The Pacific Research Platform (PRP) aims to achieve transparent and rapid data access among collaborating scientists at multiple institutions through an integrated implementation of data-focused networking that extends the university campus Science DMZ model to a regional, national, and, eventually, a global scale. PRP researchers are routinely achieving high-performance end-to-end networking from their labs to their collaborators’ labs and data centers, traversing multiple, heterogeneous Science DMZs and wide-area networks connecting multiple campus gateways, enabling researchers across the partnership to transfer data over dedicated optical lightpaths at speeds from 10Gb/s to 100Gb/s.