Customer Newsletter September 2007
Contents
• Short Profile Director of R&D and Tech support
• Nitrocellulose Slides
• Customized solutions
• Application report: Nexterion 70mer Kit
• News and Exhibition calendar
Powerpoint exploring the locations used in television show Time Clash
Microarray Solutions newsletter #3
1. Microarray Solutions
The Nexterion® Newsletter Edition # 3 / September 2007
SCHOTT LAUNCHES A NEW RANGE OF
NITROCELLULOSE SLIDES,
NEXTERION® SLIDE NC,
IN PARTNERSHIP WITH SARTORIUS STEDIM BIOTECH
…read more on pages 4-5
Also featured this edition:
page 3 INTERVIEW WITH DR. RUEDIGER DIETRICH
Microarray Solutions talks to SCHOTT’s Director of R&D and Tech Support
page 6 CUSTOMIZED AND OEM PRODUCTS FROM SCHOTT
Looking for a supplier of gold coated substrates? Interested in having a
company logo on your microarray slides? Microarray Solutions outlines
®
some of the custom products and features now available in the Nexterion
product range.
page 7 TECHNICAL SUPPORT IN FOCUS – THE UNIVERSITY
OF LJUBLJANA
page 8 LATEST NEWS FROM SCHOTT
Microarray Solutions
SCHOTT North America Inc.
5530 Shepherdsville Road
Louisville, KY 40228
USA
Phone: +1- 502-657-4417
Fax: +1- 502-966-4976
E-Mail: coatedsubstrate@us.schott.com
www.us.schott.com/nexterion
2. Microarray Solutions page 2
General Manager Talk
Dear Reader,
Welcome to the latest edition of the “Microarray Solutions” newsletter, my first as
General Manager of the Microarray Solutions business at SCHOTT. You may recall my
name from a previous edition of the newsletter, in my capacity as Production Manager.
I recently took over the role of General Manager from Dr. Lutz Wehmeier, who has
been promoted to General Marketing & Sales Manager for SCHOTT Borofloat &
Aerospace. I very much look forward to being a part of the hugely successful
“Microarray Solutions” publication, as we continue to provide our readers with the latest
information on developments at SCHOTT Microarray Solutions and highlight some of
the interesting applications being developed by our customers.
Since the last edition of the newsletter, we have been working hard behind the scenes
to develop new, innovative products to further strengthen our position as the leading
supplier of microarray slides and accessories for DNA and protein microarrays. This
®
edition of “Microarray Solutions” will focus on SCHOTT’s new range of Nexterion
Slide NC nitrocellulose slides, as we continue to expand our range of slide surfaces
®
Christian Jabschinsky dedicated to protein microarraying. Nexterion Slide NC (nitrocellulose) was developed
General Manager in conjunction with Sartorius Stedim Biotech and the partnership has allowed SCHOTT
Nexterion – Microarray Solutions to rapidly introduce a high quality nitrocellulose slide to the market, complementing our
range of already well established substrates for protein microarrays. The article on
pages 4 and 5 expands on our relationship with Sartorius Stedim and provides details
of the nitrocellulose product range that we will offer from September 2007. We are very
confident that this will become a hugely popular product in the SCHOTT portfolio, and
we look forward to a long and successful partnership with Sartorius Stedim Biotech.
Other highlights from this edition of the newsletter include; an interview with SCHOTT
Microarray Solutions’ Director of Research & Development, information about our
customized products, and an interesting story about how our technical customer
support was able to assist a customer at the University of Ljubljana.
I hope that you enjoy reading this edition of “Microarray Solutions”, and thank you for
choosing SCHOTT as your preferred microarray substrate supplier.
Regards,
Christian Jabschinsky
General Manager – SCHOTT Microarray Solutions
3. Microarray Solutions page 3
SCHOTT Profile – Dr. Ruediger Dietrich – Director of R&D and Technical
Support at Microarray Solutions
MS: What are your responsibilities as Director of R&D at Microarray Solutions?
