomedical Research Fellowship, 6/02-8/02 [co-advisor])
James Southwell (Summer Research Fellow and Medical Student, Received UHS Excellence in
Biomedical Research Fellowship, 6/01-8/01)
Christopher Kim (Medical Student Lab rotation, 9/00-5/01)

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Chicago Medical School/ Finch University of Health Sciences
William Hartman (Doctoral Thesis Advisor, 9/95-6/99)
Rob Buechler (Doctoral Thesis Committee Member, 9/95-6/99)
Seon H. Yuh (Lab rotation, 2/97-7/97, Doctoral Thesis Co-advisor, 6/98-5/99)
John Callaci (Lab rotation, 6/96-12/96)
Xiao-He Yang (Doctoral Thesis Defense Committee, Microbiology Dept., 12/96)
R. Michael Hinds (Lab rotation, 1/95-5/95)
Sid Hasan (Summer Research Fellow, Received the Leichtling Oncology Research Award, 6/94)
Long Wen Chen (Lab rotation, 1/94-3/94)
Beatrice Mounts (Minority medical student research rotation, 10/92-6/93)
Karuna Naik (Lab rotation, 8/92-10/92, Doctoral Thesis Committee Member)
Kelly Wentz (Lab rotation, 7/91-9/91)
PUBLISHED BOOKS, MONOGRAPHS, BOOK REVIEWS AND PAPERS:
Peer-reviewed Publications—All PubMed cited
Sundin T, Peffley DM, Mollica P, Hentosh P. Perillyl alcohol and rapamycin-mediated inhibition of
migration and invasion of human prostate cancer cells is associated with matrix metalloproteinase-2 and
-9 down-regulation. Submitted.
Block K, et al. Designing a broad-spectrum integrative approach for cancer prevention and therapy.
Semin Cancer Biol 35:S276-S304, 2015
Yaswen P, MacKenzie KL, Keith N, Hentosh P, et al. Therapeutic targeting of replicative immortality.
Semin Cancer Biol; http://dx.doi.org/10.1016/j.semcancer.2015.03.007, 2015
Sundin T, Peffley DM, Hentosh P. Eukaryotic initiation factor 4E-overexpression imparts perillyl
alcohol and rapamycin-mediated regulation of telomerase reverse transcriptase. Exp Cell Res 319: 2103-
12; doi: 10.1016/j.yexcr.2013.05.029, 2013
Sundin T, PeffleyDM, Hentosh P. Disruption of an hTERT-mTOR-RAPTOR protein complex by a
phytochemical perillyl alcohol and rapamycin. Molec Cellular Biochem 375: 97-104; doi:
10.1007/s11010-012-1532-3, 2013
Sundin T, PeffleyDM, Gauthier D, Hentosh P. The isoprenoid perillyl alcohol inhibits telomerase
activity in prostate cancer cells. Biochimie 94: 2639-48; doi: 10.1016/j.biochi.2012.07.028, 2012
Sundin T, Hentosh P. InTERTesting association among telomerase, mTOR, and phytochemicals.
Expert Reviews Molec Medicine 14: e8; doi: 10.1017/erm.2012.1, 2012
Peffley DM, Hentosh P. Plant-derived isoprenoids mediate regulation of mTOR signaling in tumor
cells. In “Natural Compounds as Inducers of Cell Death”, M Diederich and K Noworyta (eds), Springer
Publishing, Vol. 1, pg 373-400, 2012.
Hentosh P, Benjamin T, Hall L, Leap S, Loescher J, Poyner E, Sundin T, Whittle M, Wilkinson S, Peffley
DM. Xeroderma Pigmentosum Variant: Complementary molecular approaches to detect a 13 bp deletion
in the polymerase eta gene. Exp Molec Pathology 91: 528-33; doi: 10.1016/j.yexmp.2011.05.004, 2011
Hentosh P, Peffley DM. The cladribine conundrum: deciphering the drug’s mechanism of action. Expert
Opinion Drug Metabolism Toxicology 6: 75-81; doi: 10.1517/17425250903393745, 2010.

