Details of Vitamin E and K

1. VITAMINE
AND
VITAMINK
PREDENTED BY –
MUKUL TAMBE

2. VITAMIN E
 Fat soluble
 Tochopherol
 Vitamin in search of disease
 Anti-sterility vitamin
 Natural Antioxidant

3. VITAMIN E
CHEMISTRY:
About 8 tochopherols of Vit. E
Most active are α, β,γ-
tochopherol

4. DIETARY SOURCES:
1. Primary: Wheat gram oil, Cotton seed oil,
Peanut oil, Sunflower Oil etc.
2. Secondary: Meat, Milk, Egg Yolk.

5. NORMAL REQUIREMENT & RDA:
1. Infants : 4-5 mg/day
(0 to 6 months)
2. Children : 6 to 11 mg/day
(1 to 14 yrs)
3. Adults : 15 mg/day
 RDA: 10mg/day

6. ABSORPTION
TRANSPORT &
STORAGE:
A- Small intestine with fats &
bile salts
T- Liver through LDL & VLDL
S- Adipose tissues of Liver

7. BIOCHEMICAL FUCTIONS:
1. Essential for Membrane structure & integrity
(MEMBRANE ANTIOXIDANT)
2. Prevents oxidation of PUFA & RBC from
Haemolysis
3. Closely associated with Reproductive Function
4. Synthesis of haem by enhancing activity of enzyme
δ-aminolevulinic acid (ALA)synthatase & ALA
dehyratase
5. Cellular respiration through electron transport chain

8. 6. Prevents oxidation of Vit. A & carotenes
7. Storage of creatinine in skeletal muscle
8. Optimal absorption of A.A. from intestine
9. Synthesis of neucliec acids
10. Protection of liver from toxic compounds like
CCl4
11. With association with Vit. A,C & β-
carotene to delay Cataract
12. Prevention of cronic diseases like Cancer

9.  DEFICIENCY SYMPTOMS:
Degenerative changes in muscle
Megaloblastic anaemia
Changes in CNS
Sterility
TOXICITY:
Least toxic

10. VITAMIN K
Fat soluble
Coagulation of blood
German word-Koagulation
 Naphthoquinone derivatives- K1, K2, K3

11. VITAMIN K

12. DIATORY SOURCES:

13. NORMAL REQUIREMENT & RDA:
Infants : 10 to 20 micrograms/day
Children :15 to 100 micrograms/day
14 to 25 yr old Men: 120 micrograms/day
Adult Wemen : 90 micrograms/day
RDA : 70 to 140 microgram/day

14. ABSORPTION
TRANSPORT &
STORAGE:
A- Along with Fats(chylomicrons) & bile salts
T- along with LDL
S- liver & other tissues

15. BIOCHEMICAL FUNCTIONS:
1. Blood clotting:

16. 2. Coenzyme for carboxylation of glutamic acid
3. Conversion of glutamate(Glu) to
γ-carboxyglutamate (Gla) by dicumarol

17. Deficiency Diseases:
Incrased blood clotting time
Hypervitaminosis:
Haemolytic anaemia
Jaundice

18. THANK YOU!!