RD: The R&D Group at Microarray Solutions has three key responsibilities; provide
support to current and potential SCHOTT customers, identify and research new market
trends, and develop new products in collaboration with the marketing department.
Being successful with these three tasks requires close consultation and cooperation
with both the SCHOTT Sales Managers and Technical Support Specialists, who deal
directly with customers, and operate in the market on a daily basis. This allows my
R&D group to obtain feedback from the market very quickly. In addition to focusing on
customers and the market, it is also my responsibility to manage the R&D group and
create an exciting, challenging and innovative atmosphere to ensure that the group
enjoy their work and are motivated to produce the best possible results.
MS: What are the key projects you and your team have been working on in 2006?
RD: In R&D we continue to work on improving the sensitivity, reproducibility and overall
quality of our substrates and there were several projects in 2006 that reflected this
®
philosophy. There were two new product launches in 2006, Nexterion HiSens
substrates and Nexterion® MTP-96. The HiSens optical interference coating was
something we have worked on for some time, and we were really pleased by how well
it was received in the market. The MTP-96 microplate was really an extension of
SCHOTT’s desire to offer solutions for higher throughput microarraying and our
microtiterplate system was developed in conjunction with one of our key customers in
the U.S.
Developing substrates suitable for protein microarraying was identified as a key goal
for R&D in 2006, and this resulted in the co-development of a new nitrocellulose slide
with Sartorius Stedim Biotech. We also continue to work behind the scenes to improve
our current portfolio of microarray substrates e.g. increase batch sizes (for further
details see the news section), develop improved QC methods, improved packaging etc.
Developing accessories that will help users to obtain optimal results with our slides,
such as the new low evaporation buffers, the 70mer oligo microarraying kit and new
and improved protocols is another important area of focus for my group.
Dr. Ruediger Dietrich joined MS: And what kind of projects will you be working on in 2007/08?
SCHOTT as Director of R&D RD: We will continue to focus on developing new protein array surfaces, and optimized
around 2 years ago, after reagents, to ensure that SCHOTT is a leading player in supplying substrates for as
previously having worked in many protein array applications as possible. Resources will also be allocated to
academia at the Institute of developing optimized protocols and kits, and possibly new slide surfaces, for Array
Molecular Biotechnology in CGH as this has been identified as an increasingly popular application among our
Jena, and the Max Planck customers. SCHOTT R&D has also received a number of requests for customized
Institute for Biophysics in products in recent months, and we will continue to dedicate resources to this, in
Göttingen. addition to several other projects that at this stage have to remain confidential!
MS: From an R&D standpoint, what are the main challenges facing SCHOTT at
Microarray Solutions asks present? What is SCHOTT doing in response to these challenges?
Ruediger about the work of his RD: I would not say that there are any specific challenges that we have to confront
R&D team over the past year right now. We obviously have to continue to work hard to support our customers as
and sheds light on his R&D much as possible, and develop new and innovative products that will help SCHOTT
goals for the future… become the number one microarray substrate supplier. As with most R&D
departments, we have a wealth of ideas and projects to work on to ensure that we can
maintain our edge over the competition.
MS: What are the key trends you have noticed in the microarray world since you
joined SCHOTT? How has SCHOTT R&D responded to these trends?
RD: The microarray world seems to be constantly evolving with many customers
starting to focus on new applications such as miRNA arrays, aCGH, glycan arrays and
demanding more from substrate suppliers, both in terms of consistency and new
surfaces to offer superior performance. Examples of this include gold coatings for SPR
detection technology, optical interference coatings for increased sensitivity and
substrates with defined wells that allow analysis of several target samples
simultaneously, both in slide and microtiterplate format, for higher throughput
microarraying.
It has also been noticeable from interaction with our customers that microarrays are
moving closer to becoming accepted as a diagnostic tool, with some products already
having received FDA or other regulatory approval. This means that we have to strive to
offer the highest quality substrates and develop certification and quality assurances
systems such as the ISO 9001 certification gained by SCHOTT last year. With a view
to our products being used in diagnostics, for example, we worked hard to ensure that
the CVs for our MTP-96 product were well below 10%, a figure that has impressed
several customers in the diagnostic field.