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Peffley, DM, Sharma C, Hentosh P, Buechler RD. Perillyl alcohol and genistein differentially regulate
PKB/Akt and 4E-BP1 phosphorylation as well as eIF4E/eIF4G interactions in human tumor cells. Arch
Biochem Biophys 465: 266-273, 2007.
Hartman WR, Walters DE, Hentosh P. Presence of the anti-leukemic nucleotide analog, 2-chloro-2'-
deoxyadenosine-5'-monophosphate, in a promoter sequence alters DNA binding of TATA binding
protein (TBP). Arch Biochem Biophys 459: 223-232, 2007.
Hartman WR, Hentosh P. The anti-leukemia drug 2-chloro-2’-deoxyadenosine: An intrinsic
transcriptional antagonist. Molec Pharmacol 65: 227-234, 2004.
Foley T, Hentosh P, Walters DE. 2-Chloro-2’-deoxyadenosine: Alteration of DNA:TATA element
binding protein (TBP) interactions. J Molec Model 10: 32-37, 2004.
Lawrenzi J, Bunnell A, Hentosh P. Nucleotide excision repair-deficient human cells in culture exhibit
decreased survival after 2-chlorodeoxyadenosine treatment. Anticancer Res 23: 3141-3146, 2003.
Hentosh P, Yuh SH, Elson CE, Peffley DM. Sterol-independent regulation of 3-hydroxy-3-
methylglutaryl coenzyme A (HMG-CoA) reductase in tumor cells. Molec Carcinog 32: 154-166, 2001.
Elson CE, Peffley DM, Hentosh P, Mo H. Isoprenoid-mediated inhibition of mevalonate synthesis:
potential application to cancer. Proc Soc Exper Biol Med 221: 294-311, 1999.
Yuh SH, Tibudan M, Hentosh P. Analysis of 2-chloro-2'-deoxyadenosine incorporation into cellular
DNA by quantitative polymerase chain reaction. Analytical Biochem 262: 1-8, 1998.
Hentosh P, Tibudan M. 2-Chloro-2'-deoxyadenosine, an antileukemic drug, has an early effect on
cellular mitochondrial function. Molec Pharmacol 51: 613-619, 1997.
Hentosh P, Tibudan M. In vitro transcription of DNA containing 2-chloro-2'-deoxyadenosine
monophosphate. Molec Pharmacol 48: 897-904, 1995.
Hentosh P, Tibudan M, Grippo P. A human factor that recognizes DNA substituted with 2-
chloroadenine, an antileukemic purine analog. Molec Carcinogenesis 13: 245-253, 1995.
Hentosh P, Grippo P. 2-Chloro-2'-deoxyadenosine monophosphate residues in DNA enhance
susceptibility to 3' – 567-571, 1994.
Hentosh P, Grippo P. Template 2-chloro-2'-deoxyadenosine monophosphate inhibits in vitro DNA
synthesis. Molec Pharmacol 45: 955-961, 1994.
Hentosh P. Establishment of hypoxic conditions for cultured monolayer cells: hypoxia in five minutes
or less. Analytical Biochem 210: 249-252, 1993.
Hentosh P, McCastlain JC, Grippo P, Bugg BY. Polymerase chain reaction amplification of single-
stranded DNA containing a base analog, 2-chloroadenine. Analytical Biochem 201:277-281, 1992.
Hentosh P, McCastlain JC. Effects of 2-chloroadenine substitution in DNA on restriction endonuclease
cleavage reactions. Nucleic Acids Res 19: 3143-3148, 1991.
Hentosh P, McCastlain JC, Blakley RL. Effects of 2-chloro-2'-deoxyadenosine 5’ triphosphate on DNA
synthesis in vitro by purified bacterial and viral DNA polymerases. Biochem 30: 547-554, 1991.
Hentosh P, Collins A, Correll L, Fornace AJ Jr, Giaccia A, Waldren CA. Genetic and biochemical
characterization of the CHO-UV-1 mutant defective in post replication recovery of DNA. Cancer Res
50:2356-2362, 1990.
Hentosh P, Koob R, Blakley RL. Incorporation of 2-halogeno-2'-deoxyadenosine 5'-triphosphates into
DNA during replication by human polymerases alpha and beta. J Biol Chem 265:4033-4040, 1990.

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Hentosh P. The induction and repair of DNA damage in gamma-irradiated human lymphoblasts:
irradiation in the presence and absence of misonidazole. Radiat Res 115: 436-447, 1988.
Hentosh P, Henner WD, Reynolds RJ. Sequence specificity of DNA cleavage by Micrococcus luteus
gamma endonuclease. Radiat Res 102: 119-129, 1985.
Steuer A, Rhim J, Hentosh P, Ting R. Survival of human cells in the aggregate form: potential index of
in vitro cell transformation. J Natl Cancer Inst 58: 917-921, 1977.
Steuer A, Hentosh P, Diamond L, Ting R. Survival differences exhibited by normal and transformed rat
liver epithelial cell lines in the aggregate form. Cancer Res 37: 1864-1867, 1977.
Other Publications
Elson CE, Peffley DM, Hentosh P, Mo H. Functional Consequences of Isoprenoid Mediated Inhibition
of Mevalonate Synthesis: Application to Cancer and Cardiovascular Disease – In Essential Oils and
Cancer, Proceedings 4th Wholistic Aromatherapy Conference, 2000.
CREATIVE WORKS:
MLRS 601 Advanced Molecular Diagnostics Laboratory Manual, 2009-2013
TECHNICAL REPORTS:
“Gender Equality and the Role of Women in Cuban Society”, American Association of University
Women, (group report by all participants in the AAUW-sponsored research delegation to Havana, Cuba)
Feb. 2011
DOCTORAL THESIS:
“Radiation-induced DNA damage recognized by Micrococcus luteus gamma endonuclease”
PUBLISHED ABSTRACTS (SINCE 2000):
1. Sundin T, Peffley D, Hentosh P. Dietary isoprenoids prevent human prostate tumor cell migration and
invasion. The Ireland–Northern Ireland – National Cancer Institute Cancer Consortium Conference,
Belfast, N. Ireland, May, 2015.
2. Mollica PA, Sundin T, Hentosh P. Poly-Q aggregate trap (PQAT) interference with DNA repair genes in
Huntington disease cells. American Society for Biochemistry and Molecular Biology Annual Research
Meeting (Experimental Biology), April, 2014.
3. Sundin T, Peffley D, Hentosh P. Perillyl alcohol and rapamycin-mediated inhibition of migration and
invasion. American Society for Biochemistry and Molecular Biology Annual Research Meeting
(Experimental Biology), April, 2013.
4. Sundin T, Gauthier D, Peffley D, Hentosh P. The isoprenoid perillyl alcohol inhibits telomerase activity
in prostate cancer cells. American Society for Biochemistry and Molecular Biology Annual Research
Meeting, April, 2012.
5. Hentosh P, Phadke HR, Bao HP, Knisley SB. Modulation of PC3 cell growth on titanium surfaces with
altered surface roughness and electric current. Biomedical Engineering Society 2011 Annual Meeting,
October, 2011.
6. Sundin T, Peffley DM, Gauthier D, Hentosh P. Chemopreventives, a critical factor in reducing the
economic burden of cancer. 6th
Annual Virginia Council of Graduate Schools (VCGS) Research Forum
Feb. 2011.
7. Hentosh P, Thomas S, Hill K, Thompson SK, Peffley, DM. Chromatin-associated protein networks as
potential biomarkers for lung adenocarcinoma. 57th
Annual Meeting, American Society of Cytopathology,
November, 2009.
8. Polychronopoulos S, Balas A, Hentosh P, Bondi S, Polychronopoulou A. Effects of smoking, alcohol,
fruit and vegetable consumption on oral cancer. Academy of Health Annual Research Meeting, June
2009.

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9. Hentosh P, Thomas S, Bonchev D, Hill K, Hatcher P, Thompson SK, Kier L, Peffley, DM. Identifying
potential lung cancer protein biomarkers by bioinformatics and mass spectrometry. Research Expo 2008,
Norfolk, VA, April, 2008.