4. Microarray Solutions page 4
SCHOTT Partners with Sartorius Stedim Biotech to Develop New Range of
Nitrocellulose Coated data / images Protein Microarrays
• Insert Slides for
Building on its position as the leading supplier of glass substrates for
DNA microarrays, SCHOTT is pleased to announce the launch of a new
range of nitrocellulose slides as part of its ongoing commitment to
providing high quality slide surfaces for protein microarrays. SCHOTT
has partnered with Sartorius Stedim Biotech to develop the new
Nexterion® Slide NC range, and will officially launch the product at the
Discovery to Diagnostics (D2D) conference in Philadelphia, on 17 – 19
September 2007.
Protein Microarray Market
Protein microarray technology provides a robust way to study protein function in a
rapid, economical, and system-wide fashion. The protein microarray market is growing
Fig. 1: rapidly as a result of the increased understanding of the involvement of proteins in
SCHOTT Nexterion® Slide NC-W and disease, and their use as diagnostic markers. Consequently, there is considerable
®
SCHOTT Nexterion Slide NC-D commercial and academic interest in developing protein microarrays for diagnostic
White and dark grey single pad applications and there has been a significant increase in demand for suitable glass
nitrocellulose slide
substrates over the past 18 months. However, many protein microarray applications
(see figure 2), such as ELISA format assays and reverse phase (micro-Western) arrays
using cell or tissue lysates, are difficult to perform on conventional two-dimensional
coated slides, for example Epoxy- or Amino-silane.
SCHOTT Substrates for Protein Microarrays
Fig. 2:
Typical application for Nitrocellulose SCHOTT launched its first dedicated slide surface for protein microarrays in 2004 with
slides: the introduction of Nexterion® Slide H. This permeable, three dimensional thin film
coating preserves the native three-dimensional structure of proteins, thereby
• ELISA format (sandwich assay) maintaining protein stability and functionality, and SCHOTT believed that the
experiments using antibody arrays exceptionally low non-specific binding made possible by this slide surface would make
• Reverse phase (micro-Western) it a very attractive alternative to nitrocellulose slides. In addition to Nexterion® Slide H,
arrays using cell or tissue lysates SCHOTT customers have also been successful in using standard two-dimensional
• Purified protein arrays slide surfaces, such as Epoxy, Aldehyde or Aminosilane for antibody and peptide
• Carbohydrate arrays arrays.
• Lipids While these slide surfaces have been successfully used for certain protein array
• Glycoproteins such as Lectins applications, the slide surface of choice for many protein applications is undoubtedly
nitrocellulose. Nitrocellulose membranes have proven to be a reproducible substrate
for protein detection for decades, with applications ranging from Western Blots to
diagnostic tests. After extensive market research SCHOTT decided the time was right
®
to add a range of high quality nitrocellulose slides to the Nexterion slide portfolio.
Alistair Rees, Product Manager at Partnership with Sartorius Stedim Biotech
SCHOTT Microarray Solutions
commented: When SCHOTT decided to launch a range of nitrocellulose slides, it was agreed that
the fastest way to market would be to partner with a company with extensive expertise
“The Nexterion® Slide NC range was in Nitrocellulose manufacturing. Sartorius Stedim Biotech quickly emerged as a leading
developed in response to customers candidate for such a partnership thanks to over seventy years experience in
approaching SCHOTT looking for a nitrocellulose production and its significant expertise in membrane production for
high quality alternative to the diagnostic applications, such as lateral flow diagnostic tests. SCHOTT believed that
nitrocellulose slides currently on the this kind of technical expertise would prove invaluable, particularly as microarray slides
market. We are confident that this move into the demanding diagnostic arena.
product range will have a real impact
in the market”.
Product Development
The performance of nitrocellulose-coated slides is strongly dependent on the internal
membrane structure as well as surface quality and SCHOTT and Sartorius Stedim
Biotech focused heavily on combining competencies to address this issue. The
®
Nexterion NC slides use a nitrocellulose coating developed by Sartorius Stedim
Biotech specifically for protein microarray applications and this is applied to high quality
®
Nexterion glass substrates. The three-dimensional structure and pore size has been
5. Microarray Solutions page 5
optimized to offer a high binding affinity for proteins and to better stabilize their active
conformation. The slide membranes are also manufactured using a newly developed
casting process, where solvents evaporate from a mix of different cellulose nitrate
polymers and additives to form the unique micro-porous structure. The thickness and
physical characteristics of the coating are tightly controlled during manufacture and
this, together with a sophisticated surface finishing process, enables us to produce
slides with exceptional reproducibility. With many nitrocellulose slide users feeling
disillusioned with their current nitrocellulose slide suppliers, typically complaining of
poor product reproducibility and consistency and long lead times, SCHOTT is now able
to fill this void by offering a new range of nitrocellulose slides demonstrating
outstanding consistency and performance.
Innovative Dark Grey Membrane
Fig. 3:
The new SCHOTT Nitrocellulose slides In addition to the standard white nitrocellulose surface typically used for protein
have significantly lower background signals microarray applications, SCHOTT can now offer an innovative dark grey membrane
than the market leading slide slide (see figure 1). This newly developed surface offers a very low, and homogenous
auto-fluorescence to achieve a significantly improved dynamic range. Conventional
white nitrocellulose films scatter and reflect large amounts of excitation and emission
light, leading to high background fluorescence. To overcome this problem, Sartorius
Stedim Biotech has developed a new process to generate grey membranes which
absorb the scattered light, significantly reducing the background auto-fluorescence
thus offering a very low and homogenous auto-fluorescence to achieve a significantly
improved dynamic range (see figure 3).
Product Range
SCHOTT will initially offer Nexterion® Slide NC (Nitrocellulose) slides in two formats,
single pad and 16-pad slides. The pad dimensions and locations conform to the
industry standard, with the well spacing of the 16 array pads making the NC-W/D slide
fully compatible with standard microarray printing instruments (see figure 4). Both
these formats will be available with either dark grey or white Nitrocellulose pads
(Ordering details are shown in the table below).
Outlook
SCHOTT will consult closely with the market over the next few months with a view to
developing the next generation of Nexterion® Slide NC products. In line with our
commitment to offer customers solutions for high throughput microarraying, this might
include a 96-pad Nitrocellulose SBS microplate format or other slide formats such as 2-
pad or a barcoded 14-pad slide.
Fig. 4:
® By adding the Nexterion® Slide NC range to our product portfolio, SCHOTT is now able
Dimensions of Nexterion Slide NC
to offer the most diverse range of high quality glass substrates for DNA and protein
microarraying. It also demonstrates our commitment to developing new and innovative
slide surfaces for protein microarray applications, complementing the already widely
used Nexterion® Slide H and traditional two-dimensional slide surfaces.
Item Color of nitrocellulose Number Size of Code Quantity Material
of pads pads 128 per pack number
per [mm] label
slide Barcode
®
Nexterion Slide NC-W White 1 21 x 51 Yes 20 1178057
Nexterion® Slide NC-D Dark grey 1 21 x 51 Yes 20 1178058
®
Nexterion Slide NC-W 16 White 16 6x6 No 10 1178059
®
Nexterion Slide NC-D 16 Dark grey 16 6x6 No 10 1178060
®
5-slide evaluation packs of all slides in the Nexterion Slide NC range will soon
be available. Please contact your local Nexterion® sales representative or
distributor for further information.
6. Microarray Solutions page 6
Did you know that SCHOTT can offer Glass Substrates in Custom Formats,
or as an OEM Product?
The manufacture of special technical glasses is one of the SCHOTT group’s core
competencies. SCHOTT produces an extremely wide range of technical glasses,
including borosilicate type, optical, and fused silica. In addition, SCHOTT has
extensive experience in high technology glass processing methods. SCHOTT
Microarray Solutions is able to take full advantages of SCHOTT’s entire product
range and facilities to offer customers in the life science market substrates in
custom formats or OEM products tailor-made for specific applications. The
customization may range from simply supplying a unique barcode sequence on
®
standard Nexterion slides, to a custom coated substrate for a microfluidic chip
application.