10. Hentosh P, Thomas S, Bonchev D, Hill K, Hatcher P, Thompson SK, Kier L, Peffley, DM. Identifying
potential lung cancer protein biomarkers by bioinformatics and mass spectrometry. Molecular Medicine:
Applying Current and Emerging Technologies, March, 2008.
11. Thomas S, Bonchev D, Hentosh P, Peffley D. Complex analysis of chromatin-associated genes in lung
adenocarcinoma. Summit on Systems Biology, June, 2007.
12. Peffley D, Hentosh P, Sharma C, Morgan W, Shipulina N, Keightly A. Regulation of 14-3-3 protein in
PC3 human prostate tumor cells through the mTOR (mammalian Target of Rapamycin) signal
transduction pathway. ODU Research Expo 2007, Norfolk, VA
13. Hentosh P, Sheets D, Peffley D, Sharma C, Shipulina N, Morgan W, Keightly A. Proteomic analysis of
cellular responses to the anti-leukemic drug and nucleoside analog, 2-chloro-2’-deoxyadenosine
(Cladribine). ODU Research Expo 2007, Norfolk, VA
14. Buxton BA, Tanner S, Hentosh P, Peffley D. Regulation of inflammatory mediator secretion by dietary
isoprenoids in an in vitro model of atherosclerosis. Experimental Biology 2005 Meeting, April 2005.
15. Invited speaker, 9th
World Congress on Advances in Oncology and the 7th
International Symposium on
Molecular Medicine (parallel conferences), Crete, Greece. Molecular studies on the mechanism of action
of an antileukemia drug, 2-chloro-2′-deoxyadenosine (Cladribine), Oct. 2004.
16. Lawrenzi J, Savage J, Bunnell A, Hentosh P. Effects of a 2-chlorodeoxyadenosine monophosphate-
substituted TATA element on in vivo gene expression. 95th Annual Meeting, American Association for
Cancer Research, March 2004.
17. Sharma N, Hentosh P, Peffley D. Differential inhibition of invasive properties in PC3 and DU145 cancer
cells by genistein, perillyl alcohol and gamma-tocotrienol. 94th Annual Meeting, American Association
for Cancer Research, July 2003.
18. Foley T, Hentosh P, Walters DE. 2-Chlorodeoxyadenosine: Mechanism of disruption of DNA:TATA
element binding protein (TBP) interactions. 94th Annual Meeting, American Association for Cancer
Research, July 2003.
19. Foley T, Hentosh P, Walters DE. The effect of incorporating 2-chlorodeoxyadenosine (Cladribine) into
the TATA element of DNA on the TATA element binding protein (TBP) core domain complexed to the
TATA element. Chicago Medical School Research Symposium, October 2001.
20. Peffley DM, Hentosh P, Elson C. Action cytoxique specifique des terpenoides sur les cellules tumorales
(Specific cytotoxic action of terpenoids on tumoral cells). 4th
International Scientific Aromatherapy
Symposium, Grasse, France, March 2001.
RESEARCH PAPERS PRESENTED AT PROFESSIONAL MEETINGS:
Same as Abstracts
GRANTS AWARDED:
Previous:
Old Dominion University
“Modeling and testing complex interactions of chromatin-associated proteins in cancer cells”
Principal Investigator: P. Hentosh, Sc.D.; Co-PI: D. Peffley, Ph.D.; Co-investigators: P.
Hatcher, Ph.D. [ODU], S. Thompson, M.S. [ODU] and D. Bonchev, Ph.D.
[VCU]
Agency: ODU Research Foundation
Type and Dates: Multidisciplinary Seed Grant, Period: 01/07 – 02/08
Funding: $78,000

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“Significance of bonding strength between Bcl-2-related proteins in adenocarcinoma of the lung”
Principal Investigator: Sophie Thompson, M.S.; Co-investigators: P. Hentosh, Sc.D., J. Poutsma,
Ph.D. [ODU] and D. Bonchev, Ph.D. [VCU]
Agency: ODU Research Foundation
Type and Dates: TIPS; August 2006 - June 2007
Funding: $14,000
Others
“Functional Consequences of 2-Chloroadenine in DNA”
Principal Investigator: Patricia Hentosh, Sc.D.
Agency: NIH - National Cancer Institute
Type and Dates: RO1 (CA 55414), Period: 06/01/1991 – 06/30/2005
Funding: $2,334,000 (Direct and indirect costs)
This study examined the molecular mechanisms of action of an anti-leukemia drug and nucleoside
analog, 2-chlorodeoxyadenosine (Cladribine). This grant was renewed twice during the above time
period
“Proteomic Analysis of Isoprenoid and Isoflavone-mediated Regulation of Cap-dependent and Cap-
independent Protein Translation in Human Prostate Tumor Cells”
Principal Investigator: D. Peffley, Ph.D.; Co-investigators: P. Hentosh, Sc.D. and W. Morgan,
Ph.D.
Agency: Kansas City Area Life Sciences Institute
Type and Dates: Research Development Grant; Period 12/01/03 - 04/30/05
Funding Amount: $25,000
This study focused on the molecular mechanism of cancer and/or metastasis prevention by dietary
isoprenoids (i.e., tocotrienol, perillyl alcohol) and genistein found in fruits and vegetables.
"Cancer Prevention by Isoprenoid Constituents of Plants"
Principal Investigator: C. Elson, Ph.D.; Co-investigators: P. Hentosh, Sc.D. and D. Peffley,
Ph.D.
Agency: NIH - National Cancer Institute
Type and Dates: R01 (CA73418), Period 09/30/96 - 09/29/01
Funding Amount: $641,250 (Direct and indirect costs)
This study determined how dietary isoprenoids affected tumor cell 3-hydroxy-3-methylglutaryl
coenzyme A (HMG-CoA) reductase, a key regulator of cholesterol biosynthesis.
PATENTS AWARDED:
“Composition and Method for Treating Cancer” #7,074,825 (Co-inventors: Mo, H., Elson, C., Hentosh,
P., and Peffley, D.), 2006
PATENTS APPLIED FOR (Old Dominion University):
“A method to identify protein networks for detection of lung cancer” (Inventors: P. Hentosh, D. Peffley,
S. Thomas and S. Thompson), submitted September, 2008 to Old Dominion University Office of
Research
CONSULTING ACTIVITIES:
Consultant for LabLine Instruments, Inc. (1994-1998)
HONORS, AWARDS AND PRIZES:

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Old Dominion University:
Nominated for the American Society Biochemistry Molecular Biology (ASBMB) Exemplary
Contributions to Education Award, 2013
Invited to participate on the Halifax Project–an international task force of researchers that is focused on
“A Broad-Spectrum Integrative Design for Cancer Prevention and Therapy” with emphasis on tumor
cell replicative immortality, 2012 - present
Attended 2-day workshop in Halifax, Nova Scotia, August, 2013
Selected as Outstanding Faculty Member in the February 2012 ODU Graduate Newsletter
Nominated for College of Health Sciences Hirschfeld Award for Faculty Excellence, April, 2011
Nominated for Old Dominion University Tonelson Faculty Award for commitment to excellence in
research, scholarly activities, teaching and service, February, 2011
Recipient of the Old Dominion University Shining Star Award (presented to faculty members who have
helped students succeed academically, professionally and personally both inside and outside of the
classroom), January, 2011
Participant in the American Association of University Women (AAUW) Research Delegation to Cuba:
“Gender Equity and Role of Cuban Women in Society”, October 30 - November 4, 2010 (One of 45
women asked to participate)
Co-Recipient of the “Excellence Award in Molecular Medicine” for abstract and poster presented at
Molecular Medicine: Applying Current and Emerging Technologies Symposium, Orlando, FL. March
2008
Prior to ODU:
Nominated for the 2004 Irvin Korr Basic Science Research Award, American Osteopathic Association,
2004
Recipient of the University of Health Sciences Research Support Award, 2002
Recipient of the University of Health Sciences Faculty Publication Award, 2002
Recipient of $10,000 Incentive Award (top application) from the Soy Health Research Program for pre-
proposal research study entitled “Cancer preventive effects of genistein on prostate cancer” 2001
Phi Beta Kappa
MEMBERSHIP IN PROFESSIONAL SOCIETIES:
Old Dominion University:
American Association of University Women (AAUW) (2000-present)
Selected for AAUW Insiders—those who demonstrate exceptional dedication to breaking
through barriers for women and girls (2011)
ODU University Women’s Caucus (2006 - 2013)
Biomedical Engineering Society (2011-2013)
American Society for Biochemistry and Molecular Biology (2011-present)
Prior to ODU:
American Association for Cancer Research (AACR)
Radiation Research Society
American Society for Pharmacology and Experimental Therapeutics (ASPET)
Women in Cancer Research
Sigma Xi
Association of Medical School Pharmacology Chairs (AMSPC)

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UNIVERSITY SERVICE:
Committees and Miscellaneous—Old Dominion University:
2010-2012 Outstanding Graduate Teaching Assistant Award Selection Committee (University
Committee)
2010-2011 Member, COHS Faculty Search Committee, Molecular Diagnostics Faculty Position
2009-2013 Graduate Program Committee Member - College of Health Sciences (COHS)
2009-2013 Ph.D. Planning Committee Member-COHS
2009, 2010 Reviewer, Student Research Presentations, Capstone Conference, Virginia Modeling
Analysis and Simulation Center (VMASC)
2007-2013 Member, ODU Library Acquisitions Committee (University Committee)
2007-2009 Scientific judge, Navy Medical Center, Portsmouth Research Poster Session
2007, 2008 Scientific judge, Old Dominion University/Eastern VA Medical School Research
Symposium
2008 Member, ODU/COHS Steering Subcommittee for Research Expo 2008
2007-2008 Chair, ODU Faculty Search Committee, Bioelectrics/COHS Faculty
2007 Member, ODU Search Committee, Grant Writer Position (2nd
search)
2007 Member, ODU Search Committee, Grant Writer Position (1st
search)
2006-2008 Chair, ODU-COHS Research Council
2006-2009 Co-Chair, ODU-COHS-Navy Medical Center Portsmouth Coordinating Council
2006-2007 Chair, ODU Faculty Search Committee, Modeling, Simulation & Visualization Faculty
2006 Scientific Judge, Old Dominion University/Eastern VA Medical School Research
Symposium
2006 Contributed to the conception, organization and writing of an ODU-COHS major
initiative entitled “Virginia Environmental Health Sciences Initiative”
Old Dominion University Special Services Assignments:
2010-2013 Program Director for the Molecular Diagnostics Track / Ph.D. in Health Sciences
program (designed curriculum for the track in molecular diagnostics, have initiated
teaching several of the graduate level courses)
2008-2013 Program Director for the Molecular Diagnostics Certificate (recruit and interview all
potential students, design and teach 4 courses and a molecular lab rotation)
Committees and Miscellaneous –previous academic institutions:
2004-2005 Animal Care Committee (KCUMB)
2004 KCUMB Faculty Evaluation Committee
2002 Basic Sciences Faculty Search Committee (KCUMB)
2002 Microbiology Chair Search Committee (KCUMB)
2001-2002 Chairperson, UHS (KCUMB) Research Symposium 2002
2000-2005 KCUMB Research Peer Review Panel
2000-2005 KCUMB Curriculum Committee
2000-2004 Basic Sciences Research Facility Planning Committee (KCUMB)
2000-2003 KCUMB Research Committee, Chair
2000 KCUMB Institutional Review Board

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2000 Pharmacology Faculty Search Committee, Chair (KCUMB)
1997 Scientific Judge and Chairperson, Summer Research Fellow Poster Session–Chicago
Medical School
1996 Co-Chairperson, Annual Sigma Xi/Senate Faculty Research Poster Session–Chicago
Medical School
1993 Scientific Judge, Summer Research Fellow Poster Session—Chicago Medical School
PROFESSIONAL SERVICE:
Research Review Appointments:
The International Fellowships Review Panel of the National Chapter of the American Association of
University Women (AAUW), Washington, DC. Review doctoral and postdoctoral research grant
applications in Biological Sciences and accompanying letters of support (2011-2015)
Grant Reviewer and Medical Advisory Board, Leukemia Research Foundation (1999-2006)