Glass Types and Formats
The SCHOTT group produces several hundred different types of glass. Typical glasses
used in life science products include, BOROFLOAT® 33, D263T, BK7, B270, and fused
silica wafers. The format of these substrates tends to be standardized around SBS
microplate, microscope slide, or coverslip formats, presumably as a result of
standardized laboratory hardware. SCHOTT can offer these standard formats, as well
as other sizes in rectangular, square or circular shapes. The range of glass
thicknesses available is very wide, ranging from 0.03 up to 25.4 mm (depending on the
Examples of custom products include:
glass type). Substrates may be laser cut into the final size, or partially diced to allow
• Glass bottomed microplates
the separation of individual components at a later time.
• Glass plates for gel electrophoresis
• Microfluidic chip substrates Further Glass Processing
• Coated coverslips for DNA analysis, Along with the more traditional glass processing methods, such as cutting, grinding,
sequencing or gene expression polishing and water jet cutting. SCHOTT has invested heavily in new technologies,
• Optical coated substrates for label free such as ultrasonically enhanced drilling for high precision circular holes (400•m up to
detection systems 3 mm). SCHOTT also has sand blasting capabilities, allowing us to create round and
• Conductive Maldi substrates rectangular holes, caverns and channels in the glass ranging from 30•m up to 1.5 mm.
• SPR biosensors
• Small microarray substrates for use in Custom Coatings
microfuge tubes Applying thin-film coatings to glass is another SCHOTT core competence. Production
takes place in a class 100 clean room environment at the SCHOTT Microarray
Solutions facility in Jena, Germany. Our quality control system also conforms to the
ISO 9001-2000 standard, guaranteeing extremely high quality standards for surface
finish, flatness, parallelism and absence of surface defects. The coating technologies
available include dip coating, chemical vapour deposition (CVD), sputter, solvent based
reactor method, and spin-coating. Any of the standard microarray slide format
®
Nexterion functional coatings can be applied to just about any custom format.
SCHOTT Microarray Solutions is also able to coat glass with coating chemistries
developed by third parties, allowing you the opportunity to outsource this function to
SCHOTT.
Over the past 12 months, SCHOTT has received an increasing number of enquiries
about inorganic coatings on glass, such as gold and other metallic coatings. These
can be used as conductive MALDI substrates, or for surface plasmon resonance (SPR)
biosensors. SCHOTT’s long-standing reputation for excellence in optics has lead to the
development of optical and reflective multi-layer dielectric coatings optimised for
enhancement of signals from the fluorescent dyes typically used in life science
®
research (for example Nexterion HiSens). SCHOTT has also been building up
expertise in the area of nanoparticle technology, working with customers and our
corporate R&D facility in Mainz, Germany to develop the next generation of glass
substrates.
Logos, Fudicial Marks, and Barcodes
Finally, SCHOTT can offer customers the opportunity to customise their slides and
substrates with graphics, logos, company names, barcodes or 2-D barcodes. These
Please contact us to find out how markings may be added at any location on or within the glass surface, and may feature
we can help you to develop a a combination of items, for example a logo with a barcode. SCHOTT can offer a
custom product tailored to your number of methods for marking the glass substrates. The laser bonded foil method
specific requirements! produces robust surface markings in black and other colours. A method of printing with
hydrophobic ink can be used to produce graphics, logos, as well as multi-well patterns.
The Laser ablation process produces marks on the surface of the glass. A four
method, called laser-induced internal marking, introduces markings by the creation of
micro cavities within the glass. Markings applied by any of these four methods are
robust enough to withstand standard hybridisation and washing procedures.