Member, Review Committee, Ladies Auxiliary to the Veterans of Foreign Wars Postdoctoral Cancer
Research Fellowships (2003, 2005)
Member, American Fellowships Awards Panel of the American Association of University Women
Educational Foundation (2001-2005)
Reviewer, United States Department of State/U.S. Civilian Research and Development Foundation
(International program to provide peaceful, productive research opportunities to weapons scientists
of the former Soviet Union) (2004)
Reviewer, American Cancer Society, Illinois Division, Grant Review Program (1992-1997; 1998-2000)
Reviewer, U.S. Army Breast Cancer Research Grant Study Section (1997, 1998)
Appointed Full Member, Experimental Therapeutics-2 Study Section, NIH (1994, deferred)
Ad hoc Member, Experimental Therapeutics-2 Study Section, NIH (1993)
Editorial/Reviewer Activities:
2006 to present:
Integrative Cancer Therapies (Sept. 2015)
Expert Reviews Molecular Medicine (Mar. 2013)
Experimental Dermatology (Oct. 2012)
Environmental Molecular Mutagenesis (Sept. 2012)
Archives Biochem Biophys (Sept. 2011)
Archives Biochem Biophys (July 2011)
Archives Biochem Biophys (Apr. 2011)
Letters in Drug Design & Discovery (Apr. 2010)
Archives Biochem Biophys (Jan. 2009)
Archives Biochem Biophys (Dec. 2008)
Previous:
Archives Biochem Biophys
Editorial Advisory Board, Immunological Investigations
Ad hoc Reviewer Biochemistry
Ad hoc Reviewer Radiation Research
Ad hoc Reviewer Blood
Ad hoc Reviewer Cancer Research

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Invited Seminars:
College of Health Sciences, Old Dominion University–Research Series (Mar, 2011)
Medical Laboratory Sciences Student Association Conference, Old Dominion University (Feb, 2011)
Touro College of Osteopathic Medicine, NYC (July, 2008)
Department of Biological Sciences, Old Dominion University (Mar, 2007)
Lincoln Memorial University College of Osteopathic Medicine (Jan, 2006)
North Carolina State University (Aug, 2005)
Feist-Weiller Cancer Center (Mar, 2003)
Department of Pharmacology, University of Indiana (Mar, 2003)
Invited speaker, Kansas City Area Life Sciences 2nd
Annual Research Symposium (Mar, 2003)
Department of Pathology, University of Kansas Medical Center (Feb, 2003)
Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University (June,
2002)
Department of Pharmacology, Morehouse School of Medicine (Mar, 2002)
Department of Pharmacology, University of Missouri-Kansas City School of Pharmacy (Oct, 2001)
Department of Pharmacology, Kirksville College of Osteopathic Medicine (Feb, 2001)
Department of Biochemistry, University of Mississippi School of Medicine (Feb, 2000)
American Health Foundation (Dec, 1999)
Department of Cancer Biology, Harvard University School of Public Health (Oct, 1999)
Department of Biochemistry, East Tennessee State University (Sept, 1999)
Division of Radiation Oncology, City of Hope Cancer Center (July, 1998)
School of Biomedical Sciences, University of Wisconsin, Madison (Dec, 1997)
Inhalation Toxicology Research Institute, Lovelace Medical Foundation (May, 1995)
Department of Pathology and Laboratory Medicine, Temple University (April, 1995)
Department of Microbiology, Chicago Medical School (Feb, 1995)
Department of Molecular and Cellular Biochemistry, Loyola University (Feb, 1995)
Department of Biochemistry, Chicago Medical School (Dec, 1994)
Department of Pharmacology, Yonsei University, Seoul, Korea (April, 1994)
Department of Physiology, Chicago Medical School (Jan, 1994)
COMMUNITY SERVICE:
Since 2006:
Speaker at Prostate Health Educational Symposium, co-sponsored by Prostate Health Education
Network (PHEN) and Hampton Roads Prostate Health Forum, Newport News, VA (June, 2014)
Board of Governors Member, Mildred McDaniel Concert Series, Newport News, VA (2013 to present)
Speaker at Hampton Roads Prostate Health Forum-sponsored prostate cancer workshop and early cancer