7. Microarray Solutions page 7
Technical Support in Focus – University of Ljubljana and the use of the
SCHOTT Nexterion® 70mer Oligo Kit
®
Nexterion 70-mer Oligo Arraying Kit “Microarray Solutions” looks back on an interesting technical support
troubleshooting case addressed by Dr. Ruediger Dietrich with the University of
In 2005, SCHOTT Microarray Solutions Ljubljana in Slovenia earlier this year. Vid Mlakar, a long-term user of SCHOTT’s
® ®
and OPERON Biotechnologies pooled Nexterion Slide E epoxysilane coated substrate in the Nexterion 70mer oligo
together their technical expertise in the kit, contacted Ruediger for advice with a new project where he intended to
microarray field to develop a complete produce an array with 13600 spots on one slide. His project was to look for
kit-based solution for high quality self-
cancer and apoptosis marker gene expression for medical diagnosis. For Mr.
spotted microarrays, comprising of
oligonucleotide sets, optimized Mlakar, this would be a higher density array than he had worked on in the past
microarray slides and reagents. and consequently a number of issues came to the fore, including printing buffer
selection and the consequent effect on spot size and evaporation, spot
The 70mer Oligo Arraying Kit morphology and the number of pre-spots required if working with a viscous
components cover the most important printing buffer.
steps of the microarray process chain:
spotting, blocking, hybridization and Print Buffer Selection – How to Control Evaporation Over Long Printing Runs
washing. All the reagents were
The Nexterion® 70-mer Oligo Arraying Kit from SCHOTT provides the user with
optimized for the use of OPERON 70mer
probes (although the kit can also be printing, blocking and hybridization solutions that have been optimized for Nexterion®
used with oligo probe sets from other Slide E. Mr. Mlakar purchased such a kit from SCHOTT and, in close consultation with
manufacturers). the company, began an evaluation using the standard 70-mer kit low evaporation
spotting buffer, Nexterion® Spot LE. The customer’s print run was expected to last
several days and therefore a low evaporation printing buffer, which keeps the
concentration of the oligos more or less constant, appeared to be the perfect solution.
University of Ljubljana Set-Up Ruediger Dietrich advised the customer on optimal printing conditions, recommending
a printing humidity of 60 - 65% to help reduce evaporation without having a detrimental
®
Slide Surface: Nexterion Slide effect on the slide surface. Vid Mlakar found 60% to be optimal and reported back to
E(poxysilane) SCHOTT that he was very happy with low evaporation properties offered by Nexterion®
®
Printing Buffer: Nexterion Spot LE Spot LE, but did express some concern with spot sizes using Micropot 10K split pins.
Probe: Operon 70mer Print Buffer Selection – How to Obtain the Desired Spot Size
oligonucleotides The customer was looking to obtain smaller spot sizes than he had initially obtained
Immobilization Protocol: SCHOTT with Nexterion® Spot LE, as he was unable to achieve the density he required for his
70mer oligo arraying kit protocol application (Spot LE is a low evaporation spotting buffer containing a fixed amount of
detergent which meets the needs of most customers). Mr. Mlakar consulted with
Arrayer: GS MicroGrid SCHOTT to address this issue and Ruediger decided to send him a Nexterion® LEB
Pin Type: Microspot 10K split pin Kit. This kit was designed to accommodate the needs of customers that require specific
®
spot sizes and comprises the Nexterion Spot LE printing buffer, plus a detergent
Printing Conditions: 60% RH solution that allows the customer – guided by additional information about the
Hyb Protocol: Tecan optimized correlation of the detergent concentration to the spots size in a worksheet - to add the
protocol provided by SCHOTT appropriate detergent concentration to Spot LE to obtain the desired spot size. Vid
Mlakar was able to quickly establish the appropriate detergent concentration for his
Hyb Station: Tecan HS480 high density array, achieving a spot size of 60 – 70µm. When scanning at 4 µm
Scanner: Tecan LS200 resolution with his Tecan scanner, he was now able to see 80-100 data points, which
he felt was sufficient for reliable data analysis. He was now in a position where he felt
Software: ArrayPro very confident using the Nexterion® 70-mer Oligo Arraying Kit for his new application.
Selecting Optimal Hybridization Conditions with the Tecan Hyb Station
Now that the printing issues on Nexterion® Slide E had been addressed to the
“I would like to inform you that we customer’s satisfaction, Mr. Mlakar expressed an interest in working with SCHOTT to
successfully printed 162 arrays with ascertain the optimal hybridization conditions for his application. He uses an automated
your chemistry. We have also hybridization system from Tecan, which enables him to standardize this process, but
performed a successful hybridization the original Slide E protocol only included instructions for customers performing manual
with these slides using the Tecan hybridizations. In order to benefit from using the hyb station, Mr. Mlakar was interested
HS400 hybridization station and the in finding out more information from SCHOTT on buffers, incubation times, flow rates
protocol that you provided…So thanks
etc., which would enable him to obtain the same, or even better, results than he had
again for all the help you provided I am
now very happy with the arrays.”
previously seen with his lower density arrays. Fortunately SCHOTT had already
developed a modified version of the standard protocol for the use of hyb stations and
Vid Mlakar, the University of this protocol worked extremely well in Vid Mlakar’s hands. He was able to consistently
Ljubljana obtain low background and see a nice distinction between spots and background.
Conclusion
The University of Ljubljana is a good example of a successful technical support
collaboration with a customer. Although it is very difficult to solve all customer
troubleshooting issues in this manner, SCHOTT has been able to support many
customers over the years, thanks to its strong commitment to offering full-time
8. Microarray Solutions page 8
®
technical support to all Nexterion slide users. We now have a wealth of knowledge
and experience, both from work that has been carried out in-house and from our
interactions with customers willing to share their experiences and know-how. SCHOTT
For your enquiries please contact customers should therefore feel free to contact SCHOTT either before, during or after
Jami Lomax ®
their experiments with Nexterion slides knowing that they will get an immediate
(jami.lomax@us.schott.com)
response (typically the same day, or worst case within 2 business days). Whether it be
protocol optimization, troubleshooting or any other technical issue, SCHOTT
Microarray Solutions is here to support you and ensure that you are able to obtain
optimal performance from our microarray slides and accessories.
SCHOTT Microarray Solutions News
Increase in Nexterion® Slide E Batch Sizes
Despite the extremely low batch-to-batch variation observed with SCHOTT slides,
some customers prefer to purchase all their slides for a specific project or print run
from a single production batch. We are pleased to announce that we have successfully
implemented an upgrade in the Nexterion® Slide E production process. The upgrade
®
will allow us to provide customer with up to 4,000 Nexterion Slide E slides from one
coating batch. Please contact SCHOTT for further details.
®
New Nexterion Slide H 25-slide Mailer Boxes
SCHOTT is pleased to announce that Nexterion® Slide H will now be supplied to
Fig.: 5 customers in new 25-slide mailer boxes (see figure 5). These boxes replace the 5 x 5-
®
Nexterion Slide H in 25 slide box slide mailer boxes previously used. This change will greatly reduce the slide, and box
handling required during the setting up of large print runs.
Conference and Exhibition Calendar 2007/08
Event Location Date Weblink
Discovery-2- Philadelphia, PA / September 17 - 19, www.ibclifesciences.com/D3176/6097.xml
Diagnostics USA 2007
ASHG Annual meeting San Diego, CA / USA October 23 - 27, 2007 www.genetics.faseb.org/genetics/ashg/menu-
annmeet.shtml
LabAutomation Palm Springs, CA / January 27-29, 2008 www.labautomation.org/LA08/
USA
Statusseminar Frankfurt / Germany January 31 - www.events.dechema.de/events/Tagungen/
Chiptechnologie 2008 February 1, 2008 Statusseminar+Chiptechnologien.html
ISAFG 2008 Edinburgh/UK April 7 – 9, 2008 www.ark-genomics.org/ISAFG/
Advances in Microarray Barcelona/Spain May 7 - 8, 2008
Technology
If you are interested in presentations given by SCHOTT at past conferences please
contact us (coatedsubstrates@us.schott.com).