detection event, seminar entitled “Nutrition and Prostate Cancer Prevention”, Hampton, VA (Feb. &
Sept. 2013)
Scientific judge for the 14th Annual Tidewater Student Research Poster Session, Christopher Newport
University, Newport News, VA (Nov. 2012)
Speaker at Hampton Roads Prostate Health Forum-sponsored prostate cancer workshop, seminar entitled
“Role of Nutrition in Prostate Cancer Survivors”, Newport News, VA (Nov. 2012)

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Speaker at Riverside Hospital Cancer Care Center public forum; seminar entitled “Nutrition and Cancer
Prevention”, Newport News, VA (May, 2012)
Volunteer/speaker at the Hampton Roads Prostate Health Forum-sponsored Prostate Cancer Early
Detection Event and Workshop, Hampton, VA (Feb, 2012)
Volunteer at the Hampton Roads Prostate Health Forum-sponsored free workshop entitled “Regaining
Continence and Restoring Sexual Health” for prostate cancer survivors and their family members (April,
2011)
Secretary (elected) of the Hampton Roads Prostate Health Forum (June 2008 to present)
Board of Directors, Hampton Roads Prostate Health Forum (Sept. 2007 to present)
Presentation on “Molecular Diagnostics: a key to detecting disease” to public school students (grades 6-
8) in attendance at the MathScience Innovation Center session entitled “Let’s Innovate ! Student
Conference”, Richmond, VA (Dec. 5, 2009)
Presentation on “Molecular Diagnostics: a key to detecting disease” to public high school students
(grades 9-12) in attendance at the MathScience Innovation Center session entitled “Let’s Innovate !
Student Conference”, Richmond, VA (Nov. 21, 2009)
Presentation on using bioinformatics and proteomics to understand disease pathways to 6th
and 7th
graders in attendance at the MathScience Innovation Center summer session entitled “Disease
Detectives”, Richmond, VA. The event was featured on National Public Radio (July 22 and 23, 2009)
Participant on Public Panel Discussion “Global Climate Change”, 5th
Annual Old Dominion University/
Eastern Virginia Medical School Research Expo, Presented “Potential Future Health Impacts of Climate
Change” (April, 2008)
Prior to 2006:
DO-CARE Medical Mission to Santa Maria de Jesus, Guatemala (Feb 2002)
Guest Speaker-American Cancer Society Relay for Life, Shawnee Mission, KS (June 2001)
DO-CARE Medical Mission to Santa Maria de Jesus, Guatemala (Jan 2001)
Research Presentation-Missouri Society of American College of Osteopathic Family Physicians (Jan
2001)
Research Presentation for American Cancer Society-Heartland Division (Oct 2000)
Research Presentation for American Cancer Society-Galesburg, IL Fundraising Campaign (Feb 2000)
Radio interview on cancer; research presentation for American Cancer Society-Jacksonville, IL
Fundraising Campaign (Mar 1999)
Research Presentation for American Cancer Society Donor Recognition Reception-Chicago, IL (Mar
1999)
Research presentation for American Cancer Society-Lake County, IL Unit Board of Directors Meeting
(Dec 1998)
TV and newspaper interviews on cancer; research presentation for American Cancer Society-
Collinsville, IL Fundraising Kickoff (Mar 1998)
Cable TV show (leukemia and dietary prevention of cancer) for American Cancer Society-DuPage
County, IL (Dec 1997)
Research presentation at American Cancer Society-Northbrook Unit Annual Meeting (Nov 1997)
Research presentation at American Cancer Society-Rotary Club of Northbrook (July 1997)
Research presentation at American Cancer Society-Rockford Area Fundraising Campaign (Feb 1997)
Research presentation at American Cancer Society-Chicago Area Fundraising Campaign (Mar 1996)
Research presentation at American Cancer Society-Gurnee, Illinois Fundraising Luncheon (Mar 1996)

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Cable TV, public radio, and Peoria Journal Star interviews on cancer (Bloomington, IL) and research
presentation at American Cancer Society-West Central Illinois Fundraising Dinner (Nov 1995)